A SYSTEMATIC ANALYSIS ON THE THERAPEUTIC BENEFITS OF PROBIOTICS

2017 ◽  
Vol 4 (2) ◽  
pp. 161-168
Author(s):  
Magdalena Toda
Keyword(s):  
Systematic Analysis ◽  
Therapeutic Benefits

scholarly journals Immunity Depletion, Telomere Imbalance, and Cancer-associated Metabolism Pathway Aberrations in Intestinal Mucosa upon Caloric Restriction

2021 ◽  
Author(s):  
Evan Maestri ◽  
Kalina Duszka ◽  
Vladimir A Kuznetsov
Keyword(s):  
Gene Expression ◽  
Cancer Biology ◽  
Cell Activation ◽  
Expression Profiles ◽  
Specific Treatment ◽  
Metabolic Reprogramming ◽  
Telomere Maintenance ◽  
Systematic Analysis ◽  
Therapeutic Benefits ◽  
Anti Cancer

AbstractSystematic analysis of calorie restriction (CR) mechanisms and pathways in cancer biology has not been carried out, leaving therapeutic benefits unclear. Using a systems biology approach and metadata analysis, we studied gene expression changes in the response of normal mouse duodenum mucosa (DM) to short-term (2-weeks) 25% CR as a biological model. We found a high similarity of gene expression profiles in human and mouse DM tissues. Surprisingly, 26% of the 467 CR responding differential expressed genes (DEGs) in mice consist of cancer-associated genes—most never studied in CR contexts. The DEGs were enriched with over-expressed cell cycle, oncogenes, and metabolic reprogramming pathways (MRP) that determine tissue-specific tumorigenesis, cancer, and stem cell activation; tumor suppressors and apoptosis genes were under-expressed. DEG enrichments suggest a misbalance in telomere maintenance and activation of metabolic pathways playing dual (anti-cancer and pro-oncogenic) roles. Immune system genes (ISGs) consist of 37% of the total DEGs; the majority of ISGs are suppressed, including cell-autonomous immunity and tumor immune evasion controls. Thus, CR induces MRP suppressing multiple immune mechanics and activating oncogenic pathways, potentially driving pre-malignant and cancer states. These findings change the paradigm regarding the anti-cancer role of CR and may initiate specific treatment target development.

Prevention of endometrial hyperplasia without atypia in women of reproductive age

GYNECOLOGY ◽  
2021 ◽  
Vol 23 (5) ◽  
pp. 454-458
Author(s):  
Mekan R. Orazov ◽  
Ljudmila M. Mihaleva ◽  
Roman E. Orekhov ◽  
Irina A. Mullina
Keyword(s):  
Endometrial Hyperplasia ◽  
Scientific Evidence ◽  
Treatment Options ◽  
Reproductive Age ◽  
Systematic Analysis ◽  
The Past ◽  
Therapeutic Benefits ◽  
Wide Range ◽  
Personalized Approach ◽  
Excessive Proliferation

Objective of this review is a systematic analysis of the data available in the current literature on the efficacy and safety of progestogens for the prevention of atypical endometrial hyperplasia (EH) in patients of reproductive age. EH is an excessive proliferation that results in increased volume and changes in endometrial tissue architectonics with an increase in the endometrial glands to stroma ratio of more than 1:1. This review will consider the use of progestogens for the prevention of (EH) based on evidence-based scientific evidence over the past 5 years. The expansion of the range of effective treatment options allows the adaptation of treatment to the needs of patients and offers a personalized approach to their management. Progestogens are an effective and safe method for the prevention of atypical hyperplasia, with a wide range of therapeutic benefits associated with reliable favorable fertility prognosis, especially in young women.

scholarly journals Deep Brain Stimulation of the Subthalamic Nucleus Modulates Reward-Related Behavior: A Systematic Review

2020 ◽  
Vol 14 ◽  
Author(s):  
Yvan M. Vachez ◽  
Meaghan C. Creed
Keyword(s):  
Deep Brain Stimulation ◽  
Subthalamic Nucleus ◽  
Brain Stimulation ◽  
Systematic Analysis ◽  
Reward Seeking ◽  
Therapeutic Benefits ◽  
Motivated Behavior ◽  
Stn Dbs ◽  
Deep Brain ◽  
Stimulation Of

Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an effective treatment for the motor symptoms of movement disorders including Parkinson's Disease (PD). Despite its therapeutic benefits, STN-DBS has been associated with adverse effects on mood and cognition. Specifically, apathy, which is defined as a loss of motivation, has been reported to emerge or to worsen following STN-DBS. However, it is often challenging to disentangle the effects of STN-DBS per se from concurrent reduction of dopamine replacement therapy, from underlying PD pathology or from disease progression. To this end, pre-clinical models allow for the dissociation of each of these factors, and to establish neural substrates underlying the emergence of motivational symptoms following STN-DBS. Here, we performed a systematic analysis of rodent studies assessing the effects of STN-DBS on reward seeking, reward motivation and reward consumption across a variety of behavioral paradigms. We find that STN-DBS decreases reward seeking in the majority of experiments, and we outline how design of the behavioral task and DBS parameters can influence experimental outcomes. While an early hypothesis posited that DBS acts as a “functional lesion,” an analysis of lesions and inhibition of the STN revealed no consistent pattern on reward-related behavior. Thus, we discuss alternative mechanisms that could contribute to the amotivational effects of STN-DBS. We also argue that optogenetic-assisted circuit dissection could yield important insight into the effects of the STN on motivated behavior in health and disease. Understanding the mechanisms underlying the effects of STN-DBS on motivated behavior-will be critical for optimizing the clinical application of STN-DBS.

scholarly journals A network pharmacology perspective for deciphering potential mechanisms of action of Solanum nigrum L. in bladder cancer

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yang Dong ◽  
Lin Hao ◽  
Kun Fang ◽  
Xiao-xiao Han ◽  
Hui Yu ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Target Genes ◽  
Mendelian Inheritance ◽  
Solanum Nigrum ◽  
Network Pharmacology ◽  
Therapeutic Effects ◽  
Systematic Analysis ◽  
Ppi Networks ◽  
Therapeutic Benefits ◽  
Go Terms

Abstract Background Solanum nigrum L. decoction has been used as a folklore medicine in China to prevent the postoperative recurrence of bladder cancer (BC). However, there are no previous pharmacological studies on the protective mechanisms of this activity of the plant. Thus, this study aimed to perform a systematic analysis and to predict the potential action mechanisms underlying S. nigrum activity in BC based on network pharmacology. Methods Based on network pharmacology, the active ingredients of S. nigrum and the corresponding targets were identified using the Traditional Chinese Medicines for Systems Pharmacology Database and Analysis Platform database, and BC-related genes were screened using GeneCards and the Online Mendelian Inheritance in Man database. In addition, ingredient-target (I–T) and protein–protein interaction (PPI) networks were constructed using STRING and Cytoscape, Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were conducted, and then the pathways directly related to BC were integrated manually to reveal the pharmacological mechanism underlying S. nigrum-medicated therapeutic effects in BC. Results Seven active herbal ingredients from 39 components of S. nigrum were identified, which shared 77 common target genes related to BC. I-T network analysis revealed that quercetin was associated with all targets and that NCOA2 was targeted by four ingredients. Besides, interleukin 6 had the highest degree value in the PPI network, indicating a hub role. A subsequent gene enrichment analysis yielded 86 significant GO terms and 89 significant pathways, implying that S. nigrum had therapeutic benefits in BC through multi-pathway effects, including the HIF-1, TNF, P53, MAPK, PI3K/Akt, apoptosis and bladder cancer pathway. Conclusions S. nigrum may mediate pharmacological effects in BC through multi-target and various signaling pathways. Further validation is required experimentally. Network pharmacology approach provides a predicative novel strategy to reveal the holistic mechanism of action of herbs.

Preparatory Procedures for Electron Microscopic Analysis at the Molecular Level of Resolution

1978 ◽  
Vol 36 (3) ◽  
pp. 516-520
Author(s):  
F.J. Sjostrand
Keyword(s):  
Electron Microscope ◽  
Molecular Level ◽  
Microscopic Analysis ◽  
Resolving Power ◽  
Cellular Structures ◽  
Electron Microscopic ◽  
Systematic Analysis ◽  
Technical Developments ◽  
Thin Sectioning ◽  
Obvious Reason

In the 1940's and 1950's electron microscopy conferences were attended with everybody interested in learning about the latest technical developments for one very obvious reason. There was the electron microscope with its outstanding performance but nobody could make very much use of it because we were lacking proper techniques to prepare biological specimens. The development of the thin sectioning technique with its perfectioning in 1952 changed the situation and systematic analysis of the structure of cells could now be pursued. Since then electron microscopists have in general become satisfied with the level of resolution at which cellular structures can be analyzed when applying this technique. There has been little interest in trying to push the limit of resolution closer to that determined by the resolving power of the electron microscope.

Therapeutic benefits of coming home program retreats

2013 ◽  
Author(s):  
J. Bobrow ◽  
E. Cook ◽  
C. Knowles ◽  
C. Vieten
Keyword(s):  
Home Program ◽  
Therapeutic Benefits

A SYSTEMATIC ANALYSIS OF THE EFFECTS OF MOBILE PHONE APPLICATIONS ON PHYSICAL ACTIVITY

2020 ◽  
Vol 2020 ◽  
pp. 1483-1484
Author(s):  
Masoumeh Hosseinpour ◽  
◽  
Ralf Terlutter ◽  
Holger Roschk
Keyword(s):  
Physical Activity ◽  
Mobile Phone ◽  
Systematic Analysis ◽  
Mobile Phone Applications

Interactions in psychiatric care consultation in Akan speaking communities

2019 ◽  
Vol 15 (1) ◽  
pp. 40-52
Author(s):  
Nana Aba Appiah Amfo ◽  
Ekua Essumanma Houphouet ◽  
Eugene K. Dordoye ◽  
Rachel Thompson
Keyword(s):  
Diagnostic Tool ◽  
Psychiatric Care ◽  
Code Mixing ◽  
Therapeutic Benefits ◽  
Patient Interactions ◽  
Health Practitioners ◽  
Care Consultation ◽  
Discourse Pragmatics

The present paper examines interactions in psychiatric care consultation in selected hospital settings in three Akan-speaking communities in Ghana, based on 45 audio-recorded doctor/nurse-patient interactions. Using a discourse pragmatics approach, we note how language is used in the management of communication in psychiatric consultations, and how the dominance of healthcare practitioners is enacted. Specifically, we focus on some of the strategies used by the participants to manage the multilingual communicative settings, such as code-mixing. Our findings also suggest that the use of proverbs as a diagnostic tool in psychiatric consultations in Ghana needs to be reviewed. We propose that in order for patients to experience consultation sessions that are more interactive, with possible therapeutic benefits, health practitioners need to make considerable efforts to involve the patients in decisions regarding their health.

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