scholarly journals Genetic determinants in hyperplasic illnesses of the reproductive system

2021 ◽  
Vol 51 (3) ◽  
pp. 25-27
Author(s):  
V. E. Radzinsky ◽  
А. V. Itkes ◽  
I. M. Ordiiants ◽  
L. O. Orazmuradova ◽  
О. T. Lobanova ◽  
...  
Keyword(s):  
Risk Factor ◽  
Reproductive System ◽  
Genetic Factors ◽  
Genetic Determinants ◽  
Complex Investigation

It were studied some aspects, detecting the role of genetic factors in the genesis of hyperplasic illnesses of reproductive system organs (uterus myoma, inside endometriosis, ovaries endometriosis) on the base of complex investigation of 145 patients with such diseases. Obtained data allow consider the absence in allele PL-All of women the gene GPIII is a risk factor in origin and development of hyperplasic illnesses in reproductive system.

scholarly journals Taste receptors are our mediators in shaping the taste preferences of a child

2018 ◽  
pp. 50-55
Author(s):  
I. N. Zakharova ◽  
A. N. Kasyanova ◽  
Yu. А. Dmitrieva ◽  
Е. B. Machneva
Keyword(s):  
Genetic Factors ◽  
Sweet Taste ◽  
Practical Significance ◽  
Cellular Structures ◽  
Taste Preferences ◽  
Taste Receptors ◽  
Genetic Determinants ◽  
Umami Taste ◽  
Sweet Taste Receptors

The article presents modern data on the main molecular and genetic determinants of shaping the taste preferences. The authors present the structure and mechanism of the functioning of sweet taste receptors, umami taste, acidic and bitter tastes, as well as other molecules and cellular structures influencing the perception of flavors – the gust protein, toll-like receptors. They described the role of structures ensuring perception of taste outside the oral cavity – the cells of the hypothalamus. The article underlines the importance of the genetic polymorphism of these structures and the importance of interaction of genetic factors and environmental factors in shaping the taste preferences and eating behavior of the infant. Particular attention is given to the practical significance of the presented data in the context of introduction of supplemental foods for infants.

The role of genetic factors in the formation of dependence on opiates

2015 ◽  
Vol 6 (4) ◽  
pp. 27-31
Author(s):  
Viktor Vasil’evich Vostrikov ◽  
Natal'ya Olegovna Selizarova ◽  
Anastasiya Yur’evna Grigor’eva ◽  
Sergei Nikolaevich Proshin
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Drug Users ◽  
Genetic Factors ◽  
Early Age ◽  
Drug Addicts ◽  
Psychoactive Substances ◽  
High Level ◽  
Genetically Determined

Sociological surveys show that the average age of drug users in recent years has drastically decreased from 18 years to 13 years. Among children of aged from 5 to 7 years the episodes of drug use have been reported. At the same time their parents addicts contribute to this. Statistics show that more than 60 % of drug addicts are young people aged from 17 to 35 years. More than 20 % are children, students, and only 15 % are people older than 35 years. The use by mother during pregnancy psychoactive substances (PAS) is one of the major risk factor for congenital addiction. The most important risk factors for drug abuse are genetic ones. There are two main genetically dependent factors. The first factor is genetically determined high level of the dopamine which encourage a person on a constant search for new sensations, dissatisfaction peace, and search risky situations. The second one is a low level of the hormone serotonin which results in depression in stressful situations. The stressful situations become very deep. Certain factors increase the risk of addictive behavior of offspring may appear at birth. Many people who started the abuse at early age consciously preferred drug to alcohol. That is the adoption of alcohol caused them to aversion to alcohol because of the memories of his father-alcoholic. However based on the biological characteristics while it is not so easy to predict the likelihood of addiction and clearly define in advance the tendency or, on the contrary, human resistance to drug intoxication and dependence.

scholarly journals Molecular genetics of thyroid cancer

2016 ◽  
Vol 98 ◽  
Author(s):  
MAHA REBAЇ ◽  
AHMED REBAЇ
Keyword(s):  
Thyroid Cancer ◽  
Prognostic Value ◽  
Genetic Factors ◽  
Nucleotide Polymorphisms ◽  
Genetic Determinants ◽  
Single Nucleotide ◽  
Sequence Variations ◽  
Disease Aetiology ◽  
Diagnostic And Prognostic Value

SummaryThe pathogenesis of the development and progression of thyroid cancer (TC) is far from being clear at present. Accumulated evidence suggests that it is a complex polygenic disorder for which genetic factors play an important role in disease aetiology. Here we review the literature to report the genetic variations and alterations that have been described in the aetiology of TC. The functional effects of some mutations and single nucleotide polymorphisms on TC are validated, establishing the role of sequence variations in this cancer. However, large prospective studies are still required to evaluate the diagnostic and prognostic value of these genetic determinants in clinical practice.

scholarly journals Genetic determinants of the development and course of membranous nephropathy

2018 ◽  
Vol 90 (6) ◽  
pp. 105-111 ◽  
Author(s):  
E S Kamyshova ◽  
I N Bobkova ◽  
I A Gorelova ◽  
P A Kakhsurueva ◽  
E E Filatova
Keyword(s):  
Membranous Nephropathy ◽  
Genetic Factors ◽  
Genetic Determinants ◽  
Systemic Autoimmune Diseases ◽  
Phospholipase A2 Receptor ◽  
Common Causes ◽  
Human Leucocyte Antigen Class ◽  
Circulating Antibodies

Membranous nephropathy (MN) is one of the most common causes of nephrotic syndrome in adults and is classified as either primary (idiopatic) or secondary MN according to underlying etiology (the later result from some known disease such as systemic autoimmune diseases, infections, malignancies, drugs, etc). In recent years, phospholipase A2 receptor 1 (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A) were identified as two major podocytic antigens involved in the pathogenesis of idiopatic MN (IMN). And the discovery of circulating antibodies specific for these target antigens has transformed the diagnostic workup and significally improved management of IMN. However why do such antibodies develop is not conclusively established. The role of underlying genetic factors is discussed. The review presents the results of recent studies, that have shown significant associations of specific genetic factors (particularly human leucocyte antigen class II and PLA2R1 genes) with IMN.

scholarly journals The role of genes of the second phase of detoxification of xenobiotics in the pathogenesis of multifactorial diseases

2022 ◽  
pp. 16-20
Author(s):  
T. A. Shumatova ◽  
D. V. Kovalenko
Keyword(s):  
Reproductive System ◽  
Genetic Factors ◽  
Diagnosis And Treatment ◽  
Second Phase ◽  
Glutathione S Transferase ◽  
Multifactorial Diseases ◽  
Pathological Conditions ◽  
Genetic Status ◽  
Oncological Diseases

The genetic status of a person is currently assigned a major role in the pathogenesis, diagnosis and treatment of various diseases. The most important genetic factors that have been attached great importance to are the genes of the glutathione-S-transferase family (GSTs). The genes of the glutathione-S-transferase family belong to the second phase of detoxification of xenobiotics and their altered activity leads to the development of many pathological conditions. GSTM, GSTT, GSTP are considered to be the most polymorphic. The issues of the participation of polymorphic GSTs in the development of infectious, allergic and oncological diseases, disorders of the reproductive system, as well as in the development of Alzheimer's disease are discussed in the article.

Epigenetic factors and molecular markers of the risk of early pregnancy losses

GYNECOLOGY ◽  
2019 ◽  
Vol 21 (3) ◽  
pp. 9-16
Author(s):  
Nataly I Frolova ◽  
Tatiana E Belokrinitskaya
Keyword(s):  
Early Pregnancy ◽  
Genetic Factors ◽  
Molecular Genetic ◽  
Pregnancy Complication ◽  
Common Complication ◽  
Epigenetic Factors ◽  
Genetic Determination ◽  
Periconceptional Period ◽  
Combined Impact

Background. Miscarriage is a common complication in early pregnancy. Current studies have shown a higher prevalence of miscarriage, ranging from 10 to 20%. The review is devoted to modern concepts of etiology and pathogenesis of early pregnancy losses. Aim. Assess the role of epigenetic factors and molecular-genetic markers in the pathogenesis and prediction of early pregnancy losses Materials and methods. In order to write this review domestic and foreign publications were searched in Russian and international search systems (PubMed, eLibrary, etc.) for the last 10-15 years. Relevant articles from the peer-reviewed literature and clinical practice guidelines were included. Results. Many recent studies have proved the contribution of various epigenetic factors to the pathogenesis of spontaneous miscarriages, and the molecular-genetic determination such kinds of pregnancy complication has been confirmed. Conclusion. The miscarriage in early gestation is driven by combined impact of epigenetic and molecular-genetic factors, as well as the presence of intergenic interactions. It is may lead to deterioration of physiological functions, and maternal pathologenic pathways could be changed as during her periconceptional period as so during the pregnancy.

ROLE OF ULTRASOUND IN THE DETECTION OF RECURRENT OVARIAN CANCER

2020 ◽  
Vol 6 (1) ◽  
pp. 23-31
Author(s):  
M. Alisherova ◽  
◽  
M. Ismailova
Keyword(s):  
Ovarian Cancer ◽  
Surgical Treatment ◽  
Reproductive System ◽  
Malignant Tumors ◽  
Recurrent Ovarian Cancer ◽  
Primary Diagnosis ◽  
Female Reproductive System

Currently, there are no standard approaches to monitoring patients with ovarian cancer (OC). While the role of ultrasound (US) has been identified in the primary diagnosis of OS, it is still controversial during the subsequent surgical treatment of OC. In world statistics, ovarian cancer is consistently among the four main localizations of malignant tumors of the female reproductive system, along with tumors of the breast, body and cervix.

Role of genetic factors in the development of hypertension in young patients with metabolic syndrome

2020 ◽  
pp. 23-32
Author(s):  
Elena Korneeva ◽  
Mikhail Voevoda ◽  
Sergey Semaev ◽  
Vladimir Maksimov
Keyword(s):  
Metabolic Syndrome ◽  
High Risk ◽  
Arterial Hypertension ◽  
Genetic Factors ◽  
Young Patients ◽  
Integrin Αiibβ3 ◽  
Ace Gene ◽  
The Metabolic Syndrome

Results of the study related to polymorphism of ACE gene (rs1799752)‎, integrin αIIbβ3, and CSK gene (rs1378942) influencing development of arterial hypertension in young patients with metabolic syndrome are presented. Hypertension as a component of the metabolic syndrome was detected in 15.0% of young patients. Prevalence of mutant alleles of the studied genes among the examined patients was quite high, so homozygous DD genotype was found in 21.6%, and mutant D allele of the ACE gene in 47.4%. A high risk of hypertension in patients with MS was detected in carriers of the T allele of the CSK (rs1378942) gene – 54.8%, which was most often observed in a combination of polymorphic ACE and CSK gene loci (p = 0.0053).

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