scholarly journals GENETIC POLYMORPHISM OF BREAST CANCER IN KYRGYZ POPULATION

2020 ◽  
pp. 71-71
Author(s):  
kyzy Semetei ◽  
Z.T. Isakova ◽  
E.K. Makimbetov ◽  
I.O. Kudaybergenova ◽  
Z.P. Kamarli
Keyword(s):  
Breast Cancer ◽  
Genetic Polymorphism ◽  
Kyrgyz Population

Genetic polymorphism of manganese superoxide dismutase (MnSOD) and breast cancer susceptibility

2004 ◽  
Vol 23 (1) ◽  
pp. 73-76 ◽  
Author(s):  
Neslihan Ayg�n Kocaba? ◽  
Semra ?arda? ◽  
Suzanne Cholerton ◽  
Ann K. Daly ◽  
Atilla H. Elhan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Superoxide Dismutase ◽  
Genetic Polymorphism ◽  
Manganese Superoxide Dismutase ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Manganese Superoxide

scholarly journals Genetic polymorphism of miRNA-196a and its target gene annexin-A1 expression based on ethnicity in Pakistani female breast cancer patients

2019 ◽  
Vol 35 (6) ◽  
Author(s):  
Amena Rahim ◽  
Muhammad Afzal ◽  
Abdul Khaliq Naveed
Keyword(s):  
Breast Cancer ◽  
Genetic Polymorphism ◽  
Breast Cancer Risk ◽  
Protein Expression ◽  
Cancer Patients ◽  
Target Gene ◽  
Female Breast Cancer ◽  
Annexin A1 ◽  
Breast Cancer Patients ◽  
Female Breast

Objective: To evaluate the association of miR-196a rs11614913 C/T genetic variation and its target gene annexin A1 mRNA expression with breast cancer risk in Pakistani female ethnicities. Methods: This case control study, conducted from March 2017 to November 2018 included 295 breast cancer patients, 295 controls of three Pakistani ethnicities and archived 100 samples of cohort group for genotyping and expression profiling. Genotyping of miR-196a (rs11614913 C/T) was done by ARMS PCR technique. Annexin-A1 (ANXA1) mRNA expression was measured with qRT-PCR and detection of protein expression of ANXA1 was done by immunohistochemistry. Results: CC homozygous genotype of miR-196a rs11614913 was present in 81.4% of cases and 73.9% controls. C/T polymorphism was found to be significantly associated with decrease risk of breast cancer (OR=0.25 (0.11- 0.58, p <0.05). Similar trend was seen with the minor T allele (OR=0.55 (0.39-0.77, p <0.05, and both dominant and recessive models (OR=0.64; p=0.02 and OR=0.26, p=0.00). In the KPK ethnic group significant decrease association with breast cancer risk was observed (OR= 0.22 (0.09-0.53, p < 0.05). Immunohistochemical staining showed loss of ANXA1 protein expression in 72 samples, and significant association was observed with pathological type p=0. 00 and triple negative receptor status p=0.03 and with genotypes of miR-196a p=0.00. Increase relative expression of 2.81± .88 by qPCR analysis of ANXA1 mRNA was noted with TT genotype. Conclusions: Our results demonstrate that miR-196a rs11614913 C/T polymorphism is associated with a decreased risk and loss of protein expression in breast cancer in the Pakistani population. doi: https://doi.org/10.12669/pjms.35.6.1322 How to cite this:Rahim A, Afzal M, Naveed AK. Genetic polymorphism of miRNA-196a and its target gene annexin-A1 expression based on ethnicity in Pakistani female breast cancer patients. Pak J Med Sci. 2019;35(6):1598-1604. doi: https://doi.org/10.12669/pjms.35.6.1322 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Genetic Polymorphism of SUMO-Specific Cysteine Proteases − SENP1 and SENP2 in Breast Cancer

2016 ◽  
Vol 22 (4) ◽  
pp. 817-823 ◽  
Author(s):  
Alicja Mirecka ◽  
Zbigniew Morawiec ◽  
Katarzyna Wozniak
Keyword(s):  
Breast Cancer ◽  
Genetic Polymorphism ◽  
Cysteine Proteases

scholarly journals Impacts of RETN genetic polymorphism on breast cancer development

2020 ◽  
Vol 11 (10) ◽  
pp. 2769-2777 ◽  
Author(s):  
Chao-Qun Wang ◽  
Chih-Hsin Tang ◽  
Huey-En Tzeng ◽  
Lulu Jin ◽  
Jin Zhao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Genetic Polymorphism ◽  
Cancer Development ◽  
Breast Cancer Development

Interleukin 7 receptor alpha Thr244Ile genetic polymorphism is associated with susceptibility and prognostic markers in breast cancer subgroups

Cytokine ◽  
2018 ◽  
Vol 103 ◽  
pp. 121-126 ◽  
Author(s):  
Glauco Akelinghton Freire Vitiello ◽  
Roberta Losi Guembarovski ◽  
Marla Karine Amarante ◽  
Jesus Roberto Ceribelli ◽  
Elaine Cristina Baraldi Carmelo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Genetic Polymorphism ◽  
Prognostic Markers ◽  
Receptor Alpha ◽  
Interleukin 7

scholarly journals Genetic polymorphism of calcium-sensing receptor in women with breast cancer

2018 ◽  
Vol 35 (3) ◽  
Author(s):  
Larysse Maira Campos-Verdes ◽  
João Paulo da Silva-Sampaio ◽  
Danylo Rafhael Costa-Silva ◽  
Victor Alves de Oliveira ◽  
Airton Mendes Conde Junior ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Genetic Polymorphism ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing
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