scholarly journals Immunohistochemical Study of Estrogen Receptor Expression in Adenoid Cystic Carcinoma and Mucoepidermoid Carcinoma of the Salivary Gland

2016 ◽  
Vol 8 (2) ◽  
pp. 3-3
Author(s):  
Seyed Hossein Tabatabaei ◽  
Najmeh Jafari ◽  
Mahmood Akhavan Tafti ◽  
Ali Tavakoli Hosseini
Keyword(s):  
Estrogen Receptor ◽  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Mucoepidermoid Carcinoma ◽  
Immunohistochemical Study ◽  
Receptor Expression ◽  
Estrogen Receptor Expression ◽  
Adenoid Cystic

Estrogen receptor expression in salivary gland mucoepidermoid carcinoma and adenoid cystic carcinoma

2004 ◽  
Vol 10 (3) ◽  
pp. 166-168 ◽  
Author(s):  
Fábio Ramôa Pires ◽  
Danyel Elias da Cruz Perez ◽  
Oslei Paes de Almeida ◽  
Luiz Paulo Kowalski
Keyword(s):  
Estrogen Receptor ◽  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Mucoepidermoid Carcinoma ◽  
Receptor Expression ◽  
Estrogen Receptor Expression ◽  
Adenoid Cystic

Kallikrein-related peptidase 10 expression in salivary gland tissues and tumours

2012 ◽  
Vol 27 (4) ◽  
pp. 381-388 ◽  
Author(s):  
Mark R. Darling ◽  
Nelly N. Hashem ◽  
Irene Zhang ◽  
Mohamed Mohamed ◽  
Kevin Fung ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Mucoepidermoid Carcinoma ◽  
Salivary Gland Tumour ◽  
Immunoperoxidase Staining ◽  
Aberrant Expression ◽  
Adenoid Cystic ◽  
Gland Tumour

Objectives Kallikrein-related peptidase 10 (KLK10) has been implicated in the development of several types of cancer. The purpose of this study was to analyze the expression of KLK10 in 3 types of salivary gland tumour and normal salivary glands. Materials and methods: A standard immunoperoxidase staining technique was used to assess the Immunoexpression profile of KLK10 in normal salivary glands and 3 types of salivary gland tumour: pleomorphic adenoma, adenoid cystic carcinoma and mucoepidermoid carcinoma. Results Pleomorphic adenomas showed significantly lower KLK10 levels than control tissues. Neither of the malignant tumours (adenoid cystic carcinoma and mucoepidermoid carcinoma) showed a significant alteration in the immunoreactive scores of KLK10 in comparison with the normal salivary gland tissues. KLK10 immunoreactive scores were comparable in adenoid cystic carcinoma and mucoepidermoid carcinoma. Pleomorphic adenoma had significantly lower levels of KLK10 than mucoepidermoid carcinoma. Conclusions The finding of lower KLK10 levels in pleomorphic adenoma suggests aberrant expression in a tumour that develops primarily from myoepithelial cells. A kallikrein cascade may play a role in the development and/or outcome of some salivary gland tumours.

scholarly journals GAMBARAN HISTOPATOLOGI TUMOR KELENJAR LIUR DI MANADO PERIODE JULI 2010 – JULI 2013

e-CliniC ◽  
2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Marcella P. J. Merung
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Glands ◽  
Mucoepidermoid Carcinoma ◽  
Cell Lymphoma ◽  
Large Cell ◽  
Basal Cell Adenoma ◽  
Cell Adenoma ◽  
Adenoid Cystic ◽  
Large Cell Lymphoma

Abstract: Salivary glands tumor is relatively rare. In Indonesia, there’s still no complete data about the estimated incidence of salivary glands tumor. Objective:To determine the histopathology of the salivary gland tumor in Manado from July 2010 to July 2013. Methode: This was a descriptive retrospective study. Result: There were 70 patients had salivary gland tumorswith52.9% femaleand47.1% male). By age groups found that ≤16 age group for 1,4%, 17 - 30 for 28.6%, 31 – 40 for18.%), 41 – 50 for21.4%, 51 – 60 for14.3%, 61 – 70 for8.6%, ≥71 for 7.1%. By classification histopathology, Pleiomorphic adenoma for 57.2%, Whartin’s tumor for 11.4%, Oncocytoma, Mucoepidermoid carcinoma, and Adenocarcinoma each for 5.7%, Adenoid cystic carcinoma for4.3%,Cystadenoma for 3.0%, Myoepithelioma, Basal cell adenoma, Canalicular adenoma, Cystadenocarcinoma,and Large cell lymphoma malignant each for 1.4%. By the location, parotis gland for 47.1%, submandibula gland for 27.1%, minor salivary gland for 12.9% and the other location for 12.9%. Conclusion: Female is more than male, the highest incidence is in the group 17-30 years old, the most common benign tumors is pleomorphic adenoma while the most common type of malignant tumors is mucoepidermoid carcinoma and adenocarcinoma. The most frequent tumor’s location is parotid gland. Keywords: Salivary glands tumor, histopathology.   Abstrak: Tumor kelenjar liur merupakan tumor yang jarang ditemukan. Indonesia masih belum ada data lengkap mengenai insiden tumor kelenjar liur.Tujuan: Untuk mengetahui gambaran histopatologi tumor kelenjar liur di Manado periode Juli 2010 – Juli 2013. Metode:Penelitian ini bersifat deskriptif retrospektif. Hasil: Dari 70 penderita tumor kelenjar liurditemukan perempuan 52,9% dan laki-laki 47,1%. Kelompok usia ≤16 tahun sebanyak 1,4%, 17 - 30 tahun sebanyak 28,6%,31 – 40 tahun sebanyak 18,6%, 41 – 50 tahun sebanyak 21,4%, 51 – 60 tahun sebanyak 14,3%, 61 – 70 tahun sebanyak 8,6%, ≥71 tahun sebanyak 7,1%. Berdasarkan klasifikasi histopatologi jenis Pleimorphic adenoma sebanyak 57,2%, Whartin’s tumor sebanyak 11,4%, Oncocytoma,Mucoepidermoid carcinoma, dan Adenocarcinoma masing-masing sebanyak 5,7%,Adenoid cystic carcinoma sebanyak 4,3%, Cystadenoma sebanyak 3,0%, Myoepithelioma,Basal cell adenoma,Canalicular adenoma, Cystadenocarcinoma,dan Large cell lymphoma malignant masing-masing sebanyak 1,4%. Berdasarkan lokasi tumor, kelenjar parotis sebanyak 47,1%, kelenjar submandibula sebanyak 27,1%, kelenjar liur minor sebanyak 12,9% dan lokasi yang tidak jelas sebanyak 12,9%. Kesimpulan:Penderita perempuan lebih banyak dari laki-laki, insiden tertinggi pada kelompok usia17 – 30 tahun, tumor jinak paling banyak ditemukan adalah pleomorphic adenoma sedangkan tipe ganas adalah mucoepidermoid carcinoma dan adenocarcinoma. Lokasi tumor tersering adalah kelenjar parotis. Kata Kunci: Tumor kelenjar liur, histopatologi.

Estrogen receptor assay in polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma of salivary gland origin

1994 ◽  
Vol 77 (1) ◽  
pp. 36-40 ◽  
Author(s):  
Arthur S. Miller ◽  
Grace G. Hartman ◽  
Sow-Yeh Chen ◽  
Pamela R. Edmonds ◽  
Signe A. Brightman ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Low Grade ◽  
Adenoid Cystic ◽  
Receptor Assay

scholarly journals Expression of galectin-3 in adenoid cystic carcinoma & mucoepidermoid carcinoma of salivary glands- a study from Pakistan

2017 ◽  
Vol 5 (1) ◽  
pp. 10
Author(s):  
Sunila Hussain ◽  
Muhammad Rashid Siraj ◽  
Rabia Anjum ◽  
Ihtesham-ud-Din Qureshi ◽  
A H Nagi ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Glands ◽  
Mucoepidermoid Carcinoma ◽  
Tertiary Care ◽  
Cell Types ◽  
Lymph Node Status ◽  
Staining Reaction ◽  
Adenoid Cystic ◽  
Galectin 3

Background: Adenoid cystic carcinoma (AdCC) and mucoepidermoid carcinoma (MEC) are the commonest salivary gland malignancies in Pakistan constituting almost 75% of all malignant salivary gland tumours.Objective: The objective of this study was to determine the expression of galectin-3 (Gal-3) in AdCC and MEC of salivary glands and to see its relationship with histological differentiation in these tumours.Method: This descriptive study was conducted at the Department of Morbid Anatomy and Histopathology/ Oral Pathology, University of Health Sciences Lahore, Pakistan. Biopsies and detailed clinical data of 20 cases each of adenoid cystic carcinoma and mucoepidermoid carcinoma reported at local tertiary care hospitals from Jan. 2014 to Sep. 2015 were retrieved. The histologic diagnosis was made on Hematoxylin and Eosin staining. The tumours were graded into grades I, II & III according to the most recent grading criteria. AdCC was studied with respect to its morphological patterns (tubular, cribriform and solid) while MEC was studied with special concern to the cell types seen in it (mucous, intermediate, squamous and clear cells). Immunohistochemical expression of galectin-3 was determined in these tumours with respect to histological grades, patterns and cell types seen.Results: Moderate positivity (55%) for anti-galectin-3 antibody was the most frequently observed score for galectin-3 in both MEC and AdCC. Moderate positive (55%) staining reaction was followed by weak positive (30%) staining reaction in AdCC. Total score for antigalectin-3 antibody, positive stromal reaction (intensity) and location of cellular signals for anti-galectin-3 antibody were all found to be significantly associated with grades of AdCC. Also, histological pattern of AdCC (tubular, cribriform and solid) were significantly associated with type of anti-galectin-3 staining pattern of cells (p<0.001). In MEC, moderate positive (55%) staining for anti-galectin-3 antibody was followed by strong positive reaction (30%). The total score for anti-galectin-3 antibody was significantly associated with grades of the tumour and lymph node status. Also, the type of staining reaction in cells was significantly associated with cell type (mucous, squamous and intermediate cells).Conclusion: It can be concluded from the current study that expression of Gal-3 decreases with decreasing differentiation in parenchyma of malignant tumours while its expression in tumour extracellular environment increases with increasing grade of the tumour.Also, it can be concluded that nuclear expression of Gal-3 is associated tumour differentiation and cytoplasmic expression with tumour cell proliferation.

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