scholarly journals Indexes of arterial blood flow in the utero-placental and fetal-placental circulation

2002 ◽  
Vol 51 (2) ◽  
pp. 10-12
Author(s):  
A. A. Polyanin ◽  
Igor Y. Kogan
Keyword(s):  
Blood Flow ◽  
Renal Artery ◽  
Middle Cerebral Artery ◽  
Pulsatility Index ◽  
Uterine Artery ◽  
Umbilical Artery ◽  
Normal Pregnancy ◽  
Arterial Blood Flow ◽  
Arterial Blood ◽  
Normal Ranges

The aim of this study was to asses the normal ranges for S/D ratio and pulsatility index (PI) for umbilical artery (UA), aorta (A), middle cerebral artery (MCA), renal artery (RA) and uterine artery (UtA) during normal pregnancy. Results showed decrease of S/D ratio and PI for UA, UtA from 8 to 40 weeks of gestation and PI for RA from 20 to 40 weeks of gestation. S/D ratio and PI for A was not changed during second half of normal pregnancy. S/D ratio and PI for MCA were increased from 20 to 30 weeks of gestation and after that had tendency of decreasing to term.

scholarly journals P2-415: LOWER ARTERIAL BLOOD FLOW AND HIGHER PULSATILITY INDEX ARE ASSOCIATED WITH NEURONAL INJURY

2019 ◽  
Vol 15 ◽  
pp. P767-P769
Author(s):  
Jack F.V. Hunt ◽  
Nicholas M. Vogt ◽  
Paul Cary ◽  
Douglas C. Dean ◽  
Erin Jonaitis ◽  
...  
Keyword(s):  
Blood Flow ◽  
Pulsatility Index ◽  
Neuronal Injury ◽  
Arterial Blood Flow ◽  
Arterial Blood

Abstract P214: Mechanotransduction And Uterine Blood Flow In Preeclampsia- The Role Of Piezo 1 Ion Channels.

Hypertension ◽  
2020 ◽  
Vol 76 (Suppl_1) ◽  
Author(s):  
Olufunke O Arishe ◽  
Vanessa Dela Justina ◽  
Fernanda B Priviero ◽  
Clinton R Webb
Keyword(s):  
Blood Flow ◽  
Vascular Remodeling ◽  
Vascular Reactivity ◽  
Small Diameter ◽  
Subsequent Development ◽  
Normal Pregnancy ◽  
Arterial Blood Flow ◽  
Pregnant Rats ◽  
Arterial Blood

Background: There is a large increase in uterine arterial blood flow during normal pregnancy. Structural and cellular adjustments occur in the uterine vasculature during pregnancy to accommodate this increased blood flow through a process is known as ‘vascular remodeling’. The etiology of preeclampsia involves aberrant placentation and vascular remodeling leading to reduced uteroplacental perfusion. However, the underlying source of the deficient vascular remodeling and the subsequent development of preeclampsia remains to be fully understood. Piezo 1 channels have been shown to be highly expressed in vascular smooth muscle cells of small-diameter arteries and play a role in the structural remodeling of the arteries. Studies have also shown that Piezo 1 is present in uterine arteries and it’s not exclusive to the endothelial cells. Hypothesis: This study tests the hypothesis that reduced Piezo 1 activity contributes to decreased uterine vascular relaxation in hypertensive pregnant rats. Methods: Hypertension was induced by treating the pregnant rats with synthetic CpG ODN (ODN 2395) via three intraperitoneal injections (100μg/rats) while the normotensive controls were treated with saline (vehicle) on the 14 th , 17th and 18 th days of pregnancy. Mean arterial pressure (MAP) was measured. In vitro vascular reactivity of uterine arterial (UA) ring segments were evaluated using isometric wire myograph system. Rings were pre-contracted with 3μM phenylephrine (PE), concentration responses of to Yoda1; a pharmacological agonist of Piezo 1 channel were compared. Statistical analysis was performed using nonlinear regression and Students’ t-test. Results: Our results show that MAP was greater in rats treated with ODN2395 vs untreated rats (112 ± 1 vs 90 ± 1 p =0.0004). Concentration-dependent relaxation responses to Yoda1 were greater in UAs of untreated rats compared to those treated with ODN2395 (EC50 0.06571 ± 0.09781 vs. 0.5774 ± 0.1187 p =0.0018). Conclusion: These results suggest that the reduced vasodilation in pregnancy-associated hypertension may be due to a reduced Piezo 1 channel activity.

scholarly journals Fetal Aortic-cerebral Doppler Resistance Index Ratio: An Indicator of Physiologic Blood Flow Distribution

2009 ◽  
Vol 3 (3) ◽  
pp. 91-96
Author(s):  
Zoltán Tóth ◽  
János Aranyosi ◽  
Tamás Deli ◽  
Péter Bettembuk ◽  
Bence Kozma ◽  
...  
Keyword(s):  
Blood Flow ◽  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Resistance Index ◽  
Flow Distribution ◽  
Arterial Blood Flow ◽  
Blood Flow Distribution ◽  
Descending Aorta ◽  
Arterial Blood ◽  
Index Ratio

Abstract Identical hemodynamic impedance and constant ratio of the fetal descending aorta and middle cerebral artery of uncomplicated pregnancies at term. Fetal aortic-cerebral Doppler resistance index ratio: An indicator of physiologic blood flow distribution. Objective To interpret the physiologic fetal arterial blood flow distribution by relating the vascular impedance of the fetal descending aorta (DA) and middle cerebral artery (MCA) and to establish the reference ranges for the aortic-cerebral Doppler resistance index ratio (ACRI). Study design Ninety-six patients with uncomplicated pregnancies were recruited for the cross-sectional assessment of the Doppler resistance index (RI) in the fetal DA and MCA between the 38rd and 40th weeks of gestation. The normal ranges of the ACRI were calculated. A cut-off value was designed to facilitate the clinical application of the ACRI. Results Between the 38th and 40th weeks of gestation in normal pregnancies the ACRI of healthy fetuses is constant, the overall mean is: 1.062 (+/– 0.087). A single cut-off value of 1.2 is recommended to assist separating normal and pathologic arterial blood flow patterns. Conclusion The normal ACRI reflects the identical vascular resistance of the descending aorta and the cerebral vessels, which maintains the physiologic fetal central arterial blood flow. Additional clinical studies are necessary to assess the diagnostic efficacy of the abnormal ACRI (>1.2) as a potentially useful marker of the centralized arterial circulation indicating the early stage of fetal hypoxemic jeopardy.

Cord Hemangioma Complicated by Umbilical Vein Rupture; What We Missed on Color Doppler

2018 ◽  
Vol 1 ◽  
pp. 10
Author(s):  
Matin Goldooz ◽  
Mike Draper ◽  
Jessica Comstock ◽  
Anne Kennedy
Keyword(s):  
Blood Flow ◽  
Umbilical Cord ◽  
Doppler Ultrasound ◽  
Umbilical Artery ◽  
Umbilical Vein ◽  
Color Doppler ◽  
Arterial Blood Flow ◽  
Arterial Blood ◽  
Cystic Component ◽  
Flow Through

Umbilical cord hemangiomas are rare tumors of the umbilical cord. Doppler ultrasound has been shown to be useful in the diagnosis of cord hemangioma and evaluation of arterial blood flow through the mass. In this study, we present a 28-year-old pregnant woman with an umbilical cord mass with solid and cystic components. She was followed with weekly umbilical artery (UA) Doppler ultrasound, but the fact that the umbilical vein (UV) ran in the wall of the mass was not noted prospectively. At the time of placental delivery, the cystic component of the mass ruptured tearing the UV causing significant bleeding. The case illustrates the importance of using Doppler ultrasound to both look for UA compromise and to map the UV location through the entirety of the cord.

scholarly journals IC-P-109: LOWER ARTERIAL BLOOD FLOW AND HIGHER PULSATILITY INDEX ARE ASSOCIATED WITH NEURONAL INJURY

2019 ◽  
Vol 15 ◽  
pp. P93-P95
Author(s):  
Jack F.V. Hunt ◽  
Nicholas M. Vogt ◽  
Paul Cary ◽  
Douglas C. Dean ◽  
Erin Jonaitis ◽  
...  
Keyword(s):  
Blood Flow ◽  
Pulsatility Index ◽  
Neuronal Injury ◽  
Arterial Blood Flow ◽  
Arterial Blood

scholarly journals Mechanotransduction and Uterine Blood Flow in Preeclampsia: The Role of Mechanosensing Piezo 1 Ion Channels

2019 ◽  
Vol 33 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Olufunke O Arishe ◽  
Anthony B Ebeigbe ◽  
R Clinton Webb
Keyword(s):  
Blood Flow ◽  
Shear Stress ◽  
Vascular Remodeling ◽  
Vascular System ◽  
Perinatal Death ◽  
Small Diameter ◽  
Subsequent Development ◽  
Normal Pregnancy ◽  
Arterial Blood Flow ◽  
Arterial Blood

Abstract There is a large increase in uterine arterial blood flow during normal pregnancy. Structural and cellular adjustments occur in the uterine vasculature during pregnancy to accommodate this increased blood flow through a complex adaptive process that is dependent on multiple coordinated and interactive influences and this process is known as “vascular remodeling.” The etiology of preeclampsia involves aberrant placentation and vascular remodeling leading to reduced uteroplacental perfusion. The placental ischemia leads to development of hypertension and proteinuria in the mother, intrauterine growth restriction, and perinatal death in the fetus. However, the underlying source of the deficient vascular remodeling and the subsequent development of preeclampsia remain to be fully understood. Mechanoreceptors in the vascular system convert mechanical force (shear stress) to biochemical signals and feedback mechanisms. This review focuses on the Piezo 1 channel, a mechanosensitive channel that is sensitive to shear stress in the endothelium; it induces Ca2+ entry which is linked to endothelial nitric oxide synthase (eNOS) activation as the mechanoreceptor responsible for uterine vascular dilatation during pregnancy. Here we describe the downstream signaling pathways involved in this process and the possibility of a deficiency in expression of Piezo 1 in preeclampsia leading to the abnormal vascular dysfunction responsible for the pathophysiology of the disease. The Piezo 1 ion channel is expressed in the endothelium and vascular smooth muscle cells (VSMCs) of small-diameter arteries. It plays a role in the structural remodeling of arteries and is involved in mechanotransduction of hemodynamic shear stress by endothelial cells (ECs).

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