scholarly journals The questions of pathogenesis of uterine cervix elongation (clinical-morphological and immunohistochemical investigation)

2005 ◽  
Vol 54 (3) ◽  
pp. 5-11
Author(s):  
D. F. Kostyuchek ◽  
А. S. Gordeladze ◽  
А. S. Klyukovkina
Keyword(s):  
Connective Tissue ◽  
Uterine Cervix ◽  
Collagen Synthesis ◽  
Immunohistochemical Examination ◽  
Immunohistochemical Investigation ◽  
Connective Tissue Dysplasia

Theclinical-morphological, immunohistochemical examination of the elongation of uterine cervix (EUC) in patients aged of 29-70 years old was conducted. The correlation of the systemic connective tissue dysplasia (SCTD) with the reconstruction of the tissue architectonics of the cervix, disorders of collagen synthesis, redistribution of the I, III and IV types of collagen was established, which testify the role of SCTD in the pathogenesis of the EUC.

The Displays of Connective Tissue Dysplasia (Hypermobility) in Patients with Vertebral Syndrome of Lumbosacral Spine

2016 ◽  
pp. 149-154
Author(s):  
Oleksandr Piantkovskiy
Keyword(s):  
Connective Tissue ◽  
Varicose Veins ◽  
Pain Syndrome ◽  
Lumbosacral Spine ◽  
Duration Of Treatment ◽  
Medical Practitioners ◽  
Clinical Neurological Examination ◽  
Connective Tissue Dysplasia ◽  
Neurological Features

In recent years medical practitioners more often pay their attention on role of pathology of different organs and systems of human’s body which are associated with connective tissue dysplasia. The importance of this problem is caused by the great prevalence of connective tissue dysplasia, systemacity of damage, high probability of different diseases’ formation. Connective tissue dysplasia is the violation of the connective tissue structure during embryonic and postnatal periods because of genetically modified fibrillogenesis of extracellular matrix, leading to homeostasis disorder on tissue and organ levels with the progressive course. There was held the clinical neurological examination with 120 patients, who had neurological features of vertebral syndrome of lumbosacral spine. Analysis of the clinical examination results demonstrated that patients with vertebral syndrome of lumbosacral spine (p<0,05) more common can occur pathology of joints and varicose veins of the lower extremities. Significantly (p<0,05) (scoliosis, kyphosis, kyphoscoliosis, tendency to dislocation, stretching the ligaments) increase the duration of treatment and the expression of a pain syndrome. The results of examination and monitoring of patients in the dynamics of the treatment showed that patients with vertebral syndrome of lumbosacral spine (p<0,05) more often have anatomical changes in the lumbosacral spine than patients without evidence of DST.

The role of connective tissue dysplasia in the development of varicocele and its postoperative recurrence

2019 ◽  
Vol 7 (3) ◽  
pp. 29-34
Author(s):  
R.Yu. Andreev ◽  
◽  
P.I. Rasner ◽  
E.A. Prilepskaya ◽  
I.V. Semenyakin ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Postoperative Recurrence ◽  
Connective Tissue Dysplasia

scholarly journals Analysis of the frequency of connective tissue dysplasia

2016 ◽  
pp. 21-25
Author(s):  
A. Pyantkovsky
Keyword(s):  
Connective Tissue ◽  
High Probability ◽  
Tissue Homeostasis ◽  
Lumbosacral Spine ◽  
Neurological Manifestations ◽  
Duration Of Treatment ◽  
Connective Tissue Dysplasia ◽  
Data Screening ◽  
Progressive Course

In recent decades, increasing attention attracts practitioners role of pathology of different organs and systems of the human body associated with connective tissue dysplasia (DST). The significance of this problem is due to a large prevalence of GOST, system damage, high probability of the formation of different kinds of diseases. Dysplasia of connective tissue (display breach) a violation of the structure of the connective tissue in the embryonic and postnatal periods due to genetically modified extracellular matrix, leading to frustration on tissue homeostasis and organ levels with a progressive course. There have been clinical and neurological examination of 120 patients with neurological manifestations of the syndrome vertebrogenic lumbar spine. Analysis of the results of the clinical study demonstrated that in patients with vertebral syndrome, lumbosacral spine against the background displays GOST significantly (p <0.05) more common protrusion m / s disk changes are more pronounced yellow ties as its thickening. And also more common syndrome joints and vascular dystonia. Significantly (p <0.05) displays GOST (scoliosis, kyphosis, kyphoscoliosis, joints, tendency to dislocation, stretching the ligaments of the joints) - increases the duration of treatment and the severity of pain. The data screening and monitoring of patients in the dynamics of the treatment showed that patients with symptoms GOST significantly (p <0.05) more often aggravation vertebrogenic syndrome lumbosacral spine.

The role of connective tissue dysplasia manifestations in the development of variants of gastric acidity disorders

Therapy ◽  
2018 ◽  
Vol 6_2018 ◽  
pp. 91-96
Author(s):  
M.Yu. Rozhkova Rozhkova ◽  
G.I. Nechaeva Nechaeva ◽  
E.A. Lyalyukova Lyalyukova ◽  
O.M. Kulikova Kulikova ◽  
◽  
...  
Keyword(s):  
Connective Tissue ◽  
Gastric Acidity ◽  
Connective Tissue Dysplasia

Role of Extracellular Matrix in Adaptation of Tendon and Skeletal Muscle to Mechanical Loading

2004 ◽  
Vol 84 (2) ◽  
pp. 649-698 ◽  
Author(s):  
MICHAEL KJÆR
Keyword(s):  
Physical Activity ◽  
Mechanical Properties ◽  
Skeletal Muscle ◽  
Extracellular Matrix ◽  
Connective Tissue ◽  
Mechanical Loading ◽  
Collagen Synthesis ◽  
Cross Linking ◽  
Collagen Turnover

Kjær, Michael. Role of Extracellular Matrix in Adaptation of Tendon and Skeletal Muscle to Mechanical Loading. Physiol Rev 84: 649–698, 2004; 10.1152/physrev.00031.2003.—The extracellular matrix (ECM), and especially the connective tissue with its collagen, links tissues of the body together and plays an important role in the force transmission and tissue structure maintenance especially in tendons, ligaments, bone, and muscle. The ECM turnover is influenced by physical activity, and both collagen synthesis and degrading metalloprotease enzymes increase with mechanical loading. Both transcription and posttranslational modifications, as well as local and systemic release of growth factors, are enhanced following exercise. For tendons, metabolic activity, circulatory responses, and collagen turnover are demonstrated to be more pronounced in humans than hitherto thought. Conversely, inactivity markedly decreases collagen turnover in both tendon and muscle. Chronic loading in the form of physical training leads both to increased collagen turnover as well as, dependent on the type of collagen in question, some degree of net collagen synthesis. These changes will modify the mechanical properties and the viscoelastic characteristics of the tissue, decrease its stress, and likely make it more load resistant. Cross-linking in connective tissue involves an intimate, enzymatical interplay between collagen synthesis and ECM proteoglycan components during growth and maturation and influences the collagen-derived functional properties of the tissue. With aging, glycation contributes to additional cross-linking which modifies tissue stiffness. Physiological signaling pathways from mechanical loading to changes in ECM most likely involve feedback signaling that results in rapid alterations in the mechanical properties of the ECM. In developing skeletal muscle, an important interplay between muscle cells and the ECM is present, and some evidence from adult human muscle suggests common signaling pathways to stimulate contractile and ECM components. Unaccostumed overloading responses suggest an important role of ECM in the adaptation of myofibrillar structures in adult muscle. Development of overuse injury in tendons involve morphological and biochemical changes including altered collagen typing and fibril size, hypervascularization zones, accumulation of nociceptive substances, and impaired collagen degradation activity. Counteracting these phenomena requires adjusted loading rather than absence of loading in the form of immobilization. Full understanding of these physiological processes will provide the physiological basis for understanding of tissue overloading and injury seen in both tendons and muscle with repetitive work and leisure time physical activity.

scholarly journals The role of echocardiography in the assessment of hemodynamics in patients with connective tissue dysplasia

2015 ◽  
Vol 14 (2) ◽  
pp. 16-25
Author(s):  
E. V. Fomenko ◽  
S. B. Tkachenko ◽  
N. F. Beresten ◽  
E. S. Pavochkina
Keyword(s):  
Connective Tissue ◽  
Central Hemodynamics ◽  
Cardiac Pathology ◽  
Ultrasound Diagnostics ◽  
Connective Tissue Dysplasia ◽  
Clinically Significant

The article describes the features of ultrasound diagnostics and central hemodynamics in patients with minor heart anomalies. In vivo visualization of these anomalies has become possible after the introduction of echocardiography. The working classification of minor heart anomalies, as well as the description of clinically significant syndromes and abnormalities are considered. The role of connective tissue dysplasia in the development of cardiac pathology is highlighted, and its place in the structure of connective tissue dysplasia syndrome of the heart and heritable disorders of connective tissue is described.

scholarly journals The significance of connective tissue dysplasia in the development of cervical incompetence

2009 ◽  
Vol 8 (4(2)) ◽  
pp. 74-76
Author(s):  
L. I. Kokh ◽  
L. P. Nazarenko ◽  
J. V. Tsukanova ◽  
I. V. Satysheva
Keyword(s):  
Connective Tissue ◽  
Physical Examination ◽  
Cervical Incompetence ◽  
Loss Of Weight ◽  
Connective Tissue Dysplasia

100 pregnancy women at 13—30 weeks gestations were examined to study significance of connective tissue dysplasia in the development of cervical incompetence. Data of objective examination, anamnesis, physical examination. The role of connective tissue dysplasia was firmed by presence its markers, loss of weight, diseases with connective tissue dysplasia.

scholarly journals FEATURES OF APONEUROSIS PATHOMORPHOLOGICAL CHANGES IN PATIENTS WITH EVENTRATION

2021 ◽  
Vol 19 (4) ◽  
Author(s):  
Ya.Yu Voitiv ◽  
O.O. Dyadyk
Keyword(s):  
Smooth Muscle ◽  
Monoclonal Antibodies ◽  
Connective Tissue ◽  
Vascular Wall ◽  
Collagen Iv ◽  
Treatment Results ◽  
Positive Expression ◽  
Connective Tissue Dysplasia ◽  
Connective Tissue Pathology

Objective – to improve the treatment results of patients with eventration by determiningthe role of undifferentiated connective tissue dysplasia in the development of thiscomplication.Material and methods. The object of the study comprises 33 patients with eventrationwho were treated in the department of thoracoabdominal surgery of Shalimov NationalInstitute of Surgery and Transplantology during 2017-2020.Results. At complex pathomorphological research of aponeurosis fragments similarmorphological changes have been revealed in groups of patients with phenotypic signsof undifferentiated connective tissue dysplasia and eventration. Immunohistochemicalexamination of tissues with monoclonal antibodies to α-SMA revealed uneven, focalexpression in smooth muscle differentiation cells and fibroblasts in both groups. In thestudies with monoclonal antibodies to Collagen IV, moderate positive expression in thebasement membrane of the blood vessels, in smooth muscle cells of the muscular layerof the vascular wall, in areas of the connective tissue was observed, that is a sign ofpathological remodeling of the connective tissue.Conclusions. Similar pathomorphological changes of the aponeurosis in groups withphenotypic signs of undifferentiated connective tissue dysplasia and post-operativeeventration confirm the role of the connective tissue pathology in the development of thiscomplication.

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