scholarly journals Cushing's disease. The case hystory

2011 ◽  
Vol 3 (1) ◽  
pp. 53-58
Author(s):  
Elena L. Sojustova ◽  
Оlga J. Povarova ◽  
Elizaveta E. Kazantseva
Keyword(s):  
Pituitary Adenoma ◽  
Clinical Experience ◽  
Cushing’S Disease ◽  
Clinical Manifestations ◽  
Diagnosis And Treatment ◽  
Cushing's Disease ◽  
Topical Diagnosis ◽  
Modern Methods

Cushing's disease - one of rare neuroendocrine disorders which is based on adrenocorticotropin - hormone secreting pituitary adenoma. The article presents information about clinical manifestations, modern methods of topical diagnosis and treatment. The description of own clinical experience is given.

scholarly journals Severe hepatocytolisis syndrome - a challenge in medical therapy of Cushing’s disease

2015 ◽  
Vol 21 (3) ◽  
pp. 132-136
Author(s):  
Ana Valea ◽  
Mara Carsote ◽  
Adina Ghemigian ◽  
Andra Morar ◽  
D.P. Dumitru ◽  
...  
Keyword(s):  
Pituitary Adenoma ◽  
Medical Therapy ◽  
Cushing’S Disease ◽  
Tumor Resection ◽  
Clinical Manifestations ◽  
Cushing's Disease ◽  
Technical Equipment ◽  
Acth Secretion ◽  
Surgery Outcome ◽  
Disease Case

ABSTRACT Introduction Cushing’s disease is a rare endocrine disorder characterized by persistent hypercortisolism due to excessive, autonomous ACTH secretion by a pituitary adenoma. Transsphenoidal adenomectomy is the main therapeutic option in Cushing’s disease. When imaging studies are unable to demonstrate an obvious pituitary mass complete tumor resection is difficult and often encumbered by risk of relapse. Medical therapy is a second-line option or the first-line treatment for patients with high surgical risk, incomplete surgical resection or relapse. Rarely classic clinical manifestations limit the selection of medical therapy for Cushing’s disease. Case presentation We present the case of a male patient with Cushing’s disease complicated with diabetes mellitus and severe hepatocytolisis syndrome with no visible pituitary adenoma on MRI studies. In the absence of technical equipment petrosal sinus sampling could not be performed in order to improve surgery outcome Conclusion The presence of unbalanced diabetes and severe hepatocytolisis syndrome made it impossible to use steroidogenesis inhibitors (mitotane, ketoconazole, metyrapone, etomidate) or inhibitors of ACTH secretion as pasireotide that represent a new option in achieving control of hypercortisolism

Cyclic Cushing's Disease in Mixed Gangliocytoma–Pituitary Adenoma Tumor: Case Report

2020 ◽  
Author(s):  
Yury Anania ◽  
Venteicher S. Andrew ◽  
Pearce M. Thomas ◽  
Gardner A. Paul
Keyword(s):  
Case Report ◽  
Pituitary Adenoma ◽  
Cushing’S Disease ◽  
Cushing's Disease

scholarly journals Diagnosis and Multimodality Management of Cushing’s Disease: A Practical Review

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Gabriel Zada
Keyword(s):  
Pituitary Adenoma ◽  
Cushing’S Disease ◽  
Patient Survival ◽  
Clinical Laboratory ◽  
Management Strategies ◽  
Serum Cortisol ◽  
Cushing's Disease ◽  
First Line ◽  
Stepwise Approach

Cushing’s Disease is caused by oversecretion of ACTH from a pituitary adenoma and results in subsequent elevations of systemic cortisol, ultimately contributing to reduced patient survival. The diagnosis of Cushing’s Disease frequently involves a stepwise approach including clinical, laboratory, neuroimaging, and sometimes interventional radiology techniques, often mandating multidisciplinary collaboration from numerous specialty practitioners. Pituitary microadenomas that do not appear on designated pituitary MRI or dynamic contrast protocols may pose a particularly challenging subset of this disease. The treatment of Cushing’s Disease typically involves transsphenoidal surgical resection of the pituitary adenoma as a first-line option, yet may require the addition of adjunctive measures such as stereotactic radiosurgery or medical management to achieve normalization of serum cortisol levels. Vigilant long-term serial endocrine monitoring of patients is imperative in order to detect any recurrence that may occur, even years following initial remission. In this paper, a stepwise approach to the diagnosis, and various management strategies and associated outcomes in patients with Cushing’s Disease are discussed.

Itsenko-Cushing’s disease in the practice of a nurse

2021 ◽  
pp. 76-80
Author(s):  
Polina Denisovna Samokhvalova ◽  
Nikita Dmitrievich Matveev ◽  
Vsevolod Vladimirovich Skvortsov
Keyword(s):  
Survival Rate ◽  
Cushing’S Disease ◽  
Palliative Treatment ◽  
Diagnosis And Treatment ◽  
Cushing's Disease ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal System

Itsenko-Cushing’s disease is a disease characterized by dysfunctions of the hypothalamic-pituitary-adrenal system. Without therapy during the first five years, the survival rate is 50 %, and the patient’s condition improves markedly with palliative treatment, increasing the survival rate to 86 %. Today, there are a number of criteria for the diagnosis, diagnosis and treatment of this pathology.

Two-step development of a pituitary adenoma: From hyperprolactinemic syndrome to Cushing’s disease

1997 ◽  
Vol 20 (4) ◽  
pp. 240-244 ◽  
Author(s):  
R. G. Gheri ◽  
W. Boddi ◽  
F. Ammannati ◽  
J. Olivotto ◽  
C. Nozzoli ◽  
...  
Keyword(s):  
Pituitary Adenoma ◽  
Cushing’S Disease ◽  
Cushing's Disease
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