Screening of child health reserves by the local immunity indices

N. Kh. Amirov; D. I. Sadykova; O. I. Pikuza

doi:10.17816/kazmj65265

Screening of child health reserves by the local immunity indices

Kazan medical journal ◽

10.17816/kazmj65265 ◽

2001 ◽

Vol 82 (2) ◽

pp. 81-83

Author(s):

N. Kh. Amirov ◽

D. I. Sadykova ◽

O. I. Pikuza

Keyword(s):

Child Health ◽

Sensitive Indicator ◽

Anthropogenic Influences ◽

Independent Group ◽

Local Immunity ◽

Inflammatory Processes ◽

Indicator Systems ◽

Special Relevance ◽

Real Danger

Under the conditions of an increasing ecologically unfavorable situation and the increasing influence of a large number of anthropogenic influences, the resistance of the child's body decreases, which inevitably manifests itself in an increase in morbidity [5]. In recent years, the so-called eco-dependent states, which affect the nature of the course of many pathological processes, have been allocated to an independent group [1,2]. Thus, more and more often, inflammatory processes in children are initially low-symptom, without causing a real danger, but later on, the manifestation of the disease, which threatens the child's life, quickly occurs [4]. Therefore, the tactics of prenosological diagnostics based on the development of new sensitive indicator systems for testing health reserves is acquiring special relevance.

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CHRONIC ENDOMETRITIS AS A СAUSE OF DISORDERS OF THE FEMALE REPRODUCTIVE FUNCTION

Health and Ecology Issues ◽

10.51523/2708-6011.2015-12-3-2 ◽

2015 ◽

pp. 9-16

Author(s):

Yu. A. Lyzikova

Keyword(s):

Risk Factors ◽

Reproductive Function ◽

Receptor Expression ◽

Immunohistochemical Method ◽

Main Role ◽

Reproductive Disorders ◽

Local Immunity ◽

Chronic Endometritis ◽

Inflammatory Processes

The review deals with the main role of chronic endometritis in the genesis of disorders of the female reproductive function and reveals the etiologic risk factors for the development and starting mechanism of chronic inflammatory processes in the endometrium, features of the pathogenesis and clinical picture of chronic endometritis. The work shows the importance of diagnosis of chronic endometritis with immunohistochemical method, reasonability of immunohistochemical research for the assessment of receptor expression and expressiveness of local immunity in the endometrium, the necessity of detection of fertility alpha-2-microglobulin (AMGF) protein for prediction of reproductive disorders.

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THE LEVEL OF ANTIVIRAL ANTIBODIES AND INDEXES OF LOCAL IMMUNITY INTHE DYNAMICS OF THE TREATMENT OF CHILDREN WITH GLOMERULONEPHRITIS IN THE PRESENCE OF HERPESVIRAL INFECTION

Ukrainian Journal of Nephrology and Dialysis ◽

10.31450/ukrjnd.3(51).2016.02 ◽

2016 ◽

pp. 22-27

Author(s):

V. Kruglikov ◽

І. Bagdasarova ◽

І. Kruglikova ◽

Е. Kornilina

Keyword(s):

Antiviral Therapy ◽

Standard Therapy ◽

Antiviral Treatment ◽

Antiviral Agents ◽

Healthy Individuals ◽

Active Infection ◽

Local Immunity ◽

Latent Stage ◽

Inflammatory Processes ◽

Apparently Healthy

The aim of the work was to study of indicators characterizing the state of local immunity, tension of specific immunity in children with variousforms of glomerulonephritis (GN) by presence of herpesviral infection (HVI) in the dynamics oftreatment using antiviral therapy. Materials and methods. A quantitative assessment of the content of slgA, SLPI, MCP-1 and IL-8 in the urine of 37 patients with glomerulonephritis and 10 apparently healthy individuals was conducted. In serum of blood were determined specific IgGand IgMantibodies to HSV, CMVand EBV. Results. The most common HVI was caused by EBV (78,4%) in children with GN. The use of antiviral therapy helped to reduce the level ofspecific IgGin the blood ofchildren with GN in 86.1%of the active (reactivated) HVIand in 38,9% - below the diagnostically significant parameters. Inclusion of antiviral agents to standard therapy of GNpatients in the presence of HVI can reduce the level of MCP-1 and IL-8 in the urine, which indicates the reduction of inflammatory processes in the kidney. There was noted an increase in urine the slgA and SLPI concentrations due to antiviral treatment, but these changes were within the physiological norm, in contrast to patients who had received only standard therapy, which were determined by considerably exceeding the norm value. Conclusion. Appointment of antiviral therapy leads to a transitionfrom active infection to the latent stage of theflow, which improves the clinical condition.

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Immunoglobulin A and its selective deficiency

Kazan medical journal ◽

10.17750/kmj2017-809 ◽

2017 ◽

Vol 98 (5) ◽

pp. 809-813 ◽

Cited By ~ 1

Author(s):

O V Moskalets

Keyword(s):

Literature Review ◽

Primary Immunodeficiency ◽

Laboratory Testing ◽

Patient Management ◽

Clinical Presentation ◽

Immunoglobulin A ◽

Local Immunity ◽

True Prevalence ◽

Inflammatory Processes ◽

Methods Of Treatment

Immunoglobulin A plays a key role in local immunity preventing microorganism adhesion and its activity. Besides, it participates in virus and antigenes neutralizing. In the blood Immunoglobulin A circulates predominantly as a monomer, and at secretion as dimer in complex with S-component. Transitory decrease of Immunoglobulin A develops in different states: infectious and inflammatory processes, allergies, tumors. Specific disease is selective Immunoglobulin A deficiency which is a primary immunodeficiency. It is considered the most prevalent primary immunodeficiency but its true prevalence is unknown as in most cases it is asymptomatic and is revealed accidentally at laboratory testing. No specific methods of treatment of selective Immunoglobulin A deficiency exist. The literature review contains data on the character of the pathology, clinical presentation and tactics of patient management.

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Inflammageing in the cardiovascular system: mechanisms, emerging targets, and novel therapeutic strategies

Clinical Science ◽

10.1042/cs20191213 ◽

2020 ◽

Vol 134 (17) ◽

pp. 2243-2262

Author(s):

Danlin Liu ◽

Gavin Richardson ◽

Fehmi M. Benli ◽

Catherine Park ◽

João V. de Souza ◽

...

Keyword(s):

Cardiovascular Diseases ◽

Cardiovascular System ◽

Nlrp3 Inflammasome ◽

Molecular Mechanisms ◽

Molecular Targets ◽

Therapeutic Interventions ◽

Low Grade ◽

Cardiovascular Research ◽

Inflammatory Processes ◽

Ach Receptors

Abstract In the elderly population, pathological inflammation has been associated with ageing-associated diseases. The term ‘inflammageing’, which was used for the first time by Franceschi and co-workers in 2000, is associated with the chronic, low-grade, subclinical inflammatory processes coupled to biological ageing. The source of these inflammatory processes is debated. The senescence-associated secretory phenotype (SASP) has been proposed as the main origin of inflammageing. The SASP is characterised by the release of inflammatory cytokines, elevated activation of the NLRP3 inflammasome, altered regulation of acetylcholine (ACh) nicotinic receptors, and abnormal NAD+ metabolism. Therefore, SASP may be ‘druggable’ by small molecule therapeutics targeting those emerging molecular targets. It has been shown that inflammageing is a hallmark of various cardiovascular diseases, including atherosclerosis, hypertension, and adverse cardiac remodelling. Therefore, the pathomechanism involving SASP activation via the NLRP3 inflammasome; modulation of NLRP3 via α7 nicotinic ACh receptors; and modulation by senolytics targeting other proteins have gained a lot of interest within cardiovascular research and drug development communities. In this review, which offers a unique view from both clinical and preclinical target-based drug discovery perspectives, we have focused on cardiovascular inflammageing and its molecular mechanisms. We have outlined the mechanistic links between inflammageing, SASP, interleukin (IL)-1β, NLRP3 inflammasome, nicotinic ACh receptors, and molecular targets of senolytic drugs in the context of cardiovascular diseases. We have addressed the ‘druggability’ of NLRP3 and nicotinic α7 receptors by small molecules, as these proteins represent novel and exciting targets for therapeutic interventions targeting inflammageing in the cardiovascular system and beyond.

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