COST-EFFECTIVENESS ANALYSIS OF OPTIMAL CONTROL STRATEGIES FOR BREAST CANCER TREATMENT WITH KETOGENIC-DIET

628 Background: Trastuzumab has shown activity in patients with early breast cancer that overexpress HER2. However, significant resources have to be allocated to finance this therapy, therefore its cost-effectiveness is called for and treatment’s value for money should be calculated. We aimed to evaluate the marginal cost effectiveness of trastuzumab in adjuvant treatment of HER2 positive early breast cancer in a model based cost-effectiveness-analysis (CEA). Methods: A breast cancer treatment model was set up. Societal costs were calculated according to Norwegian prices as in September 2005 and converted to Euros at the rate of 1Euro = 7.81 NOK. Life expectancy data were based on the literature and prolonged according to qualified guess (10% and 20% improved overall survival (OS). The comparator was the present practice, the FEC100 regimen alone. The human capital approach was employed and a sensitivity analysis was added. Results: The median raised cost per patient treated was calculated at Euro16,713 - 35,714. The yielding cost per life year saved was in the range between Euro 5,571 and 32,616, depending on survival gain (10% or 20% improved OS) and discount rate (0% or 3%) employed. The sensitivity analyses documented survival gain, discount rate and price of trastuzumab the major factors influencing cost-effectiveness ratio. Conclusion: The economic evaluation indicates trastuzumab cost effective in adjuvant breast cancer treatment. No significant financial relationships to disclose.

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Optimal Control Problem for Cholera Disease and Cost-Effectiveness Analysis

Journal of Mathematical and Fundamental Sciences ◽

10.5614/j.math.fund.sci.2021.53.2.3 ◽

2021 ◽

Vol 53 (2) ◽

pp. 200-2017

Author(s):

Jhoana Patricia Romero-Leiton ◽

Muhammad Ozair ◽

Takasar Hussaing

Keyword(s):

Optimal Control ◽

Cost Effectiveness ◽

Optimal Control Problem ◽

Control Problem ◽

Control Strategies ◽

Cost Effectiveness Analysis ◽

Effectiveness Analysis ◽

Using Data ◽

Theoretical Results

Cholera is a disease that continues to be a threat to public health globally and is an indicator of inequity and lack of social development in countries. For this reason, strategies for its control need to be investigated. In this work, an optimal control problem related to cholera disease was formulated by introducing personal protection, drug treatment and water sanitation as control strategies. First, the existence and characterization of controls to minimize the performance index or cost function was proved by using classic control theory. Then, the theoretical results were validated with numerical experiments by using data reported in the literature. Finally, the effectiveness and efficiency of the proposed controls were determined through a cost-effectiveness analysis. The results showed that the use of the three controls simultaneously is the cheapest and most effective strategy to control the disease.

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Optimal Control Strategies and Cost-effectiveness Analysis Applied to Real Data of Cholera Outbreak in Ethiopia’s Oromia Region

Chaos Solitons & Fractals ◽

10.1016/j.chaos.2020.109933 ◽

2020 ◽

Vol 138 ◽

pp. 109933

Author(s):

Hailay Weldegiorgis Berhe

Keyword(s):

Optimal Control ◽

Cost Effectiveness ◽

Control Strategies ◽

Real Data ◽

Cost Effectiveness Analysis ◽

Cholera Outbreak ◽

Effectiveness Analysis

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Optimal Control Analysis of an Age-Structured Malaria Model Incorporating Children under Five Years and Pregnant Women

Journal of Advances in Mathematics and Computer Science ◽

10.9734/jamcs/2019/v30i630096 ◽

2019 ◽

pp. 1-23

Author(s):

George Theodore Azu-Tungmah ◽

Francis T. Oduro ◽

Gabriel A. Okyere

Keyword(s):

Optimal Control ◽

Cost Effectiveness ◽

Pregnant Women ◽

Control Strategies ◽

Cost Effectiveness Analysis ◽

Under Five ◽

Effectiveness Analysis ◽

Age Structured ◽

The Cost ◽

Malaria Model

In this article, we apply the optimal control theory to a new age-structured malaria model with three infectious compartments for people under five years, over five years and pregnant women. The model is formulated for malaria endemic areas in the world and the following malaria control strategies ITN, IRS, Chemoprophylaxis and Improved Clinical Treatment were examined and analysed on the mode. The Cost-effectiveness Analysis points out that more attention should be given Insecticide -Treated bed nets (ITNs) in order to eliminate the malaria disease globally because the female Anopheles mosquitoes need human blood to lay their eggs. The expression for the effective reproduction number has been derived by using the next-generation method. The impact of the controls on the was studied and it came out that all the four controls have a positive impact such that the ITNs can reduce to zero as the value of ITNs approaches one. Pontryagin’s Maximum Principle was applied to analyse the optimal control model theoretically and the optimality system was solved numerically through an iterative scheme. The optimal plots (Figs. 4-8) reveal that best control strategies for malaria elimination is the combination of ITN, Chemoprophylaxis and Improved Clinical Treatment. However, the Cost-effectiveness Analysis points out that ITN is economically best solution for fighting malaria in poor malaria endemic areas.

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