Psychoemotional disorders in postmenopausal women and methods of their correction

2021 ◽  
Vol 50 (4) ◽  
pp. 90-95
Author(s):  
D. A. Niauri ◽  
N. N. Petrova ◽  
O. G. Chanysheva ◽  
O. V. Grobova
Keyword(s):  
Replacement Therapy ◽  
Postmenopausal Women ◽  
Emotional Disorders ◽  
Cognitive Dysfunction ◽  
Social Factors ◽  
Emotional Disturbances ◽  
Hormonal Replacement Therapy ◽  
Hormonal Replacement ◽  
Anxiety Depression

Psycho-emotional disorders in postmenopausal women are caused by interaction of neuroendocrine changes, psychological and social factors. They include anxiety, depression, dissomnia,psychosexual and cognitive dysfunction. Hormonal replacement therapy is widely used in correction of psycho-emotional disturbances in postmenopausal women. Combination of estrogens and antidepressants appears to have good prospects.

scholarly journals Effect of Combined Hormonal Replacement Therapy on the Aldosterone/Renin Ratio in Postmenopausal Women

2017 ◽  
Vol 102 (7) ◽  
pp. 2329-2334 ◽  
Author(s):  
Ashraf H. Ahmed ◽  
Richard D. Gordon ◽  
Gregory Ward ◽  
Martin Wolley ◽  
Brett C. McWhinney ◽  
...  
Keyword(s):  
Replacement Therapy ◽  
Postmenopausal Women ◽  
Plasma Renin ◽  
Plasma Aldosterone ◽  
Hormonal Replacement Therapy ◽  
Friedman Test ◽  
Hormonal Replacement ◽  
Contraceptive Agents ◽  
Plasma Electrolytes ◽  
Positive Results

Abstract Background: Plasma aldosterone/renin ratio (ARR) is the most popular screening test for primary aldosteronism (PA). Because both estrogen and progesterone (including in oral contraceptive agents) affect aldosterone and renin levels, we studied the effects of combined hormonal replacement therapy (HRT) on ARR; renin was measured as both direct renin concentration (DRC) and plasma renin activity (PRA). Methods: Fifteen normotensive, healthy postmenopausal women underwent measurement (seated, midmorning) of plasma aldosterone, DRC, PRA, electrolytes, and creatinine and urinary aldosterone, cortisol, electrolytes, and creatinine at baseline and after 2 weeks and 6 weeks of treatment with combined HRT (conjugated estrogens 0.625 mg and medroxyprogesterone 2.5 mg daily). Results: Combined HRT was associated with statistically significant increases in aldosterone [median (range): baseline, 150 (85 to 600); 2 weeks, 230 (129 to 790); 6 weeks, 434 (200 to 1200) pmol/L; P < 0.001 (Friedman test)] and PRA [2.3 (1.2 to 4.3), 3.8 (1.4 to 7.0), 5.1 (1.4 to 10.8) ng/mL/h, respectively; P < 0.001] but decreases in DRC [21 (10 to 31), 21 (10 to 39), and 14 (8.0 to 30) mU/L, respectively; P < 0.01], leading to increases in ARR calculated by DRC [7.8 (3.6 to 34.8), 11.4 (5.4 to 48.5), and 30.4 (10.5 to 90.2), respectively; P < 0.001]. The ARR calculated by DRC exceeded the cutoff value (70) in three patients after 6 weeks. There were no significant changes in ARR calculated by PRA [79 (26 to 184), 91 (23 to 166), and 88 (50 to 230), respectively; P = 0.282], plasma electrolytes and creatinine, or any urinary measurements. Conclusion: The combined oral HRT used in this study is capable of significantly increasing ARR with a risk of false-positive results during screening for PA but only if DRC (and not PRA) is used to calculate the ratio.

scholarly journals Muscle and Bone Health in Postmenopausal Women: Role of Protein and Vitamin D Supplementation Combined with Exercise Training

Nutrients ◽  
2018 ◽  
Vol 10 (8) ◽  
pp. 1103 ◽  
Author(s):  
Deborah Agostini ◽  
Sabrina Donati Zeppa ◽  
Francesco Lucertini ◽  
Giosuè Annibalini ◽  
Marco Gervasi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Vitamin D ◽  
Exercise Training ◽  
Replacement Therapy ◽  
Postmenopausal Women ◽  
Calcium Supplementation ◽  
Hormonal Replacement Therapy ◽  
Term Care ◽  
Hormonal Replacement

Menopause is an age-dependent physiological condition associated with a natural decline in oestrogen levels, which causes a progressive decrease of muscle mass and strength and bone density. Sarcopenia and osteoporosis often coexist in elderly people, with a prevalence of the latter in elderly women. The profound interaction between muscle and bone induces a negative resonance between the two tissues affected by these disorders worsening the quality of life in the postmenopausal period. It has been estimated that at least 1 in 3 women over age 50 will experience osteoporotic fractures, often requiring hospitalisation and long-term care, causing a large financial burden to health insurance systems. Hormonal replacement therapy is effective in osteoporosis prevention, but concerns have been raised with regard to its safety. On the whole, the increase in life expectancy for postmenopausal women along with the need to improve their quality of life makes it necessary to develop specific and safe therapeutic strategies, alternative to hormonal replacement therapy, targeting both sarcopenia and osteoporosis progression. This review will examine the rationale and the effects of dietary protein, vitamin D and calcium supplementation combined with a specifically-designed exercise training prescription as a strategy to counteract these postmenopausal-associated disorders.

Sign in / Sign up

Export Citation Format

Share Document