scholarly journals Significance of C-reactive protein in predicting fetal inflammatory response syndrome

2015 ◽  
Vol 86 (12) ◽  
Author(s):  
Daiva Bartkevičienė ◽  
Ingrida Pilypienė ◽  
Diana Ramašauskaitė ◽  
Jolita Zakarevičienė ◽  
Dalia Laužikienė ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Fetal Inflammatory Response

scholarly journals Interleukin-6 and C-Reactive Protein Are Overexpressed in the Liver of Perinatal Deaths Diagnosed with Fetal Inflammatory Response Syndrome

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Lívia Helena M. Pereira ◽  
Juliana R. Machado ◽  
Janaínna G. P. Olegário ◽  
Laura P. Rocha ◽  
Marcos V. Silva ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Acute Stress ◽  
University Hospital ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Ascending Infection ◽  
Term Births ◽  
Liver Fragments ◽  
Fetal Inflammatory Response

Anatomopathologic studies have failed to define the fetal inflammatory response syndrome (FIRS) as a cause of fetal death. Here, liver fragments of perinatal autopsies were collected at a university hospital from 1990 to 2009 and classified according to the cause of death, perinatal stress, and gestational age (GA) of the fetus. IL-6, TNF-α, and C-reactive protein (CRP) expression were immunostained, respectively, with primary antibody. Cases with congenital malformation, ascending infection, and perinatal anoxia showed increased IL-6, CRP, and TNF-α, respectively. Prematures presented higher expression of IL-6 whereas term births showed higher expression of CRP. Cases classified as acute stress presented higher expression of IL-6 and TNF-αand cases with chronic stress presented higher expression of CRP. GA correlated negatively with IL-6 and positively with CRP and TNF-α. Body weight correlated negatively with IL-6 and positively with CRP and TNF-α. Despite the diagnosis of FIRS being clinical and based on serum parameters, the findings in the current study allow the inference of FIRS diagnosis in the autopsied infants, based on anin situliver analysis of these markers.

Role of umbilical interleukin-6, procalcitonin and C-reactive protein measurement in the dia gnosis of fetal inflammatory response syndrome

2021 ◽  
Vol 86 (2) ◽  
pp. 80-85
Author(s):  
Zbyněk Straňák ◽  
◽  
Ivan Berka ◽  
Jan Širc ◽  
Jan Urbánek ◽  
...  
Keyword(s):  
High Risk ◽  
Inflammatory Response ◽  
Neonatal Mortality ◽  
Interleukin 6 ◽  
C Reactive Protein ◽  
Term Infants ◽  
Mortality And Morbidity ◽  
Reactive Protein ◽  
High Risk Infants ◽  
Fetal Inflammatory Response

Overview Objective: Fetal Inflammatory Response Syndrome (FIRS) is a serious complication accompanied by increased neonatal mortality and morbidity. Early dia­gnosis of FIRS is essential to detect high risk infants. The aim of the study was to evaluate the correlation between interleukin-6 
(IL-6), procalcitonin (PCT), C-reactive protein (CRP) in cord blood and histologically proven funisitis/ chorioamnionitis in high-risk infants after preterm birth. Methods: Blood sampling for the measurement of inflammatory bio­markers was performed immediately after placental delivery and umbilical cutting. Umbilical and placental inflammatory changes were assessed using a recently released scoring system (Amsterdam Placental Workshop Group Consensus). Results: One hundred preterm infants (30.5 ± 2.5 gestational week, birth weight 1,443 ± 566 grams) and 21 health term infants were analyzed. Histologic chorioamnionitis was confirmed in 19% cases and chorioamnionitis with funisitis in 7% cases. Thirty-three infants (33%) fulfilled criteria of FIRS (funistis and/ or umbilical IL-6 > 11 ng/ L). The presence of FIRS correlated significantly with maternal leukocytosis (P < 0.001), preterm premature rupture of membrane (P < 0.001) and preterm uterine contraction (P < 0.0001). In comparison to preterm and healthy term infants we found statistically significant higher levels of umbilical inflammatory bio­markers (IL-6, PCT, CRP) in FIRS group (P < 0.0001). Composite mortality and morbidity (bronchopulmonary dysplasia, intraventricular haemorrhage, periventricular leukomalacia) was higher in FIRS group (28.1 vs 22.4% in preterm group). However, the difference was not statistically significant (P = 0.53). Conclusion: Our study confirmed the correlation of umbilical inflammatory bio­markers levels (IL-6, PCT, CRP) and the presence of FIRS. We did not find significant adverse impact of FIRS on neonatal mortality and morbidity. Nevertheless, our results could be influenced by the size of study group and strict inclusion criteria (only cases after C-section were analyzed). Keywords: fetal inflammatory response syndrome – neonatal mortality – morbidity – interleukin-6 – C-reactive protein – procalcitonin – chorioamnionitis and funisitis

Enhanced inflammatory response of blood monocytes to C-reactive protein in patients with unstable angina

2005 ◽  
Vol 352 (1-2) ◽  
pp. 127-133 ◽  
Author(s):  
Jian-Jun Li ◽  
Hai-Rong Wang ◽  
Cong-Xin Huang ◽  
Jia-Lin Xue ◽  
Geng-Shan Li
Keyword(s):  
Inflammatory Response ◽  
Unstable Angina ◽  
Blood Monocytes ◽  
C Reactive Protein ◽  
Reactive Protein

Modified C-reactive protein may enhance inflammatory response in acute myocardial infarction

2020 ◽  
Vol 315 ◽  
pp. e226
Author(s):  
I. Melnikov ◽  
S. Kozlov ◽  
O. Saburova ◽  
Y. Avtaeva ◽  
M. Zvereva ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Inflammatory Response ◽  
C Reactive Protein ◽  
Reactive Protein

Inflammatory response in outpatients with chronic heart failure: has the C reactive protein measure any clinical usefulness?

2003 ◽  
Vol 9 (5) ◽  
pp. S75
Author(s):  
Eduardo R. Perna ◽  
Natalia Augier ◽  
Stella M. Macin ◽  
Juan P. Cimbaro Canella ◽  
Jorge Cialzeta ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Inflammatory Response ◽  
Clinical Usefulness ◽  
C Reactive Protein ◽  
Reactive Protein

C-reactive protein and inflammation: conformational changes affect function

2015 ◽  
Vol 396 (11) ◽  
pp. 1181-1197 ◽  
Author(s):  
Yi Wu ◽  
Lawrence A. Potempa ◽  
Driss El Kebir ◽  
János G. Filep
Keyword(s):  
Endothelial Cells ◽  
Inflammatory Response ◽  
Host Defense ◽  
Conformational Changes ◽  
Acute Phase Reactant ◽  
Dependent Manner ◽  
C Reactive Protein ◽  
Inflammatory Microenvironment ◽  
Reactive Protein ◽  
Phase Reactant

Abstract The prototypic acute-phase reactant C-reactive protein (CRP) has long been recognized as a useful marker and gauge of inflammation. CRP also plays an important role in host defense against invading pathogens as well as in inflammation. CRP consists of five identical subunits arranged as a cyclic pentamer. CRP exists in at least two conformationally distinct forms, i.e. native pentameric CRP (pCRP) and modified/monomeric CRP (mCRP). These isoforms bind to distinct receptors and lipid rafts, and exhibit distinct functional properties. Dissociation of pCRP into its subunits occurs within the inflammatory microenvironment and newly formed mCRP may then contribute to localizing the inflammatory response. Accumulating evidence indicates that pCRP possesses both pro- and anti-inflammatory actions in a context-dependent manner, whereas mCRP exerts potent pro-inflammatory actions on endothelial cells, endothelial progenitor cells, leukocytes and platelets, and thus may amplify inflammation. Here, we review recent advances that may explain how conformational changes in CRP contribute to shaping the inflammatory response and discuss CRP isomers as potential therapeutic targets to dampen inflammation.

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