scholarly journals STUDY OF THE INFLUENCE OF DIFFERENT FACTORS ON TUMOR GROWTH ON A MODEL OF TRANSPLANTED EHRLICH’S MAMMARY GLAND ADENOCARCINOMA

2021 ◽  
pp. 22-29
Author(s):  
L.A. Savluchinskaya ◽  
N.I. Ryzhova ◽  
V.P. Deryagina ◽  
L.V. Krivosheeva ◽  
I.A. Khitrovo
Keyword(s):  
Mammary Gland ◽  
Tumor Growth

Targeting heparanase to the mammary epithelium enhances mammary gland development and promotes tumor growth and metastasis

2018 ◽  
Vol 65 ◽  
pp. 91-103 ◽  
Author(s):  
Ilanit Boyango ◽  
Uri Barash ◽  
Liat Fux ◽  
Inna Naroditsky ◽  
Neta Ilan ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Tumor Growth ◽  
Mammary Gland Development ◽  
Mammary Epithelium ◽  
Tumor Growth And Metastasis ◽  
Gland Development

scholarly journals Baicalin Promotes Mammary Gland Development via Steroid-Like Activities

2021 ◽  
Vol 9 ◽  
Author(s):  
Weizhen Chen ◽  
Wei Wei ◽  
Liya Yu ◽  
Xin Zhang ◽  
Fujing Huang ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Tumor Growth ◽  
Cell Line ◽  
Cancer Progression ◽  
Mammary Gland Development ◽  
Biological Activities ◽  
Xenograft Model ◽  
Mammary Development ◽  
Tumor Xenograft ◽  
Gland Development

Baicalin, the main flavonoid component extracted from Scutellaria roots, has a variety of biological activities and is therefore used in the treatment of many kinds of diseases. However, whether baicalin affects the normal development of tissues and organs is still unclear. Here, using a mouse mammary gland model, we investigated the effects of baicalin on the expansion of mammary stem cells (MaSCs) and mammary development, as well as breast cancer progression. Interestingly, we found that baicalin administration significantly accelerates duct elongation at puberty, and promotes alveolar development and facilitates milk secretion during pregnancy. Furthermore, self-renewal of MaSCs was significantly promoted in the presence of baicalin. Moreover, in a tumor xenograft model, baicalin promoted tumor growth of the MDA-MB-231 cell line, but suppressed tumor growth of the ZR-751 cell line. Mechanistically, baicalin can induce expression of the protein C receptor, while inhibiting the expression of the estrogen receptor. Transcriptome analysis revealed that baicalin is involved in signaling pathways related to mammary gland development, immune response, and cell cycle control. Taken together, our results from comprehensive investigation of the biological activity of baicalin provide a theoretical basis for its rational clinical application.

Effect of Sulpiride on Mammary Tumor Growth

1976 ◽  
Vol 62 (1) ◽  
pp. 123-126 ◽  
Author(s):  
Elsa B. Anton ◽  
Ricardo Rozados
Keyword(s):  
Mammary Gland ◽  
Tumor Growth ◽  
Mammary Tumor ◽  
Prolactin Level ◽  
Subcutaneous Injection ◽  
Mammary Gland Tumor ◽  
Gland Tumor ◽  
Mammary Tumor Growth

The daily subcutaneous injection of sulpiride produced increase tumor growth and decrease of survival in DBA/2 mice bearing a transplanted mammary gland tumor. It is proposed that sulpiride effect may be mediated by the augment of prolactin level in serum.

scholarly journals The amino-terminal oligomerization domain of Angiopoietin-2 affects vascular remodeling, mammary gland tumor growth, and lung metastasis in mice

2020 ◽  
pp. canres.1904.2019
Author(s):  
Emmi Kapiainen ◽  
Minna K. Kihlström ◽  
Riikka Pietilä ◽  
Mika Kaakinen ◽  
Veli-Pekka Ronkainen ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Tumor Growth ◽  
Lung Metastasis ◽  
Vascular Remodeling ◽  
Mammary Gland Tumor ◽  
Gland Tumor ◽  
Amino Terminal ◽  
Angiopoietin 2 ◽  
Oligomerization Domain

Prolyl hydroxylase mediated inhibition of fatty acid synthase to combat tumor growth in mammary gland carcinoma

Breast Cancer ◽  
2016 ◽  
Vol 23 (6) ◽  
pp. 820-829 ◽  
Author(s):  
Manjari Singh ◽  
Uma Devi ◽  
Subhadeep Roy ◽  
Pushpraj S. Gupta ◽  
Shubhini A. Saraf ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Fatty Acid ◽  
Tumor Growth ◽  
Fatty Acid Synthase ◽  
Prolyl Hydroxylase ◽  
Mammary Gland Carcinoma ◽  
Gland Carcinoma

scholarly journals Evaluation of estrogenic potency of a standardized hops extract on mammary gland biology and on MNU-induced mammary tumor growth in rats

2017 ◽  
Vol 174 ◽  
pp. 234-241 ◽  
Author(s):  
Annekathrin M. Keiler ◽  
Dana Macejova ◽  
Birgit M. Dietz ◽  
Judy L. Bolton ◽  
Guido F. Pauli ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Tumor Growth ◽  
Mammary Tumor ◽  
Mammary Tumor Growth ◽  
Mammary Gland Biology

scholarly journals Prolactin gene-disruption arrests mammary gland development and retards T-antigen-induced tumor growth

Oncogene ◽  
2000 ◽  
Vol 19 (8) ◽  
pp. 1077-1084 ◽  
Author(s):  
Archie J Vomachka ◽  
Scott L Pratt ◽  
Jason A Lockefeer ◽  
Nelson D Horseman
Keyword(s):  
Mammary Gland ◽  
Tumor Growth ◽  
Gene Disruption ◽  
Mammary Gland Development ◽  
T Antigen ◽  
Prolactin Gene ◽  
Gland Development
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