scholarly journals ULTRASOUND CRITERIA FOR DIAGNOSIS AND MONITORING OF DRUG THERAPY OF COMBINED PROLIFERATIVE DISEASES OF THE UTERUS

2014 ◽  
Vol 5 (3) ◽  
pp. 25-34
Author(s):  
Kedrova Genrikhovna AG ◽  
Levakov Aleksandrovich SA ◽  
Nechaeva Evgen'evna OE ◽  
Tazitdinov Khallilovich RH ◽  
Chelnokova Nikolaevna NN
Keyword(s):  
Drug Therapy ◽  
Diagnostic Accuracy ◽  
Surgical Management ◽  
Uterine Fibroid ◽  
Endometrial Hyperplasia ◽  
Imaging Modality ◽  
Uterine Fibroids ◽  
Before And After ◽  
Criteria For Diagnosis ◽  
Therapeutic Alternatives

The aim of the paper was to evaluate the diagnostic accuracy of transvaginal tenderness-guided ultrasonography in the identification of location of genital endometriosis, endometrial hyperplasia and uterine fibroids before and after treatment dienogest. It is a selective progestin for the treatment of endometriosis. Adenomyosis was diagnosed when a poorly defined area of abnormal echo-texture (decreased or increased echogenicity, heterogeneous echotexture, myometrial cysts) presented in myometrium. Typical ultrasonic changes of efficacy were: homogeneity of myometrium; clear and intense contours of uterine fibroid with increased echogenicity; reduction of the echogenic endometrial stripe with the average echogenicity and clear lines of myo- and endometrium with a reduction in local blood. These criteria can be used to select non-surgical management of patients. In cases where a poorly defined area of abnormal echotexture (decreased or increased echogenicity, heterogeneous echotexture, myometrial cysts) did not change the surgery or the embolization of artery uterine is required. The preferred imaging modality for the evaluation of uterine on therapeutic alternatives to hysterectomy and myomectomy is transvaginal ultrasonography.

scholarly journals Surgical Management of Uterine Fibroids at Aminu Kano Teaching Hospital

2012 ◽  
Vol 2012 ◽  
pp. 1-6
Author(s):  
Abiodun Omole-Ohonsi ◽  
Francis Belga
Keyword(s):  
Postoperative Complications ◽  
Surgical Management ◽  
Teaching Hospital ◽  
Uterine Fibroid ◽  
Clinical Presentation ◽  
Uterine Fibroids ◽  
Abdominal Hysterectomy ◽  
High Parity ◽  
The Mean ◽  
Surgical Operations

Objective. To determine the influence of age and parity on the surgical management of uterine fibroids, clinical presentation, presence of pelvic adhesions, cadre of surgeons, and postoperative complications at the Aminu Kano Teaching Hospital, Kano, Nigeria.Methods. A retrospective analysis of 105 cases of uterine fibroids that were managed between 1st January 2003 and 31st December 2007.Results. The period prevalence of uterine fibroids was 24.7% of all major gynecological operations. The mean age was 35.8 ± 7.6 and mean parity 4.7 ± 2.8. Abdominal hysterectomy accounted for 58.1% of the cases and myomectomy 41.9%. The odd of using abdominal hysterectomy was about twice that of myomectomy. Pelvic adhesions were found in 67.6% of the cases. Menorrhagia (86.7%) was the commonest symptom, while post operative anemia and pyrexia showed significant association with myomectomy. There was no maternal mortality.Conclusion. Surgical operations for uterine fibroids are safe and common kind of gynecological operations at the Aminu Kano Teaching Hospital. Uterine fibroid is associated more with high parity and dominance of abdominal hysterectomy over myomectomy, because early girl marriage is common in our community.

SEGMENTATION OF UTERINE USING NEIGHBORHOOD INFORMATION AFFECTED POSSIBILISTIC FCM AND GAUSSIAN MIXTURE MODEL IN UTERINE FIBROID PATIENTS MRI

2014 ◽  
Vol 26 (01) ◽  
pp. 1450010
Author(s):  
Alireza Fallahi ◽  
Hassan Khotanlou ◽  
Mohammad Pooyan ◽  
Hassan Hashemi ◽  
Mohammad Ali Oghabian
Keyword(s):  
Gaussian Mixture Model ◽  
Mixture Model ◽  
Uterine Fibroid ◽  
Clustering Algorithm ◽  
Uterine Fibroids ◽  
Gaussian Mixture ◽  
Volume Measurement ◽  
Fuzzy C Means ◽  
Neighborhood Information ◽  
Before And After

Uterine fibroids are common tumors of female pelvis. Uterine volume measurement before and after surgery has an important role in predicting the outcome and later on in comparing with the result of the uterine fibroid shrinkage surgery. Because of inhomogeneity and different shapes and sizes of uterus and fibroids, segmentation of uterus is a difficult task. In this paper, using T1 and Enhanced-T1 MR images uterine is initially segmented using a new clustering algorithm named neighborhood information affected possibilistic fuzzy C-means (NIAPFCM). NIAPFCM uses membership, typicality and spatial neighborhood information to cluster each voxel. Finally, the redundant parts are removed by superimposing the segmented region of the T1-enhanced image over the registered T1 image. Gaussian mixture model (GMM) is applied to the extracted region histogram as a model for accurate tresholding. The results obtained using the proposed method are evaluated by comparing with manual segmentations using volume-based and distance-based metric methods. Also, the result of NIAPFCM is compared with fuzzy C-means (FCM) and possibilistic fuzzy C-means (PFCM) algorithms. We found this algorithm efficient, which provides good and reliable results.

Etiological structure and diagnosis of abnormal uterine bleeding

GYNECOLOGY ◽  
2018 ◽  
Vol 20 (2) ◽  
pp. 14-17
Author(s):  
G E Chernukha ◽  
I A Ivanov ◽  
Z N Efendieva ◽  
M R Dumanovskaya ◽  
A V Asaturova
Keyword(s):  
Diagnostic Accuracy ◽  
Endometrial Hyperplasia ◽  
Ultrasound Examination ◽  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding ◽  
Histological Diagnosis ◽  
Reproductive Age ◽  
Endometrial Polyps ◽  
Chronic Endometritis ◽  
Endometrial Pathology

Abnormal uterine bleeding (AUB) is one of the most common indications for hysteroscopy. Most of the AUB cases occur due to endometrial or myometrium pathology. Among it, endometrial polyps (EP) and chronic endometritis (CE) prevalent in reproductive age, while endometrial hyperplasia (EH) and EP dominate in perimenopause. It was determined that EP and CE are characterized with menorrhagia and metrorrhagia approximately equally, whereas EH reveals AUB with oligomenorrhoea. Verification of exact endometrial pathology by ultrasound examination is hindered, that results in deviations of ultrasound and histological diagnosis. The usage of ultrasound data and AUB’s characteristics may improve the diagnostic accuracy on preadmission period.

A pilot study on the effect of ulipristal acetate on myoma angiogenesis, measured by 2D ultrasound and VEGF serum levels

2020 ◽  
pp. 19-29
Author(s):  
Patricia Diaz Ortega ◽  
Manuel García Manero
Keyword(s):  
Pilot Study ◽  
Power Doppler ◽  
Uterine Fibroids ◽  
Premenopausal Women ◽  
Serum Levels ◽  
Ulipristal Acetate ◽  
Before And After ◽  
Angiogenesis Process ◽  
2D Ultrasound ◽  
Average Size

Introduction: Symptomatic uterine fibroids can cause symptoms that can be disabling. There are many treatments, including ulipristal acetate, whose role in reducing symptoms and decreasing the size of the fibroid is well known. With this preliminary study, we also try to evaluate the correlation between myoma vascularization measured by ultrasound (Power Doppler 2D) and serum VEGF levels, before and after treatment with ulipristal acetate; in patients diagnosed with symptomatic uterine fibroids. Materials and Methods: A preliminary, prospective observational pilot study was designed. Twenty-four premenopausal women, diagnosed with symptomatic uterine fibroids, were included and all of them completed the study. Four cycles of ulipristal acetate were administered according to the dose and indications specified in the data sheet. In order to assess the influence of this treatment on the angiogenesis process of the fibroids, measurements of VEGF serum levels were made and their vascularization was assessed by means of 2D power doppler ultrasound; at the beginning and the end of treatment. In addition, several determinations of the same parameters were made throughout the successive visits. Endpoints were defined as the decrease in VEGF levels from previous levels, the decrease in myoma vascularization on ultrasound, and the reduction in myoma size. Result: 24 patients who met the inclusion criteria were enrolled (n=24). The average size of myomas was reduced from 45,08 ? 24,02mm to 29?16,96mm after treatment. The average VEGF serum level significantly decreased after the first treatment cycle (from 147,17 ? 153,51 pg/ml to 102,04 ? 186,08pg/ml). Vascularization of myomas after treatment with ulipristal acetate was analyzed, and a significantly decrease was achieved in 83,3% of cases. Conclusion: There is a correlation between myoma vascularization and treatment with Ulipristal acetate. SPRMs may provide effective treatment for women with symptomatic fibroids by two ways: supports selective progesterone receptor modulators and reduced angiogenesis. Keywords: Angiogenesis; Ulipristal Acetate; Uterine fibroids; VEGF

scholarly journals Transcriptome Analyses of Myometrium from Fibroid Patients Reveals Phenotypic Differences Compared to Non-Diseased Myometrium

2021 ◽  
Vol 22 (7) ◽  
pp. 3618
Author(s):  
Emmanuel N. Paul ◽  
Gregory W. Burns ◽  
Tyler J. Carpenter ◽  
Joshua A. Grey ◽  
Asgerally T. Fazleabas ◽  
...  
Keyword(s):  
Uterine Fibroid ◽  
Three Dimensional ◽  
Uterine Fibroids ◽  
Principal Component ◽  
Leading Edge ◽  
Gene Set Enrichment ◽  
Phenotypic Differences ◽  
False Discovery ◽  
Gene Sets ◽  
High Concordance

Uterine fibroid tissues are often compared to their matched myometrium in an effort to understand their pathophysiology, but it is not clear whether the myometria of uterine fibroid patients represent truly non-disease control tissues. We analyzed the transcriptomes of myometrial samples from non-fibroid patients (M) and compared them with fibroid (F) and matched myometrial (MF) samples to determine whether there is a phenotypic difference between fibroid and non-fibroid myometria. Multidimensional scaling plots revealed that M samples clustered separately from both MF and F samples. A total of 1169 differentially expressed genes (DEGs) (false discovery rate < 0.05) were observed in the MF comparison with M. Overrepresented Gene Ontology terms showed a high concordance of upregulated gene sets in MF compared to M, particularly extracellular matrix and structure organization. Gene set enrichment analyses showed that the leading-edge genes from the TGFβ signaling and inflammatory response gene sets were significantly enriched in MF. Overall comparison of the three tissues by three-dimensional principal component analyses showed that M, MF, and F samples clustered separately from each other and that a total of 732 DEGs from F vs. M were not found in the F vs. MF, which are likely understudied in the pathogenesis of uterine fibroids and could be key genes for future investigation. These results suggest that the transcriptome of fibroid-associated myometrium is different from that of non-diseased myometrium and that fibroid studies should consider using both matched myometrium and non-diseased myometrium as controls.

scholarly journals Phantom Eye Syndrome: A Review of the Literature

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Agda M. Andreotti ◽  
Marcelo C. Goiato ◽  
Eduardo P. Pellizzer ◽  
Aldiéris A. Pesqueira ◽  
Aimée M. Guiotti ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Drug Therapy ◽  
Phantom Pain ◽  
Direct Influence ◽  
Psychological Approach ◽  
Review Of The Literature ◽  
Eye Trauma ◽  
Pubmed Database ◽  
Before And After

The purpose of this literature review was to describe the main features of phantom eye syndrome in relation to their possible causes, symptoms, treatments, and influence of eye amputation on quality of life of anophthalmic patients. For this, a bibliographical research was performed in Pubmed database using the following terms: “eye amputation,” “eye trauma,” “phantom eye syndrome,” “phantom pain,” and “quality of life,” associated or not. Thirteen studies were selected, besides some relevant references contained in the selected manuscripts and other studies hallowed in the literature. Thus, 56 articles were included in this review. The phantom eye syndrome is defined as any sensation reported by the patient with anophthalmia, originated anophthalmic cavity. In phantom eye syndrome, at least one of these three symptoms has to be present: phantom vision, phantom pain, and phantom sensations. This syndrome has a direct influence on the quality of life of the patients, and psychological support is recommended before and after the amputation of the eyeball as well as aid in the treatment of the syndrome. Therefore, it is suggested that, for more effective treatment of phantom eye syndrome, drug therapy should be associated with psychological approach.

The effect of hirudotherapy on cerebral circulatory homeostasis in patients with genital endometriosis

2020 ◽  
pp. 58-66
Author(s):  
Ya. I. Uraeva ◽  
I. I. Ivanova ◽  
N. N. Lazarenko ◽  
E. V. Filatova ◽  
I. A. Pankova ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Drug Therapy ◽  
Cerebral Circulation ◽  
The State ◽  
Control Group ◽  
Complex Treatment ◽  
Statistical Regression ◽  
Treatment Results ◽  
Standard Drug ◽  
Before And After

The results of the treatment of women (n = 94) suffering from genital endometriosis are presented. The first (control, n = 30) group of women received standard drug therapy; the second (main, n = 64) group of women additionally had hirudotherapy procedures using medical leeches. The course of treatment consisted of 10–12 procedures. The state of cerebral circulation was assessed according to the rheoencephalography data before and after the treatment, as well as after 1, 3, 6, and 9 months. As a result, in patients in the 2-nd (main) group receiving complex treatment, the state of cerebral circulation improved signifi cantly. Moreover, according to the statistical regression analysis, it was possible to predict its further decrease by two periods ahead, compared with the treatment results in patients in the 1-st (control) group.

scholarly journals PAX2 in endometrial carcinogenesis and in differential diagnosis of endometrial hyperplasia: A systematic review and meta-analysis of diagnostic accuracy

2019 ◽  
Vol 98 (3) ◽  
pp. 287-299 ◽  
Author(s):  
Antonio Raffone ◽  
Antonio Travaglino ◽  
Gabriele Saccone ◽  
Massimo Mascolo ◽  
Luigi Insabato ◽  
...  
Keyword(s):  
Systematic Review ◽  
Differential Diagnosis ◽  
Diagnostic Accuracy ◽  
Endometrial Hyperplasia ◽  
Meta Analysis

scholarly journals Elasto-mammography: Theory, Algorithm, and Phantom Study

2006 ◽  
Vol 2006 ◽  
pp. 1-11 ◽  
Author(s):  
Z. G. Wang ◽  
Y. Liu ◽  
L. Z. Sun ◽  
G. Wang ◽  
L. L. Fajardo
Keyword(s):  
Elastic Moduli ◽  
Imaging Modality ◽  
Contrast Ratio ◽  
Reconstruction Algorithm ◽  
Displacement Measurement ◽  
Breast Compression ◽  
Before And After ◽  
Breast Tissues ◽  
Displacement Information

A new imaging modality framework, called elasto-mammography, is proposed to generate the elastograms of breast tissues based on conventional X-ray mammography. The displacement information is extracted from mammography projections before and after breast compression. Incorporating the displacement measurement, an elastography reconstruction algorithm is specifically developed to estimate the elastic moduli of heterogeneous breast tissues. Case studies with numerical breast phantoms are conducted to demonstrate the capability of the proposed elasto-mammography. Effects of noise with measurement, geometric mismatch, and elastic contrast ratio are evaluated in the numerical simulations. It is shown that the proposed methodology is stable and robust for characterization of the elastic moduli of breast tissues from the projective displacement measurement.

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