scholarly journals POLYMORPHISMS OF CIRCADIAN GENES AS A FACTOR OF SCHIZOPHRENIA DEVELOPMENT

2021 ◽  
pp. 3-3
Author(s):  
K.V. Mekhantseva
Keyword(s):  
Circadian Genes

Network of co-expressed circadian genes, childhood maltreatment and sleep quality in bipolar disorders

2021 ◽  
pp. 1-8
Author(s):  
D. Grillault Laroche ◽  
E. Curis ◽  
F. Bellivier ◽  
C. Nepost ◽  
G. Gross ◽  
...  
Keyword(s):  
Sleep Quality ◽  
Childhood Maltreatment ◽  
Bipolar Disorders ◽  
Circadian Genes

PEPTIDE REGULATES HUMAN CIRCADIAN RHYTHMS GENES EXPRESSION DURING PINEAL GLAND ACCELERATED AGING

2020 ◽  
pp. 429-435
Author(s):  
О. М. Ивко ◽  
Н. С. Линькова ◽  
А. Р. Ильина ◽  
А. А. Шарова ◽  
Г. А. Рыжак
Keyword(s):  
Circadian Rhythms ◽  
Pineal Gland ◽  
Circadian Clock ◽  
Peripheral Blood ◽  
Accelerated Aging ◽  
Peripheral Blood Lymphocytes ◽  
Circadian Genes ◽  
Blood Lymphocytes ◽  
Aged People ◽  
Genes Expression

Ночная работа приводит к десинхронизации биоритмов, нарушению мелатонинобразующей функции и ускоренному старению эпифиза человека. Одним из перспективных геропротекторов, восстанавливающих синтез эпифизарного мелатонина, является пептид AEDG ( Ala-Glu-Asp-Gly ). Последний в 1,7 раза повышает экскрецию 6-сульфатоксимелатонина в моче людей среднего возраста, у которых этот показатель исходно снижен. Кроме того, у людей со сниженной мелатонинобразующей функцией эпифиза, пептид AEDG нормализует повышенную экспрессию циркадных генов Clock и Csnk 1 e в лейкоцитах и в 2 раза повышает сниженную экспрессию гена Cry 2 в лимфоцитах крови. В основе геропротекторного эффекта пептида AEDG лежит его способность восстанавливать мелатонинобразующую функцию эпифиза через регуляцию экспрессии часовых генов человека. Night work provides biorhythms desynchronization, disorder of melatonin-producing function and accelerated pineal gland aging. One of the promising geroprotectors restoring the pineal melatonin synthesis is the AEDG ( Ala-Glu-Asp-Gly ) peptide. AEDG peptide increases in 1,7 times the 6-sulfatoxymelatonin (6-SOMT) excretion in the urine of middle-aged people. Moreover, AEDG peptide normalized circadian Clock and Csnk1e genes hyper expression in leukocytes in 1,9-2,1 times and increases the Cry 2 gene hypo expression in peripheral blood lymphocytes in 2 times in people with reduced melatonin-producing epiphysis function. The geroprotective effect of the AEDG peptide is based on its ability to restore the epiphysis melatonin-producing function by means regulation of human circadian genes expression.

scholarly journals Circadian Rhythms, the Mesolimbic Dopaminergic Circuit, and Drug Addiction

2007 ◽  
Vol 7 ◽  
pp. 194-202 ◽  
Author(s):  
Colleen A. McClung
Keyword(s):  
Circadian Rhythms ◽  
Drug Addiction ◽  
Molecular Mechanisms ◽  
Dopaminergic System ◽  
Treatment Options ◽  
Drug Induced ◽  
Circadian Genes ◽  
Dopaminergic Transmission ◽  
Central Pacemaker

Drug addiction is a devastating disease that affects millions of individuals worldwide. Through better understanding of the genetic variations that create a vulnerability for addiction and the molecular mechanisms that underlie the progression of addiction, better treatment options can be created for those that suffer from this condition. Recent studies point to a link between abnormal or disrupted circadian rhythms and the development of addiction. In addition, studies suggest a role for specific genes that make up the molecular clock in the regulation of drug sensitivity, sensitization, and reward. The influence of circadian genes and rhythms on drug-induced behaviors may be mediated through the mesolimbic dopaminergic system. This system has long been implicated in the development of addiction, and recent evidence supports a regulatory role for the brain's central pacemaker and circadian gene expression in the regulation of dopaminergic transmission. This review highlights the association between circadian genes and drug addiction, and the possible role of the mesolimbic dopaminergic system in this association.

The Dietary Polyphenol Metabolite Enterolactone Activates Estrogen Signaling in Reproductive and Non-Reproductive Tissues and Regulates the Expression of Circadian Genes in Mice

2011 ◽  
pp. OR34-3-OR34-3
Author(s):  
Pauliina Damdimopoulou ◽  
Tarja Nurmi ◽  
Anu Salminen ◽  
Maria Yli-Heikkila ◽  
Anastasios E Damdimopoulos ◽  
...  
Keyword(s):  
Estrogen Signaling ◽  
Circadian Genes ◽  
Reproductive Tissues

Circadian Genes: Information and Legal Issues

2019 ◽  
pp. 30-37
Author(s):  
Andrey A. Inyushkin ◽  
Alexey N. Inyushkin ◽  
Valentina D. Ruzanova ◽  
Vladimir I. Belyakov ◽  
Elena S. Kryukova
Keyword(s):  
Legal Issues ◽  
Circadian Genes

scholarly journals Circadian regulation of kidney function: finding a role for Bmal1

2018 ◽  
Vol 314 (5) ◽  
pp. F675-F678 ◽  
Author(s):  
Dingguo Zhang ◽  
David M. Pollock
Keyword(s):  
Kidney Function ◽  
Recent Progress ◽  
The Body ◽  
Renal Physiology ◽  
Pressure Regulation ◽  
Circadian Genes ◽  
Aryl Hydrocarbon ◽  
Circadian Control ◽  
Electrolyte Homeostasis ◽  
Function Finding

Mounting evidence suggests that there is an internal molecular “clock” within the kidney to help maintain normal renal function. Disturbance of the kidney circadian rhythm may pose a threat to water and electrolyte homeostasis and blood pressure regulation, among many other problems. The identification of circadian genes facilitated a more comprehensive appreciation of the importance of “keeping the body on time”; however, our knowledge is very limited with regard to how circadian genes regulate kidney function. In this brief review, we summarize recent progress in circadian control of renal physiology, with a particular focus on aryl hydrocarbon receptor nuclear translocator-like protein (Arntl1; also called Bmal1).

scholarly journals Circadian genes and risk of prostate cancer in the prostate cancer prevention trial

2018 ◽  
Vol 57 (3) ◽  
pp. 462-466 ◽  
Author(s):  
Lisa W. Chu ◽  
Cathee Till ◽  
Baiyu Yang ◽  
Catherine M. Tangen ◽  
Phyllis J. Goodman ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Prevention ◽  
Prevention Trial ◽  
Circadian Genes ◽  
Prostate Cancer Prevention ◽  
Prostate Cancer Prevention Trial
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