COMPLICATIONS AFTER SURGERY FOR INVASIVE BREAST CANCER: COHORT STUDY

2016 ◽  
Vol 6 (1) ◽  
pp. 1-7
Author(s):  
Hawar Hasan Ali Ghalib ◽  
Keyword(s):  
Breast Cancer ◽  
Cohort Study ◽  
Invasive Breast Cancer ◽  
Breast Cancer Cohort

Abstract PR06: Exposure to phthalates and risk of invasive breast cancer: The Multiethnic Cohort Study

2020 ◽  
Author(s):  
Anna H. Wu ◽  
Adrian A. Franke ◽  
Chiuchen Tseng ◽  
Shannon M. Conroy ◽  
Yuqing S. LI ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cohort Study ◽  
Invasive Breast Cancer ◽  
Multiethnic Cohort

scholarly journals Recalibration of the Gail model for predicting invasive breast cancer risk in Spanish women: a population-based cohort study

2013 ◽  
Vol 138 (1) ◽  
pp. 249-259 ◽  
Author(s):  
Roberto Pastor-Barriuso ◽  
Nieves Ascunce ◽  
María Ederra ◽  
Nieves Erdozáin ◽  
Alberto Murillo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cohort Study ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Invasive Breast Cancer ◽  
Population Based ◽  
Gail Model ◽  
Spanish Women

scholarly journals Construction of the secondary care administrative records frailty (SCARF) index and validation on older women with operable invasive breast cancer in England and Wales: a cohort study

BMJ Open ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. e035395 ◽  
Author(s):  
Yasmin Jauhari ◽  
Melissa Ruth Gannon ◽  
David Dodwell ◽  
Kieran Horgan ◽  
Karen Clements ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Overall Survival ◽  
Cohort Study ◽  
Older Women ◽  
Invasive Breast Cancer ◽  
Secondary Care ◽  
Regression Models ◽  
Frailty Index ◽  
External Validation ◽  
Administrative Records

ObjectivesStudies that use national datasets to evaluate the management of older women with breast cancer are often constrained by a lack of information on patient fitness. This study constructed a frailty index for use with secondary care administrative records and evaluated its ability to improve models of treatment patterns and overall survival in women with breast cancer.DesignRetrospective cohort study.ParticipantsWomen aged ≥50 years with oestrogen receptor (ER) positive early invasive breast cancer diagnosed between 2014 and 2017 in England.MethodsThe secondary care administrative records frailty (SCARF) index was based on the cumulative deficit model of frailty, using International Statistical Classification of Diseases, Injuries and Causes of Death, 10th revision codes to define a set of deficits. The index was applied to administrative records that were linked to national cancer registry datasets. The ability of the SCARF index to improve the performance of regression models to explain observed variation in the rate of surgery and overall survival was evaluated using Harrell’s c-statistic and decision curve analysis. External validation was performed on a dataset of similar women diagnosed in Wales.ResultsThe SCARF index captured 32 deficits that cover functional impairment, geriatric syndromes, problems with nutrition, cognition and mood, and medical comorbidities. In the English dataset (n=67 925), the prevalence of frailty in women aged 50–69, 70–79 and ≥80 years was 15%, 28% and 47%, respectively. Adding a frailty measure to regression models containing age, tumour characteristics and comorbidity improved their ability to: (1) discriminate between whether a woman was likely to have surgery and (2) predict overall survival. Similar results were obtained when the models were applied to the Welsh cohort (n=4 230).ConclusionThe SCARF index provides a simple and consistent method to identify frailty in population level data and could help describe differences in breast cancer treatments and outcomes.

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