scholarly journals DNA adduction in context

2008 ◽  
Author(s):  
James J. Glick
Keyword(s):  
Dna Adduction

scholarly journals Dietary phenolics as anti-mutagens and inhibitors of tobacco-related DNA adduction in the urothelium of smokers

1996 ◽  
Vol 17 (10) ◽  
pp. 2193-2200 ◽  
Author(s):  
Christian Malaveille ◽  
Agnfès Hautefeuille ◽  
Brigitte Pignatelli ◽  
Glenn Talaska ◽  
Paolo Vineis ◽  
...  
Keyword(s):  
Dna Adduction

scholarly journals Genotoxicity Study on Nicotine and Nicotine-Derived Nitrosamine by Accelerator Mass Spectrometry

Radiocarbon ◽  
1996 ◽  
Vol 38 (2) ◽  
pp. 347-353 ◽  
Author(s):  
X. S. Li ◽  
H. F. Wang ◽  
J. Y. Shi ◽  
X. Y. Wang ◽  
Y. F. Liu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Dna Adducts ◽  
Accelerator Mass Spectrometry ◽  
Chemical Speciation ◽  
Animal Experiments ◽  
Tobacco Consumption ◽  
Carcinogenic Risk ◽  
Dna Adduction ◽  
Carcinogenic Risk Assessment ◽  
Potential Carcinogen

We have studied DNA adduction with 14C-labeled nicotine and nicotine-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), by accelerator mass spectrometry (AMS) in mouse liver at doses equivalent to low-level exposure of humans. The dose ranges of nicotine and NNK administered were from 0.4 μg to 4.0×102 μg kg b.w.-1, and from 0.1 μg to 2.0×104 μg kg b.w.-1, respectively. In the exposure of mice to either nicotine or NNK, the number of DNA adducts increased linearly with increasing dose. The detection limit of DNA adducts was 1 adduct per 1011 nucleotide molecules. This limit is 1–4 orders of magnitude lower than that of other techniques used for quantification of DNA adducts. The results of our animal experiments enabled us to speculate that nicotine is a potential carcinogen. According to the procedure for 14C-labeled-NNK synthesis, we discuss the ultimate chemical speciation of NNK bound to DNA. From the animal tests we derived a directly perceivable relation between tobacco consumption and DNA adduction as the carcinogenic risk assessment.

scholarly journals Histone Adduction with Nicotine: A Bio-Ams Study

Radiocarbon ◽  
1997 ◽  
Vol 39 (3) ◽  
pp. 293-297 ◽  
Author(s):  
X. H. Wu ◽  
H. F. Wang ◽  
Y. F. Liu ◽  
X. Y. Lu ◽  
J. J. Wang ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Accelerator Mass Spectrometry ◽  
Human Exposure ◽  
Mouse Liver ◽  
Dose Range ◽  
The Other ◽  
Histone 3 ◽  
Protein Adduction ◽  
Dna Adduction

Based on the study of DNA adduction with nicotine, we have measured the mouse hepatic histone adduction with 14C-labeled nicotine in vivo by bio-accelerator mass spectrometry (bio-AMS). In the exposure of mice to nicotine, the dose range administered was from 0.2 μg to 6.0 μg kg b.w.-1, which was equivalent to a very low level of human exposure to cigarette smoke. The adducts of either histone 1 (H1) or histone 3 (H3) with nicotine in mouse liver increased markedly with increasing nicotine dose. Our results have demonstrated that in the study of protein adduction with toxic xenobiotics as a biomarker, the AMS method achieves the highest sensitivity, 4.6 × 10-17 mol (46 amol) adducts per mg H1 protein, compared to all the other methods used previously.

Reaction ofN-(2-Chloroethyl)-N-nitrosoureas with DNA:  Effect of Buffers on DNA Adduction, Cross-Linking, and Cytotoxicity

1996 ◽  
Vol 9 (1) ◽  
pp. 208-214 ◽  
Author(s):  
Fa-Xian Chen ◽  
William J. Bodell ◽  
Gangning Liang ◽  
Barry Gold
Keyword(s):  
Cross Linking ◽  
Dna Adduction

In VivoAflatoxin B1Metabolism and Hepatic DNA Adduction in Zebrafish (Danio rerio)

1997 ◽  
Vol 143 (1) ◽  
pp. 213-220 ◽  
Author(s):  
Claudia M. Troxel ◽  
Ashok P. Reddy ◽  
Patricia E. O'Neal ◽  
Jerry D. Hendricks ◽  
George S. Bailey
Keyword(s):  
Danio Rerio ◽  
Dna Adduction
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