scholarly journals The role of physical activity on blood factors, lipid profile, and liver enzymes of tile factory workers (A Case Study)

2020 ◽  
Author(s):  
MH Dashti khavidaki ◽  
AA Minaeifar ◽  
F Rassekh ◽  
A Baghiani
Keyword(s):  
Physical Activity ◽  
Lipid Profile ◽  
Liver Enzymes ◽  
Venous Blood ◽  
Dust Particles ◽  
Factory Workers ◽  
Cross Sectional ◽  
Tile Factory ◽  
Blood Factors

Introduction: Inhalation of dust particles is prone to chronic diseases, and regular exercise reduces the risk of cardiovascular disease and improves blood variables. The purpose of this study was to investigate the role of physical activity on blood factors, lipid profile, and liver enzymes in tile factory workers. Materials and Methods: This is a cross-sectional study. 70 workers who were eligible to participate in the study were selected based on the sampling method available at the workplace. According to the Beck questionnaire, 15 people were included in each active and inactive groups. After 12 hours of worker's last meal, 10 ml of venous blood was used to evaluate biochemical variables of Blood factors (RBC, Hematocrit, Hemoglobin, WBC), lipid profile (Cholesterol, Triglyceride). Liver enzyme (ALT, AST, ALP) tests of both groups were performed in the occupational medicine laboratory of Meybod city, and SPSS Ver.23 software was used for analysis. Results: The results showed that red blood cells (p = 0.003) and hemoglobin (p = 0.034) in the active group were significantly higher than the inactive group. Also triglyceride (p = 0.025) and cholesterol (p = 0.042) of liver enzymes, (p = 0.011) ALT and AST (p = 0.047) were significantly lower. Conclusion: It seems that physical activity can have a positive effect; it can improve blood factors, liver enzymes, and fat profile in workers. According to the results, tile factory workers can achieve the desired blood factors with minimal physical activity.

scholarly journals Correlation of Gamma Glutamyl Transferase with Traditional Risk Markers of Cardiovascular Disease in Different Obesity Phenotypes

2021 ◽  
Author(s):  
Amit Kumar Meena ◽  
Sonali Sharma ◽  
Barkha Gupta ◽  
Asrar Ahmed
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Lipid Profile ◽  
Liver Enzymes ◽  
Tertiary Care ◽  
Gamma Glutamyl Transferase ◽  
Strong Positive Correlation ◽  
Positive Correlation ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase

Introduction: The increased prevalence of overweight, obesity, and metabolic syndrome has revealed that liver enzymes have a potential role as determinants of metabolic conditions such as, hyperlipidemia, and Cardiovascular Disease (CVD). Aim: The study aimed to investigate the correlation between liver enzymes with anthropometric indices of obesity and lipid profile in different obese phenotypes at a tertiary care. Materials and Methods: The present observational study was conducted on a total of 180 obese participants of either gender in the age group 18-59 years from December 2018 to May 2019. These were further divided into two phenotypic groups viz., Metabolically Healthy Obese (MHO group; n=90) and Metabolically Unhealthy Obese (MUHO group; n=90) according to NCEP ATP III criteria.Traditional cardiovascular risk factors were evaluated in the study participants through anthropometric viz., Body Mass Index (BMI), Waist Circumference (WC), Hip Circumference (HC), waist–hip ratio (WHR), blood pressure and biochemical investigations i.e., serum glucose, lipid profile and liver enzymes. Data was analysed by using Microsoft excel software. Results: Among 180 obese participants, 76 were males and 104 females with mean age 40.42±10.84 years. In MUHO phenotype, Gamma Glutamyl Transferase (GGT) showed a strong positive correlation with BMI (r=0.413, p=0.00001), lipid parameters viz., LDL-C (r=0.3785, p=0.0001), TC (r=0.2953, p=0.0023), TG (r=0.2623, p=0.006) and negative correlation with HDL-C (-r=0.3167, p=0.001). No significant correlation was found in MHO phenotype between liver enzymes, BMI and lipid profile parameters. Conclusion: The results of this study indicated that GGT shows a strong positive correlation with traditional risk factors in MUHO participants. Thus, raised GGT may be considered as a risk marker of CVD in MUHO phenotype.

Effect of garlic powder supplementation on hepatic steatosis, liver enzymes and lipid profile in patients with non-alcoholic fatty liver disease: a double-blind randomised controlled clinical trial

2020 ◽  
Vol 124 (4) ◽  
pp. 450-456
Author(s):  
Abbas Ali Sangouni ◽  
Mohammad Reza Mohammad Hosseini Azar ◽  
Mohammad Alizadeh
Keyword(s):  
Liver Disease ◽  
Treatment Group ◽  
Lipid Profile ◽  
Hepatic Steatosis ◽  
Fatty Liver Disease ◽  
Liver Enzymes ◽  
Control Group ◽  
Alcoholic Fatty Liver ◽  
Garlic Powder ◽  
Alcoholic Fatty Liver Disease

AbstractNon-alcoholic fatty liver disease (NAFLD) includes a range of disorders from simple steatosis to non-alcoholic steatohepatitis. There is no proven drug treatment for NAFLD, and diet modification is considered part of the main line of treatment for this disease. The aim of this study was to investigate the efficacy of garlic supplementation in NAFLD patients. The effect of garlic powder supplementation on hepatic steatosis, liver enzymes and lipid profile was investigated in NAFLD patients. Ninety NAFLD patients were randomly assigned to take either a garlic powder supplement or a placebo for 12 weeks. The treatment group received four tablets of garlic daily (each tablet contained 400 mg garlic powder). The control group received four tablets of placebo (each placebo contained 400 mg starch). At the end of the study, hepatic steatosis was significantly reduced in the treatment group compared with the control group (P = 0·001). In addition, a significant decrease was seen in the serum concentration of alanine transaminase (P < 0·001), aspartate transaminase (P = 0·002), γ-glutamyltransferase (P = 0·003) as well as total cholesterol (P = 0·009), TAG (P < 0·001), HDL-cholesterol (P < 0·001) and LDL-cholesterol (P = 0·01) in the treatment group compared with the control group. No significant difference was seen between the two groups in serum concentration of alkaline phosphatase. Overall, garlic powder supplementation improved hepatic features and lipid profile among NAFLD patients.

scholarly journals Effect of aqueous extract of Thymus serpyllum on lipid profile and some liver enzymes in alloxan-induced diabetic rabbit

2017 ◽  
Vol 12 (1) ◽  
pp. 58
Author(s):  
Alamgeer . ◽  
Muhammad Naveed Mushtaq
Keyword(s):  
Lipid Profile ◽  
Aqueous Extract ◽  
Liver Enzymes ◽  
Hdl Cholesterol ◽  
Diabetic Control ◽  
Cholesterol Ratio ◽  
Diabetic Rabbit ◽  
Group 3 ◽  
Group 5 ◽  
Thymus Serpyllum

<p class="Abstract">The present study was designed to evaluate the effects of aqueous extract of<em> Thymus serpyllum</em> on lipid profile and some liver enzymes level in the diabetic rabbit. Rabbits were made diabetic with a single intravenous injection of alloxan and were divided into groups. Group 1 and 2 served as normal and diabetic control, respectively. Group 3 and 4 were given standard drugs glibenclamide and acarbose respectively while Group 5 was treated with 500 mg/kg of extract for 30 days. Blood samples were taken on day 0 and 30. The extract significantly reduced the level of serum cholesterol, triglyceride, LDLs, VLDLs, alkaline phosphatase and transaminases without affecting the HDLs level. Total cholesterol/HDL-cholesterol ratio was significantly reduced as compared to diabetic control. It is conceivable that<em> T. </em>serpyllum possesses antihyperlipidemic and hepatoprotective effects in diabetic rabbit.</p>

scholarly journals Effect of conjugated linoleic acid and different type of dietary fat on serum lipid profile, liver enzymes activity and oxidative stress markers in wistar rats

2018 ◽  
pp. 27-33
Author(s):  
Magdalena Franczyk-Żarów ◽  
Edyta Kuś ◽  
Renata B. Kostogrys
Keyword(s):  
Fatty Acids ◽  
Linoleic Acid ◽  
Lipid Profile ◽  
Conjugated Linoleic Acid ◽  
Significant Influence ◽  
Dietary Fat ◽  
Serum Lipid ◽  
Wistar Rats ◽  
Liver Enzymes ◽  
The Body

Background. Nutritional recommendations emphasize the need to limit consumption of saturated fatty acids and to increase the intake of polyunsaturated fatty acids in the prevention of non-communicable chronic diseases, particularly cardiovascular diseases. Among the fatty acids with health-related effects on the body, conjugated fatty acids are mentioned (i.e. CLA). Objective. The current study was designed to determine the effects of conjugated linoleic acid (CLA) on serum lipid profile, glucose, liver enzymes activity (AST and ALT), malonic dialdehyde (MDA) as well as lipid hydroperoxide (LPO) concentrations in rats fed diet differing in type of dietary fat. Material and methods. Male Wistar rats were divided into six groups and fed the following diets: control AIN-93G diet contained soybean oil (O) and diets with modification of fat source: butter (B) and margarine (M). The experimental diets were supplemented with 1% of conjugated linoleic acid (O+CLA, B+CLA, M+CLA). After 21 days the blood was collected and lipid profile, glucose, liver enzymes, MDA as well as LPO were analyzed. Results. The dietary treatments had no significant effect on the body weight and liver weight of the animals. The concentrations of total cholesterol (TC) and LDL+VLDL cholesterol were unchanged. Both experimental factors (fat source and CLA) had a significant influence on the TAG and HDL levels. Margarine (M) significantly increased the TAG concentration, whereas CLA had a significant impact on the TAG reduction (M+CLA). Glucose level was significantly decreased in all groups fed diets supplemented with CLA. Serum ALT significantly increased in all CLA groups. Fat source had statistically significant influence on the MDA concentration. The LPO level was significantly elevated in all CLA groups. There was statistically significant interaction of experimental factors (fat source and CLA supplementation) on LPO level. Conclusions. Margarine had an adverse effect on the rat’s lipid profile. However, in the group fed with margarine, the addition of CLA decreased the concentration of TAG. Regardless of the type of the dietary fat, CLA supplementation increased the level of LPO in the blood serum of animals.

scholarly journals Liver enzymes and lipid profile of malaria patients before and after antimalarial drug treatment at Dembia Primary Hospital and Teda Health Center, Northwest, Ethiopia

2021 ◽  
Author(s):  
Fentahun Megabiaw ◽  
Tegegne Eshetu ◽  
Zeleke Kassahun ◽  
MULUGETA AEMERO
Keyword(s):  
Drug Treatment ◽  
Lipid Profile ◽  
Antimalarial Drug ◽  
Liver Enzymes ◽  
Lipid Profiles ◽  
Malaria Treatment ◽  
Normal Range ◽  
Primary Hospital ◽  
The Mean ◽  
Study Participants

Abstract Backgroundinfection with malaria in humans involves liver cell destruction, which alters the levels of liver enzymes and lipid profiles. Although a number of studies have been conducted to address the impact of malaria on liver enzymes and lipid profiles, their findings lack consistency and no studies were conducted after antimalarial drug treatment in the Ethiopian context. This study, therefore, is intended to fill this gap. MethodsAn observational cohort study was conducted at Dembia Primary Hospital and Teda Health Center, from June to August 2020. A total of 88 study participants were recruited using random sampling techniques. Socio-demographic data, capillary and venous blood samples were collected from confirmed Plasmodium -infected individuals. Assessment of liver enzymes and lipid profiles was done using Beckman Coulter DC-700 clinical chemistry analyzer. Data were entered using Epi-data and exported to SPSS version 20 software for analysis. One way ANova, independent t-test, and paired t-test were used to compare the mean liver enzymes and lipid profile. A p -value<0.05 was considered statistically significant. RESULTSBefore anti-malaria treatment, among 88 malaria-infected study participants, abnormally elevated AST was observed in 87.5% of them. Similarly, elevated ALT, ALP, and TG were observed among 12.5%, 43.2%, and 17.2% of the study subjects, respectively. A lower level of HDL was observed among 87.5% of the study participants, while LDL and TC levels were within the normal range. After anti-malaria treatment,100% of AST, ALT, HDL, and LDL, and 92% of ALP, 94.3% of TC, and 86.4% of TG results were in the normal range. The mean level of AST (39.70±3.55and 55.35±9.6) and ALT (22.11±11.75, and23.24±16.05) results were increased, whereas HDL (28.88±11.63and22.73±14.26) level decreased from low to higher density parasitaemia. The mean level of AST at posttreatment (33.90±15.15) was significantly lower compared to the pretreatment (47.60±9.65). The mean levels of ALT had not altered during pretreatment(23.53±16.28)and posttreatment (23.49±11.10).Moreover, the mean of HDL, LDL, and TC at posttreatment were found to be increased when compared with pretreatment, though it is statistically insignificant ( P >0.05). CONCLUSIONMalaria parasites could be responsible for increased liver enzymes and certain lipids while decreasing some lipid profiles compared with the normal range. After anti-malaria treatment, these parameters were reversed to normal from 86.4% to 100%. When the mean values are compared, a significant change was observed in AST level while ALT level remains the same. Hence, prompt treatment is important to improve liver enzymes and lipid profile impairment during malaria infection.

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