scholarly journals The influence of virginity and induced sterility on Drosophila melanogaster females and males life span

2007 ◽  
Vol 5 (3) ◽  
pp. 15-20
Author(s):  
Mikhail V Shaposhnikov ◽  
Aleksey A Moskalev ◽  
Elena V Turysheva
Keyword(s):  
Sex Differences ◽  
Drosophila Melanogaster ◽  
Life Span ◽  
Costs Of Reproduction ◽  
Mating Cost ◽  
Molecular Signals

Reproduction and life span are negatively interrelated in both sexes, however sex differences in costs of reproduction are poorly understood. It was shown that mating cost has a main contribution to costs of reproduction in both sexes. molecular signals from gonads exceed cost of gametes production.

Quantitative Untersuchungen über die Ommochromvorstufen in den Malpighischen Gefäßen verschiedener Drosophila-Mutanten

1968 ◽  
Vol 23 (4) ◽  
pp. 547-554 ◽  
Author(s):  
Dieter Eichelberg
Keyword(s):  
Sex Differences ◽  
Drosophila Melanogaster ◽  
Quantitative Determination ◽  
Paper Chromatography ◽  
Type A ◽  
Individual Development ◽  
Wild Type ◽  
Strong Reduction ◽  
The Individual

This paper concerns with the quantitative determination of ommochrome precursors in the Malpighian tubes of Drosophila melanogaster during the individual development. After separation by paper chromatography the amounts of tryptophane, kynurenine and 3-hydroxykynurenine have been estimated by a spectrophotometer. The concentrations of these three substances obtained from wild-type Malpighian tubes have been compared with the quantities of the mutants brown (bw) and red Malpighian tubes (red). During development there are significant variabilities in contents of tryptophane, kynurenine and 3-hydroxykynurenine in the Malpighian tubes. In the larval tubes large quantities of ommochrome precursors are accumulated. With the beginning of metamorphosis there is a distinct decrease in these substances. After hatching the amount increases steadily until reaching a constant level. In the Malpighian tubes there are also sex differences: in females the concentration of kynurenine and 3-hydroxykynurenine is higher than in males. The results obtained from the mutants brown and red Malpighian tubes are on principle the same as those obtained from wild-type. A strong reduction of kynurenine contents is found in the mutant red Malpighian tubes. Perhaps in this mutant the kynurenine-hydroxilase-activity is lower than in wild-type. The amounts of ommochrome precursors, accumulated in the larval Malpighian tubes, do not correspond in all cases to the contents of xanthommatine formed in the eyes of the adults.

scholarly journals Neuronal Expression of p53 Dominant-Negative Proteins in Adult Drosophila melanogaster Extends Life Span

2005 ◽  
Vol 15 (22) ◽  
pp. 2063-2068 ◽  
Author(s):  
Johannes H. Bauer ◽  
Peter C. Poon ◽  
Heather Glatt-Deeley ◽  
John M. Abrams ◽  
Stephen L. Helfand
Keyword(s):  
Drosophila Melanogaster ◽  
Life Span ◽  
Dominant Negative ◽  
Neuronal Expression ◽  
Adult Drosophila

scholarly journals Monoassociation withLactobacillus plantarumDisrupts Intestinal Homeostasis in AdultDrosophila melanogaster

mBio ◽  
2018 ◽  
Vol 9 (4) ◽  
Author(s):  
David Fast ◽  
Aashna Duggal ◽  
Edan Foley
Keyword(s):  
Drosophila Melanogaster ◽  
Stem Cell ◽  
Simple Model ◽  
Life Span ◽  
Lactobacillus Plantarum ◽  
Adult Longevity ◽  
Intestinal Homeostasis ◽  
Content Type ◽  
Cell Divisions ◽  
Stem Cell Divisions

ABSTRACTAdultDrosophila melanogasterraised in the absence of symbiotic bacteria have fewer intestinal stem cell divisions and a longer life span than their conventionally reared counterparts. However, we do not know if increased stem cell divisions are essential for symbiont-dependent regulation of longevity. To determine if individual symbionts cause aging-dependent death inDrosophila, we examined the impacts of common symbionts on host longevity. We found that monoassociation of adultDrosophilawithLactobacillus plantarum, a widely reported fly symbiont and member of the probioticLactobacillusgenus, curtails adult longevity relative to germfree counterparts. The effects ofLactobacillus plantarumon life span were independent of intestinal aging. Instead, we found that association withLactobacillus plantarumcauses an extensive intestinal pathology within the host, characterized by loss of stem cells, impaired epithelial renewal, and a gradual erosion of epithelial ultrastructure. Our study uncovers an unknown aspect ofLactobacillus plantarum-Drosophilainteractions and establishes a simple model to characterize symbiont-dependent disruption of intestinal homeostasis.IMPORTANCEUnder homeostatic conditions, gut bacteria provide molecular signals that support the organization and function of the host intestine. Sudden shifts in the composition or distribution of gut bacterial communities impact host receipt of bacterial cues and disrupt tightly regulated homeostatic networks. We used theDrosophila melanogastermodel to determine the effects of prominent fly symbionts on host longevity and intestinal homeostasis. We found that monoassociation withLactobacillus plantarumleads to a loss of intestinal progenitor cells, impaired epithelial renewal, and disruption of gut architecture as flies age. These observations uncover a novel phenotype caused by monoassociation of a germfree host with a common symbiont and establish a simple model to characterize symbiont-dependent loss of intestinal homeostasis.

Sign in / Sign up

Export Citation Format

Share Document