scholarly journals CHARACTERISTICS OF THE QUALITATIVE COMPOSITION OF PATHOGENS AND EMPIRICAL ANTIBACTERIAL THERAPY IN PATIENTS WITH ILEO-PELVIC PHLEGMONS

2021 ◽  
pp. 105-105
Author(s):  
K.I. Popandopulo ◽  
A.Y. Korovin ◽  
E.E. Porodenko ◽  
S.B. Bazlov ◽  
O.V. Cherneva ◽  
...  
Keyword(s):  
Antibacterial Therapy ◽  
Qualitative Composition ◽  
Empirical Antibacterial Therapy

scholarly journals Biomarkers for Sepsis

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Cesar Henriquez-Camacho ◽  
Juan Losa
Keyword(s):  
Antibacterial Therapy ◽  
Respiratory Infections ◽  
Bloodstream Infections ◽  
Signs And Symptoms ◽  
Antibiotic Consumption ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Inflammatory Conditions ◽  
Empirical Antibacterial Therapy ◽  
New Biomarkers

Bloodstream infections are a major concern because of high levels of antibiotic consumption and of the increasing prevalence of antimicrobial resistance. Bacteraemia is identified in a small percentage of patients with signs and symptoms of sepsis. Biomarkers are widely used in clinical practice and they are useful for monitoring the infectious process. Procalcitonin (PCT) and C-reactive protein (CRP) have been most widely used, but even these have limited abilities to distinguish sepsis from other inflammatory conditions or to predict outcome. PCT has been used to guide empirical antibacterial therapy in patients with respiratory infections and help to determine if antibacterial therapy can be stopped. New biomarkers such as those in this review will discuss the major types of biomarkers of bloodstream infections/sepsis, including soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), soluble urokinase-type plasminogen receptor (suPAR), proadrenomedullin (ProADM), and presepsin.

scholarly journals Optimization of starting empirical antibacterial therapy in patients with HIV infection – specialized hospital patients

2019 ◽  
Vol 11 (2) ◽  
pp. 97-106
Author(s):  
S. I. Dvorak ◽  
D. A. Gusev ◽  
T. N. Suborova ◽  
N. G. Zakharova ◽  
N. V. Sizova ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Antibiotic Therapy ◽  
Antibacterial Therapy ◽  
Empirical Therapy ◽  
Risk Groups ◽  
Infectious Complications ◽  
Empirical Antibiotic Therapy ◽  
Multiresistant Pathogens ◽  
Specialized Hospital ◽  
Empirical Antibacterial Therapy

Objective: to analyze the adequacy of the scheme of empirical antibiotic therapy in patients with complicated forms of HIV infection in a specialized hospital and propose a set of measures for its optimization.Materials and methods: Clinical and demographic characteristics, results of bacteriological studies, risk factors of infection with resistant and multiresistant pathogens were studied in patients with HIV infection at the stage of progression with infectious complications of bacterial etiology, and the adequacy of empirical antibiotic therapy was evaluated. Results: The analysis of bacterial infectious complications in 21 HIV-infected patients with advanced stages of the disease was carried out. It was established that the profiles of the starting ABT only in 47% of cases coincide with the results of the antibiogram. To increase the effectiveness of empirical antibacterial therapy, stratification of risk groups for the detection of multiresistant bacterial pathogens has been developed. The basis of stratification: the severity of immunodeficiency, the presence of previously conducted antibacterial therapy, the period and place of detection of infectious complications, the localization of the infectious process.Conclusion: the use in clinical practice of a differentiated approach to the appointment of antibacterial drugs for starting empirical therapy in patients with HIV infection can improve the quality of treatment of infectious complications in patients with immunosuppression.

scholarly journals Empirical antibacterial therapy in febrile, granulocytopenic bone marrow transplant patients.

1984 ◽  
Vol 26 (2) ◽  
pp. 136-138 ◽  
Author(s):  
P K Peterson ◽  
P McGlave ◽  
N K Ramsay ◽  
F Rhame ◽  
A I Goldman ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplant ◽  
Antibacterial Therapy ◽  
Marrow Transplant ◽  
Transplant Patients ◽  
Empirical Antibacterial Therapy

scholarly journals Regional Features of the Course of Pneumonia at the Present Stage

2020 ◽  
Vol 65 (1-2) ◽  
pp. 33-37
Author(s):  
F. A. Kuchmezova ◽  
M. Ya. Shabatukova ◽  
R. M. Aramisova ◽  
Z. A. Kambachokova ◽  
I. Kh. Borukaeva ◽  
...  
Keyword(s):  
Antibacterial Therapy ◽  
Community Acquired Pneumonia ◽  
Age Group ◽  
Present Stage ◽  
The Real ◽  
Regional Features ◽  
Empirical Antibacterial Therapy ◽  
Real Picture

The article discusses the regional features of the diagnosis, course, and treatment of community-acquired pneumonia (CAP). The cohort of patients with CAP was dominated by males in the age group of 70 years or older, who had many concomitant diseases. Staphylococcal flora was found to be the main pathogen. Empirical antibacterial therapy was mainly carried out, which does not always correspond to the real picture of the microflora of the patient.

Monocytosis in rational empirical antibacterial therapy in moderate forms of COVID-19

2021 ◽  
Vol 2 (3(5)) ◽  
pp. 35-40
Author(s):  
A.V. Kovalev ◽  
◽  
M.I. Shperling ◽  
A.S. Polyakov ◽  
Ya.А. Nоskov ◽  
...  
Keyword(s):  
Antibacterial Therapy ◽  
Blood Cells ◽  
White Blood Cells ◽  
Absolute Number ◽  
Glucocorticoid Therapy ◽  
Control Group ◽  
Blood Monocytes ◽  
Significant Difference ◽  
Empirical Antibacterial Therapy ◽  
The Absolute

Microbiologically confirmed bacterial co-infection occurs in 1.2%–7% of hospitalized patients with COVID-19. The study of rational approaches to empirical antibacterial therapy (ABT) of SARS-CoV-2 virus-induced pneumonia continues. Glucocorticoid (GCS) therapy, the main method for pathogenetic treatment of moderate forms of CОVID-19, can lead to the development of neutrophilic leukocytosis. The criterion for the differential diagnosis of leukocytosis could be determining the quantity of peripheral blood monocytes. Assessing the significance of identifying the monocyte quantity can serve as an additional criterion for assigning empirical ABT in the treatment of pneumonia caused by the new coronavirus infection. The aim of the study was to identify the characteristics of glucocorticoid-induced leukocytosis in patients with moderate COVID-19. The study included 86 patients with a confirmed diagnosis of COVID-19 (ICD codes: U07.1, U07.2) of moderate severity. The patients were divided into 2 groups. The comparison group consisted of 40 patients who were prescribed ABT after the manifestation of leukocytosis on the background of glucocorticoid therapy. The control group included 46 people who were not prescribed ABT after the manifestation of leukocytosis on the background of glucocorticoid therapy and until the end of their stay in the hospital. We compared the parameters of the clinical blood tests (the absolute number of white blood cells, neutrophils and monocytes (×109/L)) on days 3, 6 and 9 from the start of GCS therapy. As a result, on the 3rd day, both groups had neutrophilic leukocytosis (>9.0×109/L) and absolute monocytosis (>0.8×109/L). There was a statistically signif icant decrease in the absolute number of white blood cells, neutrophils and monocytes by days 6 and 9, compared with day 3 from the start of glucocorticoid therapy. When comparing blood parameters between the groups, there was no statistically significant difference in the number of cells on the 3rd, 6th and 9th day of GCS therapy (p>0.05). Glucocorticoid-induced leukocytosis is associated with absolute monocytosis. The administration of ABT in response to the occurrence of leukocytosis in this study did not affect the change in the level of white blood cells. At the same time, a likely factor in reducing these indicators was a decrease in the daily dosage of corticosteroids.

Sign in / Sign up

Export Citation Format

Share Document