scholarly journals Influence of the anterior chamber depth on the accuracy of IOL optical power calculation in short eyes

2021 ◽  
Author(s):  
Кирилл Борисович Першин ◽  
Надежда Федоровна Пашинова ◽  
Иван Александрович Лих ◽  
Александр Юрьевич Цыганков ◽  
Абдусамад Аристанович Ахраров
Keyword(s):  
Anterior Chamber ◽  
Anterior Chamber Depth ◽  
Optical Power ◽  
Power Calculation ◽  
Group Iii ◽  
Group I ◽  
Retrospective Comparison ◽  
Group Ii ◽  
The Relationship

Aim. Determination of the relationship between the anterior chamber depth and the and accuracy of the IOL optical power calculating in the eyes with an axial length of less than 22 mm. Materials and methods. A total of 86 patients (133 eyes) with a short axis (from 18.54 to 21.98 (20.7 0.9) mm) were included in the study. Group I (n=40) consisted of patients with an ACD of less than 2, 5 mm. Group II (n=49) included patients with ACD from 2.5 to 2.9 mm Group III (n=44) included patients with ACD greater than 2.9 mm The calculation of the IOL optical power was carried out according to the formula SRK / T, retrospective comparison - according to the formulas Hoffer-Q, Holladay II, Olsen, Haigis and Barrett Universal II. Results. In group I, there were no significant differences when comparing MedAE for the six formulas (p0.05). The highest MedAE values ​​(0.51 and 0.49, respectively) and the smaller MNE range (-0.03 0.89 and -0.01 0.97, respectively) are shown for the formulas Haigis and Barrett Universal II. In group II, the MedAE for the Haigis formula was 0.45, for SRK / T and Olsen it was 0.59 and 0.66. For the Haigis formula, the lowest MNE value (0.05 0.69) is shown. In group III, no significant differences were found when comparing the average values ​​of MedAE (0.05). The lowest MedAE (0.17) and the best MNE values ​​(-0.01 0.58) are shown for the Haigis formula, while the SRK / T formula was characterized by the highest MedAE (0.37). In group II, the refractive index 0.25 and 0.50 D for the Haigis formula was significantly higher. Conclusion. For eyes with an ACD of less than 2.4 mm, none of the formulas showed a significant advantage, while with an ACD of 2.4-2.9 mm and higher, the use of the Haigis formula is recommended, and the SRK / T formula showed the worst result. The data obtained dictate the need to review existing standards for calculating the IOL optical power in patients with short eyes depending on ACD.

Effect of light backscattering from anterior segment structures on automated flare meter measurements

2021 ◽  
pp. 112067212110393
Author(s):  
Murat Hasanreisoglu ◽  
Cem Kesim ◽  
Duygu Yalinbas ◽  
Mervenur Yilmaz ◽  
Nur Sena Uzunay ◽  
...  
Keyword(s):  
Anterior Chamber ◽  
Scattered Light ◽  
Anterior Segment ◽  
Anterior Chamber Depth ◽  
Laser Flare Photometry ◽  
Aqueous Flare ◽  
Group I ◽  
Lens Density ◽  
Laser Flare ◽  
Group Ii

Background: To evaluate effect of maximal anterior cortical lens density, iris scatter and anterior chamber depth on laser flare photometry. Methods: Patients diagnosed with clinical uveitis were enrolled in the study. Clinical flare gradings were recorded upon the Standardization of Uveitis Nomenclature. Aqueous flare was measured with an automated device (Kowa FM-700). Back-scattering from anterior cortical lens and anterior iris surface was calculated from Scheimpflug images. A curvilinear regression model was used to calculate estimated values for each clinical grade. These values were used to split cases in Group I (laser flare photometry lower than estimated) and Group II (laser flare photometry higher than estimated). Mean anterior chamber depth, pupil aperture, maximal anterior cortical lens density and iris scatter values were compared between two groups. A stepwise multiple regression analysis was performed to determine the effect of clinical flare gradings and ocular parameters on aqueous flare measurements. Results: The study included 228 eyes of 114 cases. Scheimpflug images were obtained from 105 eyes. Estimated aqueous flare measurements (in photons/milliseconds) were 4.87, 8.50, 14.81, 25.83, 45.04 and 136.93 for 0, 0.5+, 1+, 1.5+, 2+ and 3+ clinical flare respectively. Group II had higher maximal anterior cortical lens density than Group I (96.6 ± 37.1 vs 77.9 ± 17.1 pixel unit, p = 0.001). The measured aqueous flare was significantly related to clinical flare, maximal anterior cortical lens density and pupil aperture (adjusted R2: 0.480, p < 0.001). Conclusion: The back-scattered light from anterior cortical lens could affect laser flare photometry measurements. This effect might be quantified by Scheimpflug imaging.

scholarly journals Morphologic and functional changes in the retina and sclera induced by form deprivation high myopia in guinea pigs

2019 ◽  
Author(s):  
yingxin zi ◽  
Yu Deng ◽  
Jingru Zhao ◽  
Meiqi Ji ◽  
Yali Qin ◽  
...  
Keyword(s):  
Axial Length ◽  
Guinea Pigs ◽  
High Myopia ◽  
Light And Electron Microscopy ◽  
Anterior Chamber Depth ◽  
Control Group ◽  
Group Iii ◽  
Functional Changes ◽  
Group I ◽  
Group Ii

Abstract Background Our aim was to study the morphologic and functional changes in the retina and sclera induced by form deprivation high myopia (FDHM) in guinea pigs and explore the possible mechanisms FDHM formation. Methods Forty 3-weeks-old guinea pigs were randomized into the blank control (Group I, 20 cases) and model groups (20 cases). In the model group, the right eyes of the guinea pigs were sutured 8 weeks to induce FDHM (Group II) and the left eyes were considered a self-control group (Group III). The diopters were measured with retinoscopy. The anterior chamber depth (AC), lens thickness (L), vitreous depth (V) and axial length (AL) were measured using ultrasonometry A. Retinal and scleral morphology and ultrastructural features were observed with light and electron microscopy. The content of malondialdehyde (MDA) and the activity of superoxide dismutase (SOD) in the retina and sclera were detected with a chemical colorimetric assay. Results After remaining stitched for eight weeks, the diopters of Group II changed from (+3.59±0.33) D to (-7.96±0.55) D, and these values were significantly higher than those of Group I (+0.89±0.32) D and Group III (-0.55±0.49) D. The vitreous chamber depth (4.12±0.13) mm and axial length (8.93±0.22) mm of Group II were significantly longer than that of Group I [(3.71±0.23) mm and (7.95±0.37) mm, respectively] and Group III [(3.93±0.04) mm and (8.01±0.15) mm, respectively] (P < 0.05). With the prolongation of form deprivation, the retina and scleral tissue became thinner, the ganglion cell and inner and outer nuclear layers of the retina became decreased, and the arrangement was disordered. In Group II, the activity of SOD was significantly lower than that in Group I and Group III, and the content of MDA was significantly higher in Group II than in Group I and Group III. The differences were statistically significant (P < 0.05). Conclusions These findings suggested that in the FDHM guinea pigs model, the diopter, the vitreous chamber depth, and axial length increased significantly with prolongation of monocular FD time, and morphological structural changes in the retina and sclera were observed. Oxygen free radicals might participate in the formation of FDHM.

scholarly journals The Relationship Between Dental Caries and YKL-40 Levels in Saliva

2020 ◽  
Author(s):  
Gülsüm Duruk ◽  
Esra Laloglu
Keyword(s):  
Dental Caries ◽  
Group Iii ◽  
Group I ◽  
Pufa Index ◽  
Icdas Ii ◽  
Significant Difference ◽  
Group Ii ◽  
And Gender ◽  
Post Hoc ◽  
The Relationship

Abstract Objective : YKL-40, a new biomarker of localized inflammation, is secreted by macrophages and regulates inflammation and immune responses. The aim of this study was to investigate YKL-40 levels in saliva and compare the level of this mediator in healthy and unhealthy oral cavity. Methods: 85 children (46 girls, 39 boys), aged 6-15 (mean±SD: 9.15±2.16) were included in this study. The children were divided into three groups: Group-I (control, n=25, DMFT/dmft=0), Group-II (n=30, exist of localized dental caries) and Group-III (n=30, exist of localized advanced dental caries). Gingival index (GI), plaque index (PI), DMFT/dmft, DMFS/dmfs, and the number of advanced dental caries according to the ICDAS II and PUFA/pufa index were recorded. Saliva was collected and YKL-40 concentrations were measured. One-way ANOVA with Tukey post hoc, Kruskal-Wallis, multiple regression analysis, and Sperman’s correlation tests were used for statistical analysis. Results: The highest level of YKL-40 was obtained in group III , followed by groups II and I , respectively (p<0.01). In Group II, DMFT/dmft scores and the number of caries (DT/dt) were higher than in group III (p<0.01). In group III, there was a statistically significant correlation between YKL-40 levels in saliva and the number of advanced dental caries. In addition, there was no statistically significant difference in terms of age and gender (p>0.05). Conclusion: Advanced dental caries, rather than DMFT/dmft score, may play an important role in the increasing levels of YKL-40 in saliva.

scholarly journals Chest CTA in children younger than two years – a retrospective comparison of three contrast injection protocols

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Eszter Nagy ◽  
Sebastian Tschauner ◽  
Robert Marterer ◽  
Regina Riedl ◽  
Erich Sorantin
Keyword(s):  
Image Quality ◽  
Young Patients ◽  
Noise Signal ◽  
Contrast Injection ◽  
Group Iii ◽  
Group I ◽  
Peak Enhancement ◽  
Retrospective Comparison ◽  
Vessel Enhancement ◽  
Group Ii

AbstractTo obtain the highest diagnostic information with least side effects when performing thoracic CT angiography (CTA) is challenging in young children. The current study aims to compare three contrast agent (CA) injection protocols regarding image quality and CA characteristic: a standard CTA, a fixed-bolus delay protocol, and the “microbolus technique (MBT)” developed in our institution. Seventy chest CTA scans of patients (<2 years) were divided into three groups. MBT was applied in group I, the standard protocol in group II and a fixed bolus delay in group III. Objective image quality was assessed by measuring peak enhancement, image noise, signal-to-noise (SNR) and contrast-to-noise ratios (CNR). Two observers scored subjective image quality and artifacts. Significantly lower amounts of CA (mean ± SD) were used in the MBT group compared to Group II (9.0 ± 3.7 ml vs. 12.9 ± 4.5 ml). A lower, but still diagnostic (>400 HU) enhancement was registered in all major thoracic vessels in group I without significant differences regarding SNR and CNR in most regions (p < 0.05). The best scores for image quality and artifacts were reached in group I. All three chest CTA contrast injection protocols offered diagnostic vessel enhancement in young patients. MBT was associated with reduced image artifacts and less injected CA.

scholarly journals DIAGNOSTIC CRITERIA FOR UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA IN PATIENTS WITH ARTERIAL HYPERTENSION

2020 ◽  
pp. 49-54
Author(s):  
Ye. H. Zaremba ◽  
N. O. Rak ◽  
O. V. Zaremba ◽  
O. V. Zaremba-Fedchyshyn ◽  
M. M. Virna ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Arterial Hypertension ◽  
Control Group ◽  
Severe Dysplasia ◽  
Moderate Severity ◽  
Group Iii ◽  
Group I ◽  
Connective Tissue Dysplasia ◽  
Group Ii

The aim – to improve the diagnosis efficiency of patients with arterial hypertension (AH) combined with undifferentiated connective tissue dysplasia (UCTD) based on the study of clinical course, the severity of UCTD external and internal symptoms with determining the levels of IL-1, IL-6, TNF-a, free and general blood oxyproline. Material and Methods. The study implied examination of 90 patients (52 women and 38 men) with AH of stage 2 from first to third degrees with manifestations of UCTD, who were on inpatient treatment in the Cardiology Department of the Lviv City Communal Clinical Emergency Hospital. The mean age of patients was (61.14±2.58) years. Patients were divided into 3 groups depending on the stage and degree of hypertension. Group I (n=16) included patients with hypertension of the first degree, group II (n=35) – with AH of the second degree, group III (n=39) – with AH of the third degree. The control group consisted of 20 patients with hypertension without manifestations of CTD. Patients underwent clinical (checkup, palpation, percussion, auscultation), laboratory (determination of IL-1, IL-6, TNF-a, free and general oxyprolin blood levels) and instrumental studies (ECG, echocardiography, DBPM, ultrasound examination of internal organs and vessels of the lower extremities, ultrasound duplex examination of the carotid and vertebral arteries, radiological examination of the osteoarticular system), consultations of an ophthalmologist, neurologist, traumatologist and dentist. Results. As a result of the study, in the group I of patients (n=16) UCTD of slight degree of severity was revealed in 13 (81 %), of medium degree – in 3 (19 %) persons. In the group II of patients (n=35), UCTD of moderate severity was found in 30 (86 %), severe – in 5 patients (14 %). In the group III of patients (n=39), UCTD of moderate severity was found in 32 patients (82 %), severe – in 7 (18 %). In the study of the level of TNF-a, an increase compared to the control group was detected, particularly, in the group I of patients its level exceeded in 37.4 times, in the group II – in 39.6 times, in the group III – in 46.2 times (p<0.001). IL-1b increased by 2.6-fold (р<0.05) in the group I of patients compared to the control group, 3.1-fold (р<0.01) – in the group II, and by 3.7-fold, that was the foremost (р<0.001), in patients of the group III. In turn, IL-6 in the group I of patients exceeded the indicators of the control group by 4.3 times (p<0.001), in the group II – 4.8 times (p<0.001), in the group III – 5.7 times (р<0.001). The study of the level of free oxyproline revealed its increase in comparison with the control group, namely in the group I of patients exceeded in 6.12 times, in the group II – in 6.81 times, in the group III – by 7.56 times (р<0.01). The study of the general of bound oxyproline revealed its increase in comparison with the control group, namely in the group I of patients exceeded by 6.98 times, in the group II – by 7.79 times, in the group III – by 9.42 times (p<0.01), which indicates an increase in fibrillogenesis and more pronounced destructive and inflammatory processes in connective tissue. Conclusions. Patients with AH of the stage 2 from first to third degrees with manifestations of UCTD have increased levels of IL-1, IL-6 and TNF-a, which are not only sensitive markers of inflammation, but also play an important role in the pathogenesis and progression of vascular lesions, occurrence and destabilization of atherosclerotic plaques and thrombotic vessels occlusion. The determination of blood oxyprolin in patients with hypertension combined with UCTD confirms the presence of CTD, namely the decay of collagen is more pronounced in patients with severe dysplasia.

Intraocular lenses optic power calculation with seven formulas in short eyes

2021 ◽  
pp. 37-40
Author(s):  
K.B. Pershin ◽  
◽  
N.F. Pashinova ◽  
I.A. Likh ◽  
А.I. Tsygankov ◽  
...  
Keyword(s):  
Axial Length ◽  
Mean Absolute Error ◽  
Optical Power ◽  
Absolute Error ◽  
Intraocular Lenses ◽  
Power Calculation ◽  
Group I ◽  
The Mean ◽  
Group Ii ◽  
Axial Eye Length

Purpose. The choice of the optimal formula for calculating the IOL optical power in patients with an axial eye length of less than 20 mm. Material and methods.A total of 78 patients (118 eyes) were included in theprospective study. Group I included 30 patients (52 eyes) with short eyes (average axial eye length of 19.60 ± 0.42 (18.54-20.0) mm), group II consisted of 48 patients (66 eyes) with a axial length (22.75 ± 0.46 (22.0-23.77) mm. Various monofocal IOL models were used. The average follow-up period was 13 months. IOL optical power was calculated using the SRK/T formula, retrospective comparison - according to the formulas Hoffer-Q, Holladay II, Olsen, Haigis, Barrett Universal II and Kane. Results. In group I, the mean absolute error was determined for the formulas Haigis, Olsen, Barrett Universal II, Kane, SRK / T, Holladay 2 and Hoffer-Q (0.85; 0.78; 0.21; 0.17; 0.79; 0.73; 0.19 respectively). When comparing the formulas, significant differences were found for the formulas Hoffer-Q, Barrett Universal II and Kane in comparison with the formulas Haigis, Olsen, SRK / T and Holladay II (p <0.05) in all cases, respectively. In group I, the mean absolute error was determined for the formulas Haigis, Olsen, Barrett Universal II, Kane, SRK / T, Holladay 2 and Hoffer-Q (0.15; 0.16; 0.23; 0.10; 0.19; 0.23; 0.29 respectively) In group II, there were no significant differences between the studied formulas (p> 0.05). Conclusion. This paper presents an analysis of data on the effectiveness of seven formulas for calculating the IOL optical power in short (less than 20 mm) eyes in comparison with the normal axial length. The advantage of the Hoffer-Q, Barrett Universal II and Kane formulas over Haigis, Holladay 2, Olsen, and SRK / T is shown. Key words: cataract; hypermetropia; short eyes; calculation of the IOL optical power.

scholarly journals Signal-averaged electrocardiogram in chronic Chagas' heart disease

1995 ◽  
Vol 113 (2) ◽  
pp. 851-857 ◽  
Author(s):  
Aguinaldo Pereira de Moraes ◽  
Paulo Jorge Moffa ◽  
Eduardo A. Sosa ◽  
Giovanni M. V. Bellotti ◽  
Carlos A. Pastore ◽  
...  
Keyword(s):  
Heart Disease ◽  
Time Domain Analysis ◽  
Group Iv ◽  
Root Mean Square Amplitude ◽  
Group Iii ◽  
Group I ◽  
Chagas Heart Disease ◽  
Group Ii ◽  
The Relationship

The aim of the study was to register the prevalence of late potentials (LP) in patients with chronic Chagas' heart disease (CCD) and the relationship with sustained ventricular tachycardia (SVT). 192 patients (96 males), mean age 42.9 years, with CCD were studied through a Signal Averaged ECG using time domain analysis. According to presence or absence of bundle branch block (BBB) and SVT, four groups of patients were created: Group I (n = 72): without SVT (VT-) and without BBB (BBB-): Group II (n = 27): with SVT (VT+) and BBB-; Group III (n = 63): VT- and with BBB (BBB+); and Group IV (N = 30): VT+ and BBB+. The LP was admitted, with 40 Hz filter, in the groups without BBB using standard criteria of the method. In the group with BBB, the root-mean-square amplitude of the last 40 ms (RMS) < =14µV was considered as an indicator of LP. RESULTS: In groups I and II, LP was present in 21 (78%) of the patients with SVT and in 22 (31%) of the patients without SVT (p < 0.001), with Sensitivity (S) 78%; Specificity (SP) 70% and Accuracy (Ac) 72%. LP was present in 30 (48%) of the patients without and 20 (67%) of the patients with SVT, in groups III and IV. p = 0.066, with S = 66%; SP = 52%; and Ac = 57%. In the follow-up, there were 4 deaths unrelated to arrhythmic events, all of them did not have LP. Eight (29,6%) of the patients from group II and 4 (13%) from group IV presented recurrence of SVT and 91,6% of these patients had LP. CONCLUSIONS: LP occurred in 77.7% of the patients with SVT and without BBB. In the groups with BBB, there was association of LP with SVT in 66,6% of the cases. The recurrence of SVT was present in 21% of the cases from which 91,6% had LP.

scholarly journals Hospitalized Patients with a Therapeutic Profile: The Relationship Between the Type of Attitude Towards Illness and the Quality of Life

2020 ◽  
Vol 9 (4) ◽  
pp. 36-56
Author(s):  
N.V. Zarishnyak ◽  
A.M. Kulbaisov ◽  
E.V. Gavrilova
Keyword(s):  
Quality Of Life ◽  
Hospitalized Patients ◽  
High Rate ◽  
Chronic Obstructive ◽  
Disease Group ◽  
Group Iii ◽  
Group I ◽  
Group Ii ◽  
The Relationship

The article presents the results of a study of attitudes towards illness, quality of life and their relationship in hospitalized patients. An empirical study of three groups of hospitalized patients aged 40 to 80 years was carried out: with ischemic heart disease (group I, n = 22; 55,3(13,8) years), with chronic obstructive pulmonary disease (group II, n=22; 53,7(12,0) years) and with osteochondrosis (group III, n=22; 59,6(14,8) years). Distribution by sex in all groups – 50% of men and 50% of women. To determine the type of attitude towards the disease, the Bekhterev Institute's questionnaire "Type of attitude towards the disease" (TOBOL) was used, the quality of life – the questionnaire of the Assessment of the quality of life (SF-36). The results of the study showed that in patients of all groups maladaptive types of attitudes towards the disease prevailed: Group I – hypochondriacal; apathetic; Group II – neurasthenic, dysphoric, paranoid; Group III – anxious, apathetic types. The quality of life of patients of all groups did not differ from each other: the physical component of health was assessed as low; the psychological component of health was average. A high rate of pain syndrome and social functioning was found in patients in group I, and in general health in patients in group II. Factor analysis revealed the relationship between the general state of health of patients (the patient's subjective assessment of his health) and the type of attitude towards the disease. Most of the patients needed psychological help to correct the type of attitude towards the disease and improve the quality of life. The revealed relationship between the internal picture of the disease and the quality of life requires additional research.

scholarly journals Early Prognosis Effect of Cellular Immune Paralysis on Brain Complications of Extracorporeal Membrane Oxygenation Children with Severe Sepsis

2021 ◽  
pp. 1-15
Author(s):  
Yan Xing ◽  
Dongliang Cheng ◽  
Changsong Shi ◽  
Zhiqing Shen
Keyword(s):  
Immune Response ◽  
Severe Sepsis ◽  
Extracorporeal Membrane Oxygenation ◽  
Adaptive Immune Response ◽  
Group Iii ◽  
Adaptive Immune ◽  
Brain Complications ◽  
Group I ◽  
Group Ii ◽  
The Relationship

<b><i>Objective:</i></b> The aim of the study was to explore the relationship between criticality, brain complications, and immune mechanisms in extracorporeal membrane oxygenation (ECMO) children with pneumonia and severe sepsis. <b><i>Methods:</i></b> Patients with simple pneumonia (group I), ECMO patients with pneumonia and severe sepsis accompanied by brain complications (group II), and those without brain complication (group III) admitted to our pediatric intensive care unit were selected to be investigated. The relationship among the peripheral blood subgroups of immune cells, immune factors, adaptive immune responses, endothelial factors, and criticality and brain complications was then studied. <b><i>Results:</i></b> Severe paralysis of normal immunity, excess abnormal immunity, and endothelial injury were consistent with the increase in the absolute value of base excess, lactic acid (Lac) content, and average hospitalization days and brain complications involved in group II (vs. group I). The ratio of CD63<sup>+</sup> macrophage and CD63<sup>+</sup> neutrophil subpopulation increased (<i>p</i> &#x3c; 0.05); the expression levels of elastase<sup>+</sup> neutrophil denatured subgroup (<i>p</i> &#x3c; 0.05), the ratio of CCR2<sup>high</sup>CX3CR1<sup>low</sup>/CCR2<sup>low</sup>CX3CR1<sup>high</sup> of macrophages and neutrophils (<i>p</i> &#x3c; 0.0001), high-mobility group box 1 (HMGB1), YTHDF1, interleukin-17 protein and mRNA, and RAGE gene decreased to some extent (<i>p</i> &#x3c; 0.05); the expression levels of Th1 cells chemokine CXCL9 protein and mRNA and sTIE2 protein increased to some extent (<i>p</i> &#x3c; 0.05); the adaptive immune response of CD8<sup>+</sup> CTL stimulated by lipopolysaccharide (LPS) was slightly enhanced (<i>p</i> &#x3c; 0.05) in group III(vs. group II), which was consistent with the improvement of criticality, average hospitalization days, and the absence of brain complications in group III (vs. group II). <b><i>Conclusion:</i></b> ECMO support with brain complication was related to the upregulation of HMGB1 and YTHDF1 protein; the decreased number of CD63<sup>+</sup> macrophages and neutrophils; the increased denatured neutrophil subgroup, especially the upregulated ratio of CCR2<sup>high</sup>CX3CR1<sup>low</sup>/CCR2<sup>low</sup>CX3CR1<sup>high</sup> of macrophages and neutrophils; the imbalance of Th17/Th1, LPS-specific CD8<sup>+</sup> CTL adaptive immune response paralysis; and the reduced endothelial sTIE2 protein expression level which caused clinical deterioration and prolonged average hospitalization days.

scholarly journals The Relationship Between Dental Caries and YKL-40 Levels in Saliva

2019 ◽  
Author(s):  
Gülsüm Duruk ◽  
Esra Laloglu
Keyword(s):  
Dental Caries ◽  
Group Iii ◽  
Group I ◽  
Pufa Index ◽  
Icdas Ii ◽  
Significant Difference ◽  
Group Ii ◽  
And Gender ◽  
Post Hoc ◽  
The Relationship

Abstract Objective: YKL-40, a new biomarker of localized inflammation, is secreted by macrophages and regulates inflammation and immune responses. The aim of this study was to investigate YKL-40 levels in saliva and compare the level of this mediator in oral cavity. Methods: 85 children (46 girls, 39 boys), aged 6-15 (mean±SD: 9.15±2.16) were included in this study. The children were divided into three groups: Group-I (control, n=25, DMFT/dmft=0), Group-II (n=30, exist of localized dental caries) and Group-III (n=30, exist of localized advanced dental caries). Gingival index (GI), plaque index (PI), DMFT/dmft, DMFS/dmfs, and the number of advanced dental caries according to the ICDAS II and PUFA/pufa index were recorded. Saliva was collected and YKL-40 concentrations were measured. One-way ANOVA withTukey post hoc, Kruskal-Wallis, multiple regression analysis, and Sperman’s correlation tests were used for statistical analysis. Results: The highest level of YKL-40 was obtained in group III, followed by groups II and I, respectively (p<0.01). In Group II, DMFT/dmft scores and the number of caries (DT/dt) were higher than in group III (p<0.01). In group III, there was a statistically significant correlation between YKL-40 levels in saliva and the number of advanced dental caries. In addition, there was no statistically significant difference in terms of age and gender (p>0.05). Conclusion: Advanced dental caries, rather than DMFT/dmft score, may play an important role in the increasing levels of YKL-40 in saliva.

Sign in / Sign up

Export Citation Format

Share Document