scholarly journals Flexible GnRH antagonist protocol vs. long GnRH agonist protocol in patients with polycystic ovary syndrome treated for IVF: comparison of clinical outcome and embryo quality.

2016 ◽  
Vol 87 (04) ◽  
pp. 265-270 ◽  
Author(s):  
Milan Trenkić ◽  
Jasmina Popović ◽  
Vesna Kopitović ◽  
Artur Bjelica ◽  
Radomir Živadinović ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Polycystic Ovary Syndrome ◽  
Gnrh Agonist ◽  
Embryo Quality ◽  
Gnrh Antagonist ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Gnrh Antagonist Protocol ◽  
Antagonist Protocol

scholarly journals The Early Coasting Method during Ovarian Stimulation in Antagonist Protocols with Combined Use of Cabergoline is Useful in Patients with Polycystic Ovary Syndrome

2021 ◽  
Vol 6 (3) ◽  
pp. 1-6
Author(s):  
Akira Nakashima ◽  
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Gnrh Antagonist ◽  
Polycystic Ovary ◽  
Gonadotropin Releasing Hormone ◽  
Ovary Syndrome ◽  
Early Administration ◽  
Combined Use ◽  
Gnrh Antagonist Protocol ◽  
Ovarian Syndrome ◽  
Antagonist Protocol

Purpose: This study aimed to investigate the efficacy of withholding gonadotropins (coasting) and early administration of cabergoline in a flexible Gonadotropin-Releasing Hormone (GnRH) antagonist protocol for patients with Polycystic Ovarian Syndrome (PCOS).

scholarly journals Comparison of a progestin-primed ovarian stimulation protocol with a flexible GnRH antagonist protocol in patients with polycystic ovary syndrome who are participating in an IVF programme: study protocol for a randomised controlled trial

BMJ Open ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. e038153
Author(s):  
Ningling Wang ◽  
Qianqian Zhu ◽  
Meng Ma ◽  
Zhou Liang ◽  
Yu Tao ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Ovarian Stimulation ◽  
Gnrh Antagonist ◽  
Polycystic Ovary ◽  
Controlled Trial ◽  
Pregnancy Rates ◽  
Ovary Syndrome ◽  
Gnrh Antagonist Protocol ◽  
Randomised Controlled ◽  
Antagonist Protocol

IntroductionWomen with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization (IVF) protocols are typically characterised by an increased number of oocytes retrieved. The oocytes are often of poor quality, leading to lower pregnancy rates, higher miscarriage rates and an increased risk of developing ovarian hyperstimulation syndrome (OHSS). Since our previous preliminary study showed that a novel progestin-primed ovarian stimulation (PPOS) protocol blocked the luteinising hormone (LH) surge during IVF and achieved a higher pregnancy rate with a lower incidence of OHSS, we designed a prospective randomised controlled trial to compare the efficacy and safety of this PPOS protocol with the flexible gonadotropin-releasing hormone (GnRH) antagonist protocol in patients with PCOS who are undergoing IVF procedures.Methods and analysisPatients with PCOS will be randomised to one of two controlled ovarian stimulation regimens—GnRH antagonist or PPOS—using a computer-generated random number. A freeze-all strategy using embryo vitrification techniques and frozen embryo transfer will be performed in both groups. The primary outcome is the live-birth rate per transfer. Secondary outcomes include the incidence of premature LH surges, the duration and total dose of human menopausal gonadotropin stimulation, the number of oocytes retrieved, the incidence of moderate or severe OHSS, the number of embryos available for transfer, implantation rates, clinical pregnancy rates, pregnancy loss rates, ectopic pregnancy rates, pregnancy and neonatal complications, and congenital anomalies. The necessary sample size for this trial was estimated as 392 participants, with 196 participants in each group. Intention-to-treat analysis was used in processing our experimental data.Ethics and disseminationThis study was approved by the Institutional Review Board of the hospital (2016-133-T82). The trial will be conducted according to the principles of the World Medical Association’s Declaration of Helsinki and in accordance with Good Clinical Practice standards. The findings of this trial will be published in a peer-reviewed journal.Trial registration numberChiCTRIPR16009580.

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