scholarly journals Chest MRI of a pregnant woman with COVID-19 pneumonia

2020 ◽  
Vol 1 (1) ◽  
pp. 61-68
Author(s):  
Yuriy A. Vasilev ◽  
Alexander V. Bazhin ◽  
Amir G. Masri ◽  
Yulia N. Vasileva ◽  
Olga Yu. Panina ◽  
...  
Keyword(s):  
Pregnant Woman ◽  
Ionizing Radiation ◽  
Risk Groups ◽  
Diagnostic Information ◽  
The Novel ◽  
Lung Condition ◽  
Pulmonary Pathology ◽  
Novel Coronavirus ◽  
Bilateral Lesions ◽  
Pcr Test

This paper presents a clinical case of a 39-year-old pregnant woman with respiratory signs of the novel coronavirus Covid-19 infection. Chest MRI showed bilateral lesions in basal segments. The PCR test was positive. A lung condition was assessed without loss of significant diagnostic information. Besides that, the absence of exposure to ionizing radiation allowed to avoid a high loading dose on the patient and the fetus. This case reveals potential opportunities of MRI in the diagnosis of pulmonary pathology without exposure to ionizing radiation, especially in patient risk groups (children, pregnant women, etc.).

scholarly journals The Novel Coronavirus in Pediatric and Geriatric Population- What We Know

2021 ◽  
Vol 15 (1) ◽  
pp. 300-304
Author(s):  
Amit Reche ◽  
Anjali Nandanwar ◽  
Aniket Hedaoo ◽  
Kumar G. Chhbra ◽  
Punit Fulzele ◽  
...  
Keyword(s):  
Older Adults ◽  
Lung Diseases ◽  
Heart Diseases ◽  
Treatment Modalities ◽  
Renal Diseases ◽  
The Novel ◽  
Geriatric Population ◽  
Pulmonary Pathology ◽  
Coronavirus Infection ◽  
Novel Coronavirus

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)is a virus responsible for the coronavirus infection that is currently causing a severe outbreak of the disease in the world, infecting and killing thousands to lacs of people. The pediatric and geriatric population is no exception to this. Children and older adults have less immunity, which makes them more susceptible to infection than other populations. But still the number of cases of Children where less as compared to adults and those having underlying pulmonary pathology or immunocompromising conditions are more vulnerable to infection. Some studies have shown that this virus causes more death in the older age population as compared to adults or children. Patients having any systemic conditions like diabetes, raised blood pressure, heart diseases, lung diseases and chronic renal diseases were more vulnerable to this infection. In this article, we will outline the epidemiology, symptoms, diagnosis, and treatment modalities of the novel coronavirus-2019(COVID 19) infection in humans, with more focusing on infection in children as well as in older adults.

scholarly journals Questionnaire for initial self-assessment in post-COVID period: Recommendations of Multidisciplinary expert board on screening of post-COVID syndrome during an expanded medical check-up

2021 ◽  
Vol 31 (5) ◽  
pp. 599-612
Author(s):  
Alexander G. Chuchalin ◽  
Alexander S. Ametov ◽  
Gregory P. Arutyunov ◽  
Oksana M. Drapkina ◽  
Mikhail Yu. Martynov ◽  
...  
Keyword(s):  
Clinical Examination ◽  
Risk Groups ◽  
Initial Assessment ◽  
Patient Questionnaire ◽  
The Novel ◽  
Self Assessment ◽  
Symptom Complex ◽  
Coronavirus Infection ◽  
Set Up ◽  
Novel Coronavirus

The post-COVID symptom complex is wide enough and requires special vigilance during clinical examination of patients after the novel coronavirus infection. The aim of the Multidisciplinary Expert Board study was to develop a standardized questionnaire for initial self-assessment by patients who had had COVID-19 before the expanded medical check-up.Methods. The existing validated international and national questionnaires and scales were analyzed to assess their relevance, convenience, and ease of filling out. Results of the analysis were used to set up a screening for post-COVID symptoms.Results. The work of the Multidisciplinary Expert Board in June-August 2021 resulted in a new screening questionnaire for the initial assessment of the health status of patients who have COVID-19. The questionnaire is intended for self-filling before the further clinical examination.Conclusion. A new standardized patient questionnaire to screen for post-COVID symptoms may significantly optimize the doctor’s working time, increase the efficiency of diagnosis, improve the principles of selection and formation of risk groups of patients during an expanded medical check-up.

scholarly journals COVID-19 and Slums: A Pandemic Highlights Gaps in Knowledge About Urban Poverty

10.2196/19578 ◽  
2020 ◽  
Vol 6 (3) ◽  
pp. e19578
Author(s):  
John Friesen ◽  
Peter F Pelz
Keyword(s):  
Health Status ◽  
Cardiovascular Diseases ◽  
United Nations ◽  
Urban Poverty ◽  
Risk Groups ◽  
Data Availability ◽  
Noncommunicable Diseases ◽  
The Novel ◽  
Limited Extent ◽  
Novel Coronavirus

According to the United Nations, about 1 billion persons live in so-called slums. Numerous studies have shown that this population is particularly vulnerable to infectious diseases. The current COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, emphatically underlines this problem. The often high-density living quarters coupled with a large number of persons per dwelling and the lack of adequate sanitation are reasons why measures to contain the pandemic only work to a limited extent in slums. Furthermore, assignment to risk groups for severe courses of COVID-19 caused by noncommunicable diseases (eg, cardiovascular diseases) is not possible due to inadequate data availability. Information on people living in slums and their health status is either unavailable or only exists for specific regions (eg, Nairobi). We argue that one of the greatest problems with regard to the COVID-19 pandemic in the context of slums in the Global South is the lack of data on the number of people, their living conditions, and their health status.

scholarly journals COVID-19 and Slums: A Pandemic Highlights Gaps in Knowledge About Urban Poverty (Preprint)

2020 ◽  
Author(s):  
John Friesen ◽  
Peter F Pelz
Keyword(s):  
Health Status ◽  
Cardiovascular Diseases ◽  
United Nations ◽  
Urban Poverty ◽  
Risk Groups ◽  
Data Availability ◽  
Noncommunicable Diseases ◽  
The Novel ◽  
Limited Extent ◽  
Novel Coronavirus

UNSTRUCTURED According to the United Nations, about 1 billion persons live in so-called slums. Numerous studies have shown that this population is particularly vulnerable to infectious diseases. The current COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, emphatically underlines this problem. The often high-density living quarters coupled with a large number of persons per dwelling and the lack of adequate sanitation are reasons why measures to contain the pandemic only work to a limited extent in slums. Furthermore, assignment to risk groups for severe courses of COVID-19 caused by noncommunicable diseases (eg, cardiovascular diseases) is not possible due to inadequate data availability. Information on people living in slums and their health status is either unavailable or only exists for specific regions (eg, Nairobi). We argue that one of the greatest problems with regard to the COVID-19 pandemic in the context of slums in the Global South is the lack of data on the number of people, their living conditions, and their health status.

scholarly journals Challenges for a Cancer Center in the Novel Coronavirus Pneumonia Epidemic

2020 ◽  
Vol 19 ◽  
pp. 153303382094577
Author(s):  
Xiao Shan Wang ◽  
Ming Zeng
Keyword(s):  
Radiation Therapy ◽  
Inpatient Treatment ◽  
Risk Groups ◽  
Cross Infection ◽  
Cancer Center ◽  
The Novel ◽  
Local Conditions ◽  
Treatment Services ◽  
Novel Coronavirus ◽  
Tertiary Cancer Center

Introduction: The novel Coronavirus disease 2019 pandemic is sweeping through China, posing the greatest ever threat to its public health and economy. As a tertiary cancer center in Southwest China, we formulated and implemented an anti-infection protocol to prevent the spread of Coronavirus disease 2019 in our department. Methods: The anti-infection protocol divided patients into 3 categories, namely outpatients, inpatients, and patients receiving radiation therapy at our cancer center, and each category had a distinct anti-infection protocol to minimize the risk of Coronavirus disease 2019 transmission. In each category, the patients were classified into high-, intermediate-, and low-risk groups. Each risk group was managed differently. A survey of patient volume changes prior to and during the Coronavirus disease 2019 outbreak was performed. Results: We carried out the anti-infection protocol at our cancer center during the Coronavirus disease 2019 outbreak. We found that the total volume of both outpatient visits and inpatient treatment declined significantly depending on the conditions of each group. Radiation therapy and palliative service had the lowest and highest volume reductions at 58.3% and 100%, respectively. The decline in outpatient volumes was higher than the decline in inpatient treatment services (78.8% vs 71.8%). There was no Coronavirus disease 2019 cross-infection at our center, or Coronavirus disease 2019–related injury or death. The anti-infection protocol measures continue to be taken at the hospital even today but they have been modified depending on the prevalent local conditions. Conclusions: Challenges from the Coronavirus disease 2019 pandemic remain in our community. The anti-infection protocol implemented at our cancer center has been effective in preventing cross-infection. Whether our anti-infection protocol experience can be applied to curb the spread of the infection in other parts of the world remains to be tested.

scholarly journals Persistence of SARS-COV-2 in body fluids: a bystander or whistle blower

2020 ◽  
Author(s):  
Ishani Bora ◽  
Sanjib Gogoi ◽  
Vaishnavi Venkatasubramanian ◽  
Roshan Mathew ◽  
Ritin Mohindra
Keyword(s):  
Clinical Improvement ◽  
Body Fluids ◽  
The Novel ◽  
Test Results ◽  
Rt Pcr ◽  
Clinical Recovery ◽  
Novel Virus ◽  
Novel Coronavirus ◽  
Government Authority ◽  
Pcr Test

The novel Coronavirus COVID-19 is wrecking a havoc across the globe and has been declared as a pandemic by WHO. Apart from transmission and shedding of the virus through respiratory secretions in the form of droplets (mainly), several studies have shown the presence of the virus in various samples such as stool, urine and occasionally in blood, semen, tears and breastmilk. Whereas government authority guidelines consider a person as cured from COVID-19 when along with clinical improvement no more virus can be detected primarily on respiratory samples along with clinical improvement; the persistence of the virus in these body fluids even after clinical recovery and negative RT-PCR test results on respiratory samples, has raised many questions about the elusive nature of this novel virus along with the possibility of other routes of transmission of this virus in the community. Although studies performed till now across the globe on persistence of SARSCOV-2 in various body fluids are sparse, in this review we would like to present and analyse the results of those studies performed globally on the aforesaid topic to get a better insight of this side of the COVID-19 story.

A case of the rapid course of the novel coronavirus infection (COVID-19) in a pregnant woman

2021 ◽  
Vol 1_2021 ◽  
pp. 186-193
Author(s):  
Bezhenar V.F. Bezhenar ◽  
Zazerskaya I.E. Zazerskaya ◽  
Kucheryavenko A.N. Kucheryavenko ◽  
Meshchyaninova S.G. Meshchyaninova ◽  
Mazurok V.A. Mazurok ◽  
...  
Keyword(s):  
Pregnant Woman ◽  
The Novel ◽  
Coronavirus Infection ◽  
Novel Coronavirus

scholarly journals MS, pregnancy and COVID-19

2020 ◽  
Vol 26 (10) ◽  
pp. 1137-1146 ◽  
Author(s):  
Charmaine Yam ◽  
Vilija Jokubaitis ◽  
Kerstin Hellwig ◽  
Ruth Dobson
Keyword(s):  
Multiple Sclerosis ◽  
Pregnant Woman ◽  
Antenatal Care ◽  
Pregnant Women ◽  
Clinical Management ◽  
The Novel ◽  
Relative Paucity ◽  
Novel Coronavirus ◽  
The Impact ◽  
Current Advice

Concerns regarding infection with the novel coronavirus SARS-CoV-2 leading to COVID-19 are particularly marked for pregnant women with autoimmune diseases such as multiple sclerosis (MS). There is currently a relative paucity of information to guide advice given to and the clinical management of these individuals. Much of the limited available data around COVID-19 and pregnancy derives from the obstetric literature, and as such, neurologists may not be familiar with the general principles underlying current advice. In this article, we discuss the impact of potential infection on the pregnant woman, the impact on her baby, the impact of the current pandemic on antenatal care, and the interaction between COVID-19, MS and pregnancy. This review provides a framework for neurologists to use to guide the individualised advice given to both pregnant women with MS, and those women with MS who are considering pregnancy. This includes evidence derived from previous novel coronavirus infections, and emerging evidence from the current pandemic.

scholarly journals Pulmonary Pathology of Early Phase 2019 Novel Coronavirus (COVID-19) Pneumonia in Two Patients with Lung Cancer

2020 ◽  
Author(s):  
Sufang Tian ◽  
Weidong Hu ◽  
Li Niu ◽  
Huan Liu ◽  
Haibo Xu ◽  
...  
Keyword(s):  
Early Phase ◽  
Giant Cells ◽  
Lung Pathology ◽  
The Novel ◽  
Cellular Infiltration ◽  
Multinucleated Giant Cells ◽  
Time Of Surgery ◽  
Pulmonary Pathology ◽  
Novel Coronavirus ◽  
Reactive Hyperplasia

There is currently a lack of pathologic data on the novel coronavirus (SARS-CoV-2) pneumonia, or COVID-19, from autopsy or biopsy. Two patients who recently underwent lung lobectomies for adenocarcinoma were retrospectively found to have had COVID-19 at the time of surgery. These two cases thus provide important first opportunities to study the pathology of COVID-19. Pathologic examinations revealed that, apart from the tumors, the lungs of both patients exhibited edema, proteinaceous exudate, focal reactive hyperplasia of pneumocytes with patchy inflammatory cellular infiltration, and multinucleated giant cells. Hyaline membranes were not prominent. Since both patients did not exhibit symptoms of pneumonia at the time of surgery, these changes likely represent an early phase of the lung pathology of COVID-19 pneumonia.

scholarly journals COVID-19 Mini-Review: D614G Mutation as an Independent Risk-Factor to the Expression of ACE2 and DPP4 Associated Increased Severity in COVID-19

2021 ◽  
Vol 50 (4) ◽  
pp. 1175-1186
Author(s):  
Siti Asmaa Mat Jusoh ◽  
Parisa Foroozandeh ◽  
Yan Fen Lee ◽  
Mardani Abdul Halim ◽  
Manoj Kumar Laskmanan ◽  
...  
Keyword(s):  
Risk Groups ◽  
Current Evidence ◽  
The Novel ◽  
Dominant Form ◽  
Angiotensin Converting Enzyme 2 ◽  
Dipeptidyl Peptidase 4 ◽  
Slowing Down ◽  
The People ◽  
Novel Coronavirus ◽  
Cluster Of Differentiation

The novel coronavirus 2019 (COVID-19) has struck more than 99 million people worldwide and had claimed more than 2 million lives as of 23 January 2021, which affecting 221 countries/nations. Until now, the pandemic has not shown signals of slowing down, with no proven vaccine in sight. People are speculating on this unprecedented event. It is well documented that the receptor-binding domain (RBD) of the viral spiked S1 glycoprotein directly bind angiotensin-converting enzyme 2 (ACE2) and dipeptidyl-peptidase-4 (DPP4) or CD26 (cluster of differentiation 26) receptors lead to their entry. The latest evidence demonstrated that SAR-CoV-2 possesses genetic heterogeneity, lead to the existence of a new SAR-CoV-2 variant, such as D614G encoded the spiked S1. The mutation involved changes in amino acid sequence of D (aspartic acid) into G (guanine) at position 614. D614G was reported to confer high infectivity and became the dominant form of the virus globally. Interestingly, current evidence found that D614G protein increases its infectivity dependent on the ACE2 receptor, and its co-binding receptor, DPP4. This proclaims implied to COVID-19 high-risk groups; the aging population and the people with comorbidities; hypertension, cardiovascular disease, and diabetes, which constituted the most of lethal cases, that overexpressed ACE2 and DPP4. The review aims to find an association between COVID-19 infectivity and severity relating to D614G mutation with the expression of ACE2 or DPP4 in these groups. We proposed that D614G mutation and expressions of ACE2 and DPP4 were mutually inclusive for increase infectivity, but not severity in COVID-19’s patients.

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