scholarly journals “Relaxin-dependent” way of implementing spontaneous preterm labor in multiple pregnancies: The involvement of placental relaxin 2

2021 ◽  
Vol 70 (2) ◽  
pp. 27-36
Author(s):  
Olga V. Pachuliya ◽  
Olesya N. Bespalova ◽  
Mariya G. Butenko ◽  
Yulia P. Milyutina ◽  
Tatyana G. Tral ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Histological Examination ◽  
Preterm Labor ◽  
Multiple Pregnancy ◽  
Chorionic Villus ◽  
Multiple Pregnancies ◽  
Spontaneous Preterm Birth ◽  
Wide Range ◽  
Relaxin 2 ◽  
Term Labor

BACKGROUND: Despite numerous studies, the etiopathogenesis of preterm birth in multiple pregnancy remains unclear, which determines the low effectiveness of measures for the prevention of preterm birth. This fact makes it necessary to study possible ways of implementing preterm birth in multiple pregnancies and to search for new biomarkers of their pathogenetic links. Experimental and clinical studies have demonstrated the contribution of the pleiotropic hormone relaxin to the regulation of a wide range of physiological processes and its role in the implementation of the pathogenetic mechanisms of pregnancy complications, primarily premature birth. The proven autocrine / paracrine mechanism of placental relaxin action, which implements important local effects, determines the prospects for studying the contribution of its dysregulation to the implementation of spontaneous preterm labor in multiple pregnancies. MATERIALS AND METHODS: A morphological examination of 92 placentas from 46 deliveries of dichorionic diamniotic twins was performed: 24 of them were spontaneous premature births and 22 spontaneous term births. Histological examination of placentas along with immunohistochemical verification of relaxin 2 expression in the chorionic villus of the dichorial twins placentas were carried out. RESULTS: Histological examination of the dichorionic twins placentas revealed that those from spontaneous preterm birth were characterized by a higher frequency of chronic placental insufficiency with reduced compensatory and adaptive mechanisms and more pronounced circulatory disorders in the circulatory bed of the villous tree, when compared to placentas from spontaneous term labor. The first verification of relaxin 2 expression in the chorionic villi of the dichorionic twins placenta showed the role of the peptide in the initiation of spontaneous preterm birth. The relative area of relaxin 2 expression in spontaneous preterm labor was significantly higher (p 0.05) compared to that in spontaneous term labor. CONCLUSIONS: The data obtained confirm the hypothesis put forward about the involvement of placental relaxin in the pathogenesis of spontaneous preterm labor in multiple pregnancies. The authors were the first to propose the definition of a relaxin-dependent way of implementing spontaneous preterm labor. To help define new preventive strategies, the prospects for further studies of the role and significance of relaxin in the implementation of pathogenic processes involved in spontaneous preterm birth in multiple pregnancies have been outlined.

Clinical and biochemical markers of spontaneous preterm birth in singleton and multiple pregnancies

2021 ◽  
pp. 1-6
Author(s):  
Sergey V. Barinov ◽  
Gian Carlo Di Renzo ◽  
Antonina A. Belinina ◽  
Olga V. Koliado ◽  
Olga V. Remneva
Keyword(s):  
Preterm Birth ◽  
Biochemical Markers ◽  
Multiple Pregnancies ◽  
Spontaneous Preterm Birth

scholarly journals Spontaneous preterm birth prevention in multiple pregnancy

2018 ◽  
Vol 20 (1) ◽  
pp. 57-63 ◽  
Author(s):  
Sarah R Murray ◽  
Sarah J Stock ◽  
Shona Cowan ◽  
Elizabeth Sarah Cooper ◽  
Jane E Norman
Keyword(s):  
Preterm Birth ◽  
Multiple Pregnancy ◽  
Spontaneous Preterm Birth

731: Prediction of spontaneous preterm birth in women with preterm labor - analysis of 27 proteins by luminex xMAP technology in amniotic and cervical fluids

2008 ◽  
Vol 199 (6) ◽  
pp. S208
Author(s):  
Rose-Marie Holst ◽  
Bo Jacobsson ◽  
Henrik Hagberg ◽  
Ulla-Britt Wennerholm ◽  
Kristin Skogstrand ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Preterm Labor ◽  
Spontaneous Preterm Birth ◽  
Xmap Technology

scholarly journals Whole Blood Gene Expression Profile Associated with Spontaneous Preterm Birth in Women with Threatened Preterm Labor

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e96901 ◽  
Author(s):  
Yujing Jan Heng ◽  
Craig Edward Pennell ◽  
Hon Nian Chua ◽  
Jonathan Edward Perkins ◽  
Stephen James Lye
Keyword(s):  
Gene Expression ◽  
Preterm Birth ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Whole Blood ◽  
Preterm Labor ◽  
Spontaneous Preterm Birth ◽  
Blood Gene Expression ◽  
Threatened Preterm Labor

scholarly journals Gut microbial-related metabolite trimethylamine-N-oxide and its precursor L-carnitine are associated with spontaneous preterm birth: a nested case-control study

2019 ◽  
Author(s):  
Xing Chen ◽  
Ning Huang ◽  
Chaoqun Liu ◽  
Yue Chen ◽  
Lulu Huang ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Preterm Labor ◽  
Case Control Study ◽  
Case Control ◽  
Normal Weight ◽  
Maternal Serum ◽  
Spontaneous Preterm Birth ◽  
Nested Case Control ◽  
Related Metabolite ◽  
Control Study

Abstract Background: Gut microbiota has been proven to disease susceptibility and may lead to increased risk of preterm birth. To date, the link of gut microbial-related metabolite trimethylamine-N-oxide (TMAO), L-carnitine, and betaine, with spontaneous preterm birth (sPTB) has not been established. This study aimed to investigate the association of TMAO, L-carnitine and betaine, with sPTB risk. Methods: A nested case-control study was designed including 129 sPTB cases and 258 controls based on Guangxi Birth Cohort Study. TMAO, L-carnitine, and betaine level in maternal serum were determined by liquid chromatography with mass spectrometry. Conditional logistic regression analyses were used to examine the association between maternal serum metabolites and sPTB. Stratified analyses were further conducted according to BMI and preterm prelabor rupture of membranes. Spline analyses were performed to explore the dose-response relationship between the metabolites and sPTB.Results: Statistically significant association with decreased sPTB risk was observed for the highest L-carnitine (OR: 0.47; 95% CI: 0.23, 0.95). In risk analyses stratified by BMI, similar results were observed in normal weight gravida (BMI: 18.5~23.9 kg/cm2). The significant subtype-specific association with TMAO (OR: 0.43; 95% CI: 0.20, 0.93) and L-carnitine (OR: 0.45; 95% CI: 0.21, 0.97) were observed for preterm labor but not PPROM. Spline regression analysis indicated non-linear associations with TMAO and sPTB risk (P for nonlinearity: 0.057). Significant associations of TMAO with sPTB were observed in normal weight gravida (P = 0.028) and preterm labor subtype (P = 0.025). No statistically significant associations with sPTB risk were observed for betaine (P > 0.05).Conclusions: TMAO and L-carnitine levels in maternal serum are inversely linked with sPTB risk. Discovery of the association between gut-microbiota initiated TMAO metabolism and sPTB may open new avenues for diagnose and therapy.

scholarly journals Analysis of antenatal risk factors in multiple pregnancies

2014 ◽  
Vol 18 (2 (70)) ◽  
Author(s):  
О. V. Kravchenko
Keyword(s):  
Risk Factors ◽  
Pregnant Women ◽  
Preterm Labor ◽  
Multiple Pregnancy ◽  
Maternity Hospital ◽  
Age Group ◽  
Multiple Pregnancies ◽  
Population Index ◽  
Average Population

We examined 42 pregnant women with twins who gave birth in 2013 in the clinical maternity hospital № 2 of Chernivtsi. It was established that multiple pregnancy is more common in multipara women of age group 25-30 years (52,3 %). The course of pregnancy with twins is aggravated in 78,5 %, which is much higher than the average population index. Dichorionic diamniotic twins dominated (57,1 %) in the structure of multiple pregnancy. The preterm labor with dichorionic diamniotic twins occur 3 times less frequently (23,6 %) than in monochorionic diamniotic multiple pregnancies (75,4 %).

40: Maternal serum biomarkers to detect spontaneous preterm birth among women in preterm labor

2007 ◽  
Vol 197 (6) ◽  
pp. S19 ◽  
Author(s):  
Peter Robilio ◽  
Jane Hitti ◽  
Jodi Lapidus ◽  
Xinfang Lu ◽  
Leonardo Pereira ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Preterm Labor ◽  
Maternal Serum ◽  
Serum Biomarkers ◽  
Spontaneous Preterm Birth

Correlation of cervical length, fetal fibronectin, phIGFBP-1, and cytokines in spontaneous preterm birth up to 14 days from sampling

2015 ◽  
Vol 43 (5) ◽  
Author(s):  
Marija Hadži-Lega ◽  
Ana Daneva Markova ◽  
Milan Stefanovic ◽  
Mile Tanturovski
Keyword(s):  
Preterm Birth ◽  
Preterm Delivery ◽  
Preterm Labor ◽  
Cervical Length ◽  
Outcome Variable ◽  
Spontaneous Preterm Birth ◽  
Fetal Fibronectin ◽  
Tnf Α ◽  
Vaginal Swabs ◽  
The Relationship

AbstractThe aim of this study was to determine the relationship between sonographic cervical length, fetal fibronectin (fFN), phIGFBP-1 (actim partus test), cytokines (IL-6, IL-2R, and TNF-α), and spontaneous preterm birth (SPTB) up to 14 days from sampling.Fifty-eight patients were recruited in a period of 6 months from September 2013 until March 2014 with symptoms or complaints suggestive of preterm labor. Consenting women were treated according to usual hospital protocol, with addition of vaginal swabs taken for fetal fibronectin, phIGFBP-1 (actim partus test) and cervical IL6, IL2R, and TNF-α. The outcome variable was occurrence of preterm delivery within 14 days from the day of hospital admission.Thirty-six patients (62.07%) were delivered within 14 days from admission. Our results indicated that the cervical length significantly inversely correlates with the concentration of IL-6 in the CVF (Spearman’s coefficient R=–0.382, P<0.05). Cervical length also correlated with a positive phIGFBP-1 test, i.e., patients with a positive test had an average cervical length of 18.5±4.63 mm, which is significantly lower than patients with a negative test –23.43±7.39 mm (P=0.003).The studied biochemical markers were only moderately successful in the prediction of preterm delivery.

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