scholarly journals RESPONSE TO CHEMOTHERAPY IN BREAST CANCER PATIENTS MAY DEPEND NOT ONLY ON TUMOR BIOLOGICAL SUBTYPE, BUT ALSO ON PATIENT’S HORMONAL STATUS

2020 ◽  
pp. 86-86
Author(s):  
V.A. Bandovkina ◽  
E.M. Frantsiyants ◽  
N.D. Cheryarina ◽  
N.Yu. Samaneva ◽  
L.Yu. Vladimirova ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Hormonal Status ◽  
Breast Cancer Patients ◽  
Response To Chemotherapy ◽  
Biological Subtype

scholarly journals Association between the nucleosome footprint of plasma DNA and neoadjuvant chemotherapy response for breast cancer

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Xu Yang ◽  
Geng-Xi Cai ◽  
Bo-Wei Han ◽  
Zhi-Wei Guo ◽  
Ying-Song Wu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Neoadjuvant Chemotherapy ◽  
Cancer Patients ◽  
Cell Receptor ◽  
Chemotherapy Response ◽  
Breast Cancer Patients ◽  
Plasma Dna ◽  
Transcription Start Sites ◽  
Response To Chemotherapy

AbstractGene expression signatures have been used to predict the outcome of chemotherapy for breast cancer. The nucleosome footprint of cell-free DNA (cfDNA) carries gene expression information of the original tissues and thus may be used to predict the response to chemotherapy. Here we carried out the nucleosome positioning on cfDNA from 85 breast cancer patients and 85 healthy individuals and two cancer cell lines T-47D and MDA-MB-231 using low-coverage whole-genome sequencing (LCWGS) method. The patients showed distinct nucleosome footprints at Transcription Start Sites (TSSs) compared with normal donors. In order to identify the footprints of cfDNA corresponding with the responses to neoadjuvant chemotherapy in patients, we mapped on nucleosome positions on cfDNA of patients with different responses: responders (pretreatment, n = 28; post-1 cycle, post-3/4 cycles, and post-8 cycles of treatment, n = 12) and nonresponders (pretreatment, n = 10; post-1 cycle, post-3/4 cycles, and post-8 cycles of treatment, n = 10). The coverage depth near TSSs in plasma cfDNA differed significantly between responders and nonresponders at pretreatment, and also after neoadjuvant chemotherapy treatment cycles. We identified 232 TSSs with differential footprints at pretreatment and 321 after treatment and found enrichment in Gene Ontology terms such as cell growth inhibition, tumor suppressor, necrotic cell death, acute inflammatory response, T cell receptor signaling pathway, and positive regulation of vascular endothelial growth factor production. These results suggest that cfDNA nucleosome footprints may be used to predict the efficacy of neoadjuvant chemotherapy for breast cancer patients and thus may provide help in decision making for individual patients.

CK-19 Expression by RT-PCR in the Peripheral Blood of Breast Cancer Patients Correlates with Response to Chemotherapy

2001 ◽  
Vol 66 (3) ◽  
pp. 249-254 ◽  
Author(s):  
Ana Rita Manhani ◽  
Reinaldo Manhani ◽  
Heloisa P. Soares ◽  
Israel Bendit ◽  
Fabiana Lopes ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Peripheral Blood ◽  
Breast Cancer Patients ◽  
Rt Pcr ◽  
Response To Chemotherapy

scholarly journals ABCB1 gene polymorphisms and response to chemotherapy in breast cancer patients: A meta-analysis

2017 ◽  
Vol 26 (4) ◽  
pp. 473-482 ◽  
Author(s):  
Adela Madrid-Paredes ◽  
Marisa Cañadas-Garre ◽  
Antonio Sánchez-Pozo ◽  
Manuela Expósito-Ruiz ◽  
Miguel Ángel Calleja-Hernández
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Breast Cancer Patients ◽  
Abcb1 Gene ◽  
Response To Chemotherapy

scholarly journals Biological subtype predicts locoregional recurrence after postmastectomy radiotherapy in Chinese breast cancer patients

2020 ◽  
Vol 9 (7) ◽  
pp. 2427-2434
Author(s):  
Jiangfeng Wang ◽  
Jurui Luo ◽  
Kairui Jin ◽  
Xuanyi Wang ◽  
Zhaozhi Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Locoregional Recurrence ◽  
Breast Cancer Patients ◽  
Postmastectomy Radiotherapy ◽  
Biological Subtype

scholarly journals MRP1 but Not MDR1 Is Associated with Response to Neoadjuvant Chemotherapy in Breast Cancer Patients

2013 ◽  
Vol 34 (6) ◽  
pp. 387-393 ◽  
Author(s):  
Mohsen Taheri ◽  
Frouzandeh Mahjoubi
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance ◽  
Neoadjuvant Chemotherapy ◽  
Cancer Patients ◽  
Histological Grade ◽  
Chemotherapeutic Agents ◽  
Response To Treatment ◽  
Breast Cancer Patients ◽  
Response To Chemotherapy ◽  
Mrp1 Expression

A major problem in the treatment of breast cancer is the development of resistance to chemotherapeutic agents. Although the role of multidrug resistance 1 (MDR1) and multidrug resistance associated protein 1 (MRP1) in inducing drug resistance in many cancers has been widely investigated the clinical significance of expression of these genes in breast cancer remains unclear and the data is still controversial. We investigated the expression of MDR1 and MRP1 in breast cancer patients as well as the possible correlation between MDR1 and MRP1 and clinical response to chemotherapy. In the present study, MDR1 and MRP1 gene expression were investigated by real time reverse transcription polymerase chain reaction (RT-PCR) assay in 54 breast cancer tumors and in corresponding adjacent normal tissues before neoadjuvant chemotherapy. The expression level of MDR1 and MRP1 were significantly higher in breast tumors than normal breast tissues. Although a significant relationship was found between the MRP1 expression and response to treatment no association was observed between MDR1 expression and response to treatment. MDR1 and MRP1 expression levels have been shown to be independent of tumor size, histological grade and the status of progesterone or estrogen receptor.

scholarly journals Correlation of the molecular biological subtype of primary tumor and regional metastases in breast cancer patients

2020 ◽  
Vol 9 (2) ◽  
pp. 33-39
Author(s):  
Yu.A. Dergunova ◽  
◽  
V.V. Rodionov ◽  
L.M. Mikhaleva ◽  
V.V. Kometova ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Primary Tumor ◽  
Breast Cancer Patients ◽  
Regional Metastases ◽  
Biological Subtype
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