Some features of the clinical course and treatment of cervical dysplasia depending on age

The objective: in this work represented part of materials of department rehabilitation of reproductive function for the examination and treatment of 250 patients with uterine fibrods in order to study and determine in detail the predictors of the disease, develop methods of treatment (conservative and surgical), as well as rehabilitation of the reproductive function, depending on the type and localization of the nodes. Materials and methods. The analysis of the anamnestic data, taking into account both objective and subjective data, analysis of anamnestic data of close relatives (maternal and paternal lines), concomitant genital and extragenital pathology is carried out. Results. The most numerical group of patients with uterine fibroids, according to our data, in the age groups of 26–35 years (32%) is 36–40 years (28.4%), which are the most socially and reproductively active. In this category, women with a high education of 33.6% and social status (30.4% and 22.4%) prevailed. The transferred inflammatory diseases of the genitals were noted in 48% of the examined, weighed gynecological anamnesis (abortions, miscarriages) were noted in 42.4%. Conclusion. Also for this category of patients is characterized by a high percentage of endometrial pathology – 60.8%, as well as concomitant adenomyosis – 34% and adhesion process of pelvic organs – 26.8%. Key words: clinical course, uterine fibroids, reproductive age.

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Expression level of Wnt signaling components possibly influences the biological behavior of colorectal cancer in different age groups

Experimental and Molecular Pathology ◽

10.1016/j.yexmp.2003.12.004 ◽

2004 ◽

Vol 76 (3) ◽

pp. 224-233 ◽

Cited By ~ 12

Author(s):

Heinrich B.K Seidler ◽

Masanori Utsuyama ◽

Sakae Nagaoka ◽

Tamiko Takemura ◽

Masanobu Kitagawa ◽

...

Keyword(s):

Colorectal Cancer ◽

Wnt Signaling ◽

Age Groups ◽

Expression Level ◽

Biological Behavior ◽

Signaling Components

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Characteristics, outcomes, and risk factors of ICANS after axicabtagene ciloleucel: Does age matter?

Journal of Clinical Oncology ◽

10.1200/jco.2021.39.15_suppl.e19556 ◽

2021 ◽

Vol 39 (15_suppl) ◽

pp. e19556-e19556

Author(s):

Kitsada Wudhikarn ◽

Radhika Bansal ◽

Arushi Khurana ◽

Matthew Hathcock ◽

Michael Ruff ◽

...

Keyword(s):

Risk Factors ◽

Risk Factor ◽

Older Patients ◽

Clinical Course ◽

International Prognostic Index ◽

Age Groups ◽

Central Nervous System Involvement ◽

Microvascular Disease ◽

B Cell Lymphoma ◽

Younger Patients

e19556 Background: CD19 chimeric antigen receptor T cell therapy possesses unique side effects including cytokine release syndrome (CRS) and immune effector cell associated neurotoxicity syndrome (ICANS). Age is a major risk factor for ICANS. However, whether ICANS in older patients is different compared to younger patients is unknown. Herein, we report clinical course, outcomes and risk factors for ICANS in older patients with large B cell lymphoma (LBCL) treated with axicabtagene ciloleucel (axi-cel). Methods: We comprehensively reviewed detailed clinical courses of ICANS in 78 adult patients with LBCL treated with axi-cel between June 2016 and October 2020. Incidence, manifestation, risk factors, treatment, and outcomes of ICANS were compared between patients age ≥60 (n=32) and <60 (n=46) years old. Results: Baseline characteristics were comparable between older and younger patients except higher proportion of high international prognostic index and underlying cerebral microvascular disease in older patients. ICANS was observed in 16 patients in the older and 24 patients in the younger age group, with a 30-day incidence of 52% and 50%, respectively. Median time to CRS and ICANS were similar between 2 age groups. The most common initial neurological findings included aphasia, dysgraphia and encephalopathy in both age groups. Table summarizes the characteristics, clinical course and interventions of ICANS in older and younger patients. In Cox regression model, the presence of CRS was the only factor associated with ICANS in both age groups. Age, history of central nervous system involvement and cerebral microvascular disease were not associated with ICANS. Importantly, all patients had complete resolution of ICANS. No elderly patients in our cohort experienced seizure as a manifestation of ICANS. Conclusions: In our study, older age was not a risk factor for ICANS. CRS was the only factor associated with ICANS in both younger and older patients. Incidence, clinical course and neurological outcomes of ICANS in older patients treated with axi-cel were comparable to younger patients. [Table: see text]

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Closed Fractures of the Distal Part of the Shin Bones. Different Types and Methods of the Treatment in Adolescence. Short Period Results

Physical and rehabilitation medicine, medical rehabilitation ◽

10.36425/rehab63615 ◽

2021 ◽

Vol 3 (1) ◽

pp. 11-23

Author(s):

Alexander I. Dorokhin ◽

Alexander I. Krupatkin ◽

Anastasia A. Adrianova ◽

Vladimir I. Khudik ◽

Dmitriy S. Sorokin ◽

...

Keyword(s):

Distal Part ◽

Clinical Investigation ◽

Morphological Changes ◽

Treatment Algorithm ◽

Age Groups ◽

Growth Zone ◽

Difficult Problem ◽

Pathological Process ◽

X Rays ◽

Short Period

Background.Fractures of the distal leg bones in children, due to the peculiarities of localization, the presence of a growth zone, the proximity of the joint and the involvement of the ligamentous apparatus in the pathological process, present a difficult problem in the choice of treatment and rehabilitation.Aims:In order to our aims we create the diagnostic and treatment algorithm in the system of early rehabilitation after fractures in the distal part of the shin bone in adolescence.Methods.Our clinical investigation based on the treatment of 56 patients in the age 817 years. Cohort of patients consist from three age groups: 811 years (n=13), 1214 years (n=28) and 1517 years (n=15). Examination was done with X-rays, CT and Ultrasound, specialy in the cases where the damage of ligamentous apparatus was suspicious. The main method of treatment was surgical osteosynthesis by pins, plates and screws. In the rehabilitation period the legs were immobilized by Plaster of Paris for 46 weeks.Results.In majority of cases the outcomes in the period of 68 weeks after trauma were good and satisfactory. The method of laser Doppler fluometry was performed in 16 cases in follow up period after trauma for examination of the regional blood circulation as a argumentation of regeneration process.Conclusion.The different choice in treatment of compound fractures of the distal part of the shin bones according to morphological changes in adolescence permits to aid good results in majority of caces.

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Features of in-hospital clinical course of pulmonary embolism in patients of different age groups

CARDIOVASCULAR THERAPY AND PREVENTION ◽

10.15829/1728-8800-2020-2423 ◽

2020 ◽

Vol 19 (5) ◽

pp. 2423

Author(s):

E. A. Shmidt ◽

S. A. Berns ◽

A. G. Neeshpapa ◽

P. A. Talyzin ◽

I. I. Zhidkova ◽

...

Keyword(s):

Pulmonary Embolism ◽

High Risk ◽

Clinical Course ◽

Diastolic Pressure ◽

Age Groups ◽

Statistical Processing ◽

Severity Index ◽

Cardiovascular Comorbidity ◽

Vein Thrombosis ◽

Comorbidity Status

Aim. To study the clinical course and management of patients with pulmonary embolism (PE) of various age groups hospitalized in a cardiology hospital.Material and methods. This prospective single-center study in the period from 2016 to 2018 included 154 patients with PE verified by computed tomography. Statistical processing was conducted using the MedCalcVersion 16.2.1 software package (Softwa, Belgium).Results. In all groups, female patients dominated, but the highest number of women (70,7%) belonged to the group of senile patients, while in the group <60 years, only half of patients with PE were women. Comorbid cardiovascular disease and deep vein thrombosis was diagnosed in eldest patients significantly more often than in those <60 years of age. The highest prevalence of cancer and recurrent PE were identified in the group of elderly patients. Thrombolytic therapy was performed most often in patients 60-75 years old, since these patients had a high risk of 30-day mortality according to Pulmonary Embolism Severity Index, but did not have severe comorbidities, as patients older than 75 years. An increase of right atrium size was found in the group of elderly and senile patients in comparison with patients <60 years. The highest pulmonary artery systolic and diastolic pressure was observed in the patients older than 75 years.Conclusion. In the Kemerovo Oblast, PE most often develops in patients aged 60-75 years and is characterized by a more severe clinical course compared with patients younger than 60 years. Patients over the 60 years of age have severe cardiovascular comorbidity status, atrial fibrillation/flutter and recurrent PE. Surgical treatment for senile patients is limited due to the high risk of postoperative complications, which specifies high mortality. Patients <60 years of age are a third of all patients hospitalized with PE. They have a low risk of mortality, but have an unfavorable course of the hospital period.

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Melanoma in Adolescents and Young Adults: Evaluation of the Characteristics, Treatment Strategies, and Prognostic Factors in a Monocentric Retrospective Study

Frontiers in Oncology ◽

10.3389/fonc.2021.725523 ◽

2021 ◽

Vol 11 ◽

Author(s):

Paolo Del Fiore ◽

Irene Russo ◽

Beatrice Ferrazzi ◽

Alessandro Dal Monico ◽

Francesco Cavallin ◽

...

Keyword(s):

Young Adults ◽

Tnm Classification ◽

Age Groups ◽

Treatment Strategies ◽

Disease Free Survival ◽

Adolescents And Young Adults ◽

Biological Behavior ◽

Veneto Region ◽

Common Cancer ◽

Caucasian Patients

The “Veneto Cancer Registry” records melanoma as the most common cancer diagnosed in males and the third common cancer in females under 50 years of age in the Veneto Region (Italy). While melanoma is rare in children, it has greater incidence in adolescents and young adults (AYA), but literature offers only few studies specifically focused on AYA melanoma. The aim of this study was to describe the characteristics, surgical treatment, and prognosis of a cohort of AYA melanoma in order to contribute to the investigation of this malignancy and provide better patient care. This retrospective cohort study included 2,752 Caucasian patients (702 AYA and 2,050 non-AYA patients) from the Veneto Region who were over 15 years of age at diagnosis, and who received diagnosis and/or treatment from our institutions between 1998 and 2014. Patients were divided in adolescents and youth (15-25 years), young adults (26-39 years) and adults (more than 39 years) for the analysis. We found statistically significant differences in gender, primary site, Breslow thickness, ulceration, pathologic TNM classification (pTNM) stage and tumor subtype among the age groups. Disease-specific survival and disease-free survival were also different among the age groups. Our findings suggest that the biological behavior of melanoma in young people is different to that in adults, but not such as to represent a distinct pathological entity. Additional and larger prospective studies should be performed to better evaluate potential biological and cancer-specific differences between AYAs and the adult melanoma population.

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FEATURES OF MANUFACTURE OF ADVANCED PROVISIONAL BRIDGE-BASED PROSTHESES

Art of Medicine ◽

10.21802/artm.2021.1.17.33. ◽

2021 ◽

pp. 33-37

Author(s):

А. В. Kostyshyn

Keyword(s):

High Efficiency ◽

Age Groups ◽

Masticatory Muscles ◽

Pathological Process ◽

Muscle Group ◽

Control Group ◽

Masticatory Muscle ◽

Orthopedic Treatment ◽

Group 2 ◽

Reinforcement Model

Abstract. The relevance of the topic is related to the need to improve methods of preparation of dentitions for orthopedic treatment, taking into account the defects of dentitions in patients with reduced occlusion height, taking into account the condition of the masticatory muscles and temporary use of plastic dentures, which provide gradual lifting of occlusion to normalize the masticatory group muscles and reorganization of myostatic reflexes. The aim of the research. Improving the effectiveness of preparation for orthopedic treatment of patients with partial tooth loss, with reduced occlusion height, by improving the design of a temporary bridge-based prosthesis. Materials and methods of research. We examined, treated and conducted clinical observation of 93 patients, who were divided into three groups according to the height of the reduction in occlusion, to achieve this goal and solve problems during the dissertation. Group 1 consisted of 32 patients with included dentition defects with reduced occlusion height up to 2 mm (n=32), group 2 - patients with included dentition defects with reduced occlusion height up to 2-4 mm (n=31), group 3 - these are patients with included dentition defects with reduced occlusion height up to 4-6 mm (n=30). All patients of the main groups belonged to the second and third age groups according to the WHO, aged 35-55 years. The control group (n=30) are young people who belonged to the 1st age group according to the WHO with intact dentition, without concomitant somatic and dental pathology, were admitted in one visit. Also, 123 fiberglass-reinforced plastic prostheses were made. Research results. When drawing up a plan for orthopedic treatment of patients with reduced occlusion height, we took into account possible complications, which are characterized by chipping of the facing material, pathological changes in the temporomandibular joint and masticatory muscle group. We have improved the method of manufacturing non-removable temporary plastic orthopedic constructions by reinforcing with fiberglass tapes and beams, to prevent them and gradually raise the bite. Expanded data on the dynamics of changes in myostatic reflexes and the effectiveness of the use of fixed orthopedic constructions, depending on the pathological process, the timing of adaptation of the masticatory muscle group to orthopedic constructions, according to the degree of reduction in occlusion height. The absence of complaints of breakage and other technical defects of the proposed temporary orthopedic constructions in 100% of cases, successfully allows to use it in the clinic of orthopedic dentistry. A new method of preparing patients for permanent orthopedic treatment by combined reinforcement of temporary non-removable bridge constructions with fiberglass tapes and beams is proposed, which differ in that after preliminary modeling of the frame of the bridge constructions, the technology of double reinforcement, model two support platforms with a step-like transition between them, in which fiberglass tapes and beams are fitted with dental tweezers, after which they are polymerized by the generally accepted method with a photopolymer lamp. Complete the modeling of the constructions and polymerize the prosthesis in the pneumopolymerizer with subsequent grinding and polymerize the prosthesis. Conclusion. The results of the research revealed the high efficiency of the improved method of manufacturing non-removable makeshift plastic of orthopedic constructions.

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COMPARISON OF BIOCHEMICAL PARAMETERS OF PATIENTS WITH LIVER CIRRHOSIS WITH AND WITHOUT COVID-19

InterConf ◽

10.51582/interconf.19-20.08.2021.028 ◽

2021 ◽

pp. 288-294

Author(s):

Nurgul Toktogulova ◽

Elvira Zhakisheva ◽

Turarbek Kaliev ◽

Umid Satarov ◽

Alena Smirnova

Keyword(s):

Liver Cirrhosis ◽

Liver Damage ◽

Biochemical Parameters ◽

Clinical Course ◽

Age Groups ◽

Coronavirus Infection ◽

Liver Tests

There have been many published studies on how COVID-19 can affect the liver and how the severity of liver damage can influence the clinical course of COVID-19. The article describes the features of the biochemical parameters of the liver in different age groups developing with a new coronavirus infection using the example of observations in the department of gastroenterology. In patients under 60 years of age with liver cirrhosis in combination with Covid-19, along with deeper changes in liver tests, a decrease in hemoglobin, leukopenia and thrombocytopenia was observed.

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Orbital Complications of Acute Sinusitis: Evaluation, Management, and Outcome

Otolaryngology ◽

10.1177/019459987808600209 ◽

1978 ◽

Vol 86 (2) ◽

pp. ORL-221-ORL-230 ◽

Cited By ~ 44

Author(s):

Victor L. Schramm ◽

Eugene N. Myers ◽

John S. Kennerdell

Keyword(s):

Antibiotic Therapy ◽

Surgical Intervention ◽

Clinical Course ◽

Age Groups ◽

Orbital Cellulitis ◽

Acute Sinusitis ◽

Study Population ◽

Orbital Complications

Acute orbital cellulitis is most commonly caused by sinusitis. This complication is based on the anatomy of the sinuses, orbit, and their venous connections. A series of 134 patients is reviewed to demonstrate the etiology and clinical course of orbital cellulitis. Antibiotic therapy alone does not prevent permanent complications. Surgical intervention is found necessary in all age groups and is required in 20% of the study population.

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ULTRASOUND DIAGNOSTICS OF CHRONIC CONSTIPATION IN CHILDREN: RESULTS OF A CLINICAL STUDY

PEDIATRIA Journal named after G N SPERANSKY ◽

10.24110/0031-403x-2021-100-6-59-65 ◽

2021 ◽

Vol 100 (6) ◽

pp. 59-65

Author(s):

L.N. Tsvetkova ◽

◽

M.M. Kolisnichenko ◽

O.A. Goryacheva ◽

◽

...

Keyword(s):

Clinical Study ◽

Anal Sphincter ◽

Chronic Constipation ◽

Diagnostic Method ◽

Age Distribution ◽

Age Groups ◽

Pathological Process ◽

Number Of Patients ◽

Ultrasound Diagnostics ◽

Sphincter Insufficiency

Chronic constipation (CC) is an important medical and social problem, as it can lead to the development of complications, fecal intoxication, social disadaptation and self-isolation of a child, as well as significantly reduce the quality of life. The article presents the results of a clinical study of CC in children using a new diagnostic method - transabdominal and transperianal ultrasound examination (US) of the colon and anorectal zone. The objective of the study was to analyze the course of CC in children depending on the mechanism of its formation according to US of the colon and anorectal zone. Materials and methods of research: the prospective cohort study included 470 children with an established diagnosis of CC at the age of 1 month to 17 years old. The patients were divided into 3 age groups: 1 month. – 3 years (n=166), 4–10 years (n=102), 11–17 years (n=202). The median follow-up was 48 months. The age distribution of children with CC was carried out on the basis of the frequency of visits, against the background of the beginning of attending kindergarten and/or elementary school groups, and the emergence of psychological problems due to the difficulty of going to a public toilet. An evaluation of analysis of the dynamics of US changes in the colon and anorectal zone was carried out by the method of ultrasound diagnosis of Hirschsprung's disease in children (patent № 2547614, authors M.I. Pykov, M.M. Kolisnichenko, I.V. Poddubny). Results: in children aged 1 month to 3 years, 66.9% of cases are statistically significantly dominated by proctogenic constipation type of constipation with US signs of anus spasm and anal sphincter insufficiency. In children aged 4 to 10 years, the mixed mechanism of CC formation prevails (41.1%), and in patients aged 11 to 17 years – cologenic (77.7%), for which the most typical ultrasound signs are dolichocolon (22.8%), anus spasm (8.7%), anal sphincter insufficiency (4.7%). It has been established that despite adequate therapy, the number of patients with the above-described mechanisms of formation of CC increases, which indicates the recurrence and progression of pathological process in children of different age groups. Conclusion: the proposed diagnostic method – transabdominal and transperianal US of the colon and anorectal zone is a highly informative, pathogenetically substantiated method for examining the state of the colon and anorectal zone in children with CC, built on precise objective criteria that are available at any age.

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