scholarly journals THE MAIN RESULTS OF THE USING OF CHEMICAL PLEURODESIS WITH IODPOVIDONE IN THE TREATMENT OF PATIENTS WITH PNEUMOTHORAXIS OF DIFFERENT ETIOLOGY

2021 ◽  
pp. 35-39
Author(s):  
A.A. Egay ◽  
B.Kh. Bebezov ◽  
A.T. Kazakbaev ◽  
A.A. Dvumarov ◽  
A.E. Tentimishev ◽  
...  
Keyword(s):  
Chemical Pleurodesis

scholarly journals Successful management of extremely high-output refractory congenital chylothorax with chemical pleurodesis using 4% povidone-iodine and propranolol: a case report

2018 ◽  
Vol 6 (4) ◽  
pp. 702-708 ◽  
Author(s):  
Kathleen Borcyk ◽  
Ammar Kamil ◽  
Kristine Hagerty ◽  
Melissa Deer ◽  
Paul Tomich ◽  
...  
Keyword(s):  
Case Report ◽  
Povidone Iodine ◽  
Successful Management ◽  
Chemical Pleurodesis ◽  
Congenital Chylothorax ◽  
High Output

scholarly journals Chemical pleurodesis for malignant pleural effusion: which agent is perfect?

2020 ◽  
Vol 28 (1) ◽  
Author(s):  
Mohamed Elshabrawy Saleh ◽  
Gehad Awad ◽  
Mohammed Sanad
Keyword(s):  
Pleural Effusion ◽  
Malignant Pleural Effusion ◽  
Chemical Pleurodesis

scholarly journals Efficacy of mistletoe for chemical pleurodesis in rats without malignancy

Open Medicine ◽  
2015 ◽  
Vol 10 (1) ◽  
Author(s):  
Hyo Yeong Ahn ◽  
Jeong Su Cho ◽  
Yeong Dae Kim ◽  
Hoseok I ◽  
Yeon Ji Kim ◽  
...  
Keyword(s):  
Lavage Fluid ◽  
Giant Cells ◽  
Saline Group ◽  
Large Animal ◽  
Sprague Dawley ◽  
Chemical Pleurodesis ◽  
Pleural Adhesion ◽  
Fluid Analysis ◽  
Significant Difference ◽  
Group B

AbstractChemical pleurodesis is an effective treatment modality to reduce recurrence of malignant effusion. Several agents have been used in chemical pleurodesis but, it is not yet clear which is better. Eighteen Sprague- Dawley rats were used and classified into three groups: a group intrapleurally injected normal saline (group A, n=6), 400mg/kg talc (group B, n=6), and 9mg/kg mistletoe extraction (ME) (group C, n=6). Autopsy was performed to evaluate the pleural adhesion, pathologic examination of pleura and lung and bronchoalveolar lavage fluid analysis 4 weeks after pleurodesis. Both group B and C showed an obvious pleural adhesion and there was no significant difference in grade of pleural adhesion between two groups (p=0.58). The parietal pleural thickness in talc group than ME group was significantly thicker (p=0.002) and the visceral pleura of talc group showed marked foreign body reaction with fibrosis and many multinucleated giant cells associated with talc crystal. This study suggests that pleurodesis using ME in condition without malignancy has comparable effect to pleurodesis using talc. However, additional experimental study in large animal or clinical trials would be required to prove a safety and an efficacy of pleurodesis using ME.

Chemical pleurodesis in the presence of persistent air leak

1989 ◽  
Vol 47 (5) ◽  
pp. 786-787 ◽  
Author(s):  
G.Hossein Almassi ◽  
George B. Haasler
Keyword(s):  
Air Leak ◽  
Chemical Pleurodesis ◽  
Persistent Air Leak

scholarly journals Experience of lodopovidone Pleurodesis at A Tertiary Care Hospital in Peshawar

1969 ◽  
Vol 11 (3) ◽  
pp. 123-127
Author(s):  
Muhammad Umar ◽  
Zia Ul Haq ◽  
Imtiaz Khan ◽  
Anila Basit ◽  
Amin Ul Haq ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Malignant Pleural Effusion ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Efficacy And Safety ◽  
Chemical Pleurodesis ◽  
Effective Agent ◽  
Age Range ◽  
Recurrent Pleural Effusion

Background: Chemical pleurodesis is used for the management of malignant /recurrent pleural effusion and pneumothorax.Malignant pleural effusion is diagnosed on histopathology or malignant cells in pleural fluid. Pneumothorax is diagnosed by chestradiograph. Pleurodesis can be performed surgically or by using medical agents. Various pleurodesis agents have been used e.g.Tetracycline.Bleomycin. Talc and lodopovidone with different success and complications rates.Objective: This study was conducted to know the efficacy and safety of lodopovidone as pleurodesis agent in themanagement of pleural effusion (malignant/recurrent) and recurrent pneumothorax.Material and Methods: This was a descriptive study conducted at department of Pulmonology Lady Reading HospitalPeshawar from February 2018 to May 2019.Results:A Total of 213 patients were included in the study, among which 120 (56.3%) were males and 93 (43.6%) werefemales. Age range was from 20 to 83 years. One hundred and thirty eight patients (74.8%) had malignant pleural effusion and75 (35.2%) had recurrent pneumothorax. The success rate with lodopovidone pleurodesis was 85 % (181) as a whole with afailure rate of 13 %( 28) in pleural effusion and 2 %( 4) in pneumothorax. Chest pain (65.7%) was the most common side effectfollowed by fever (24.4%) and dyspnea (12.2%).No serious side effects were observed in this study.Conclusion: lodopovidone is easily available, safer, cheaper and effective agent for chemical pleurodesis in pneumothorax,malignant/recurrent pleural effusion.Keywords: Pleurodesis, lodopovidone. Malignant, Pleural Effusion, Pneumothorax.

scholarly journals Release of growth factors after mechanical and chemical pleurodesis for treatment of malignant pleural effusion: a randomized control study

2015 ◽  
Vol 49 (4) ◽  
pp. 386-394 ◽  
Author(s):  
Aljaz Hojski ◽  
Maja Leitgeb ◽  
Anton Crnjac
Keyword(s):  
Quality Of Life ◽  
Growth Factors ◽  
Growth Factor ◽  
Pleural Effusion ◽  
Pleural Fluid ◽  
Malignant Pleural Effusion ◽  
Transforming Growth Factor ◽  
Chemical Pleurodesis ◽  
Thoracic Drainage

Abstract Background. Growth factors are key inducers of fibrosis but can also mediate inflammatory responses resulting in increasing pleural effusion and acute respiratory distress syndrome. The primary aim of the study was to analyse growth factors release after performing chemical and mechanical pleurodesis in the first 48 hours at the patients with malignant pleural effusion. The secondary endpoints were to evaluate the effectiveness of the both pleurodeses, symptoms release and the quality of life of patients after the treatment. Patients and methods. A prospective randomized study included 36 consecutive female patients with breast carcinoma and malignant pleural effusion in an intention-to-treat analysis. We treated 18 patients by means of thoracoscopic mechanical pleurodesis and 18 patients by chemical pleurodesis with talcum applied over a chest tube. We gathered the pleural fluid and serum samples in the following 48 hours under a dedicated protocol and tested them for growth factors levels. A quality of life and visual analogue pain score surveys were also performed. Results. Median measured serum vascular endothelial growth factor (VEGF) level after chemical pleurodesis was 930.68 pg/ml (95% CI: 388.22–4656.65) and after mechanical pleurodesis 808.54 pg/ml. (95% CI: 463.20-1235.13) (p = 0.103). Median pleural levels of transforming growth factor (TGF) β1 were higher after performing mechanical pleurodesis (4814.00 pg/ml [95% CI: 2726.51–7292.94]) when compared to those after performing chemical pleurodesis (1976.50 pg/ml [95% CI: 1659.82–5136.26]) (p = 0.078). We observed similar results for fibroblast growth factor (FGF) β; the serum level was higher after mechanical pleurodesis (30.45 pg/ml [95% CI: 20.40–59.42]), compared to those after chemical pleurodesis (13.39 pg/ml [95% CI: 5.04 – 74.60]) (p = 0.076). Mechanical pleurodesis was equally effective as chemical pleurodesis in terms of hospital stay, pleural effusion re-accumulation, requiring of additional thoracentesis, median overall survival, but, it shortened the mean thoracic drainage duration (p = 0.030) and resulted in a higher symptoms release and in a better quality of life (p = 0.047). Conclusions. We recorded an increase in serum VEGF levels after chemical pleurodesis, however on the contrary, an increase in the pleural fluid level of TGFβ1 and FGFβ] after mechanical pleurodesis with respect to compared group. Although the differences did not reach statistical significance, VEGF, TGFβ1 and FGFβ remain the most interesting parameters for future research. Considering the mechanisms of growth factors action, we conclude that in our study group mechanical pleurodesis might be more efficient in terms of growth factors release, thoracic drainage duration and resulted in a higher symptoms release and in a better quality of life than chemical pleurodesis.

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