Vagal Nerve Blocking Therapy for Weight Loss: Laparoscopic Technique for Placing Neuroregulator and Leads

CSurgeries ◽  
2017 ◽  
Author(s):  
Shaina Eckhouse ◽  
Daniel Guerron ◽  
Keri Seymour ◽  
Ranjan Sudan ◽  
Jin Yoo ◽  
...  
Keyword(s):  
Weight Loss ◽  
Vagal Nerve ◽  
Laparoscopic Technique ◽  
Vagal Nerve Blocking

Short-Term Results For Intermittent Vagal Nerve Blocking (vBloc) In The “Real-World”, Nonresearch Environment

2017 ◽  
Vol 13 (10) ◽  
pp. S195
Author(s):  
Scott Shikora ◽  
Collin Brathwaite ◽  
Frank Chae ◽  
John Dietrick ◽  
Guillermo Gomez ◽  
...  
Keyword(s):  
Real World ◽  
Vagal Nerve ◽  
Short Term ◽  
The Real ◽  
Vagal Nerve Blocking

Sustained Weight Loss and Safety At Two Years With Vagal Nerve Block In The Recharge Trial

2015 ◽  
Vol 11 (6) ◽  
pp. S30
Author(s):  
Sajani Shah ◽  
Sayeed Ikramuddin ◽  
Bruce Wolfe ◽  
Katherine Tweden ◽  
Charles Billington ◽  
...  
Keyword(s):  
Weight Loss ◽  
Nerve Block ◽  
Vagal Nerve ◽  
Sustained Weight Loss

Laparoscopic vagal nerve blocking device explantation: case series and report of operative technique

2019 ◽  
Vol 33 (11) ◽  
pp. 3600-3604
Author(s):  
Tarin C. Worrest ◽  
Bruce M. Wolfe ◽  
Samer G. Mattar ◽  
Erin W. Gilbert
Keyword(s):  
Operative Technique ◽  
Case Series ◽  
Vagal Nerve ◽  
Blocking Device ◽  
Vagal Nerve Blocking

scholarly journals GPR40 full agonism exerts feeding suppression and weight loss through afferent vagal nerve

PLoS ONE ◽  
2019 ◽  
Vol 14 (9) ◽  
pp. e0222653 ◽  
Author(s):  
Hikaru Ueno ◽  
Ryo Ito ◽  
Shin-ichi Abe ◽  
Hitomi Ogino ◽  
Minoru Maruyama ◽  
...  
Keyword(s):  
Weight Loss ◽  
Vagal Nerve ◽  
Feeding Suppression ◽  
Afferent Vagal

Weight Loss Is Durable with Vagal Nerve Blockade (VBLOC) but Not with Sham: 18-Month Results of the ReCharge Trial

2015 ◽  
Vol 39 ◽  
pp. S36 ◽  
Author(s):  
Scott A. Shikora ◽  
Mark B. Knudson ◽  
Katherine S. Tweden ◽  
Mehran Anvari ◽  
Michael G. Sarr ◽  
...  
Keyword(s):  
Weight Loss ◽  
Vagal Nerve ◽  
Nerve Blockade

Abstract 19336: Chronic Vagal Nerve Stimulation Causes Weight Loss by Reducing Food Intake and Feeding Efficiency in Mice

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Harald M Stauss ◽  
Daniel P Dias ◽  
Donald A Morgan ◽  
Kamal Rahmouni
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Oxygen Consumption ◽  
Weight Gain ◽  
Food Intake ◽  
Metabolic Rate ◽  
Body Weight Gain ◽  
Caloric Intake ◽  
Vagal Nerve ◽  
Feeding Efficiency

Chronic electrical vagal nerve stimulation (VNS) has emerged as a new tool to treat human diseases including obesity. Indeed, chronic VNS has been shown to cause weight loss in humans and in experimental animal models. However, the mechanisms for VNS-induced weight loss are largely unknown. We hypothesized that an increase in metabolic rate together with reduced caloric intake and reduced feeding efficiency (body weight gain per calories consumed) contribute to chronic VNS-induced weight loss or reduced weight gain. To test this hypothesis, we developed a miniaturized microprocessor-operated nerve stimulator for chronic use in conscious mice. Effectiveness of the stimulator was verified by bradycardia at stimulation frequencies above 5 Hz (3V, 1mA, 1ms pulses). Male C57Bl/6 mice (16 weeks old, standard mouse chow diet) were instrumented with nerve stimulators (3V, 1mA, 1ms pulses at 5 Hz) on the right cervical vagal nerve and body weight, food intake and metabolic rate (indirect calorimetry) were determined at baseline and weekly thereafter. After the initial post-surgical weight loss, sham animals (n=9, stimulators off) regained pre-surgical body weight within 16 days (100.0±2.7%). In contrast, mice with chronic VNS (n=12) never reestablished pre-surgical body weight (94.5±0.9% on day 16, P<0.05 vs. sham). Caloric intake was significantly reduced in mice with chronic VNS compared to sham animals (74.7±2.4 vs. 84.6±4.2 kcal/week, P<0.05). Likewise, mice with chronic VNS showed significantly reduced feeding efficiency compared to sham mice (2.6±2.0 vs. 10.6±2.4 mg body weight gain per kcal consumed). Oxygen consumption tended to be elevated (2734±152 vs. 2490±124 mL/kg/h, P=0.23) during the first week, but not thereafter. In conclusion reduced food intake and lower feeding efficiency contribute to reduced weight gain in mice with chronic VNS. We speculate that an initial increase in metabolic rate (assessed by oxygen consumption) may be antagonized by compensatory mechanisms in response to chronic VNS.

scholarly journals Two-Year Outcomes of Vagal Nerve Blocking (vBloc) for the Treatment of Obesity in the ReCharge Trial

2016 ◽  
Vol 27 (1) ◽  
pp. 169-176 ◽  
Author(s):  
Caroline M. Apovian ◽  
Sajani N. Shah ◽  
Bruce M. Wolfe ◽  
Sayeed Ikramuddin ◽  
Christopher J. Miller ◽  
...  
Keyword(s):  
Vagal Nerve ◽  
Treatment Of Obesity ◽  
Vagal Nerve Blocking
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