scholarly journals COMPARATIVE STUDY OF THE EFFECT OF PLANT EXTRACTS ON THE SURVIVAL OF LABORATORY ANIMALS IN VARIOUS TYPES OF BRAIN HYPOXIA IN AN EXPERIMENT

2021 ◽  
pp. 46-46
Author(s):  
T.A. Lysenko
Keyword(s):  
Comparative Study ◽  
Plant Extracts ◽  
Laboratory Animals ◽  
Brain Hypoxia

Natural plant extracts as active components in chitosan-based films: A comparative study

2019 ◽  
Vol 21 ◽  
pp. 100365 ◽  
Author(s):  
Marijan Bajić ◽  
Tina Ročnik ◽  
Ana Oberlintner ◽  
Francesca Scognamiglio ◽  
Uroš Novak ◽  
...  
Keyword(s):  
Comparative Study ◽  
Plant Extracts ◽  
Active Components ◽  
Natural Plant

Comparative study of nitrazepam metabolism in perfused isolated liver of laboratory animals

1970 ◽  
Vol 11 (3) ◽  
pp. 378-382 ◽  
Author(s):  
I. Bartošek ◽  
J. Květina ◽  
A. Guaitani ◽  
S. Garattini
Keyword(s):  
Comparative Study ◽  
Laboratory Animals ◽  
Isolated Liver

scholarly journals Comparative study of phytochemical screening, antioxidant and antimicrobial capacities of fresh and dry leaves crude plant extracts of Datura metel L

2014 ◽  
Vol 26 (3) ◽  
pp. 237-243 ◽  
Author(s):  
Tahiya Hilal Ali Alabri ◽  
Amira Hamood Salim Al Musalami ◽  
Mohammad Amzad Hossain ◽  
Afaf Mohammed Weli ◽  
Qasim Al-Riyami
Keyword(s):  
Comparative Study ◽  
Plant Extracts ◽  
Phytochemical Screening ◽  
Datura Metel

A Comparative Study on the Hepatic Toxicity and Metabolism of Crotalaria Assamica and Eupatorium Species

1989 ◽  
Vol 17 (03n04) ◽  
pp. 165-170 ◽  
Author(s):  
Mo-Yin Chan ◽  
Xiang-Lan Zhao ◽  
C.W. Ogle
Keyword(s):  
Comparative Study ◽  
Dose Level ◽  
Plant Extracts ◽  
Liver Microsomes ◽  
In Vitro Studies ◽  
Hepatic Toxicity ◽  
Liver Necrosis ◽  
Oxide Formation ◽  
Eupatorium Japonicum

The oral LD50 of Crotalaria assamica, which contains mainly monocrotaline, was found to be 154 mg/kg in mice. Neither liver necrosis nor morbidity was demonstrated with Eupatorium extract at a dose level of 144 mg/kg, which was equivalent to the LD20 of Crotalaria. Pretreatment with phenobarbitone enhanced the toxicity of both plant extracts in mice. In in vitro studies, "metabolic pyrrole" was formed by incubating Eupatorium japonicum extracts with liver microsomes. The rate of "pyrrole" formation was similar to that of Crotalaria extract and pure monocrotaline alkaloid, but was much slower than retrorsine. The rate of N-oxide formation was, in descending order, retrorsine, Eupatorium japonicum and Crotalaria/monocrotaline. It is concluded that the alkaloid in Eupatorium species is metabolized to "pyrrole" and an N-oxide metabolite in the liver, but hepatotoxicity is much lower when compared with that caused by Crotalaria.

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