Promoter methylation of eight tumor-suppressor genes and the risk of thyroid cancer: A meta-analysis protocol v1 (protocols.io.i9zch76)

protocols.io ◽  
2017 ◽  
Author(s):  
Fatemeh Khatami ◽  
Seyed Mohammad
Keyword(s):  
Thyroid Cancer ◽  
Tumor Suppressor ◽  
Promoter Methylation ◽  
Tumor Suppressor Genes ◽  
Meta Analysis ◽  
Suppressor Genes ◽  
Analysis Protocol

scholarly journals Meta-analysis of promoter methylation in eight tumor-suppressor genes and its association with the risk of thyroid cancer

PLoS ONE ◽  
2017 ◽  
Vol 12 (9) ◽  
pp. e0184892 ◽  
Author(s):  
Fatemeh Khatami ◽  
Bagher Larijani ◽  
Ramin Heshmat ◽  
Abbasali Keshtkar ◽  
Mahsa Mohammadamoli ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Tumor Suppressor ◽  
Promoter Methylation ◽  
Tumor Suppressor Genes ◽  
Meta Analysis ◽  
Suppressor Genes

Association Between Cyclin D1 Polymorphism with CpG Island Promoter Methylation Status of Tumor Suppressor Genes in Gastric Cancer

2010 ◽  
Vol 55 (12) ◽  
pp. 3449-3457 ◽  
Author(s):  
Tomomitsu Tahara ◽  
Tomoyuki Shibata ◽  
Masakatsu Nakamura ◽  
Hiromi Yamashita ◽  
Daisuke Yoshioka ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Suppressor ◽  
Cyclin D1 ◽  
Promoter Methylation ◽  
Tumor Suppressor Genes ◽  
Cpg Island ◽  
Methylation Status ◽  
Suppressor Genes ◽  
Promoter Methylation Status

scholarly journals Promoter methylation of tumor suppressor genes in esophageal squamous cell carcinoma

2013 ◽  
Vol 32 (1) ◽  
pp. 3-11 ◽  
Author(s):  
Ji-Sheng Li ◽  
Jian-Ming Ying ◽  
Xiu-Wen Wang ◽  
Zhao-Hui Wang ◽  
Qian Tao ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Tumor Suppressor ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Promoter Methylation ◽  
Tumor Suppressor Genes ◽  
Suppressor Genes

scholarly journals Promoter methylation of tumor suppressor genes induced by human papillomavirus in cervical cancer

2020 ◽  
Vol 20 (1) ◽  
pp. 955-961 ◽  
Author(s):  
Pattamawadee Yanatatsaneejit ◽  
Kanwalat Chalertpet ◽  
Juthamard Sukbhattee ◽  
Irin Nuchcharoen ◽  
Piyathida Phumcharoen ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Tumor Suppressor ◽  
Promoter Methylation ◽  
Tumor Suppressor Genes ◽  
Suppressor Genes

Detection and Analysis of RNAs Expression Profile for Methylated Candidate Tumor Suppressor Genes in Nasopharyngeal Carcinoma

2019 ◽  
Vol 19 (6) ◽  
pp. 772-782
Author(s):  
Shuang Zhao ◽  
Ye Zhang ◽  
Xujun Liang ◽  
Maoyu Li ◽  
Fang Peng ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Nasopharyngeal Carcinoma ◽  
Tumor Suppressor ◽  
Promoter Methylation ◽  
Tumor Suppressor Genes ◽  
Enrichment Analysis ◽  
Pathway Enrichment Analysis ◽  
Suppressor Genes ◽  
Multiple Tumor

Background:DNA methylation, which acts as an expression regulator for multiple Tumor Suppressor Genes (TSGs), is believed to play an important role in Nasopharyngeal Carcinoma (NPC) development.Methods:We compared the effects of 5-aza-2-deoxycytidine (decitabine, DAC) on gene expression using RNA sequencing in NPC cells.Results:We analyzed Differentially Expressed Genes (DEGs) in NPC cells using DAC demethylation treatment and found that 2182 genes were significantly upregulated (≥ 2-fold change), suggesting that they may play a key role in cell growth, proliferation, development, and death. For data analysis, we used the Gene Ontology database and pathway enrichment analysis of the DEGs to discover differential patterns of DNA methylation associated with changes in gene expression. Furthermore, we evaluated 74 methylated candidate TSGs from the DEGs in NPC cells and summarized these genes in several important signaling pathways frequently disrupted by promoter methylation in NPC tumorigenesis.Conclusion:Our study analyzes the DEGs and identifies a set of genes whose promoter methylation in NPC cells is reversed by DAC. These genes are potential substrates of DNMT inhibitors and may serve as tumor suppressors in NPC cells.

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