scholarly journals A NEW METHOD FOR THE DIAGNOSIS OF DISSEMINATED INTRAVASCULAR COAGULATION AND ITS APPLICATION FOR PATIENTS IN ANESTHESIA-RESUSCITATION AND INTENSIVE CARE UNITS

2018 ◽  
Author(s):  
G.S. Stolyarov ◽  
O.V. Minaeva ◽  
I.V. Saushev ◽  
S.Yu. Strulkova ◽  
N.A. Pyataev
Keyword(s):  
Intensive Care ◽  
Intensive Care Units ◽  
Disseminated Intravascular Coagulation ◽  
New Method ◽  
Intravascular Coagulation

Presepsin (sCD14-ST) as a biomarker of sepsis in clinical practice and in emergency department: a mini review

2015 ◽  
Vol 39 (6) ◽  
Author(s):  
Ali Kemal Erenler ◽  
Turker Yardan
Keyword(s):  
Emergency Department ◽  
Critical Care ◽  
Intensive Care ◽  
Clinical Practice ◽  
Intensive Care Units ◽  
Disseminated Intravascular Coagulation ◽  
Kidney Failure ◽  
Protein Complexes ◽  
Intravascular Coagulation ◽  
Lps Binding

AbstractPresepsin is a 13-kDa protein that is a fragment of CD14 with truncated N-terminal, the receptor for lipopolysaccharide (LPS)/LPS-binding protein complexes. It is a novel marker being sought in many diseases such as sepsis, kidney failure, disseminated intravascular coagulation, etc. In this review, we aimed to clarify its utility in critical diseases and availability in critical care settings such as emergency departments and intensive care units.

Biomarkers of disseminated intravascular coagulation in pediatric intensive care unit in Thailand

2018 ◽  
Vol 41 (1) ◽  
pp. 32-38
Author(s):  
Wiralpat Padungmaneesub ◽  
Sanit Reungrongrat ◽  
Suphara Manowong ◽  
Kanda Fanhchaksai ◽  
Noppamas Panyasit ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Pediatric Intensive Care Unit ◽  
Disseminated Intravascular Coagulation ◽  
Pediatric Intensive Care ◽  
Intravascular Coagulation

scholarly journals Endotoxins and Anti-endotoxins (Their Relevance to the Anaesthetist and the Intensive Care Specialist)

1989 ◽  
Vol 17 (1) ◽  
pp. 49-55 ◽  
Author(s):  
J. G. Brock-Utne ◽  
S. L. Gaffin
Keyword(s):  
Intensive Care ◽  
Organ Failure ◽  
Disseminated Intravascular Coagulation ◽  
Systemic Circulation ◽  
Toxic Effects ◽  
Gram Negative Bacteria ◽  
Intestinal Ischaemia ◽  
Gram Negative ◽  
Intravascular Coagulation ◽  
Care Specialist

Endotoxins (lipopolysaccharides, LPS) are potent bacterial poisons always present within the intestines in considerable amounts. Several pathophysiological conditions such as hypovolaemia, hypoxia, intestinal ischaemia, burns and radiation lead to a breakdown in the barrier and depending upon the extent of the injury, endotoxins enter the systemic circulation in increasing amounts. Antibiotics do not inactivate the endotoxins which continue to exert their toxic effects leading to nausea, vomiting, diarrhoea, fever, disseminated intravascular coagulation, vascular collapse and organ failure. When nonabsorbable antibiotics are given prior to the insult, systemic endotoxaemia is prevented. Immunotherapy, using anti-lipopolysaccharide IgG, inactivates plasma endotoxins, destroys gram-negative bacteria and opsonises them and may become a major form of therapy. An outline of endotoxin and anti-lipopolysaccharide and its importance to the anaesthetist and intensive care specialist is presented.

Studies on the Purification and Characterization of Human Urinary Plasminogen and Plasmin

1979 ◽  
Vol 42 (05) ◽  
pp. 1536-1547
Author(s):  
Hsin Fu Chen ◽  
Masao Nakabayashi ◽  
Kazuo Satoh ◽  
Shoichi Sakamoto
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Gel Electrophoresis ◽  
Specific Activity ◽  
Gel Filtration ◽  
New Method ◽  
Chronic Glomerulonephritis ◽  
Purification And Characterization ◽  
Intravascular Coagulation ◽  
Human Plasminogen

SummaryA new method is described for the preparation of highly purified human plasminogen and plasmin with specific activity of 32 CTA units per mg of protein. With this method, the purification of the urinary plasminogen + plasmin antigenic materials from patients with chronic glomerulonephritis, disseminated intravascular coagulation syndrome and severe toxemia of pregnancy was performed, and the resulting highly purified proenzyme and enzyme were analyzed by immunoelectrophoresis, separative agar electrophoresis, gel filtration and SDS-gel electrophoresis.Our findings indicated that urinary plasmin reflects more closely the extent of intraglomerular fibrinolysis, while urinary plasminogen reflects non-selective proteinuria in patients with chronic glomerulonephritis or severe toxemia of pregnancy.

scholarly journals DIAGNOSTIC CRITERIA FOR DISSEMINATED INTRAVASCULAR COAGULATION SYNDROME AND SEPSIS-INDUCED COAGULOPATHY

2021 ◽  
pp. 25-38
Author(s):  
S. O. Tarasenko ◽  
S. O. Dubrov ◽  
G. G. Suslov
Keyword(s):  
Intensive Care ◽  
Clinical Practice ◽  
Disseminated Intravascular Coagulation ◽  
Thrombus Formation ◽  
Clinical Manifestations ◽  
Underlying Disease ◽  
Multiple Organ ◽  
Review Of The Literature ◽  
Intravascular Coagulation ◽  
Current State

The clinical manifestations of disseminated intravascular coagulation syndrome (DIC) depend on the predominance of the sum of the vectors of hypercoagulation and hyperfibrinolysis and are strongly associated with the underlying disease, against which DIC is formed. The issue of understanding the complex pathogenesis, timely diagnosis of overt DIC and early manifestations of DIC remain an urgent challenge for intensive care physicians and leading specialized societies to study the problems of hemostasis and thrombus formation. This review of the literature analyzes the pathways of DIC development, the current state of the possibility of using diagnostic markers to detect DIC, especially in sepsis. The diagnosis of sepsis-induced coagulopathy against the background of the development of multiple organ failure is highlighted as a separate issue. Diagnostic scales are presented in the form of comparative tables for a more convenient perception of information, memorization and further implementation in clinical practice.

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