scholarly journals Insulin Resistance and Lipid Profile in Morbidly Obese Patients After Laparoscopic Total Gastric Vertical Plication

2012 ◽  
Vol 1 (2) ◽  
pp. 85-6
Author(s):  
Thiow Ti
Keyword(s):  
Insulin Resistance ◽  
Lipid Profile ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Vertical Plication

scholarly journals Changes in Lipid Profile and Insulin Resistance in Morbidly Obese Patients Following Laparoscopic Total Gastric Vertical Plication

2012 ◽  
Vol 1 (1) ◽  
pp. 24-29 ◽  
Author(s):  
Atefeh Golpaie ◽  
Mohammad Hosseinzadeh-Attar ◽  
Mostafa Hoseini ◽  
Zohreh Karbaschian ◽  
Mohammad Talebpour
Keyword(s):  
Insulin Resistance ◽  
Lipid Profile ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Vertical Plication

Changes in Lipid Profile and Insulin Resistance in Morbidly Obese Patients Following Laparoscopic Total Gastric Vertical Plication

2012 ◽  
Vol 1 (1) ◽  
pp. 24-9 ◽  
Author(s):  
Atefeh Golpaie ◽  
Mohammad Hosseinzadeh-Attar ◽  
Mostafa Hoseini ◽  
Zohreh Karbaschian ◽  
Mohammad Talebpour
Keyword(s):  
Insulin Resistance ◽  
Lipid Profile ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Vertical Plication

scholarly journals Obese patients with higher TSH levels had an obvious metabolic improvement after bariatric surgery

2021 ◽  
Vol 10 (10) ◽  
pp. 1326-1336
Author(s):  
Nannan Bian ◽  
Xiaomeng Sun ◽  
Biao Zhou ◽  
Lin Zhang ◽  
Qiu Wang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Bariatric Surgery ◽  
Thyroid Function ◽  
Fasting Blood Glucose ◽  
Thyroid Stimulating Hormone ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Free Triiodothyronine ◽  
The Relationship ◽  
Tsh Levels

Objective Bariatric surgery has become the most effective treatment for morbid obesity. Increasing evidence showed that bariatric surgery can alleviate insulin resistance and influence thyroid function. This study aimed to investigate the relationship between changes in thyroid function and adipose tissue insulin resistance (adipo-IR) after bariatric surgery. Methods A total of 287 non-diabetic participants with regular thyroid function were recruited and divided into the lean, overweight and obese groups. Among them, 50 morbidly obese patients submitted to bariatric surgery. Results The obese group had a higher level of adipo-IR, thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), FT3/free thyroxine (FT4) and metabolism disorders than the lean and overweight groups. BMI was correlated with TSH, FT3, FT3/FT4 and adipo-IR (r = 0.309, 0.315, 0.322 and 0.651, respectively, all P < 0.001). Adipo-IR was significantly correlated with TSH (r = 0.402, P < 0.001), FT3 (r = 0.309, P < 0.001), and FT3/FT4 (r = 0.228, P < 0.05). Bariatric surgery resulted in a sharp decline in BMI, adipo-IR, TSH, FT3 and FT3/FT4 levels, meanwhile, metabolic disorders improved. The decrease in BMI after bariatric surgery was significantly correlated with reductions in adipo-IR (r = 0.577, P < 0.001) and TSH (r = 0.401, P = 0.005). Interestingly, the fasting blood glucose, fasting insulin, adipo-IR and TSH in the higher TSH group decreased more remarkably than in the lower TSH group. Conclusion Obese individuals with higher TSH levels had an obvious metabolic improvement after bariatric surgery.

scholarly journals Osteopontin Expression in Human and Murine Obesity: Extensive Local Up-Regulation in Adipose Tissue but Minimal Systemic Alterations

Endocrinology ◽  
2007 ◽  
Vol 149 (3) ◽  
pp. 1350-1357 ◽  
Author(s):  
Florian W. Kiefer ◽  
Maximilian Zeyda ◽  
Jelena Todoric ◽  
Joakim Huber ◽  
René Geyeregger ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Plasma Concentrations ◽  
Morbidly Obese ◽  
Low Grade ◽  
Obese Patients ◽  
Multifunctional Protein ◽  
Inflammatory Processes ◽  
Low Grade Inflammation

Obesity is associated with a chronic low-grade inflammation characterized by macrophage infiltration of adipose tissue (AT) that may underlie the development of insulin resistance and type 2 diabetes. Osteopontin (OPN) is a multifunctional protein involved in various inflammatory processes, cell migration, and tissue remodeling. Because these processes occur in the AT of obese patients, we studied in detail the regulation of OPN expression in human and murine obesity. The study included 20 morbidly obese patients and 20 age- and sex-matched control subjects, as well as two models (diet-induced and genetic) of murine obesity. In high-fat diet-induced and genetically obese mice, OPN expression was drastically up-regulated in AT (40 and 80-fold, respectively) but remained largely unaltered in liver (&lt;2-fold). Moreover, OPN plasma concentrations remained unchanged in both murine models of obesity, suggesting a particular local but not systemic importance for OPN. OPN expression was strongly elevated also in the AT of obese patients compared with lean subjects in both omental and sc AT. In addition, we detected three OPN isoforms to be expressed in human AT and, strikingly, an obesity induced alteration of the OPN isoform expression pattern. Analysis of AT cellular fractions revealed that OPN is exceptionally highly expressed in AT macrophages in humans and mice. Moreover, OPN expression in AT macrophages was strongly up-regulated by obesity. In conclusion, our data point toward a specific local role of OPN in obese AT. Therefore, OPN could be a critical regulator in obesity induced AT inflammation and insulin resistance.

Insulin resistance is associated with elevated serum pigment epithelium–derived factor (PEDF) levels in morbidly obese patients

2012 ◽  
Vol 49 (S1) ◽  
pp. 161-169 ◽  
Author(s):  
Arijeet K. Gattu ◽  
Andreas L. Birkenfeld ◽  
Francois Jornayvaz ◽  
James Dziura ◽  
Fangyong Li ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Pigment Epithelium ◽  
Elevated Serum ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Pigment Epithelium Derived Factor

scholarly journals LIPID PROFILE AND ITS RATIO AS SURROGATE MARKER OF INSULIN RESISTANCE IN OBESE PATIENTS

2015 ◽  
Vol 2 (45) ◽  
pp. 8190-8195
Author(s):  
Senthil N ◽  
Sudagar Singh R B ◽  
Sneha Thomas ◽  
Sujeetha C ◽  
Sujatha S ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Lipid Profile ◽  
Surrogate Marker ◽  
Obese Patients

Effects of bariatric surgery on insulin resistance and insulin secretion in morbidly obese patients

2007 ◽  
Vol 115 (S 1) ◽  
Author(s):  
M Promintzer ◽  
G Prager ◽  
M Stadler ◽  
C Anderwald ◽  
M Mandl ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Bariatric Surgery ◽  
Insulin Secretion ◽  
Morbidly Obese ◽  
Obese Patients
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