Hormonal, metabolic and clinical manifestations of the climacteric syndrome as a marker of ecological trouble in the region

2021 ◽  
Vol 50 (4) ◽  
pp. 14-16
Author(s):  
I. A. Shutova
Keyword(s):  
Clinical Manifestations ◽  
Reproductive Function ◽  
Obstetrics And Gynecology ◽  
Climacteric Syndrome ◽  
Ecological Situation ◽  
Reproductive Science

In the early 90s, academician E.K. Ailamazyan formulated the main provisions of general ecological reproductive science and the concept arising from them, according to which indicators of the reproductive function of women can act as criteria for assessing the ecological situation in the region. In 1995, an employee of the Institute of Obstetrics and Gynecology. D.O. Ott.

CLINICAL CASE OF SUCCESSFUL TREATMENT OF INFERTILITY IN A PATIENT WITH FAILURE IVF RESULTS IN ANAMNESIS

2020 ◽  
pp. 61-67
Author(s):  
Kalinkina O.B. ◽  
Tezikov Yu.V. ◽  
Lipatov I.S. ◽  
Aravina O.R.
Keyword(s):  
Assisted Reproductive Technologies ◽  
Transvaginal Ultrasound ◽  
Clinical Manifestations ◽  
Reproductive Function ◽  
Abnormal Uterine Bleeding ◽  
Clinical Situation ◽  
Reproductive Technologies ◽  
Reproductive Age ◽  
Deficiency Anemia ◽  
Number Of Publications

Genital endometriosis is a disease of women of reproductive age, accompanied by infertility in 50% [1]. Adenomyosis can be considered as an endometriosis of the uterus. Histologically, this process is represented by ectopic, non-tumor endometrial glands, and stroma surrounded by hypertrophic and hyperplastic myometrium [2]. Adenomyosis is accompanied by pelvic pain of varying intensity as well as menstrual disorders [1]. The disease is accompanied by significant violations of reproductive function (infertility, unsuccessful attempts at pregnancy and miscarriage, abnormal uterine bleeding). Adenomyosis can be accompanied by a violation of the function of adjacent organs (such as the bladder, rectum). Often, one of the clinical manifestations of adenomyosis is the development of sideropenic syndrome, which is also caused by the development of chronic post-hemorrhagic iron deficiency anemia. This is accompanied by a deterioration in the general condition of patients, a decrease in their ability to work. Despite a large number of publications in Russian and foreign scientific sources devoted to this problem, reproductive doctors and obstetricians-gynecologists often underestimate the role of adenomyosis in pregnancy planning using assisted reproductive technologies. Without interpreting the anamnesis data obtained through an active survey, doctors do not prescribe additional methods for diagnosing this pathology, which is not complex and expensive. To confirm the diagnosis, a transvaginal ultrasound examination of the pelvic organs during the premenstrual period is sufficient. In cases that are difficult to diagnose, the MRI method of the corresponding anatomical area can be used. Underestimation of the clinical picture and under-examination of the patient did not allow prescribing timely correction of the pathology and led to unsuccessful attempts to implement the generative function using assisted reproductive technologies. The conducted examination with clarification of the cause of IVF failures and the prescribed reasonable treatment made it possible to achieve regression of endometriosis foci in this clinical situation, followed by the patient's ability to realize generative function.

scholarly journals The microbiological investigations in the diagnostics of infections affecting human reproduction

2004 ◽  
Vol 53 (1) ◽  
pp. 16-21
Author(s):  
A. М. Savicheva ◽  
М. A. Bashmakova
Keyword(s):  
Bacterial Infections ◽  
Reproductive Tract ◽  
Clinical Manifestations ◽  
Human Reproduction ◽  
Obstetrics And Gynecology ◽  
Neonatal Infections ◽  
Research Activity ◽  
Reproductive Tract Infections ◽  
Tract Infections ◽  
Research Institute

In the article there are data concerning the development of research activity in the field of reproductive tract infections fulfilled at the laboratory of microbiology, the D.O.Ott Research Institute of Obstetrics and Gynecology, for last one hundred years. The importance of microbiological investigations in diagnosing genital, perinatal and neonatal infections is underlined. Own data on diagnostics, epidemiology, clinical manifestations of listeriosis, toxoplasmosis, viral and bacterial infections are present in the article.

Evidence for a role for the neurosteroid allopregnanolone in the modulation of reproductive function in female rats

1995 ◽  
Vol 133 (3) ◽  
pp. 375-380 ◽  
Author(s):  
Andrea R Genazzani ◽  
Marco A Palumbo ◽  
Antonio A de Micheroux ◽  
Paolo G Artini ◽  
Mario Criscuolo ◽  
...  
Keyword(s):  
Sexual Behavior ◽  
Liquid Chromatography ◽  
Estrous Cycle ◽  
Brain Cortex ◽  
Reproductive Function ◽  
Ovulation Rate ◽  
Female Rats ◽  
Obstetrics And Gynecology ◽  
Intracerebroventricular Injection ◽  
Medial Basal Hypothalamus

Genazzani AR, Palumbo MA, de Micheroux AA, Artini PG, Criscuolo M, Ficarra G, Guo A-L, Benelli A, Bertolini A, Petraglia E. Purdy RH. Evidence for a role for the neurosteroid allopregnanolone in the modulation of reproductive function in female rats. Eur J Endocrinol 1995;133:375–80. ISSN 0804–4643 The present study investigated the effect of allopregnanolone (5α-pregnan-3α-ol-20-one) or of passive immunoneutralization of brain allopregnanolone, the most potent steroid produced by neurons, on ovulation rate and sexual behavior in female rats. Allopregnanolone was injected intracerebroventricularly in rats on diestrus and proestrus and tests were done on estrus. The intracerebroventricular injection of allopregnanolone significantly decreased the number of oocytes collected on estrus (p < 0.01). To support a physiological involvement, antiserum to allopregnanolone was injected centrally to block the activity of the endogenous neurosteroid. When administered on diestrus and proestrus or only on proestrus, the antiserum was shown to be correlated with a significant increase (p < 0.01) in oocytes retrieved on estrus. In female rats treated with antiserum to allopregnanolone, the lordosis intensity was augmented significantly as compared to controls. Finally, the possible changes of medial basal hypothalamus concentration of allopregnanolone throughout the estrous cycle and at the time of ovulation were investigated. Hypothalamic extracts were eluted on highpressure liquid chromatography and allopregnanolone concentration was measured by radioimmunoassay. Brain cortex was used as control tissue. Hypothalamic allopregnanolone concentration on proestrus morning and afternoon was found to be significantly lower than in the remaining phases of the estrous cycle (p < 0.01), while no significant changes were observed in brain cortex concentration of allopregnanolone. The present results suggest that hypothalamic allopregnanolone may be involved in the mechanism of ovulation, affecting hormonal and behavioral events. AR Genazzani, Institute of Obstetrics and Gynecology, University of Pisa, via Roma 67, 56100 Pisa, Italy

scholarly journals The phenomenon of rosacea-rushes (theoretical aspects)

2021 ◽  
Vol 26 (2) ◽  
pp. 33-39
Author(s):  
V.A. Bocharov ◽  
V.V. Bocharova ◽  
M.M. Lebediuk ◽  
A.A.S. Sarayreh ◽  
L.V. Kuts
Keyword(s):  
Clinical Manifestations ◽  
Reproductive Function ◽  
Local Heat ◽  
Cellular Level ◽  
Reproductive Age ◽  
Theoretical Substantiation ◽  
Promising Area ◽  
The Face ◽  
Relationship Of ◽  
The Relationship

According to the decisions of international scientific forums, the problem of phenomenon of rosacea (acne rosacea), a common dermatosis with numerous unexplained aspects of etiopathogenesis is a promising area of modern medical research. The aim of the study was theoretical substantiation of the essential features of the mechanisms of occurrence, development and clinical manifestations of the first signs of rosacea in women of reproductive age. The use of a systematic analytical methodical approach to assess the data of clinical and laboratory examinations of women with rosacea, conducted in different regions of the world, allowed to establish the originality of such manifestations of dermatosis as the appearance of unexpected rushes to limited areas of the face, accompanied by local redness and local heat areas of the skin differring significantly from similar rushes in other diseases or syndromes (menopause, migraine, etc.). It is established that the peculiarity of the relationship of these clinical characteristics (from English: rush, ruddy, redness, rosacea, reproductive age of women, reaction) allows to indicate the first signs of dermatosis as a phenomenon inherent in this disease Rush-Ruddy-Rosacea-Reproduce-Reaction (abbreviated – «5-R»), the key pathophysiological target of which (as well as the disease as a whole) is a disorder of a set of hierarchically dependent mechanisms of the evolutionarily determined motivational need to ensure reproductive function in women (both at the cellular level and extracellular structures of the ovaries, and at different levels of subcortical formations and centers of the cortex of the cerebral hemispheres). The phenomenon of rosacea rush is closely related to other phenomena of this dermatosis – hypersensitivity of bradykinin receptors, actinic elastosis, development of post erythematous telangiectasia. The prospect of further research on the problem of rosacea is to study the relationship of disorders in the functional systems of molecules of signaling compounds of different classes (hormones, eicosanoids, neuropeptides, kinins, cytokines and others) in the pathogenesis of the disease.

scholarly journals Peculiarities of the clinical course, diagnostics, and therapy of premature sexual development in the children presenting with its idiopathic form and with hypothalamic hamartoma

2012 ◽  
Vol 58 (1) ◽  
pp. 17-22
Author(s):  
A V Bolmasova ◽  
M A Kareva ◽  
E M Orlova
Keyword(s):  
Body Weight ◽  
Sexual Development ◽  
Clinical Course ◽  
Final Height ◽  
Clinical Manifestations ◽  
Reproductive Function ◽  
Hypothalamic Hamartoma ◽  
Clinical Form ◽  
Pediatric Endocrinologist ◽  
Diagnostics And Therapy

The idiopathic form of premature sexual development (PSD) is the commonest variety among the central forms of PSD (accounting for 30 to 70% of the total). It occurs primarily in the girls. The prevalence of hypothalamic hamartoma (HH) as a cause of premature sexual development is on the whole lower, but it is most frequently diagnosed in the children of either sex under the age of 3 years with the clinical manifestations of true PSD. Diagnostics and treatment of different forms of premature sexual development constitute an appreciable part of the practical work of a pediatric endocrinologist. The efficacy of PSD therapy with luliberin analogs has been definitively demonstrated in the context of increasing the final height of the children and suppressing the progression of their sexual development. Moreover, the reversibility of the effects of luliberin analogs on the gonadostatic activity has been confirmed. Nevertheless, peculiarities of the clinical course of various etiological variants of central PSD, principles of its treatment, and its efficacy remain a matter of debate. In the present paper, the special emphasis is laid on the consequences of PSD therapy using luliberin analogs including the recovery of the process of normal puberty, effects on the reproductive function, body weight, and the dependence of the treatment on the clinical form of central PSD. The data on the peculiarities of the clinical course of premature sexual development and the efficacy of its treatment in the children with the idiopathic form of gonadotropin-dependent PSD and hamartoma-associated PSD are presented

scholarly journals Role of connective tissue dysplasia in obstetrics and gynecology

2014 ◽  
Vol 95 (6) ◽  
pp. 897-904
Author(s):  
A S Gasparov ◽  
E D Dubinskaya ◽  
I A Babicheva ◽  
N V Lapteva ◽  
M F Dorfman
Keyword(s):  
Connective Tissue ◽  
Musculoskeletal Diseases ◽  
Molecular Genetic ◽  
Connective Tissue Diseases ◽  
Clinical Manifestations ◽  
Diagnostic Methods ◽  
Obstetrics And Gynecology ◽  
Special Importance ◽  
Life Threatening ◽  
Connective Tissue Dysplasia

A review of literature on the problem of connective tissue dysplasia in obstetric and gynecological practice is presented. The questions of terminology, classification, clinical manifestations and diagnosis are surveyed. Currently, many experts note the change of the classical clinical course of a significant number of internal diseases, increased prevalence of allergic and autoimmune diseases. Since the 90s of the last century, connective tissue dysplasia is considered one of the main reasons of the above mentioned conditions. Connective tissue dysplasia is the malformation, which is the basis of a significant number of internal diseases, with diverse symptoms and no clear diagnostic criteria. Researches on connective tissue dysplasia are mainly focused on cardiologic and pulmonary diseases, musculoskeletal diseases, and autoimmune processes. Researches addressing connective tissue diseases in a number of gynecological diseases and conditions in obstetrics appeared only recently. The presence of connective tissue dysplasia in women is a major problem in obstetrics and gynecology. Most reliable biochemical and molecular genetic studies are currently unavailable to a practicing doctor due to technical difficulties and considerable cost. So clinical-genealogical method of examination of patients and their families, as well as the widespread use of instrumental diagnostic methods are of special importance. Obstetricians and gynecologists while managing such patients should pay close attention to the phenotypic features of connective tissue dysplasia and carefully evaluate the cardiovascular and pulmonary systems, blood coagulation to avoid possible serious, often life-threatening, complications.

scholarly journals ОПТИМІЗАЦІЯ ЛІКУВАННЯ ЖІНОК З ХРОНІЧНИМ ЕНДОМЕТРИТОМ ЯК РЕЗЕРВ ПІДВИЩЕННЯ ФЕРТИЛЬНОСТІ

World Science ◽  
2018 ◽  
Vol 1 (10(38)) ◽  
pp. 28-32
Author(s):  
Донська Ю. В. ◽  
Лоскутова Т. О. ◽  
Сімонова Н. В. ◽  
Петулько А. П.
Keyword(s):  
Menstrual Cycle ◽  
Reproductive Potential ◽  
Clinical Manifestations ◽  
Reproductive Function ◽  
Women Of Childbearing Age ◽  
Childbearing Age ◽  
Demographic Situation ◽  
Chronic Endometritis ◽  
The Creation

The worsening demographic situation encourages the search for new reserves to improve reproductive potential. The maximum incidence of chronic endometritis (97.6%) is 26-35 years old - the most important in the implementation of reproductive function. The lack of a single concept for the pathogenesis of HE, the purge of clinical manifestations impedes the creation of well-grounded therapy in women of childbearing age. The aim of the study was to increase the effectiveness of treatment of patients with confirmed chronic endometritis in order to restore fertility. It is proved that the use of the scheme, which includes antibacterial (doxycycline 100 mg orally 2 times a day and metronidazole 500 mg 2 times a day for 14 days in one menstrual cycle) and cyclic progestogen (didrogesterone at a dose of 20 mg per day with 15 to 25 days of the menstrual cycle - within three months), therapy can restore the morpho-functional endometrium potential by 88% compared with the initial rates.

Climacteric syndrome and magnesium (literature review)

GYNECOLOGY ◽  
2018 ◽  
Vol 20 (5) ◽  
pp. 6-8 ◽  
Author(s):  
V N Prilepskaya ◽  
A N Mgeryan ◽  
E A Mezhevitinova
Keyword(s):  
Quality Of Life ◽  
Trace Elements ◽  
Negative Impact ◽  
Magnesium Deficiency ◽  
Clinical Manifestations ◽  
Heart Rhythm ◽  
Climacteric Syndrome ◽  
Dna And Rna ◽  
Blood Clots

Magnesium is one of the most important trace elements necessary for the life of the human body. It supports the normal exchange of proteins and nucleic acids (DNA and RNA), reduces spasm of the arteries, both peripheral and coronary, prevents the formation of blood clots, relaxes the uterus with hypertension, restores heart rhythm with tachycardia, contributes to the normal course of pregnancy, etc. Magnesium deficiency has a negative impact on health, especially in women in the menopause. Hypomagnesemia exacerbates the course of the main clinical manifestations and conditions characteristic of climacteric syndrome, and therefore the use of magnesium preparations in this category of patients will improve their health and quality of life.

O-068 Training of clinicians: How to do it and how to best evaluate it

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
A Feki ◽  
M Tatjana ◽  
F Roy
Keyword(s):  
Reproductive Medicine ◽  
Reproductive Function ◽  
Human Reproduction ◽  
Obstetrics And Gynecology ◽  
Practical Training ◽  
The European Union ◽  
National Agency ◽  
High Quality Research ◽  
Medical Specialties ◽  
The Eu

Abstract Training of clinicians: How to do it and how to best evaluate it? Anis Feki, Tatjana Motrenko, Roy Farquharson Many countries within Europe and EU do not have a specific national agency that provides the necessary structure or governance for appropriate training in Reproductive Medicine (RM). Therefore, The European Society of Human Reproduction and Embryology (ESHRE) has been the responsible agency for accreditation of RM training alongside its sister organization, the European Board and College of Obstetrics and Gynaecology (EBCOG). Both of these organizations are ultimately responsible to and approved by the Union of European Medical Specialties (UEMS), which represents the European Union (EU) governing body for medical practitioners’ education. The Reproductive Medicine subspecialist is a specialist in basic obstetrics and gynecology who has undergone theoretical and practical training in the medical and surgical management of infertility, including assisted reproductive techniques (ART). In general, the comprehensive management of these problems includes both diagnostic and therapeutic procedures allied to continuous audit of outcome. The global aim is to improve the care of patients with disorders of reproductive function. To reach this target, both ESHRE and EBCOG put in place a program that starts with accreditation of training centers in obstetrics and gynecology and more specifically, specialist training centers in reproductive medicine. Fellows must have a structured program of a minimum of 2 years after completing their basic obstetrics and gynecology syllabus and/or obtaining EFOG European Fellow of Obstetrics and Gynecology) diploma for non-European basic training. When a training fellow in RM has completed their logbook, the fellow will finish by assessing an individual’s knowledge and skills by passing an exit-training exam called the EFRM (ESHRE-EBCOG Fellow in Reproductive Medicine) diploma. The success of and the need for such certification has led ESHRE to structure the training also for reproductive surgeons, embryologists, as well as nurses and midwives. In addition, several countries within the EU already have a national compulsory specialist accreditation system for RM training. Recent proposals by the EU Commission to build European reference networks across all specialties, including RM may require the recognition of ESHRE/EBCOG–accreditation as an appropriate entry point for consideration of diagnostic and other interventions. Encouraging subspecialists and centers to apply for training accreditation may well prove to be an increasingly attractive option as educational needs across Europe become integrated and formalized through UEMS. ESHRE holds the view that accredited centers/subspecialists for training are beacons of excellence that often go hand in hand with high-quality research.

Urinary tract infections in obstetrics and gynecology

2015 ◽  
Vol 64 (6) ◽  
pp. 91-104 ◽  
Author(s):  
Elena Vasilyevna Shipitsyna ◽  
Tatyana Alekseyevna Khusnutdinova ◽  
Alevtina Mikhailovna Savicheva ◽  
Tatyana Aykovna Ayvazyan
Keyword(s):  
Urinary Tract ◽  
Antimicrobial Resistance ◽  
Infectious Diseases ◽  
Urinary Tract Infections ◽  
Clinical Manifestations ◽  
Clinical Importance ◽  
Infectious Complications ◽  
Obstetrics And Gynecology ◽  
Tract Infections ◽  
In Pregnancy

Urinary tract infections (UTIs) are among the most common infectious diseases in women, and are the most frequent cause of infectious complications of pregnancy. This paper reviews current scientific and methodical literature on UTIs in obstetrics and gynecology. Aspects of clinical importance of UTIs (epidemiology, clinical manifestations, complications), their etiology, antimicrobial resistance of UTIs agents were discussed, and current recommendations on diagnostics and treatment of UTIs were summarized. Special attention was paid to UTIs in pregnancy.

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