scholarly journals Modern possibilities for the prediction of the efficacy of antiviral therapy of chronic hepatitis C

2015 ◽  
Vol 20 (2) ◽  
pp. 25-29
Author(s):  
A. M Ryumin ◽  
O. V Korochkina ◽  
D. M Sobchak ◽  
O. L Sobolevskaya ◽  
T. Yu Butina ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Gene Polymorphism ◽  
Antiviral Therapy ◽  
Sustained Virological Response ◽  
Chronic Hepatitis C ◽  
Virological Response ◽  
Wide Spread

Despite numerous investigations, the problem ofpredicting of efficiency of the antiviral therapy of chronic hepatitis C (CHC) remains to be actual. As recent investigations showed polymorphism of IL-B28 gene in large part determines the achievement of the sustained virological response. In this study in 70 CHC patients there were evaluated factors which influence on the results of the treatment, their occurrence in the population, and the use the control them as a predictor of the efficacy of the therapy. There is considered the possibility of correction of some of them. This allows you to predict the achievement of sustained virological response. There has been confirmed the need for the accounting of IL-B28 gene polymorphism in the relation to the wide spread occurence in the population of normal genotypes in loci Rs12979860 and Rs8099917.

scholarly journals Hemochromatosis Gene Polymorphism as a Predictor of Sustained Virological Response to Antiviral Treatment in Egyptian Chronic Hepatitis C Patients

2017 ◽  
Vol 7 (2) ◽  
pp. 154-157 ◽  
Author(s):  
Mai I Mehrez ◽  
Dina SA Fattah ◽  
Naglaa AA Azeem ◽  
Mohamed A Saleh ◽  
Khadiga M Mostafa
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Gene Polymorphism ◽  
Sustained Virological Response ◽  
Chronic Hepatitis C ◽  
Virological Response ◽  
Antiviral Treatment ◽  
C282y Mutation ◽  
Hemochromatosis Gene ◽  
Chronic Hepatitis C Patients

ABSTRACT Aim The aim of this article is to assess HFE C282Y gene mutations as a predictor of sustained virological response (SVR) to anti-hepatitis C virus (HCV) treatment in Egyptian patients. Materials and methods One hundred and forty chronic hepatitis C (CHC) patients were divided into two groups: 70 patients achieved SVR and 70 patients were nonresponders (NRs). All patients were subjected to quantitative polymerase chain reaction (PCR) at baseline, 12 and 24 weeks after therapy commencement. Deoxyribonucleic acid (DNA) sequencing for HFE (C282Y) was done by restriction fragment length polymorphism PCR. Results Sixty five patients did not have mutation and 5 patients had C282Y mutation (GA) with SVR. While 45 NRs had heterozygous C282Y mutation (GA), 4 patients (5.7%) had homozygous mutation (AA) and 21 patients (30%) had no mutation (GG). The parameters of elevated iron [transferrin saturation (TS; p < 0.001), S iron (p < 0.02), total iron binding capacity (TIBC; p < 0.001), transferrin (p < 0.016), and soluble transferrin receptor (sTfR; p-value, 0.001)] were significantly associated with C282Y mutation. However, there was no significant difference regarding ferritin values and C282Y mutation in NR patients. Conclusion Iron overload was frequently detected in CHC patients and associated with C282Y mutation, while biochemical markers of iron overload and C282Y HFE mutation were negative prognostic factor. How to cite this article Mehrez MI, Fattah DSA, Azeem NAA, Saleh MA, Mostafa KM. Hemochromatosis Gene Polymorphism as a Predictor of Sustained Virological Response to Antiviral Treatment in Egyptian Chronic Hepatitis C Patients. Euroasian J Hepato-Gastroenterol 2017;7(2):154-157.

Sustained Virological Response in the Antiviral Therapy of Chronic Hepatitis C: Is There a Predictive Value of Interferon-Induced Depression?

Chemotherapy ◽  
2007 ◽  
Vol 53 (4) ◽  
pp. 292-299 ◽  
Author(s):  
Arne Schäfer ◽  
Michael Scheurlen ◽  
Benedikt Weissbrich ◽  
Katrin Schöttker ◽  
Michael R. Kraus
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Antiviral Therapy ◽  
Sustained Virological Response ◽  
Chronic Hepatitis C ◽  
Virological Response ◽  
Predictive Value
Sign in / Sign up

Export Citation Format

Share Document