scholarly journals Proliferative activity of the epithelium in squamous epithelial lesions of the cervix

2021 ◽  
Vol 50 (1) ◽  
pp. 34-36
Author(s):  
I. B. Manukhin ◽  
G. .N. Minkina
Keyword(s):  
Proliferative Activity ◽  
Cell Nuclei ◽  
Squamous Intraepithelial Lesion ◽  
Low Degree ◽  
Stratified Squamous Epithelium ◽  
Intraepithelial Lesion ◽  
Epithelial Lesions ◽  
High Degree ◽  
Proliferating Cell

As a criterion for precancerous changes in the stratified squamous epithelium of the cervix, its proliferative activity, studied using monoclonal antibodies PC-10 to the antigen of proliferating cell nuclei (PCNA), is considered. The results of the studies showed that patients with a low degree of squamous intraepithelial lesion are characterized by weak proliferative activity, and for patients with a high degree of lesion it is moderate and pronounced. An increase in proliferative activity is a prognostic factor that determines long-term persistence and the likely progression of the lesion.

scholarly journals Analysis of abnormal epithelial lesions in cervical Pap smears in Mid-Western Nepal

1970 ◽  
Vol 1 (1) ◽  
pp. 30-33 ◽  
Author(s):  
SK Ranabhat ◽  
R Shrestha ◽  
M Tiwari
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Pap Smear ◽  
Pap Smears ◽  
Low Grade ◽  
Squamous Intraepithelial Lesion ◽  
Pap Screening ◽  
Intraepithelial Lesion ◽  
Epithelial Lesions

Background: Like in other developing countries, cancer of cervix is one of the most common malignancies in women in Nepal. Most women never undergo a cervical Pap smear screening. The objective of this study is to determine the prevalence of abnormal cervical epithelial lesions. Materials and Methods: This was a retrospective study of 880 conventional cervical Pap smears reported from the Department of Pathology, Chitwan Medical College in Chitwan, Nepal. The time period was from June 2009 to November 2010. Results: In this study, High-grade Squamous Intraepithelial Lesion was the most common with 6 cases (40%), followed by Low-grade Squamous Intraepithelial Lesion with 3 cases (20%), then Atypical Squamous Epithelial Cells of Undetermined Significance, and atypical Glandular Cells and Squamous cell carcinoma with 2 cases each (13.3%). Eighty per cent of all the abnormal epithelial lesions were found in women above the age of 40 years. Conclusion: At least one Pap screening test of the cervix of all women between the ages of 40-50 years is recommended. Keywords: Pap smear; Cervical Intraepithelial Lesion; Squamous cell carcinoma. DOI: 10.3126/jpn.v1i1.4447Journal of Pathology of Nepal (2011) Vol.1, 30-33

scholarly journals Long-term observational approach in women with histological diagnosis of cervical low-grade squamous intraepithelial lesion: an Italian multicentric retrospective cohort study

BMJ Open ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. e024920 ◽  
Author(s):  
Andrea Ciavattini ◽  
Matteo Serri ◽  
Jacopo Di Giuseppe ◽  
Carlo Antonio Liverani ◽  
Barbara Gardella ◽  
...  
Keyword(s):  
Invasive Cancer ◽  
Secondary Outcome ◽  
Histopathological Diagnosis ◽  
Low Grade ◽  
Squamous Intraepithelial Lesion ◽  
Dna Test ◽  
Hpv Dna ◽  
Intraepithelial Lesion

ObjectiveTo evaluate the risk of progression to high-grade squamous intraepithelial lesion (HSIL) (CIN2-3) or invasive cancer in women with histopathological diagnosis of low-grade squamous intraepithelial lesion (LSIL) (CIN1), managed in a long-term observational approach up to 5 years.DesignRetrospective cohort study.SettingFour tertiary referral hospital.Participants434 women with adequate colposcopy and complete colposcopic charts were included in the present analysis. Women with glandular lesions on the referral cytology or previous diagnosis of cervical dysplasia or invasive cervical cancer or with synchronous vaginal, or with HIV infection or immunodepression were excluded.Primary and secondary outcome measuresThe main study outcome was the rate of progression to histopathological HSIL (CIN2-3) or invasive cancer at any time during 5 years of follow-up. The possible risk factors were also evaluated. As secondary outcome, we analysed the possible risk factors at the 24-month evaluation for histopathological HSIL (CIN2-3) or invasive cancer progression between 2 and 5 years from initial diagnosis.ResultsA progression to histopathological HSIL (CIN2-3) was found in a total of 32 (7.4%) cases during 5 years of follow-up. A histopathological diagnosis of HSIL (CIN3) was found in four patients (0.9%) and no case of invasive cancer was detected. High-grade cytology at inclusion and the presence of a positive high-risk human papillomavirus (HR-HPV) DNA test at 2 years from inclusion maintained a significant correlation with the risk of histopathological progression to HSIL (CIN2-3).ConclusionsThe results of our study showed a low rate (7.4%) of histopathological progression to HSIL (CIN2-3) in women with LSIL (CIN1) diagnosis during long-term follow-up up to 5 years. In case of positive HR-HPV DNA test at the 2 years evaluation an excisional treatment could be the preferred choice to prevent progression to HSIL (CIN2-3) in the following years, preferring a continuation of follow-up in case of HR-HPV DNA negative result.

scholarly journals Liquid Based Cytology for the Detection of Cervical Intraepithelial Lesions among Women in Jimma Town, Ethiopia

2020 ◽  
Author(s):  
Getnet Tesfaw ◽  
Yesuf Ahmed ◽  
Lealem Gedefaw ◽  
Lamessa Dube ◽  
Samson Godu ◽  
...  
Keyword(s):  
Cervical Dysplasia ◽  
Low Grade ◽  
Squamous Intraepithelial Lesion ◽  
Cervical Lesions ◽  
Kappa Value ◽  
Intraepithelial Lesion ◽  
Liquid Based Cytology ◽  
Epithelial Lesions ◽  
High Cervical ◽  
Intraepithelial Lesions

Abstract Background: Cervical cancer is the second leading type of female cancer in Ethiopia. Screening is primarily conducted using visual inspection with 5% acetic acid (VIA). Liquid-based cytology (LBC) has not yet been used in Ethiopia.Method: Women aged 21-65 years were tested using LBC and VIA for the detection of cervical dysplasia. Logistic regression analysis was conducted to identify associated factors. Cohen’s K test was conducted to test agreement between LBC and VIA. Results: Forty-two percent (n=188) of 448 participants were 31 to 40 years of age and only two participants were above 60. Of the 448 participants, 419 (93.5%) were tested with LBC, 294 (65.6%) VIA and 272 (60.7%) with both LBC and VIA. Among women screened using LBC, 305(72.8%) were negative for intraepithelial lesion or malignancy (NILM), 97 (23.2%) had low grade squamous intraepithelial lesion (LSIL) and 17 (4.1%) high grade squamous intraepithelial lesion (HSIL). Presence of cervical lesions was generally lower in younger and older aged women. Majority, 39(40%) with LSIL and 10 (59%) of women with HSIL were 41-50 years old. Women aged 51-60 years were more likely to have abnormal intraepithelial lesions compared to women aged 21-30 (AOR= 20.9,95%CI=[7.2-60.9], p=0.00). Out of 47 (10.8%) HIV-patients,14(32.56%) had intraepithelial lesion of which 10(23.3%) and 4(9.3%) had LSIL and HSIL, respectively. Among women screened with VIA, 18 (6.1%) were positive. Among the 272 (60.7%) women screened using both LBC and VIA, 6 (2.2%) were positive on both LBC and VIA. The level of agreement between the two tests was weak and statistically significant (kappa value=0.155, p=0.006). Conclusion: LBC detected high cervical squamous intra-epithelial lesions in our setting. VIA was a less reliable predictor of cervical squamous intra-epithelial lesions than LBC. Evaluating diagnostic accuracy of both LBC and VIA against histological endpoint should be completed before adopting either screening modalities.

scholarly journals Liquid-based Cytology for the Detection of Cervical Intraepithelial Lesions in Jimma Town, Ethiopia

2020 ◽  
Author(s):  
Getnet Tesfaw ◽  
Yesuf Ahmed ◽  
Lealem Gedefaw ◽  
Lamessa Dube ◽  
Samson Godu ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cervical Dysplasia ◽  
Low Grade ◽  
Squamous Intraepithelial Lesion ◽  
Cervical Lesions ◽  
Kappa Test ◽  
Intraepithelial Lesion ◽  
Liquid Based Cytology ◽  
Epithelial Lesions ◽  
Intraepithelial Lesions

Abstract Background: Cervical cancer is the second leading type of female cancer in Ethiopia. Screening for cervical cancer is primarily conducted using visual inspection with 5% acetic acid (VIA). Liquid-based cytology (LBC) is not yet widely used in Ethiopia. Method: Women aged 21-65 years were tested using LBC and VIA to detect cervical dysplasia. Logistic regression analysis was conducted to identify associated factors. Cohen’s Kappa test was conducted to test agreement between LBC and VIA. Results: Forty-two percent (n=188) of 448 participants were 31 to 40 years of age and only two participants were above 60. Of the 448 participants, 419 (93.5%) were tested with LBC, 294 (65.6%) VIA and 272 (60.7%) with both LBC and VIA. Among women screened using LBC, 305 (72.8%) were negative for intraepithelial lesion or malignancy (NILM), 97 (23.2%) had low-grade squamous intraepithelial lesion (LSIL) and 17 (4.1%) had high-grade squamous intraepithelial lesion (HSIL). Presence of cervical lesions was generally lower in younger and older women. Majority, 39 (40%) of women with LSIL and 10 (59%) with HSIL were 41-50 years of age. Women aged 51-60 were more likely to have abnormal intraepithelial lesions compared to women aged 21-30 (AOR= 20.9, 95% CI=[7.2-60.9], p=0.00). Out of 47 (10.8%) HIV-positive women, 14 (32.56%) had intraepithelial lesions of which 10 (23.3%) and 4 (9.3%) had LSIL and HSIL, respectively. Among women screened with VIA, 18 (6.1%) were positive; among the 272 (60.7%) women screened using both LBC and VIA, 6 (2.2%) were positive on both LBC and VIA tests. The level of agreement between the two tests was weak at a statistically significant level (kappa value=0.155, p=0.006). Conclusion: LBC demonstrated high rates of cervical squamous intra-epithelial lesions in our study. VIA was a less reliable predictor of cervical squamous intra-epithelial lesions than LBC. Evaluating diagnostic accuracy of both LBC and VIA against a histological endpoint should be completed before adopting either or both screening modalities.

scholarly journals Mechanical Properties Of Traditional And Nanofibre Textiles

2015 ◽  
Vol 15 (3) ◽  
pp. 198-206
Author(s):  
Petr Ursíny ◽  
Martin Bílek ◽  
Eva Moučková ◽  
Martina Pokorná ◽  
Petr Tumajer ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Low Degree ◽  
Deformation Properties ◽  
Degree Of Orientation ◽  
New Material ◽  
Plied Yarn ◽  
Dynamic Loading Conditions ◽  
High Degree ◽  
Static And Dynamic Loading

Abstract This study deals with a comparison of mechanical properties of a conventional yarn and a textile from nanofibres. The conventional yarn represents the textile objects with high degree of orientation of fibres and the textile from nanofibres represents the textile objects with low degree of orientation of fibres. The theoretical section is concerned with the issue of internal structure of plied yarn and resulting differences in the orientation and straightening of fibres and in utilisation of deformation properties of fibres in comparison to the referred nano textile. The experimental section describes the manner of realisation of both static and dynamic tests of conventional yarn and strips of nanofibres. The results show differences in the mechanical properties of conventional yarn and textile strip from nanofibres under static and dynamic loading conditions. The processing technology of conventional yarn has been verified in the long term. But textiles from nanofibres are a relatively new material and mechanical properties of the detected differences point out possible problems with their behaviour during standard technological processes.

Low Utility in Colposcopy-directed Biopsies for Non-high Grade Cytological Abnormalities on PAP Smear

2020 ◽  
Vol 16 (1) ◽  
pp. 18-22
Author(s):  
Eronmwon E. Gbinigie ◽  
Joshua Fogel ◽  
Maggie Tetrokalashvili
Keyword(s):  
Pap Smear ◽  
Multinomial Logistic Regression ◽  
Cervical Dysplasia ◽  
Outcome Variable ◽  
Low Grade ◽  
High Grade ◽  
Squamous Intraepithelial Lesion ◽  
Intraepithelial Lesion ◽  
Cytologic Abnormalities ◽  
Cytology Screening

Background: Clinicians commonly perform colposcopy directed biopsies on patients with low grade squamous intraepithelial lesion (LSIL) on PAP cytology even when not consistent with clinical guidelines. Objective: We study the association of PAP cytology screening results with cervical intra-epithelia neoplasia (CIN) 2-3 high-grade dysplasia, as confirmed by colposcopy-directed biopsy. Methods: A retrospective study of 263 women with an abnormality on the PAP smear. Multinomial logistic regression was performed with predictors of PAP cytology screening results with the outcome variable of colposcopy-directed biopsy. Results: High grade squamous intraepithelial lesion (HSIL) had significantly increased relative risk for CIN 2-3 (RR: 9.85, 95% CI: 1.84, 52.79, p=0.008). LSIL was not significantly associated with CIN 2-3. In the comparisons of negative with CIN-1, both HSIL and LSIL were not significantly associated with a negative biopsy. Conclusion: HSIL is associated with cervical dysplasia of CIN 2-3 while LSIL is not associated with cervical dysplasia of CIN 2-3. We do not recommend routine biopsies in patients with LSIL cytologic abnormalities unless additional compelling factors exist.

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