Inhibitors of proteolysis and plasminogen of blood serum in parturient women with an uncomplicated course of the postpartum period

1998 ◽  
Vol 79 (2) ◽  
pp. 135-136
Author(s):  
N. N. Semenkov ◽  
V. S. Gorin ◽  
S. G. Zhabin ◽  
L. V. Renge ◽  
N. G. Potekhin
Keyword(s):  
Blood Serum ◽  
Postpartum Period ◽  
Practical Interest ◽  
Point Of View ◽  
Markers Of Inflammation

Recent studies have shown that proteolysis inhibitors can be regarded as markers of inflammation with immunoregulatory properties. From this point of view, the study of inhibitors of proteinases in blood serum of puerperas with an uncomplicated course of the postpartum period is of great scientific and practical interest.

scholarly journals AB0827 SERUM NESPHATIN-1 IN PATHOGENESIS RHEUMATOID ARTHRITIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1437.2-1438
Author(s):  
T. Kvlividze ◽  
V. Polyakov ◽  
В. Zavodovsky ◽  
Y. Polyakova ◽  
L. Seewordova ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Blood Serum ◽  
Inflammatory Cytokines ◽  
Inflammatory Markers ◽  
Healthy People ◽  
Healthy Individuals ◽  
Markers Of Inflammation ◽  
High Level ◽  
Pro Inflammatory Cytokines

Background:Interest in highly specialized tissue cytokines contributed to the discovery of new biologically active molecules. Nesfatin-1 (NF) - discovered in 2006 as an anorexigenic factor. NF-1 is believed to be involved in the regulation of energy homeostasis by regulating appetite and water intake. The role of NF-1 in the pathogenesis of inflammatory diseases is poorly understood. Recently, studies have found a relationship between an increased level of NF-1 and inflammatory markers in various pathologies.Objectives:Study of the level of nesfatin-1 in the blood serum of healthy people, determination of the correlation between the level of NF-1 with the severity of clinical symptoms and classic markers of inflammation in patients with RA.Methods:120 persons were examined: 90 patients with RA and 30 healthy people. All patients underwent a complete clinical and laboratory examination. Plasma NF-1 levels were determined using commercial test systems (RaiBiotech, cat # EIA-NESF) according to the manufacturer’s instructions. Patients with various forms of RA were comparable in age to the group of healthy individuals. Statistical processing of clinical examination data was carried out using the “STATISTICA 10.0 for Windows” software package. Quantitative data were processed statistically using the parametric Student’s t-test, qualitative data using the non-parametric chi-square test. The significance of differences between groups was determined using analysis of variance. The results were considered statistically significant at p <0.05.Results:The average level of NF-1 in blood serum in healthy individuals was 31.79 ± 3.21 ng / ml (M ± σ). The level of normal NF-1 values in healthy individuals, defined as M ± 2σ, ranged from 25.3 to 37.83 ng / ml. There was no significant difference in the levels of circulating NF-1 and BMI in healthy individuals and patients with RA (p> 0.05). The inverse relationship of a lower level of NF-1 with an increase in BMI was not significant.Group 1 (66 patients with RA) with increased serum NF-1 levels (> 37.83 ng / ml), and group 2 (44 patients) with normal values (<37.83 ng / ml). A high level of NF-1 was characteristic for patients with high activity according to DAS28, RF seropositive, ACCP-positive, with extra-articular manifestations, who had been ill for 10 years or more. A reliable relationship between the level of NF-1 in the blood serum and laboratory parameters of RA activity - ESR, CRP, was shown, and secondary synovitis was more common. Our data show a direct correlation between the NF-1 level of the pro-inflammatory markers of RA.Conclusion:The positive correlation between the level of NF-1 and classical markers of inflammation, such as CRP and ESR, confirms the involvement of NF-1 in the pathophysiology of inflammation in RA. This is also evidenced by the correlation of a high level of NF-1 in the blood serum with a more severe clinical picture of RA. It is known that NF-1 can promote the release of pro-inflammatory cytokines such as interleukin-8 (IL-8), interleukin-6 (IL-6), and macrophage inflammatory protein-1a (MIP-1a) in the chondrocytes of RA patients.It is necessary to further study the role of NF-1 in the pathogenesis of systemic inflammatory reactions and the possibility of targeting pro-inflammatory cytokines, the possibility of regulating the level of NF-1 by drugs.References:[1]Kvlividze T.Z., Zavodovsky B.V., Akhverdyan Yu.R. Kvlividze T.Z., Zavodovsky B.V., Akhverdyan Yu.R., Polyakova Yu.V., Sivordova L.E., Yakovlev A.T., Zborovskaya I.A. Serum nesfatin -1 as a marker of systemic inflammation in rheumatoid arthritis. Klinicheskaya Laboratornaya Diagnostika (Russian Clinical Laboratory Diagnostics). 2019; 64 (1): 53-56 (in Russ.).Disclosure of Interests:None declared

Gorald Enell. "Stomach ulcers". Library of the Practical Physician, Vol. 30. Giz. 1929, 123 pages, price 1 p.

1929 ◽  
Vol 25 (5) ◽  
pp. 582-583
Author(s):  
R. Luria
Keyword(s):  
Peptic Ulcer ◽  
Central Europe ◽  
Practical Interest ◽  
Living Conditions ◽  
Point Of View ◽  
Made In ◽  
Stomach Ulcers

The author aims to highlight the "peptic ulcer" (Die Magengeschwrkrankheit), its pathology and therapy from the point of view of a therapist. As you know, in addition to very detailed chapters in large manuals, many separate monographs are devoted to this issue (I will name only Yarotsky, Enriquez et Durand, Ruhman, Balint, F. Ramond, Tagepa from recent works), but the enormous practical interest presented by the doctrine of peptic ulcer makes it useful to cover the issue again; especially interesting are the observations made in a country where living conditions are somewhat different than: in central Europe, in Sweden

To the clinic of infected ulcers of the stomach and duodenum

1927 ◽  
Vol 23 (5) ◽  
pp. 516-523
Author(s):  
S. A. Grosman ◽  
M. M. Brailovsky
Keyword(s):  
Clinical Manifestation ◽  
Surgical Intervention ◽  
Secondary Infection ◽  
Practical Interest ◽  
Point Of View ◽  
French School

We will not touch the controversial question of the role of infection in the genesis of ulcers and will adopt the point of view of the French school (Duval, Roux, Montier, Girault), for which the concept of an infected ulcer is only a concept of a pathological-anatomical and clinical nature, related to the concept of the evolution of an already existing ulcer, depending on its secondary infection. This evolution of the ulcer, in the presence of a new ingredient of infection, creates some peculiarities in its clinical manifestation,-peculiarities which, in suitable cases, can and must be taken into account both in the choice of time and in the choice of method of surgical intervention. Thus, the question under consideration by us has not only theoretical character, but, as we will try to state below, acquires also a certain practical interest.

scholarly journals Effect of alcohol on bards agrochemical soil properties

2017 ◽  
Vol 19 (74) ◽  
Author(s):  
N. M. Glovyn
Keyword(s):  
Practical Interest ◽  
Integrated Approach ◽  
Ecological Condition ◽  
Modern Technology ◽  
Point Of View ◽  
Nature Protection ◽  
Waste Products ◽  
Economic Point ◽  
Protection Legislation ◽  
Cattle Breeders

The influence of distillery stillage doses on the yield of wheatgrass hay on agrochemical properties of soils in general is considered in the article. The most effective dose of distillery stillage under existing conditions is revealed. Nitrogen is the decisive factor for the yield of the crops. Widespread deficiency of nitrogen represents scientific and practical interest for the agro-chemistry studying transformation of nitrogen in soil-fertilizer-plant system for the purpose of increase in efficiency of crops quality in the biological relation. Increase in the main production of distilleries and conse-quently in waste products of the spirit industry, low demand from cattle breeders on the distillery stillage (feeding of cattle with distillery stillage is precisely connected with seasons, i.e. it is fed, mainly, during the stall period) has led to the fact that nearly 50% of it could not be sold. Development and deployment of new waste-free technologies of production of alcohol will demand a lot of time and expenses, and the unused stil-lage comes to ponds stores daily which are gradually overflowed that endangers the ecological condition of croplands and open reservoirs, adjacent to distilleries. Moreover, long storage in ponds leads it to spoiling, stratification and formation of a ground deposit. Therefore the problem of stillage utilization is very actual now and demands an integrated approach to its consideration as it has to be considered in the economic point of view, and from compliance to requirements of the nature protection legislation. One of the solutions of the problem stillage utilization is its application in agriculture as fertilizer. In Ukraine, the grain bards resources are quite significant, given the volume of alcohol SE Ukrspirt. The volume pislyaspyrtovoyi bards on modern technology is per 1 dm3 alcohol 11 ... 13 dm3 bards. However, it can be stored quickly sour, costly transportation to the consumer. Reset distillery bards in the river leads to significant environmental degradation. It solids accumulate in water pipes and riverbeds, decompose and pollute the environment. To build bards were repositories (filtration fields), which naturally occurs mechanical, chemical and biological treatment of waste. In bioshari formed in a layer of filtration load, the sewage draining into the ground, organic matter biodegradable. This mechanism is similar to the process of composting cut vegetation, household food waste and so on.

scholarly journals A prospective cohort for the investigation of alteration in temporal transcriptional and microbiome trajectories preceding preterm birth: a study protocol

BMJ Open ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. e023417 ◽  
Author(s):  
Tobias Brummaier ◽  
Basirudeen Syed Ahamed Kabeer ◽  
Stephen Lindow ◽  
Justin C Konje ◽  
Sasithon Pukrittayaamee ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Blood Serum ◽  
Postpartum Period ◽  
Transcript Abundance ◽  
Ethics Committee ◽  
Capillary Blood ◽  
Oral Microbiome ◽  
Control Analysis ◽  
Term Neonates ◽  
Non Coding Rna

IntroductionPreterm birth (PTB) results from heterogeneous influences and is a major contributor to neonatal mortality and morbidity that continues to have adverse effects on infants beyond the neonatal period. This protocol describes the procedures to determine molecular signatures predictive of PTB through high-frequency sampling during pregnancy, at delivery and the postpartum period.Methods and analysisFour hundred first trimester pregnant women from either Myanmar or Thailand of either Karen or Burman ethnicity, with a viable, singleton pregnancy will be enrolled in this non-interventional, prospective pregnancy birth cohort study and will be followed through to the postpartum period. Fortnightly finger prick capillary blood sampling will allow the monitoring of genome-wide transcript abundance in whole blood. Collection of stool samples and vaginal swabs each trimester, at delivery and postpartum will allow monitoring of intestinal and vaginal microbial composition. In a nested case–control analysis, perturbations of transcript abundance in capillary blood as well as longitudinal changes of the gut, vaginal and oral microbiome will be compared between mothers giving birth to preterm and matched cases giving birth to term neonates. Placenta tissue of preterm and term neonates will be used to determine bacterial colonisation as well as for the establishment of coding and non-coding RNA profiles. In addition, RNA profiles of circulating, non-coding RNA in cord blood serum will be compared with those of maternal peripheral blood serum at time of delivery.Ethics and disseminationThis research protocol that aims to detect perturbations in molecular trajectories preceding adverse pregnancy outcomes was approved by the ethics committee of the Faculty of Tropical Medicine, Mahidol University in Bangkok, Thailand (Ethics Reference: TMEC 15–062), the Oxford Tropical Research Ethics Committee (Ethics Reference: OxTREC: 33–15) and the local Tak Province Community Ethics Advisory Board. The results of this cooperative project will be disseminated in multiple publications staggered over time in international peer-reviewed scientific journals.Trial registration numberNCT02797327; Pre-results.

scholarly journals Clinical Value of Concentrations of Inflammation Immunochemical Markers in Blood Serum in Children with Viral Meningitis

2021 ◽  
Vol 65 (6) ◽  
pp. 50-56
Author(s):  
O. G. Kimirilova ◽  
G. A. Kharchenko
Keyword(s):  
Blood Serum ◽  
Ferritin Level ◽  
Viral Meningitis ◽  
Inflammation Markers ◽  
Clinical Value ◽  
Severity Level ◽  
Markers Of Inflammation

A number of the immunochemical markers of inflammation in the blood serum, such as the lactoferrin, transferrin, ferritin, and fibrinogen were identified in 450 patients with the viral meningitis of various etiologies (enterovirus, arbovirus, mumps, adenovirus, and herpesvirus) at 14 years of age. The imbalance of the inflammation markers identified was determined, the severity of which depended on the severity, course and outcome of the disease. The decrease of the lactoferrin concentration by 29% (from 719 to 516 ng/ml) and increase of the ferritin level by 30% (from 70 to 91 ng/ml) by the period of the early convalescence met the heavy severity level of the meningitis. The decrease of the lactoferrin concentration by 2% (from 785 to 770 ng/ml) and increase of the ferritin level by 45% (from 68 to 99 ng/ l) by the period of early convalescence indicated the lingering course of the disease. The concentrations of the transferrin less than 2 g/l (1.74 to 1.68 g/l) and ferritin less than 50 ng/ml (40 to 48 ng/ml) were unfavorable prognosis of for the meningitis outcome.

scholarly journals Social Dialects in Modern French Language

2020 ◽  
Author(s):  
Galina Bernetska
Keyword(s):  
Mass Media ◽  
Special Section ◽  
Practical Interest ◽  
Spoken Language ◽  
Point Of View ◽  
French Language ◽  
Semantic Features ◽  
Literary Language ◽  
Vertical Division ◽  
Definition Of

The article is a study of phonetic-morphological and semantic-stylistic features of argotic vocabulary in contemporary French language. The work is devoted to questions of structural-semantic and phonetic-morphological peculiarities of the argotic vocabulary in printed mass media. The conducted research has shown that the argotic vocabulary can be considered as a special lexical subsystem of spoken language, which is characterized by a steady tendency to penetrate into higher linguistic levels due to its phonetic-morphological and semantic features. The systematization of phonetic and semantic processes in the argotic dictionary is carried out. We have noticed that argot from a linguistic point of view is an expressive lexical subsystem of spoken language, which is characterized by a large expressive potential and rapid changes in vocabulary and penetrates into higher levels of the French language. From the point of view of modern linguistics, the French language can be viewed in vertical and horizontal sections. Horizontal division is caused by the existence of the dialectal partition of the French language. The vertical division is explained by the existence of social groups that use one or another sociolect. Analyzing the evolution of the definition of argot, we can assume that in its development argot passed the long way from the language taboo to the special lexical subsystem of the literary-spoken language. We have noticed that it is important to distinguish argot and spoken language. In spite of the both scientific and practical interest in the spoken language problem and the emergence of numerous studies that led to the creation of colloquialism as a special section of linguistics, a number of aspects of spoken language (approaches to its identification, differentiation of spoken language and related phenomena) remain insufficiently highlighted. The spoken language (vernacular), according to modern linguistic assertions, occupies an intermediate position between the spoken-literary language, dialects and sociolects. We have noticed that the democratization of the norms of the literary language led to the emergence of a literary-colloquial form of spoken language. Such a combination of literary and spoken language is caused by the nature of social development. Key words: argot; slang; French language; dialect; argotheistic vocabulary; non-normative variant elements; semantics; phonetics; morphology; mass media.

A new view on the diagnosis of purulent-inflammatory diseases after childbirth

2017 ◽  
pp. 22-26
Author(s):  
O.V. Bulavenko ◽  
◽  
L.R. Ostapyuk ◽  
V.O. Rud ◽  
A.S. Voloshinovskii ◽  
...  
Keyword(s):  
Fluorescence Spectroscopy ◽  
Blood Serum ◽  
Postpartum Period ◽  
Treatment Process ◽  
Inflammatory Diseases ◽  
Serum Markers ◽  
Control Group ◽  
Long Wave ◽  
Wave Region ◽  
Torch Infections

Postpartum infectious diseases are ranked second (WHO, 2016) in the structure of maternal mortality and complicate postpartum period. Most of the existing methods allow to diagnose diseases in the presence of an already deployed clinical picture. The objective: of the work is to improve the diagnosis and prediction of pospartum endometritis by applying the method of fluorescence spectroscopy. Materials and methods. The main group is -120 women in the postpartum period with postpartum endometritis, the control group is 38 women with uncomplicated postpartum period. A study of their blood serum was carried out using the method of fluorescence spectroscopy. Results. Within the framework of the study, independent prognostic factors of the emergence of postpartum endometritis are inflammatory diseases of the lower department of the genital tract (p=0.01), abnormalities of labor (p=0.006) and TORCH infections (p=0.001). True markers for diagnosis of postpartum endometritis are the reduction in blood serum fluorescence intensity (IF) (p<0.0001) and the shift in magnitude lmax to the long-wave region (p=0.007). Conclusion. The use of spectrum-fluorescent blood serum markers in the comprehensive diagnosis of postpartum endometritis allows to diagnose reliably thе onset and to predict the course of the disease, including the treatment process. Key words: endometritis, postpartum purulent inflammatory diseases, method of fluorescence spectroscopy.

Privileged negative- or low-magnetic-shear equilibria in auxiliarly heated tokamaks

2000 ◽  
Vol 63 (1) ◽  
pp. 1-19 ◽  
Author(s):  
E. LAZZARO ◽  
E. MINARDI
Keyword(s):  
Practical Interest ◽  
Pressure Profile ◽  
Thermodynamic System ◽  
Point Of View ◽  
Coarse Grained ◽  
Auxiliary Heating ◽  
Strong Reduction ◽  
Magnetic Shear ◽  
Thermodynamic Relation ◽  
Magnetic Equilibrium

In this paper, a point of view is assumed where the tokamak is treated as a thermodynamic system open to external interactions. Those stationary states of the plasma are considered that are associated with a stationary entropy, i.e. with equilibrium between the entropy produced by the plasma and the entropy injected into it through the auxiliary heating. By means of the concept of magnetic entropy (a quantity that measures, in the framework of information theory and under suitable constraints, the probability of coarse-grained current density configurations), the responses can be analysed of the equilibrium magnetic configuration and of the related pressure profile to the intensity and to the deposition profile of the auxiliary heating when a condition of stationary entropy is attained. These factors are found to have considerable bearings on the magnetic equilibrium – in particular on the generation of states with negative magnetic shear. Moreover, the existence of a thermodynamic relation between entropy production and thermal conductivity involves a connection between magnetic structure and transport properties, and implies a strong reduction of the heat flow in the region of low or negative shear. Examples of practical interest are discussed both in the case of a homogeneous and that of a sharply localized power deposition.

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