scholarly journals Rapid tests in the diagnostics of sexually transmitted infections

2015 ◽  
Vol 64 (1) ◽  
pp. 34-43
Author(s):  
Olga Sergeyevna Ryzhkova
Keyword(s):  
Sexually Transmitted Infections ◽  
Point Of Care ◽  
High Specificity ◽  
Molecular Diagnostic ◽  
Sexually Transmitted ◽  
Highly Sensitive ◽  
High Prevalence ◽  
Microfluidic Biosensor ◽  
Rapid Tests ◽  
Diagnostic Technologies

High prevalence of sexually transmitted infections (STIs) and their substantial adverse effect on reproductive health of people necessitate the development of accurate and rapid tests for their diagnostics, in particular those that can be used at point-of-care (POC). The majority of current immunological POC-tests have high specificity; however, their sensitivity is mainly suboptimal. The future of POC-diagnostics of STIs - highly sensitive and specific, robust and affordable - is seen in the development and implementation of molecular diagnostic technologies (amplification, microfluidic, biosensor).

scholarly journals Modular development of a prototype point of care molecular diagnostic platform for sexually transmitted infections

2016 ◽  
Vol 38 (8) ◽  
pp. 741-748 ◽  
Author(s):  
Manoharanehru Branavan ◽  
Ruth E. Mackay ◽  
Pascal Craw ◽  
Angel Naveenathayalan ◽  
Jeremy C. Ahern ◽  
...  
Keyword(s):  
Sexually Transmitted Infections ◽  
Point Of Care ◽  
Molecular Diagnostic ◽  
Sexually Transmitted

scholarly journals Current and Future Trends in the Laboratory Diagnosis of Sexually Transmitted Infections

2021 ◽  
Vol 18 (3) ◽  
pp. 1038
Author(s):  
Giorgia Caruso ◽  
Anna Giammanco ◽  
Roberta Virruso ◽  
Teresa Fasciana
Keyword(s):  
Sexually Transmitted Infections ◽  
Point Of Care ◽  
Risk Groups ◽  
Laboratory Diagnosis ◽  
Diagnostic Tools ◽  
Sexually Transmitted ◽  
Social Burden ◽  
High Prevalence ◽  
Syndromic Diagnosis ◽  
Asymptomatic Infections

Sexually transmitted infections (STIs) continue to exert a considerable public health and social burden globally, particularly for developing countries. Due to the high prevalence of asymptomatic infections and the limitations of symptom-based (syndromic) diagnosis, confirmation of infection using laboratory tools is essential to choose the most appropriate course of treatment and to screen at-risk groups. Numerous laboratory tests and platforms have been developed for gonorrhea, chlamydia, syphilis, trichomoniasis, genital mycoplasmas, herpesviruses, and human papillomavirus. Point-of-care testing is now a possibility, and microfluidic and high-throughput omics technologies promise to revolutionize the diagnosis of STIs. The scope of this paper is to provide an updated overview of the current laboratory diagnostic tools for these infections, highlighting their advantages, limitations, and point-of-care adaptability. The diagnostic applicability of the latest molecular and biochemical approaches is also discussed.

scholarly journals P07.06 A low cost, hand-held point of care molecular diagnostic device for sexually transmitted infections

2015 ◽  
Vol 91 (Suppl 2) ◽  
pp. A122.2-A122
Author(s):  
RE Mackay ◽  
M Branavan ◽  
P Craw ◽  
A Naveenathayalan ◽  
ST Sadiq ◽  
...  
Keyword(s):  
Sexually Transmitted Infections ◽  
Point Of Care ◽  
Low Cost ◽  
Molecular Diagnostic ◽  
Diagnostic Device ◽  
Sexually Transmitted

scholarly journals P193 Development of a handheld point of care molecular diagnostic device for sexually transmitted infections

2015 ◽  
Vol 91 (Suppl 1) ◽  
pp. A80.2-A80
Author(s):  
Ruth Mackay ◽  
Pascal Craw ◽  
Manoharanehru Branavan ◽  
Tariq Sadiq ◽  
Wamadeva Balachandran
Keyword(s):  
Sexually Transmitted Infections ◽  
Point Of Care ◽  
Molecular Diagnostic ◽  
Diagnostic Device ◽  
Sexually Transmitted

High Prevalence of Sexually Transmitted Infections and Risk Factors Among HIV-Positive Individuals in Yunnan, China

2021 ◽  
Author(s):  
Wei Tu ◽  
Yu-Ye Li ◽  
Yi-Qun Kuang ◽  
Rong-Hui Xie ◽  
Xing-Qi Dong ◽  
...  
Keyword(s):  
Risk Factors ◽  
Sexually Transmitted Infections ◽  
Genital Tract ◽  
Mycoplasma Genitalium ◽  
Cross Sectional Study ◽  
Multiple Infections ◽  
Hiv Positive ◽  
Cross Sectional ◽  
Sexually Transmitted ◽  
High Prevalence

Abstract Background Yunnan has the highest rates of HIV in the country. Other treatable sexually transmitted infections (STIs) are associated with accelerated HIV transmission and poor ART outcomes, but are only diagnosed by syndromic algorithms. Methods We recruited 406 HIV-positive participants for a cross-sectional study (204 ART-naive and 202 ART). Blood samples and first-voided urine samples were collected. Real-time polymerase chain reaction methods were used for Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Mycoplasma genitalium (MG). Syphilis and HSV-2 tests were also performed. Results Among 406 participants, the overall prevalence of STI was 47.0% and 45.1% in ART-naive individuals and 49.0% in ART individuals, respectively. Testing frequency was 11.6% (11.8% vs 11.4%), 33.2% (29.4% vs 37.1%), 3.2% (3.4% vs 3.0%), 2.0% (3.4% vs 0.5%) and 4.7% (6.4% vs 3.0%) for active syphilis, HSV-2, chlamydia, gonorrhoeae and genitalium. Percentage of multiple infections in both groups was 10.8% (22/204) in ART-naive participants and 9.9% (20/202) in ART participants. Females, age between 18 to 35 years, ever injected drugs, homosexual or bisexual, HIV/HBV coinfection, and not receiving ART were identified as risk factors. Self-reported asymptom was not eliminating of having a laboratory-diagnosed STI. Conclusions STI prevalence was 47.0% (45.1% vs 49.0%), HSV-2, syphilis and MG were the most common STIs in HIV-infected individuals. We found high prevalence (6.4%) of Mycoplasma genitalium in ART-naive individuals. ART can reduce the diversity of STI-HIV coinfection but not the prevalence. HIV-positive individuals tend to neglect or maybe hide their genital tract discomfort, thus we suggest strengthening STI joint screening and treatment services among HIV-infected individuals whether they describe genital tract discomfort or not.

Bridging the gap between development of point-of-care nucleic acid testing and patient care for sexually transmitted infections

Lab on a Chip ◽  
2021 ◽  
Author(s):  
Kuangwen Hsieh ◽  
Johan H. Melendez ◽  
Charlotte A Gaydos ◽  
Jeff Tza-Huei Wang
Keyword(s):  
Nucleic Acid ◽  
Patient Care ◽  
Sexually Transmitted Infections ◽  
Medical Cost ◽  
Point Of Care ◽  
Nucleic Acid Testing ◽  
Cost Burden ◽  
Sexually Transmitted

The rate of sexually transmitted infections (STIs), including the four major curable STIs – chlamydia, gonorrhea, trichomoniasis and, syphilis – continue to increase globally, causing medical cost burden and morbidity...

scholarly journals Syndromic versus Laboratory Diagnosis of Sexually Transmitted Infections in Men in Moshi District of Tanzania

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Yuwei Cheng ◽  
Elijah Paintsil ◽  
Musie Ghebremichael
Keyword(s):  
Sexually Transmitted Infections ◽  
Laboratory Testing ◽  
High Specificity ◽  
Cost Effective ◽  
Laboratory Diagnosis ◽  
Receiver Operating Curve ◽  
Sexually Transmitted ◽  
Resource Limited ◽  
Syndromic Diagnosis ◽  
Low Sensitivity

The syndromic diagnosis of sexually transmitted infections (STIs) is widely recognized as the most practical, feasible, and cost-effective diagnostic tool in resource-limited settings. This study assessed the diagnostic accuracy of syndromic versus laboratory testing of STIs among 794 men randomly selected from the Moshi district of Tanzania. Participants were interviewed with a questionnaire that included questions on history of STIs symptoms. Blood and urine samples were taken from the participants for laboratory testing. Only 7.9% of the men reported any symptoms of STI; however, 46% of them tested positive for at least one STI. There was little agreement between syndromic and laboratory-confirmed diagnoses, with low sensitivity (0.4%–7.4%) and high specificity (96%–100%) observed for each individual symptom. The area under the receiver-operating curve was 0.528 (95% CI: 0.505–0.550), indicating that the syndromic approach has a 52.8% probability of correctly identifying STIs in study participants. In conclusion, whenever possible, laboratory diagnosis of STI should be favored over syndromic diagnosis.

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