scholarly journals Reference values for placental growth factor (PlGF) concentration and uterine artery Doppler pulsatility index (PI) at 11–13+6 weeks of gestation in the Polish population

2014 ◽  
Vol 85 (7) ◽  
Author(s):  
Przemysław Kosiński ◽  
Szymon Kozłowski ◽  
Michał Lipa ◽  
Mirosław Wielgoś ◽  
Dorota Bomba-Opoń ◽  
...  
Keyword(s):  
Growth Factor ◽  
Reference Values ◽  
Pulsatility Index ◽  
Uterine Artery ◽  
Placental Growth Factor ◽  
Polish Population ◽  
Uterine Artery Doppler

scholarly journals “Screening for small-for-gestational age neonates at early third trimester in a high-risk population for preeclampsia”

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Raquel Mula ◽  
Eva Meler ◽  
Sandra García ◽  
Gerard Albaigés ◽  
Bernat Serra ◽  
...  
Keyword(s):  
Growth Factor ◽  
High Risk ◽  
Biochemical Markers ◽  
Pulsatility Index ◽  
Uterine Artery ◽  
Placental Growth Factor ◽  
Fetal Weight ◽  
Third Trimester ◽  
Maternal Characteristics ◽  
Estimated Fetal Weight

Abstract Background Strategies to improve prenatal detection of small-for-gestational age (SGA) neonates are necessary because its association with poorer perinatal outcome. This study evaluated, in pregnancies with first trimester high risk of early preeclampsia, the performance of a third trimester screening for SGA combining biophysical and biochemical markers. Methods This is a prospective longitudinal study on 378 singleton pregnancies identified at high risk of early preeclampsia according to a first trimester multiparametric algorithm with the cutoff corresponding to 15% false positive rate. This cohort included 50 cases that delivered SGA neonates with birthweight < 10th centile (13.2%) and 328 cases with normal birthweight (86.8%). At 27–30 weeks’ gestation, maternal weight, blood pressure, estimated fetal weight, mean uterine artery pulsatility index and maternal biochemical markers (placental growth factor and soluble FMS-Like Tyrosine Kinase-1) were assessed. Different predictive models were created to evaluate their performance to predict SGA neonates. Results For a 15% FPR, a model that combines maternal characteristics, estimated fetal weight, mean uterine artery pulsatility index and placental growth factor achieved a detection rate (DR) of 56% with a negative predictive value of 92.2%. The area under receiver operating characteristic curve (AUC) was 0.79 (95% confidence interval (CI), 0.72–0.86). The DR of a model including maternal characteristics, estimated fetal weight and mean uterine artery pulsatility index was 54% (AUC, 0.77 (95% CI, 0.70–0.84)). The DR of a model that includes maternal characteristics and placental growth factor achieved a similar performance (DR 56%, AUC 0.75, 95% CI (0.67–0.83)). Conclusions The performance of screening for SGA neonates at early third trimester combining biophysical and biochemical markers in a high-risk population is poor. However, a high negative predictive value could help in reducing maternal anxiety, avoid iatrogenic interventions and propose a specific plan for higher risk patients.

THE ROLE OF SECOND TRIMESTER UTERINE ARTERY DOPPLER ULTRASOUND,INHIBIN-A AND PLACENTAL GROWTH FACTOR IN PREDICTION OF PREECLAMPSIA.

2016 ◽  
Vol 22 (4) ◽  
pp. 1-11
Author(s):  
Walid AbdelgalilElsheikh ◽  
Mohammad Behery ◽  
Elsayed Farag ◽  
Farid Hassan ◽  
Fawzy Abdelaziz ◽  
...  
Keyword(s):  
Growth Factor ◽  
Doppler Ultrasound ◽  
Uterine Artery ◽  
Placental Growth Factor ◽  
Second Trimester ◽  
Inhibin A ◽  
Uterine Artery Doppler
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