scholarly journals Prognosis of iron deficiency anemia in pregnant women with different somatotypes

2021 ◽  
Vol 70 (2) ◽  
pp. 83-89
Author(s):  
Kristina G. Tomayeva ◽  
Sergey N. Gaidukov ◽  
Elena N. Komissarova ◽  
Leonid A. Kokoyev
Keyword(s):  
Iron Deficiency ◽  
Pregnant Women ◽  
Iron Deficiency Anemia ◽  
Serum Iron ◽  
Hematological Parameters ◽  
Colorimetric Method ◽  
First Trimester ◽  
Study Groups ◽  
Deficiency Anemia ◽  
Serum Hepcidin

BACKGROUND: Anemia during pregnancy, undiagnosed and untreated promptly, is the cause of various obstetric complications: spontaneous miscarriages, premature birth, placental insufficiency, obstetric bleeding, ante- and intrapartum fetal death. AIM: The aim of this study was to evaluate the incidence of iron deficiency anemia in pregnant women with different somatotypes and to develop a prognostic model for the pathology onset. MATERIALS AND METHODS: We examined 390 pregnant women. Somatometry was performed according to the method of R.N. Dorokhov in terms of pregnancy not exceeding 9-10 weeks. Of the examined pregnant women, 110 were of the macrosomatotype, 173 of the meso- and 107 of the microsomatotype. In a clinical blood test, the levels of hemoglobin and red blood cells were determined using well-known methods. Blood iron levels were evaluated by the colorimetric method with ferrozine using a Parma Iron Reagents Kit (Parma Diagnostics Ltd., Russia). Serum hepcidin levels were determined spectrophotometrically using ELISA methods. RESULTS: Iron deficiency anemia was most commonly detected in pregnant women of the macro- and microsomatotype, when compared to those of the mesosomatotype (p 0.05). There was no severe anemia in the study groups. The levels of hematological parameters (serum iron and serum hepcidin) were significantly higher in the group of pregnant women with latent anemia, compared to the study group without signs of anemia (p 0.05). In the second trimester, iron deficiency anemia occurred in the group of patients with latent anemia. Using multiple regression analysis, a formula was obtained for predicting the onset of iron deficiency anemia in pregnant women of different somatotypes. CONCLUSIONS: Hematological parameters (serum iron and serum hepcidin) should be attributed to markers of iron deficiency anemia and timely predict the onset of pathology. The mathematical formula obtained allows predicting with high accuracy the onset of iron deficiency anemia in pregnant women, taking into account the somatotype in the first trimester of pregnancy, and timely preventing the onset of pathology.

scholarly journals Predicting the risk of anemia in pregnant women with different somatotypes

2020 ◽  
Vol 11 (2) ◽  
pp. 43-50
Author(s):  
Tatiana I. Tsidaeva ◽  
Kristina G. Tomaeva ◽  
Sergey N. Gaidukov ◽  
Nikolai N. Rukhliada ◽  
Aida A. Cheldieva ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Pregnant Women ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Serum Iron ◽  
Hematological Parameters ◽  
First Trimester ◽  
Deficiency Anemia ◽  
Body Type ◽  
Latent Iron Deficiency

The aim of the study: to study the frequency of anemia in pregnant women with different somatotypes and to develop a model for predicting the risk of this pathology. Materials and methods. 390 women were examined. Of the women studied 110 were mаcrosomatotype, 173 mesosomatotype, and 107 microsomatotype. Somatometry was performed according to R.N. Dorokhov for women in early pregnancy (before 910 weeks of gestation). In blood test the level of hemoglobin, red blood cells, and hematocrit is determined using the Medonic M-series hematological automatic analyzer. Serum iron levels were determined colorimetrically with ferrosine. Serum ferritin levels were determined spectrophotometrically using ELISA methods. Results. It was found that iron deficiency anemia was significantly more common in pregnant women of macro-and microsomatic body type compared to women with mesosomatotypes (p 0.05). Pregnant women with severe anemia were not found. There were iron deficiency anemia of mild and moderate severity, and latent iron deficiency. Hematological parameters (hematocrit, serum iron, serum ferritin) were significantly lower in pregnant women with latent iron deficiency compared to women without anemia (p 0.05). Using multiple regression analysis, we obtained the regression equation (formula), which predicts the development of iron deficiency anemia in pregnant women of different somatotypes. Conclusions. The calculations according to the presented formula, allows to predict with high accuracy the prognosis of iron deficiency anemia in pregnant women, and also allows to form among patients a high-risk group for the development of this disease in the first trimester of pregnancy when the pregnant woman is registered in the womens consultation, which will contribute to more effective implementation of therapeutic and preventive measures to prevent the development of this pathology.

Serum Hepcidin: Its Correlation with Serum Ferritin, Serum Iron and Hemoglobin in Patients of Iron Deficiency Anemia

2015 ◽  
Vol 14 (2) ◽  
pp. 105-113
Author(s):  
Sajjad H. Naqvi ◽  
Syed Faizan-ul-Hassan Naqvi ◽  
Iftikhar H. Naqvi ◽  
Muhammad Farhan ◽  
Tanveer Abbas ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Serum Iron ◽  
Deficiency Anemia ◽  
Serum Hepcidin

Iron Deficiency Anemia Following Prenatal Nutrition Interventions

2007 ◽  
Vol 68 (4) ◽  
pp. 222-225
Author(s):  
Caroline P. Leblanc ◽  
France M. Rioux
Keyword(s):  
Iron Deficiency ◽  
Pregnant Women ◽  
Iron Deficiency Anemia ◽  
Low Income ◽  
Mean Corpuscular Volume ◽  
Serum Iron ◽  
Transferrin Saturation ◽  
Deficiency Anemia ◽  
Corpuscular Volume ◽  
Prevalence Of Anemia

Purpose: Iron deficiency anemia (IDA) during pregnancy and infancy is still common in developed countries, especially in low-income groups. We examined the prevalence of anemia and IDA in healthy low-income pregnant women participating in the Early Childhood Initiatives (ECI) program, and in their infants when they reached six months of age. Methods: Pregnant women were recruited by nutritionists. In mothers, hemoglobin (Hb), mean corpuscular volume, and serum ferritin (SF) were measured at 36 ± 2 weeks of gestation. In infants, Hb, mean corpuscular volume, SF, serum iron, total iron binding capacity (TIBC), and transferrin saturation (TS) were measured at six months of age. Thirty-one mother-infant pairs participated. Results: Among the 31 pregnant women participating in the ECI program, six (19.4%) were anemic (Hb <110 g/L) and five (16.1%) suffered from IDA (Hb <110 g/L and SF <10 µg/L). Among infants, seven of 23 (30.4%) were anemic (Hb <110 g/L) and five of 23 (21.7%) suffered from IDA (Hb <110 g/L plus two of the following: TIBC >60 µmol/L, SF <10 µg/L, serum iron <5.3 µmol/L, TS ≤15%). Conclusions: The prevalence of anemia in this group of lowincome pregnant women is comparable to that in privileged women. The prevalence of IDA in infants is comparable to that observed in other high-risk groups. Effective strategies are needed to prevent IDA in vulnerable groups.

scholarly journals Iron Deficiency Anemia (IDA) in Pregnant Women of Different Ages in Swat District, Khyber Pakhtunkhwa Pakistan

2017 ◽  
Author(s):  
Atta Ullah ◽  
Ali Muhammad Yousafzai ◽  
Gul Nabi Khan ◽  
Nasir Iqbal ◽  
Bashir Ahmad
Keyword(s):  
Iron Deficiency ◽  
Pregnant Women ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Serum Iron ◽  
Deficiency Anemia ◽  
Age Group ◽  
Second Trimester ◽  
Third Trimester ◽  
Hb Concentration

Abstract: The aim of this study was to find out the incidence of anemia in pregnant women of Swat District; to analyze the iron variations and its dietary effects.Data were collected during the periods of January &ndash; September 2016. The study of samples comprised of 250 pregnant women in the different trimester. Blood sample from each woman was collected and full blood count (FBC) was conducted through Mindray BC-3000 plus hem analyzer for all pregnant individuals. Confirmed anemic cases were then examined for IDA with serum ferritin, serum iron, total iron binding capacity (TIBC) through Randox kit and serum transferrin saturation was estimated by formula (serum ferritin saturation =serum iron &times;100/TIBC). The total number of participants in the first trimester were 50, among them 26 women were suffer from iron deficiency anemia (IDA) with 52% weightage of prevalence rate, (mean Hb concentration 9.602 &plusmn; 0.87 g/dl). The rates of IDA were 63.3%; ( mean Hb concentration 8.48 &plusmn; 1.24 g/dl) and 54%; ( mean Hb concentration 9.18 &plusmn; 1.28 g/dl), among 150 and 50 participants in the second and third trimester, respectively. A significant correlation was found between serum ferritin and Hb, serum ferritin against MCV and serum ferritin against MCH. The high prevalence of anemia was found 78.2% in the age group from 26-30 followed by 78.2% in the age group 36-40 years compared to those of other age groups in the second trimester. In this study the prevalence of IDA in third trimester is lower compared to first and second trimester.

scholarly journals The effect of early weaning on iron status among exclusively breastfed infants

2021 ◽  
Vol 25 (2) ◽  
pp. 591-598
Author(s):  
Kayfi Aziz ◽  
Dlair Chalabi
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Exclusive Breastfeeding ◽  
Urban Areas ◽  
Iron Status ◽  
Hematological Parameters ◽  
Study Groups ◽  
Deficiency Anemia ◽  
Early Weaning ◽  
Breastfed Infants

Background and objective: Exclusive breastfeeding is recommended for all newborns to gain optimal physical and neurodevelopmental growth. Despite all its advantages, prolonged breastfeeding alone without weaning places the child at risk of iron deficiency and iron deficiency anemia, which is the commonest micronutrient deficiency worldwide among infants. We investigated the effect of early weaning on the iron status of infants. Methods: We selected 100 infants; all of them were six months old. Fifty of them were exclusively breastfed for four months and started weaning between four to six months while continued to breastfeed till the age of six months (early-weaning group). Another 50 infants were exclusively breastfed for six months without starting weaning (no-weaning group). Then we investigated both groups at the age of six months for both iron and hematological studies. Results: In the present study, both study groups shared some similarities. In both groups, females accounted for more than half of the cases, the majority of the infants were residing in the urban areas, and most of the infants were delivered by cesarean section. The final result of the iron study and hematological parameters in the no-weaning group was significantly lower as compared to the early-weaning group. Both serum ferritin and serum iron were 7.42 ng/ml and 25.66 µg/dl, respectively, in the no-weaning group and were 23.94 ng/ml and 46.98 µg/dl respectively in the early-weaning group. Hemoglobin level was 10.84 gm/dl in the no-weaning group compared to 11.54 gm/dl in the early-weaning group. Conclusion: We concluded that early weaning had a great role in the prevention of both iron deficiency and iron deficiency anemia in exclusively breastfed infants. Keywords: Exclusive breastfeeding; Early weaning; Iron status.

scholarly journals The Anemia Syndrome in Contemporary Women: an Unsolved Worldwide Problem. A Therapeutic Approach

Doctor Ru ◽  
2020 ◽  
Vol 19 (8) ◽  
pp. 20-24
Author(s):  
V.E. Radzinsky ◽  
◽  
A.V. Solovyeva ◽  
N.G. Fedotov ◽  
◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Pregnant Women ◽  
Iron Deficiency Anemia ◽  
Ferric Hydroxide ◽  
Abnormal Uterine Bleeding ◽  
First Trimester ◽  
Uterine Bleeding ◽  
Reproductive Age ◽  
Deficiency Anemia ◽  
Women Of Reproductive Age

Objective of the Review: To set forth the frequency and prevalence of the anemia syndrome in non-pregnant and pregnant women and approaches to treating this disorder. Key Points: Anemia syndrome is the most common health problem in contemporary women. The leading cause of iron deficiency in women of reproductive age is abnormal uterine bleeding (AUB). Anemia in women significantly reduces their ability to work and quality of life, and increases the rates and severity of complications in pregnant women and parturients. It is also a significant contributor to maternal mortality and fetal and neonatal morbidity. Treating anemia in pregnant women presents certain challenges. In the period between the first trimester and delivery, there is an 8-fold increase in the requirement for iron; therefore, hemoglobin levels return to normal slowly. The active ingredient of Ferrum Lek is a ferric hydroxide polymaltose complex, which is as effective as medications containing ferrous sulfate, but is significantly better tolerated by patients and easier to use. The active transport of iron allows its controlled absorption from the polymaltose complex, minimizing the risk of an increase in serum levels of iron not bound to transferrin. This ensures that this medication is very safe and eliminates the risk of overdose or poisoning. Conclusion: Anemia syndrome is the most common type of homeostatic imbalance in women of reproductive age. It most often results from frequent and abundant uterine bleeding (AUB). Therefore, an obstetrician-gynecologist plays the leading role in identifying menstrual disorders and choosing therapies to reduce blood loss. A gynecologist will also work with an internist (hematologist) in treating iron deficiency anemia. Keywords: anemia syndrome, iron deficiency anemia, abnormal uterine bleeding, ferric hydroxide polymaltose complex.

scholarly journals The overbearing physiological changes marring iron indices interpretation in response to iron therapy during pregnancy

2021 ◽  
Vol 18 (3) ◽  
pp. 39-42
Author(s):  
Chandrika N ◽  
Keyword(s):  
Iron Deficiency ◽  
Pregnant Women ◽  
Iron Deficiency Anemia ◽  
Biochemical Parameters ◽  
Serum Iron ◽  
Transferrin Saturation ◽  
Oral Iron ◽  
Response To Therapy ◽  
Iron Therapy ◽  
Deficiency Anemia

Background: Iron deficiency anemia (IDA) is most common cause of anemia in pregnancy. In order to prevent this iron supplementation is routinely practiced as a prophylactic measure in pregnant women all over. The biochemical parameters assessed in IDA comprise an iron profile evaluation which consists of estimation of serum ferritin, serum iron, total iron binding capacity(TIBC), serum transferrin levels and calculation of transferrin saturation. These biochemical parameters are subjected to variations due to maternal adaption phenomenon. Aim: In the current study we have chosen three iron indices, serum iron, serum TIBC and transferrin saturation percent to note their performance in diagnosing and monitoring the response to iron therapy in pregnant women. Methodology: The study population are thirty- six pregnant women in their early second trimester, who are diagnosed with mild iron deficiency anemia (Hemoglobin between 9 and 11 g %). Iron parameters, serum iron, serum TIBC and transferrin saturation levels were analyzed in these women. They are then given oral iron preparation in the form of Ferrous sulphate for a period of twelve weeks. After this the Hemoglobin level, serum iron, TIBC and transferrin saturation levels are re-analyzed in these women. Results: The hemoglobin levels increased (p= 0.002). as expected after oral iron intake. Serum iron levels improved from 58.19±39.07 to 64.78±34.96 μg/dl. Serum TIBC value before supplementation 234.22±134.49 increased to 437.33±94.95 after, which contradicts the expected pattern seen in response to therapy in general population. Similarly absurdity prevails in transferrin saturation index levels which dropped from 36.8 ± 31.8 to 16.3 ± 10.6. Conclusion: The iron status during pregnancy is highly influenced by the maternal changes. And a blind interpretation of the report can lead to erroneous diagnosis. The interpretation of values should be based on the trimester specific reference ranges during pregnancy.

scholarly journals Iron Deficiency Anemia and Serum Hepcidin Level in Children with Typhoid Fever: A Case–Control Study

2020 ◽  
Vol 15 (06) ◽  
pp. 288-292
Author(s):  
Ghada Mohamed ◽  
Samir Aboelhassan ◽  
Maysaa El Sayed Zaki ◽  
Yahya Wahba
Keyword(s):  
Iron Deficiency ◽  
Typhoid Fever ◽  
Iron Deficiency Anemia ◽  
Serum Iron ◽  
Case Control Study ◽  
Case Control ◽  
Deficiency Anemia ◽  
Hepcidin Level ◽  
Serum Hepcidin ◽  
Control Study

Abstract Objective Typhoid fever is a common systemic bacterial infection in children with a complex interplay between serum hepcidin and iron. We investigated the relationship between iron deficiency anemia (IDA) and serum hepcidin level in children with acute typhoid fever. Methods We conducted a preliminary case–control study in Mansoura University Children's Hospital, Egypt from April 2017 to May 2019 including 30 children aged 5 to 15 years with confirmed acute typhoid fever. We recruited 15 healthy nonanemic children, of comparable ages and sex as controls from the same hospital while attending for nonfebrile complaints. Typhoid fever cases were subdivided according to IDA existence into 16 cases with IDA and 14 non-IDA cases. We excluded all children having diseases which may affect serum iron and hepcidin levels, for example, liver, blood, gastrointestinal, and kidney diseases, and patients receiving drugs interfering with iron metabolism. All participants were subjected to complete blood count, serum ferritin, iron, hepcidin levels, and total iron-binding capacity (TIBC). Results In non-IDA typhoid fever group, serum iron level was significantly low, while serum hepcidin level was significantly high when compared with controls (p < 0.001 and p = 0.02, respectively). In IDA typhoid fever group, no statistically significant difference existed as regards serum hepcidin level when compared with controls (p = 0.53). No significant correlations were detected between serum hepcidin levels and hemoglobin, serum iron, ferritin, and TIBC values in each group. Conclusion Preexisting iron status could affect serum hepcidin level in patients with acute typhoid fever. Coexistence of IDA might oppose the up-regulatory effect of acute typhoid fever on serum hepcidin level.

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