scholarly journals SECUKINUMAB FOR TREATMENT OF PATIENTS WITH REFRACTORY PSORIASIS

2019 ◽  
Vol 22 (1-2) ◽  
pp. 51-55
Author(s):  
O. Yu Olisova ◽  
Victoria O. Nikuradze
Keyword(s):  
Biological Therapy ◽  
Negative Impact ◽  
Point Of View ◽  
Interleukin 17 ◽  
New Methods ◽  
Methods Of Treatment ◽  
Therapeutic Task ◽  
Convincing Data

Refractory psoriasis with a pronounced negative impact on the quality of life of patients is a high percentage. This disease is a difficult therapeutic task, both from a clinical and scientific point of view that indicates search relevance for new methods of treatment. Convincing data confirming the central role of interleukin-17 in the pathogenesis of psoriasis and the importance of biological therapy aimed at interleukin-17 in the treatment of moderate and severe psoriasis, suggest secukinumab as one of the most promising of the currently existing drugs.

scholarly journals THE ROLE OF STAPHYLOCOCCUS AUREUS IN NASAL POLYPOSIS

2013 ◽  
Vol 10 (6) ◽  
pp. 5-8
Author(s):  
G P Bondareva ◽  
A B Turovsky ◽  
O V Semkina
Keyword(s):  
Quality Of Life ◽  
Staphylococcus Aureus ◽  
Nasal Polyposis ◽  
Improve Quality ◽  
Eosinophilic Inflammation ◽  
New Methods ◽  
Methods Of Treatment

Nasal polyposis is associated with colonization of S. aureus, which secretes enterotoxine that acts as superantigen and induces formation of monoclonal IgE by analogy with severe eosinophilic inflammation. This article describes the current insights of features of inflammation caused by S. aureus. Further research aimed at a deeper study of the role of S. aureus in pathogenesis of nasal polyposis, as well as new methods of treatment that would prevent the recurrence of the disease and improve quality of life of the patients are needed.

УКРАЇНОЗНАВЧИЙ ОСВІТНІЙ ЧИННИК В УМОВАХ СУЧАСНОЇ УКРАЇНСЬКОЇ МАСОВОЇ КУЛЬТУРИ

2019 ◽  
pp. 22-29
Author(s):  
Н. В. Фрадкіна
Keyword(s):  
Mass Culture ◽  
Personal Development ◽  
Negative Impact ◽  
Educational Process ◽  
Point Of View ◽  
Character Trait ◽  
Main Task ◽  
Leading Role ◽  
The Individual

The purpose and tasks of the work are to analyze the contemporary Ukrainian mass culture in terms of its value and humanistic components, as well as the importance of cultural studies and Ukrainian studies in educational disciplines for the formation of a holistic worldview of modern youth.Analysis of research and publications. Scientists repeatedly turned to the problems of the role of spirituality in the formation of society and its culture. This problem is highlighted in the publications by O. Losev, V. Lytvyn, D. Likhachev, S. Avierintsev, M. Zakovych, I. Stepanenko and E. Kostyshyn.Experts see the main negative impact of mass culture on the quality approach, which determines mass culture through the market, because mass culture, from our point of view, is everything that is sold and used in mass demand.One of the most interesting studies on this issue was the work by the representatives of Frankfurt School M. Horkheimer and T. Adorno «Dialectics of Enlightenment» (1947), devoted to a detailed analysis of mass culture. Propaganda at all socio-cultural levels in the form is similar in both totalitarian and democratic countries. It is connected, according to the authors, with the direction of European enlightenment. The tendency to unify people is a manifestation of the influence of mass culture, from cinema to pop. Mass culture is a phenomenon whose existence is associated with commerce (accumulation in any form – this is the main feature of education), in general, the fact that it exists in this form is related to the direction of the history of civilization.Modern mass culture, with its externally attractive and easily assimilated ideas and symbols, appealing to the trends of modern fashion, becomes a standard of prestigious consumption, does not require intense reflection, allows you to relax, distract, not teach, but entertains, preaches hedonism as the main spiritual value. And as a consequence, there are socio-cultural risks: an active rejection of other people, which leads to the formation of indifference; cruelty as a character trait; increase of violent and mercenary crime; increase in the number of alcohol and drug addicts; anti-patriotism; indifference to the values of the family and as a result of social orphanhood and prostitution.Conclusions, perspectives of research. Thus, we can conclude that modern Ukrainian education is predominantly formed by the values of mass culture. Namely, according to the «Dialectic» by Horkheimer and Adorno, «semi-enlightenment becomes an objective spirit» of our modern society.It is concluded that only high-quality education can create the opposite of the onset of mass culture and the destruction of spirituality in our society. It is proved that only by realizing the importance of cultivating disciplines in the educational process and the spiritual upbringing of the nation, through educational reforms, humanitarian knowledge will gradually return to student audiences.Formation of youth occurs under the influence of social environment, culture, education and self-education. The optimal combination of these factors determines both the process of socialization itself and how successful it will be. In this context, one can see the leading role of education and upbringing. It turns out that the main task of modern education is to spread its influence on the development of spiritual culture of the individual, which eventually becomes a solid foundation for the formation of the individual. Such a subject requires both philosophical and humanitarian approaches in further integrated interdisciplinary research, since the availability of such research will provide the theoretical foundation for truly modern educational and personal development.

Physical capital stock, technological upgrading and modernisation in Hungary

2005 ◽  
Vol 55 (2) ◽  
pp. 201-221 ◽  
Author(s):  
Andrea Szalavetz
Keyword(s):  
Capital Accumulation ◽  
Physical Capital ◽  
Developed Countries ◽  
Point Of View ◽  
Technology Generation ◽  
Development Policies ◽  
Specific Factors ◽  
Physical Capital Accumulation

This paper discusses the relation between the quality and quantity indicators of physical capital and modernisation. While international academic literature emphasises the role of intangible factors enabling technology generation and absorption rather than that of physical capital accumulation, this paper argues that the quantity and quality of physical capital are important modernisation factors, particularly in the case of small, undercapitalised countries that recently integrated into the world economy. The paper shows that in Hungary, as opposed to developed countries, the technological upgrading of capital assets was not necessarily accompanied by the upgrading of human capital i.e. the thesis of capital skill complementarity did not apply to the first decade of transformation and capital accumulation in Hungary. Finally, the paper shows that there are large differences between the average technological levels of individual industries. The dualism of the Hungarian economy, which is also manifest in terms of differences in the size of individual industries' technological gaps, is a disadvantage from the point of view of competitiveness. The increasing differences in the size of the technological gaps can be explained not only with industry-specific factors, but also with the weakness of technology and regional development policies, as well as with institutional deficiencies.

scholarly journals Threat or Corrective? Assessing the Impact of Populist Parties in Government on the Qualities of Democracy: A 19-Country Comparison

2021 ◽  
pp. 1-21
Author(s):  
Davide Vittori
Keyword(s):  
Negative Impact ◽  
Quality Of Democracy ◽  
Clear Cut ◽  
Liberal Democratic ◽  
Country Comparison ◽  
Democratic Regimes ◽  
Different Types ◽  
The Impact

Abstract Scholars have long debated whether populism harms or improves the quality of democracy. This article contributes to this debate by focusing on the impact of populist parties in government. In particular, it inquires: (1) whether populists in government are more likely than non-populists to negatively affect the quality of democracies; (2) whether the role of populists in government matters; and (3) which type of populism is expected to negatively affect the quality of liberal-democratic regimes. The results find strong evidence that the role of populists in government affects several qualities of democracy. While robust, the findings related to (2) are less clear-cut than those pertaining to (1). Finally, regardless of their role in government, different types of populism have different impacts on the qualities of democracy. The results show that exclusionary populist parties in government tend to have more of a negative impact than other forms of populism.

PERANCANGAN ARSITEKTUR RUANG LIMINAL ANTARA SEBUAH DUALISME (BERTANI DAN MELAUT)

2021 ◽  
Vol 3 (1) ◽  
pp. 1087
Author(s):  
Michael Gideon Josian ◽  
Maria Veronica Gandha
Keyword(s):  
General Public ◽  
Point Of View ◽  
Common Space ◽  
Special Character ◽  
Ideal System ◽  
The World ◽  
The Future ◽  
Letting Go

The future of dwelling has a very board context and will continue to be discussed, it is possible that the discussions about “dwelling” is come from the environment of farming and fishing. Things that are not much cared for but still have a role in the survival of the world. Therefore this matter will be discussed using the role of architecture as space, to be able to create an ideal system by paying attention to the quality of farming and fishing for the future, and leaving a trace or memory to be able to carry messages for the future. Talking about the future of an interaction that occurs between the general public and farmers and fishermen, especially considering that farmers and fishermen themselves can be compared to two different poles, a liminal space is needed, which may already exist indirectly in the environment. By letting go of individual egos and emphasizing ego to the point of view of farmers and fishermen. To present a common space, or a place that contains a special character of a city that contains a message for the future. Keywords:  dualism; hope; liminal; trace;  Abstrak Masa depan cara berhuni memiliki konteks yang sangat luas dan akan terus diperbincangkan. Tidak menutup kemungkinan datang dari pembahasan mengenai cara berhuni dengan bertani dan melaut. Hal yang tidak banyak dipedulikan tetapi tetap memiliki peran dalam kelangsungan dunia. Oleh karena itu, masa depan berhuni ini akan dibahas dengan menggunakan peran arsitektur sebagai ruang, untuk dapat menciptakan sistem yang ideal dengan memperhatikan kualitas bertani dan melaut bagi masa depan, dan meninggalkan sebuah jejak atau kenangan untuk dapat membawa pesan bagi masa depan. Berbicara mengenai masa depan dari sebuah interaksi yang terjadi antara masyarakat umum dengan para petani dan nelayan, apalagi mengingat para petani dan nelayan itu sendiri dapat diibaratkan berada pada kedua kutub yang berbeda, maka dibutuhkanlah sebuah ruang liminal, yang mungkin sudah hadir secara tidak langsung pada lingkungan masyarakat. Dengan cara melepaskan ego individual dan menekankan ego kepada sudut pandang para petani dan nelayan. Untuk menghadirkan sebuah ruang bersama, atau sebuah tempat yang mengandung sebuah karakter tersendiri dari sebuah kota yang berisi pesan bagi masa depan.

scholarly journals METHOD OF EVALUATION OF FUNCTIONAL SECURITY OF INFORMATION TECHNOLOGIES FOR CREATION OF WARRANTY AUTOMATED SYSTEMS

2020 ◽  
Vol 3 (7) ◽  
pp. 153-164 ◽  
Author(s):  
Hennadii Hulak
Keyword(s):  
Information Technologies ◽  
Linear Equations ◽  
Point Of View ◽  
Automated System ◽  
Special Role ◽  
Automated Systems ◽  
Systems Of Linear Equations ◽  
Method Of Evaluation

The components of ensuring the warranty of automated systems, which are subject to increased requirements in connection with their use in many sensitive areas of public activity, including national security and defense, critical industrial technologies, energy and communications, banking, environmental protection , technologies of legitimate distance learning, etc. Certain components can significantly affect the quality and reliability of information services in regulatory conditions. In particular, the special role of the functional security of the cryptographic subsystem in terms of supporting the performance of the automated system for its tasks and functions in general, as well as in terms of ensuring the confidentiality and integrity of information. The components of the cryptographic subsystem have been identified, the poor or incorrect operation of which negatively affects the security of these subsystems. The types of the most dangerous attacks on these subsystems are analyzed, their classification from the point of view of possibility of realization in modern scientific and technical conditions and depending on capacity of available computing means and technologies on the basis of which the most real and dangerous variant of realization of remote attacks on software implementation of cryptographic subsystem is defined. . Based on the analysis, a method for evaluating the quality of cryptographic transformations based on a modified algorithm for solving the problem of finding solutions of systems of linear equations with distorted right-hand parts using the so-called decoding based on "lists" of first-order "shortened" Reed-Muller codes is proved. the correctness of the proposed algorithm.

scholarly journals The Multi-Dimensional Influence of a Sports Activity on the Process of Psycho-Social Rehabilitation and the Improvement in the Quality of Life of Persons with Physical Disabilities

2018 ◽  
Vol 14 (3) ◽  
pp. 68-85
Author(s):  
Jakub Niedbalski
Keyword(s):  
Personal Development ◽  
Physical Disabilities ◽  
Point Of View ◽  
Sports Activity ◽  
Self Identity ◽  
Major Subject ◽  
The Disabled ◽  
Physically Handicapped

Purpose: The purpose of the research is to analyze the role that sport plays in the lives of persons with physical disabilities within the process of rehabilitation and the improvement of their quality of life.Background: The article raises the notions of changes that take place in the life of a physically handicapped person which is due to their engagement in a sports activity. In the article, I refer to the subjective perspective of those researched, rendering their own point of view into the major subject of analysis.Methods: Qualitative data are exploited in the research, collected through a technique of unstructured interviews and undisguised observations conducted among the disabled practicing sports.Findings: The role of sport practiced by the disabled has been determined within several contexts, which were distinguished within the course of the research as analytical categories.Conclusion: On the basis of the research it was found that getting involved in a sports activity is significant within the process of experiencing life satisfaction, personal development and the reconstruction of the ego, self-identity, and transformations in the manner of perceiving both themselves and others. Therefore, a sports activity of a disabled person supports the rehabilitation process effectively.

Role of surface water in the formation of underground water in Aghstafachai-Ganjachai interfluve and its usage prospects

2020 ◽  
pp. 58-62
Author(s):  
A.R. Ibrahimova ◽  
Keyword(s):  
Underground Water ◽  
Point Of View ◽  
Tectonic Structure ◽  
Climate Type ◽  
Geophysical Surveys ◽  
Mineralization Degree ◽  
Well Data

With the purpose of water resources estimation of Aghstafachai-Ganjachai interfluve, geophysical surveys have been carried out. As a result, based on the well data, the maps were developed and interface conditions of the territory specified. The tectonic structure of Aghstafachai-Ganjachai interfluve lowland is associated with the formation of a sole artesian basin on its territory. Aghstafachai, Hasansu, Tovuzchai, Zeyemchai, Shamkirchai, Goshgarchai, Ganjachai and Kurekchai, being the main source of groundwater recharge, created a combined alluvial cone on the territory. The underground water of these rivers were studied in the sloping plain and the estimation of its volume carried out as well. It was revealed that the underground water on a large part of studied territory is fresh and less mineralized. From the bacteriological point of view, it is clean water. The content of microelements and harmful chemical substances in the water does not exceed the standards set for the drinkable water. Despite the long-term usage, the quality of the underground water, the mineralization degree and chemical composition remain unchanged. The regime of underground water is characterized with the irrigated climate type. Hydrogeological indexes and the parameters of ground water horizon in the studied area justify the possibility of their research for water supply.

Coping with psychosomatic symptoms: The buffering role of psychological flexibility and impact on quality of life

2016 ◽  
Vol 24 (2) ◽  
pp. 175-187 ◽  
Author(s):  
Chrysanthi Leonidou ◽  
Georgia Panayiotou ◽  
Aspasia Bati ◽  
Maria Karekla
Keyword(s):  
Quality Of Life ◽  
Negative Impact ◽  
Community Sample ◽  
Psychological Flexibility ◽  
Avoidant Coping ◽  
Screening Criteria ◽  
Illness Anxiety ◽  
The Impact

Individual differences in avoidant coping were hypothesized to exacerbate quality of life impairment associated with somatization and illness anxiety symptoms; psychological flexibility was expected to moderate this impairment. Individuals from a random community sample ( N = 298; 182 females), who met screening criteria for somatization and illness anxiety, reported lower quality of life and psychological flexibility and greater avoidant coping compared to controls. Psychological flexibility significantly moderated the impact of somatization and illness anxiety on quality of life domains. Findings suggest that decreasing avoidant coping through therapy may be promising in mitigating the negative impact of these symptom categories.

scholarly journals Pedagogical and learning theories and the improvement and development of lesson and learning studies

2015 ◽  
Vol 4 (3) ◽  
pp. 186-193 ◽  
Author(s):  
Ulla Runesson
Keyword(s):  
Design Methodology ◽  
Practical Knowledge ◽  
Point Of View ◽  
Learning Theories ◽  
Learning Study ◽  
Special Issue ◽  
Content Type ◽  
Theoretical Concepts

Purpose – It has been suggested that, if pedagogical and learning theories are integrated into lesson and learning study, a systematic construction of pedagogical knowledge is possible (Elliott, 2012). In this Special Issue, it is reported how theory and theoretical concepts can add value to lesson and learning study. The purpose of this paper is to introduce the Special Issue and explore the above concepts. Design/methodology/approach – This paper presents the Special Issue papers thematically and the main issues are discussed. Findings – Together the papers suggest that pedagogical theories and theorizing practice may contribute to the improvement of teachers’ practical knowledge and knowledge about teachers’ professional tasks and objects. Furthermore, some theories and theoretical concepts hitherto under-exploited in lesson and learning study are presented and discussed from the point of view how these might improve the quality of the studies. Originality/value – As a total, this collection of papers bring out issues about the role of pedagogical and learning theories and how these could inform lesson and learning study.

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