scholarly journals The major histocompatibility complex in mouse embryos and embryonic stem cells

2008 ◽  
Author(s):  
Paula Welter Lampton
2006 ◽  
Vol 74 (4) ◽  
pp. 160-166 ◽  
Author(s):  
Shiro Iuchi ◽  
Meytha Marsch-Moreno ◽  
Cristina Velez-DelValle ◽  
Karen Easley ◽  
Walid Kuri-Harcuch ◽  
...  

Blood ◽  
1997 ◽  
Vol 89 (1) ◽  
pp. 49-54 ◽  
Author(s):  
Futoshi Hashimoto ◽  
Kikuya Sugiura ◽  
Kyoichi Inoue ◽  
Susumu Ikehara

Graft failure is a mortal complication in allogeneic bone marrow transplantation (BMT); T cells and natural killer cells are responsible for graft rejection. However, we have recently demonstrated that the recruitment of donor-derived stromal cells prevents graft failure in allogeneic BMT. This finding prompted us to examine whether a major histocompatibility complex (MHC) restriction exists between hematopoietic stem cells (HSCs) and stromal cells. We transplanted bone marrow cells (BMCs) and bones obtained from various mouse strains and analyzed the cells that accumulated in the engrafted bones. Statistically significant cell accumulation was found in the engrafted bone, which had the same H-2 phenotype as that of the BMCs, whereas only few cells were detected in the engrafted bones of the third-party H-2 phenotypes during the 4 to 6 weeks after BMT. Moreover, the BMCs obtained from the MHC-compatible bone showed significant numbers of both colony-forming units in culture (CFU-C) and spleen colony-forming units (CFU-S). These findings strongly suggest that an MHC restriction exists between HSCs and stromal cells.


2008 ◽  
Vol 17 (1) ◽  
pp. 53-66 ◽  
Author(s):  
Lan Yin ◽  
Sai-Li Fu ◽  
Gui-Ying Shi ◽  
Ying Li ◽  
Jian-Qiang Jin ◽  
...  

Cell Research ◽  
2017 ◽  
Vol 28 (1) ◽  
pp. 126-129 ◽  
Author(s):  
Xuepeng Wang ◽  
Tianda Li ◽  
Tongtong Cui ◽  
Dawei Yu ◽  
Chao Liu ◽  
...  

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