scholarly journals Applying nanotechnology towards developing an integrative drug delivery system for inhibiting antibiotic-resistant bacteria and restoring mitochondrial genetic expression In eukaryotic host cells

2020 ◽  
Author(s):  
Nicole Joy Bassous
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Host Cells ◽  
Resistant Bacteria ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant ◽  
Genetic Expression

scholarly journals Combatting antibiotic-resistant bacteria using nanomaterials

2019 ◽  
Vol 48 (2) ◽  
pp. 415-427 ◽  
Author(s):  
Akash Gupta ◽  
Shazia Mumtaz ◽  
Cheng-Hsuan Li ◽  
Irshad Hussain ◽  
Vincent M. Rotello
Keyword(s):  
Drug Delivery ◽  
Therapeutic Agents ◽  
Resistant Bacteria ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

Nanomaterials as self-therapeutic agents and drug-delivery vehicles for antimicrobial therapies.

scholarly journals Phage Therapy Is Effective in a Mouse Model of Bacterial Equine Keratitis

2016 ◽  
Vol 82 (17) ◽  
pp. 5332-5339 ◽  
Author(s):  
Takaaki Furusawa ◽  
Hidetomo Iwano ◽  
Yutaro Hiyashimizu ◽  
Kazuki Matsubara ◽  
Hidetoshi Higuchi ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Mouse Model ◽  
Phage Therapy ◽  
Host Cells ◽  
Resistant Bacteria ◽  
Broad Host Range ◽  
Bacterial Keratitis ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant ◽  
Content Type

ABSTRACTBacterial keratitis of the horse is mainly caused by staphylococci, streptococci, and pseudomonads. Of these bacteria,Pseudomonas aeruginosasometimes causes rapid corneal corruption and, in some cases, blindness. Antimicrobial resistance can make treatment very difficult. Therefore, new strategies to control bacterial infection are required. A bacteriophage (phage) is a virus that specifically infects and kills bacteria. Since phage often can lyse antibiotic-resistant bacteria because the killing mechanism is different, we examined the use of phage to treat horse bacterial keratitis. We isolatedMyoviridaeorPodoviridaephages, which together have a broad host range. They adsorb efficiently to host bacteria; more than 80% of the ΦR18 phage were adsorbed to host cells after 30 s. In our keratitis mouse model, the administration of phage within 3 h also could kill bacteria and suppress keratitis. A phage multiplicity of infection of 100 times the host bacterial number could kill host bacteria effectively. A cocktail of two phages suppressed bacteria in the keratitis model mouse. These data demonstrated that the phages in this study could completely prevent the keratitis caused byP. aeruginosain a keratitis mouse model. Furthermore, these results suggest that phage may be a more effective prophylaxis for horse keratitis than the current preventive use of antibiotics. Such treatment may reduce the use of antibiotics and therefore antibiotic resistance. Further studies are required to assess phage therapy as a candidate for treatment of horse keratitis.IMPORTANCEAntibiotic-resistant bacteria are emerging all over the world. Bacteriophages have great potential for resolution of this problem. A bacteriophage, or phage, is a virus that infects bacteria specifically. As a novel therapeutic strategy against racehorse keratitis caused byPseudomonas aeruginosa, we propose the application of phages for treatment. Phages isolated in this work hadin vitroeffectiveness for a broad range ofP. aeruginosastrains. Indeed, a great reduction of bacterial proliferation was shown in phage therapy for mouse models ofP. aeruginosakeratitis. Therefore, to reduce antibiotic usage, phage therapy should be investigated and developed further.

Hexosomes based on cholesterol and phosphatidylcholine: a new drug delivery system for curcumin release

Planta Medica ◽  
2015 ◽  
Vol 81 (16) ◽  
Author(s):  
AR Bilia ◽  
G Capecchi ◽  
MC Salvatici ◽  
B Isacchi ◽  
MC Bergonzi
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
New Drug
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