scholarly journals IMMUNOLOGICAL DISODERS IN PATIENTS WITH CHRONIC RENAL INSUFFICIENCY AND POSSIBILITY OF IMMUNE THERAPY

2014 ◽  
Vol 5 (3) ◽  
pp. 83-88 ◽  
Author(s):  
S I Sokurenko ◽  
A N Fedoseev ◽  
T V Borisova
Keyword(s):  
Chronic Kidney Disease ◽  
Immune Responses ◽  
Impaired Renal Function ◽  
Alkylating Agents ◽  
Immune Therapy ◽  
Review Of The Literature ◽  
Effect Of Treatment ◽  
Immunological Changes ◽  
Relationship Of ◽  
The Relationship

The main evidence of the participation of immune responses in the pathogenesis of chronic renal failure (CRF) is an undoubted effect of treatment with corticosteroids, alkylating agents and cyclosporine A. This is supported by the relationship of nephrotic syndrome (NS) with atopy, Hodgkin's disease, certain HLA-types: DRw7, B12.This article presents a review of the literature, focused on the immunological changes in patients with impaired renal function, including сhroniс hemodialysis. Various aspects of immunocorrection in patients with chronic kidney disease are analyzed.

scholarly journals Hyperuricemia and chronic kidney disease

2021 ◽  
pp. 77-81
Author(s):  
Olga Kompaniets
Keyword(s):  
Chronic Kidney Disease ◽  
Uric Acid ◽  
Kidney Disease ◽  
Clinical Studies ◽  
Review Of The Literature ◽  
Relationship Of ◽  
The Impact ◽  
The Relationship

The article is devoted to a review of the literature on the impact of hyperuricemia on the development and progression of chronic kidney disease (CKD). The tendency of changes of views on the role of uric acid in the pathogenesis of CKD is demonstrated. An analysis of experimental, epidemiological and clinical studies on the effects of uric acid on the physiology of the nephron and endothelial tissues, the relationship of hyperuricemia with metabolic and cardiorenal syndromes.

scholarly journals Atherosclerotic vascular disease is more prevalent among black ESKD patients on long-term CAPD in South Africa

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
S. O. Oguntola ◽  
M. O. Hassan ◽  
R. Duarte ◽  
A. Vachiat ◽  
P. Manga ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Vascular Disease ◽  
Left Ventricular ◽  
Atherosclerotic Vascular Disease ◽  
Ckd Stage ◽  
Significant Difference ◽  
Echocardiographic Parameters ◽  
Relationship Of ◽  
The Relationship

Abstract Background Occurrence of cardiovascular disease (CVD) in the setting of chronic kidney disease (CKD) can be described as a “cruel alliance”, with CVD responsible for about half of all deaths among CKD patients. Chronic kidney disease patients are more likely to die from CVD than progress to end stage kidney disease (ESKD). Dyslipidaemia, a known traditional risk factor for CVD, is highly prevalent among CKD patients and with an even higher frequency among ESKD patients on dialytic therapies. Prolonged exposure of continuous ambulatory peritoneal dialysis (CAPD) patients to high glucose concentrations in CAPD fluid have been associated with increased risk of cardiovascular events. In this study, we investigated the relationship of atherosclerotic vascular disease (AsVD) to clinical and echocardiographic parameters among black South Africans with CKD (stage 3) and ESKD on CAPD and haemodialysis (HD). Methods This was a cross-sectional study of 40 adult (18–65 years) non-diabetic CKD patients (kidney disease outcome quality initiative [KDOQI] stage 3), 40 ESKD patients on CAPD, 40 ESKD patients on HD and 41 age and sex-matched healthy controls. An interviewer-administered questionnaire was used to obtain information on participants’ sociodemographic and cardiovascular risk factors. Anthropometric parameters were measured. Serum blood samples were analysed for creatinine, albumin and lipid profile; lipoprotein ratios, Framingham’s risk score and the 10-year risk of developing coronary heart disease (CHD) were calculated. Echocardiography was performed on all patients and carotid intima media thickness (CIMT) was measured in both right and left carotid arteries at 1 cm proximal to the carotid bulb. Spearman’s rank correlation and binary logistic regression were conducted to determine the relationship of AsVD to clinical and echocardiographic parameters. Results Atherosclerotic vascular disease was most prevalent among ESKD patients on CAPD (70%, n = 28/40). Chronic kidney disease and HD patients exhibited a similar prevalence (47.5%, n = 19/40), while the prevalence in controls was 17.1% (n = 7/41). Presence of AsVD was associated with significantly older age, higher waist hip ratio (WHR), left ventricular mass index (LVMI) and Framingham’s 10-year risk of developing CHD. Significant differences in clinical and echocardiographic parameters were observed when the study groups were compared. Age and LVH independently predicted AsVD. Conclusion Atherosclerotic vascular disease was more prevalent among CAPD patients compared to pre-dialysis CKD and HD patients. Among all lipoprotein ratios assessed, non-HDL-C showed the most consistent significant difference between the groups. Age (> 40 years) and presence of LVH were independent predictors of AsVD.

Sex Differences in Body-Weight Change following Gonadectomy of Rats

1968 ◽  
Vol 22 (2) ◽  
pp. 547-554 ◽  
Author(s):  
Jan W. Kakolewski ◽  
Verne C. Cox ◽  
Elliot S. Valenstein
Keyword(s):  
Body Weight ◽  
Sex Differences ◽  
Female Rats ◽  
Body Weight Change ◽  
Review Of The Literature ◽  
Male And Female ◽  
Male And Female Rats ◽  
Relationship Of ◽  
The Relationship ◽  
Hypothalamic Damage

Data are presented to demonstrate that the effects of gonadectomy on body weight and food consumption differ in male and female rats. The findings are related to the authors' report of sex differences in the effects of ventromedial hypothalamic damage. A review of the literature on the relationship of the gonads to body weight in different species is presented.

scholarly journals Harnessing the immune response to target tumors

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 710 ◽  
Author(s):  
Luisa Manning ◽  
John Nemunaitis
Keyword(s):  
Immune Response ◽  
Targeted Therapy ◽  
Immune Function ◽  
Immune Therapy ◽  
Signal Pathway ◽  
Limited Experience ◽  
Relationship Of ◽  
The Relationship ◽  
Anticancer Response

Development of “immune-based targeted therapy” in oncology has limited experience with signal pathway modulation. However, as we have become better versed in understanding immune function related to anticancer response, “hints” of specific targets associated with sensitivity and resistance have been identified with targeted immune therapy. This brief review summarizes the relationship of several targeted immune therapeutics and activity associated clinical responsiveness.

scholarly journals Planned Cesarean Delivery and Urinary Retention Associated With Spinal Morphine

2011 ◽  
Author(s):  
Susan DiBlasi
Keyword(s):  
United States ◽  
Cesarean Delivery ◽  
Nursing Care ◽  
The United States ◽  
Review Of The Literature ◽  
Patients Âgés ◽  
Group Design ◽  
Quasi Experimental ◽  
Relationship Of ◽  
The Relationship

<p>Cesarean delivery (CD) is the second most commonly performed surgery in the United States. As such, prevention of complications associated with this procedure is a top priority in nursing care. Nurses at the study insti- tution perceived that postcesarean patients experienced increased uri- nary retention after use of spinal morphine for postoperative pain relief. This observation prompted a review of the literature indicating that limited research had been conducted in this area. The purpose of this study was to explore the relationship of postelective CD urinary reten- tion and dose of spinal morphine. A retrospective, quasi-experimental, three-group design was used. Records of 150 patients, ages 17 to 39, undergoing elective primary or repeat CD were examined. Morphine doses included 100, 150, and 200 mcg. No statistically significant differ- ences were found between the three groups.</p>

scholarly journals CRITICAL REVIEW OF FOREIGN RESEARCHES OF THE VALUES ROLE IN ORGANIZATIONAL CHANGES

2019 ◽  
pp. 27-33 ◽  
Author(s):  
N. Yu. Lebedeva ◽  
E. M. Shironina
Keyword(s):  
Organizational Culture ◽  
Organizational Values ◽  
Value Systems ◽  
Existence Theory ◽  
Review Of The Literature ◽  
Organizational Changes ◽  
Structure Development ◽  
Spiral Dynamics ◽  
Relationship Of ◽  
The Relationship

A review of the literature on change management of foreign researchers on the relationship of organizational values and the success of organizational changes has been presented. Identification instruments of organizational values have been considered. Typology of organizational culture on eight value systems in accordance with Graves’ emergent cyclical levels of existence theory and the concept of spiral dynamics by Beck and Cowan has been proposed. Characteristic of organizational culture depending on the level of value structure development has been given.

scholarly journals The Role of Hyperuricemia in the Pathogenesis and Progressivity of Chronic Kidney Disease

2021 ◽  
Vol 9 (F) ◽  
pp. 428-435
Author(s):  
Gede Wira Mahadita ◽  
Ketut Suwitra
Keyword(s):  
Chronic Kidney Disease ◽  
Uric Acid ◽  
Kidney Disease ◽  
Serum Uric Acid ◽  
Filtration Rate ◽  
Stage Iv ◽  
Review Of The Literature ◽  
The Relationship ◽  
Uric Acid Secretion

In humans, the end product of purine metabolism is uric acid. Over 70% of uric acid is excreted through the kidneys. When renal function is impaired, uric acid secretion is also impaired. This directly correlates the prevalence of hyperuricemia with the severity of chronic kidney disease (CKD). It has been reported that the prevalence of hyperuricemia in patients with Stage I-III CKD is 40–60% and up to 70% in patients with Stage IV-V CKD. Some studies found a link between serum uric acid levels and decreased glomerular filtration rate (GFR), an independent risk factor for CKD development. Because CKD and serum uric acid levels are related, the relationship between the two frequently generates controversy. As such, this review of the literature discusses the role of uric acid in the pathogenesis and progression of CKD.

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