scholarly journals Prospective study on radiation dose escalation in the treatment of squamous cell carcinoma of oesophagus with definitive concurrent chemo-radiation using three-dimensional conformal radiation therapy

2019 ◽  
Vol 7 (5) ◽  
pp. 348-356
Author(s):  
Dr Ashwini L. ◽  
◽  
Dr. Pradeep Kumar Kn ◽  
Dr. Pavithran K. ◽  
Dr. Ragavendra H. ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Radiation Therapy ◽  
Radiation Dose ◽  
Prospective Study ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Dose Escalation ◽  
Three Dimensional ◽  
Conformal Radiation Therapy

scholarly journals Idiopathic Radiation Recall Dermatitis Developing Nine Months after Cessation of Cisplatin Therapy in Treatment of Squamous Cell Carcinoma of the Tonsil

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Stephen M. Melnyk ◽  
Kenneth F. More ◽  
Edward F. Miles
Keyword(s):  
Squamous Cell Carcinoma ◽  
Radiation Therapy ◽  
Radiation Dose ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Combined Therapy ◽  
Suspected Case ◽  
Radiation Recall ◽  
Radiation Recall Dermatitis ◽  
Recall Dermatitis

To report on a suspected case of idiopathic radiation recall dermatitis in an individual nine months after radiation and chemotherapy treatment of squamous cell carcinoma of the right tonsil. Radiation recall dermatitis is the development of a reaction in a previously irradiated area of skin after the administration of an aggravating medication. A review of the literature revealed several cases of radiation recall dermatitis that occur following radiation therapy and the institution of chemotherapy. Other medications have also been implicated in radiation recall dermatitis; however, this patient has not started any new medications since completion of his combined therapy. The patient developed this skin reaction in a distribution pattern identical to the area that received the highest radiation dose suggesting a possible link between radiation recall dermatitis and radiation dose. Radiation recall dermatitis is a reaction that is typically seen shortly after the reinstitution of chemotherapy during radiation therapy. This case illustrates that other medical etiologies are possible and suggests a relationship between radiation recall dermatitis and the total radiation dose an area receives.

scholarly journals The Biological Basis for Enhanced Effects of Proton Radiation Therapy Relative to Photon Radiation Therapy for Head and Neck Squamous Cell Carcinoma

2021 ◽  
Vol 8 (1) ◽  
pp. 3-13
Author(s):  
Li Wang ◽  
Piero Fossati ◽  
Harald Paganetti ◽  
Li Ma ◽  
Maura Gillison ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Squamous Cell Carcinoma ◽  
Radiation Therapy ◽  
Radiation Dose ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Proton Radiation ◽  
X Ray

Abstract Head and neck squamous cell carcinomas (HNSCCs) often present as local-regionally advanced disease at diagnosis, for which a current standard of care is x-ray–based radiation therapy, with or without chemotherapy. This approach provides effective local regional tumor control, but at the cost of acute and late toxicity that can worsen quality of life and contribute to mortality. For patients with human papillomavirus (HPV)–associated oropharyngeal squamous cell carcinoma (SCC) in particular, for whom the prognosis is generally favorable, de-escalation of the radiation dose to surrounding normal tissues without diminishing the radiation dose to tumors is desired to mitigate radiation-related toxic effects. Proton radiation therapy (PRT) may be an excellent de-escalation strategy because of its physical properties (that eliminate unnecessary radiation to surrounding tissues) and because of its biological properties (including tumor-specific variations in relative biological effectiveness [RBE] and linear energy transfer [LET]), in combination with concurrent systemic therapy. Early clinical evidence has shown that compared with x-ray–based radiation therapy, PRT offers comparable disease control with fewer and less severe treatment-related toxicities that can worsen the quality of life for patients with HNSCC. Herein, we review aspects of the biological basis of enhanced HNSCC cell response to proton versus x-ray irradiation in terms of radiation-induced gene and protein expression, DNA damage and repair, cell death, tumor immune responses, and radiosensitization of tumors.

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