ANKYLOSING SPONDILITIS: HYPOTHESES OF PATHOGENESIS, NEW BIOMARKERS AND FEATURES OF THERAPY

Currently, the urgent task is to search for new biomarkers as a promising tool for early detection and monitoring of breast cancer. The aim of the study was to study the level of cytokines in the saliva of patients with breast cancer. In the case-control study volunteers participated, which were divided into 3 groups: the main (breast cancer, n = 43), the comparison group (fibroadenoma, n = 32) and the control group (conditionally healthy, n = 39). All participants were questioned; biochemical examination of saliva, histological verification of the diagnosis was carried out. Intergroup differences are estimated by a nonparametric criterion. It is shown that in the context of breast cancer, the level of cytokines (IL-2, IL-4, IL-6, IL-10 and IL-18) is increasing, except for IL-8, the content of which decreases compared to the control group. When the disease progresses by the nature of the dynamics, the parameters are divided into two groups: IL-2, IL-4, IL-18 and IL-6, IL-8, IL-10. For the first group of cytokines, there was a decrease in content during the transition from the early stages to the more common ones. For the second group, when passing from stages T1-2N0M0 to T1-2NjM0, the level of cytokines remains practically constant. In the future, the level of cytokines is observed for stage T3_4N0_2M0, and for IL-2, IL-4 and IL-10, the level of cytokines reaches values corresponding to early stages, whereas for IL-6, IL-8 and IL-18 in the same direction, a significant increase in indicators was noted. Additionally, the IL-6/IL-8 ratio was calculated depending on the tumor size, as well as the presence / absence of metastasis. It is shown that this ratio is statistically significantly increased in the advanced stages of the disease. Particularly interesting is the increase in this ratio in saliva at the initial stages of the disease.

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Proteomic Profile of Silicotic Rats Identifies PTPN2, VRK1, and B-Factor as New Biomarkers of Pneumoconiosis

SSRN Electronic Journal ◽

10.2139/ssrn.3417859 ◽

2019 ◽

Author(s):

Ying Zhu ◽

Yao Jingxin ◽

Hong Xu ◽

Ming Zhang ◽

Yuxia Duan ◽

...

Keyword(s):

Proteomic Profile ◽

New Biomarkers

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Recent Advances in New Discovered Molecular Targets in Testicular Germ Cell Tumors

Current Medicinal Chemistry ◽

10.2174/0929867324666171003115807 ◽

2018 ◽

Vol 25 (5) ◽

pp. 575-583 ◽

Cited By ~ 1

Author(s):

Paolo Chieffi

Keyword(s):

Germ Cell ◽

Primordial Germ Cells ◽

Germ Cell Tumors ◽

Molecular Targets ◽

Testicular Germ Cell Tumor ◽

Research Literature ◽

Testicular Germ Cell ◽

Solid Malignancy ◽

Bibliographic Data ◽

New Biomarkers

Background: Testicular germ cell tumor (TGCT) is the most common solid malignancy occurring in young men between 20 and 34 years of age, and its incidence has increased significantly over the last decades. TGCTs can be subdivided into seminoma and nonseminoma germ cell tumors (NSGCTs), which includes yolk sac tumor, choriocarcinoma, embryonal cell carcinoma, and teratoma. Seminomas and NSGCTs present significant differences in therapy, prognosis, and both show characteristics of the Primordial Germ Cells (PGCs). Methods: I undertook a search of bibliographic data from peer-reviewed research literature. Results: Seventy papers were included in the mini-review showing that a large number of new biomarkers have given further advantages to discriminate the different histotypes and could represent useful novel molecular targets for anticancer strategies. Conclusion: A deeper understanding of the pathogenesis of TGCTs is likely to significantly improve not only our knowledge on stem cells and oncogenesis but also the disease management with more selective tumor treatment.

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Acetaminophen Oxidation and Inflammatory Markers – A Review of Hepatic Molecular Mechanisms and Preclinical Studies

Current Drug Targets ◽

10.2174/1389450121666200510014418 ◽

2020 ◽

Vol 21 (12) ◽

pp. 1225-1236

Author(s):

Silvio Terra Stefanello ◽

Nelson Rodrigues de Carvalho ◽

Simone Beder Reis ◽

Felix Alexandre Antunes Soares ◽

Rômulo Pillon Barcelos

Keyword(s):

Liver Damage ◽

Inflammatory Markers ◽

Molecular Mechanisms ◽

Easy Access ◽

Timely Manner ◽

Severe Liver ◽

Clinical Biomarkers ◽

Severe Liver Damage ◽

Acetaminophen Intoxication ◽

New Biomarkers

Acetaminophen is a widely used analgesic for pain management, especially useful in chronic diseases, such as rheumatoid arthritis. However, easy access to this medicine has increased the occurrence of episodes of poisoning. Patients often develop severe liver damage, which may quickly lead to death. Consequently, numerous studies have been conducted to identify new biomarkers that allow the prediction of the degree of acetaminophen intoxication and thus intervene in a timely manner to save patients’ lives. This review highlights the main mechanisms of the induction and progression of liver damage arising from acetaminophen poisoning. In addition, we have discussed the possibility of using new clinical biomarkers for detecting acetaminophen poisoning.

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