Thrombotic complications and changes in the hemocoagulation system in acute myocardial infarction

1982 ◽  
Vol 63 (5) ◽  
pp. 7-9
Author(s):  
L. A. Shcherbatenko ◽  
S. Z. Gabitov ◽  
I. E. Voronina ◽  
R. I. Litvinov
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Blood Coagulation ◽  
Disseminated Intravascular Coagulation ◽  
Coagulation System ◽  
Blood Coagulation System ◽  
Maximum Activation ◽  
Great Vessels ◽  
Anticoagulant System ◽  
Thrombotic Complications

A natural relationship was revealed between the incidence of thrombotic complications and changes in the indicators of the blood coagulation system in patients with acute myocardial infarction. The totality of tests revealed two periods of maximum activation of the blood coagulation system, combined with inhibition of the anticoagulant system, on the 3-5th and 9-17th days of illness. These periods coincide with the time of the maximum incidence of thrombosis of the great vessels, disseminated intravascular coagulation and recurrence of myocardial infarction.

Effect Of Intracoronary And Systemic Thrombolysis With Streptokinase In Patients With Acute Myocardial Infarction And Unstable Angina Pectoris. On Coagulation Tests And Plasminogen

1981 ◽  
Author(s):  
H Kösteriag ◽  
K L Neuhaus ◽  
U Kasten ◽  
J Schrader ◽  
U Artmann ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Blood Coagulation ◽  
Coronary Arteries ◽  
Bleeding Complication ◽  
Coagulation System ◽  
Bleeding Complications ◽  
Small Decrease ◽  
Mean Values ◽  
Systemic Thrombolysis

Streptokinase, aplicated by intracoronary infusion in pat. with acute myocardial infarction has proven to be successfull in recanalisation of occluded coronary arteries. The good clinical, angiographic, chemical and EKG results suggests that jeopardized myocardium was salvaged by acute recanalisation. Till now, we infused Streptokinase (about 2000 U/min) in 78 pat. into the ischemia related occluded coronary artery. In this presentation we intend to demonstrate the results of these pat. and of a study, done before starting intracoronary Streptokinase infusion to be safe for bleeding complication. Neither after the infusion of 50 000 U.(n = 24) of 100 000 U. (n = 15) nor in 20 pat. who received SK equal to their ASTK-titres plus 50 000 U. SK whe found severe alterations of the blood-coagulation system. Only in the last group there was a small decrease of Fibrinogen of about 100 mg% and of Plasminogen 4 mg%. In none of the 78 pat., treated by intracoronary SK aplication, we resulted bleeding complication and the mean values of blood coagulation test remained within the normal range. On the other hand, we infused SK by veins and controlled the thrombolytic effect by coronarangiography. In 5 of 6 pat. we succeded in recanalisation of occluded coronary arteries within 45 Used very high dosages of SK, (about 2 Mill U) there was only a small decrease of 210 mg of Fibrinogen and no bleeding complications.

The course of pregnancy and blood coagulation system

2016 ◽  
Vol 3 (4) ◽  
pp. 181-187
Author(s):  
A. V Murashko ◽  
Yuliya S. Drapkina ◽  
N. S Koroleva
Keyword(s):  
Tissue Factor ◽  
Blood Coagulation ◽  
Coagulation Factors ◽  
Medical Intervention ◽  
Coagulation System ◽  
Protein Z ◽  
Blood Coagulation System ◽  
High Prevalence ◽  
Thrombotic Complications ◽  
Hemostatic Disorders

Pregnancy represents the procoagulant state, giving rise in the high prevalence rate of thrombotic complications. An imbalance between coagulation and anticoagulation systems of blood during pregnancy can lead to the development of pre-eclampsia, intrauterine growth retardation, preterm labor, premature rupture offetal membranes and fetal death. These complications are mostly caused by the impaired generation of thrombin as well as changes in the concentration and activity of tissue factor TFPI (tissue factor pathway inhibitor), TAT III complex and protein Z. Nevertheless, it should be noted that the thrombotic complications during pregnancy depend not on the elevation of the concentrations of specific coagulation factors or lack of the activity of anticoagulant proteins, but on the shift in the whole system toward the procoagulant state. These disorders most of all lead to thromboses ofplacental vessels, causing disorders ofperfusion of the affected area. Placental pathology can develop as from the maternal as from the fetal side. Despite the fact that changes in the blood coagulation system occur from the very beginning of pregnancy, and often are adaptive in nature, i.e., do not require special medical intervention, the prompt diagnosis and treatment of hemostatic disorders as main pathogenetic link in the development of thrombosis is extremely important.

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