scholarly journals THE EXPRESSION ACTIVITY OF PROTEIN KINASE MΖ IN PILOCYTIC ASTROCYTOMAS CORRELATES WITH THE PROGNOSIS OF THE DISEASE

2019 ◽  
Author(s):  
P.V. Nikitin ◽  
M.V. Ryzhova ◽  
M.A. Muradyan ◽  
S.A. Galstyan ◽  
I.V. Zubova
Keyword(s):  
Protein Kinase ◽  
Pilocytic Astrocytomas ◽  
Expression Activity ◽  
Protein Kinase Mζ

scholarly journals Overexpression of protein kinase Mζ in the hippocampal dentate gyrus rescues amyloid-β-induced synaptic dysfunction within entorhinal-hippocampal circuit

2021 ◽  
Vol 101 ◽  
pp. 160-171
Author(s):  
Shayan Aliakbari ◽  
Mohammad Sayyah ◽  
Hadi Mirzapourdelavar ◽  
Niloufar Amini ◽  
Naser Naghdi ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Dentate Gyrus ◽  
Amyloid Β ◽  
Synaptic Dysfunction ◽  
Hippocampal Dentate Gyrus ◽  
Protein Kinase Mζ

scholarly journals Dendritic Transport and Localization of Protein Kinase Mζ mRNA

2004 ◽  
Vol 279 (50) ◽  
pp. 52613-52622 ◽  
Author(s):  
Ilham Aliagaevich Muslimov ◽  
Volker Nimmrich ◽  
Alejandro Ivan Hernandez ◽  
Andrew Tcherepanov ◽  
Todd Charlton Sacktor ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Translational Control ◽  
Untranslated Region ◽  
Functional Integration ◽  
Long Term Potentiation ◽  
Memory Storage ◽  
Reading Frame ◽  
Cis Acting ◽  
Translational Repressor ◽  
Protein Kinase Mζ

Protein kinase Mζ (PKMζ) is an atypical protein kinase C isoform that has been implicated in the protein synthesis-dependent maintenance of long term potentiation and memory storage in the brain. Synapse-associated kinases are uniquely positioned to promote enduring consolidation of structural and functional modifications at the synapse, provided that kinase mRNA is available on site for local input-specific translation. We now report that the mRNA encoding PKMζ is rapidly transported and specifically localized to synaptodendritic neuronal domains. Transport of PKMζ mRNA is specified by two cis-acting dendritic targeting elements (Mζ DTEs). Mζ DTE1, located at the interface of the 5′-untranslated region and the open reading frame, directs somato-dendritic export of the mRNA. Mζ DTE2, in contrast, is located in the 3′-untranslated region and is required for delivery of the mRNA to distal dendritic segments. Colocalization with translational repressor BC1 RNA in hippocampal dendrites suggests that PKMζ mRNA may be subject to translational control in local domains. Dendritic localization of PKMζ mRNA provides a molecular basis for the functional integration of synaptic signal transduction and translational control pathways.

Overexpression of protein kinase Mζ in the hippocampus mitigates Alzheimer’s disease-related cognitive deficit in rats

2021 ◽  
Vol 166 ◽  
pp. 64-72
Author(s):  
Niloufar Amini ◽  
Reza Roosta Azad ◽  
Fereshteh Motamedi ◽  
Hadi Mirzapour-Delavar ◽  
Soheil Ghasemi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Protein Kinase ◽  
Cognitive Deficit ◽  
Protein Kinase Mζ

Protein kinase Mζ in medial prefrontal cortex mediates depressive-like behavior and antidepressant response

2017 ◽  
Vol 23 (9) ◽  
pp. 1878-1891 ◽  
Author(s):  
W Yan ◽  
J-F Liu ◽  
Y Han ◽  
W Zhang ◽  
Y-X Luo ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Protein Kinase ◽  
Medial Prefrontal Cortex ◽  
Antidepressant Response ◽  
Protein Kinase Mζ

Protein Kinase Mζ Is Necessary for Cocaine-Induced Synaptic Potentiation in the Ventral Tegmental Area

2012 ◽  
Vol 71 (8) ◽  
pp. 706-713 ◽  
Author(s):  
Shih-Yin Ho ◽  
Chih-Hao Chen ◽  
Tsung-Han Liu ◽  
Hsiao-Fu Chang ◽  
Jau-Cheng Liou
Keyword(s):  
Protein Kinase ◽  
Ventral Tegmental Area ◽  
Synaptic Potentiation ◽  
Ventral Tegmental ◽  
Protein Kinase Mζ

scholarly journals Upstream Open Reading Frames Located in the Leader of Protein Kinase Mζ mRNA Regulate Its Translation

2016 ◽  
Vol 9 ◽  
Author(s):  
Natalia V. Bal ◽  
Denis Susorov ◽  
Ekaterina Chesnokova ◽  
Artem Kasianov ◽  
Tatiana Mikhailova ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Open Reading Frames ◽  
Upstream Open Reading Frames ◽  
Protein Kinase Mζ ◽  
Reading Frames
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