scholarly journals Evaluation of aerobic capacity and muscle function in a case series of patients with relapsing polychondritis

2020 ◽  
Vol 4 (1) ◽  
pp. 007-010
Author(s):  
de Oliveira Diego Sales ◽  
dos Santos Alexandre Moura ◽  
Misse Rafael Giovani ◽  
de Souza Jean Marcos ◽  
Lima Fernanda Rodrigues ◽  
...  
Keyword(s):  
Aerobic Capacity ◽  
Muscle Function ◽  
Case Series ◽  
Relapsing Polychondritis

Effects of High Frequency Exercise in Patients before and after Elective Percutaneous Coronary Intervention

2008 ◽  
Vol 7 (4) ◽  
pp. 307-313 ◽  
Author(s):  
Maria Bäck ◽  
Bertil Wennerblom ◽  
Susanna Wittboldt ◽  
Åsa Cider
Keyword(s):  
Aerobic Capacity ◽  
High Frequency ◽  
Muscle Function ◽  
Training Group ◽  
Coronary Intervention ◽  
Control Group ◽  
Maximal Aerobic Capacity ◽  
Elective Percutaneous Coronary Intervention ◽  
Percutaneous Coronary ◽  
Before And After

Background: The aim of this study was to evaluate the effects of high frequency exercise for patients before and after an elective percutaneous coronary intervention (PCI), with special reference to maximal aerobic capacity, muscle function, health related quality of life (HRQoL), waist–hip ratio (WHR) and restenosis. Methods: A randomised, controlled study was performed in Sweden between 2004 and 2006 in thirty-seven patients (five women) with stable coronary artery disease (CAD), age 63.6 ± 6.9 years, randomised to either high frequency exercise or control group. The patients in the training group performed three endurance resistance exercises and trained on a cycle ergometer 30 min, 5 times a week for 8 months at 70% of VO2max. Results: Patients in the training group significantly improved their maximal aerobic capacity (15 (9–46) vs. 8 (0–18)% p ≤ 0.05), shoulder flexion ( p ≤ 0.01), shoulder abduction ( p ≤ 0.01) and heel-lift ( p ≤ 0.05) compared to the control group. There were no significant differences between the groups in HRQoL, WHR and restenosis. Conclusion: High frequency exercise in patients treated with PCI seems to improve maximal aerobic capacity and muscle function, which may reduce the risks of further progression of atherosclerosis. However, further larger studies are needed to fully investigate the effects of exercise in patients with PCI.

The effect of creatine supplementation on muscle function in childhood myositis: A randomized, double-blind, placebo-controlled feasibility study

2020 ◽  
pp. jrheum.191375
Author(s):  
Saunya Dover ◽  
Samantha Stephens ◽  
Jane E. Schneiderman ◽  
Eleanor Pullenayegum ◽  
Greg D. Wells ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Aerobic Capacity ◽  
Muscle Function ◽  
Statistical Significance ◽  
Creatine Supplementation ◽  
Muscle Metabolism ◽  
Resonance Spectroscopy ◽  
Double Blind

Objective To evaluate the feasibility of studying creatine in juvenile dermatomyositis (JDM). Secondary objectives were to determine the effect of creatine on muscle function and metabolism, aerobic capacity, fatigue, physical activity and quality of life, as well as its safety. Methods We conducted a 6-month double-blind, randomized, multiple-baseline design; patients were assigned to creatine or placebo. Feasibility was assessed using attended study visits, completed study procedures, and adherence. Muscle function, aerobic capacity and muscle strength were assessed with standardized exercise tests. Muscle metabolism was assessed using a 31-Phosphorus Magnetic Resonance Spectroscopy protocol. Fatigue, physical activity and quality of life were assessed by questionnaires. Statistical significance was estimated using a randomization (permutation) test. Changes in outcome measures taken at baseline and end-of-study were calculated using paired t tests. Results Median (range) adherence to the study drug was 88.5% (20.5-95.5%) and the proportion of subjects with 80% adherence or higher was 76.9%. There were no missed study visits. There were no statistically significant changes in muscle function, strength, aerobic capacity, disease activity, fatigue, physical activity or quality of life while subjects were on creatine compared to placebo. There were statistically significant adaptations in muscle metabolism (e.g., decrease in change in muscle pH following exercise, and decrease in Phosphate/Phosphocreatine ratio) at the end-of-study, compared to baseline. There were no significant adverse effects. Conclusion Creatine supplementation in children with JDM is feasible to study, and is safe and well-tolerated; it may lead to improvements in muscle metabolism.

Aerobic capacity and skeletal muscle function in children with asthma

2011 ◽  
Vol 96 (6) ◽  
pp. 554-559 ◽  
Author(s):  
Fabiane Villa ◽  
Ana Paula Beltran Moschione Castro ◽  
Antonio Carlos Pastorino ◽  
José Maria Santarém ◽  
Milton Arruda Martins ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Aerobic Capacity ◽  
Muscle Function ◽  
Skeletal Muscle Function ◽  
Children With Asthma

scholarly journals Importance of Chemical Therapy in Relapsing Polychondritis � a Disease with Impact on the Eye Tissues

2020 ◽  
Vol 71 (8) ◽  
pp. 284-291
Author(s):  
Sanda Jurja ◽  
Mihaela Mehedinti ◽  
Rodica Sirbu ◽  
Malina Coman ◽  
Emin Cadar
Keyword(s):  
Drug Treatment ◽  
Rare Disease ◽  
Case Series ◽  
Relapsing Polychondritis ◽  
Team Approach ◽  
Specific Chemical ◽  
Treatment Pathways ◽  
True Incidence ◽  
Ocular Manifestations ◽  
Case Series Report

Relapsing polychondritis (RP), falls into the category of rare diseases. The true incidence and prevalence of this rare disease is unknown. The ocular implications in relapsing polychondritis (RP) are numerous and variable, including mainly inflammation in different structures of the eye. As a complication of this inflammatory condition, a closed secondary angle glaucoma has been described. The purpose of our work is to highlight the diversity of ocular determinations of the same rare disease, including different types of glaucoma that may occur under the same circumstances and to make a detailed analysis of chemical therapies based on drug treatment pathways. The paper includes a report of the cases series admitted to the Clinic of Ophthalmology in St. Andrew Emergency Clinical Hospital, Constanta, between 2007 and 2018, cases analyzed and compared with international literature. One of the cases is a 43-year-old male patient with bilateral open-angle bilateral glaucoma. Other cases with RP, are patients of 41 and 46 years old, respectively, presented with unilateral episcleritis. This case series report aims to show that RP can associate even more protean ocular manifestations than already discussed in the literature, with specific chemical therapies and to emphasize the need for team approach and ophthalmological monitoring in the care of RP patients with chemical therapy (drug treatment) for each patient.

scholarly journals Development and Evaluation of a Prosthetic Ankle Emulator with an Artificial Soleus and Gastrocnemius

2021 ◽  
Author(s):  
David M Ziemnicki ◽  
Joshua M. Caputo ◽  
Kirsty A. McDonald ◽  
Karl E. Zelik
Keyword(s):  
Activities Of Daily Living ◽  
Soleus Muscle ◽  
Muscle Function ◽  
Knee Flexion ◽  
Daily Living ◽  
Case Series ◽  
Calf Muscle ◽  
Wide Range ◽  
Transtibial Prosthesis ◽  
Force Tracking

Abstract In individuals with transtibial limb loss, a contributing factor to mobility-related challenges is the disruption of biological calf muscle function due to transection of the soleus and gastrocnemius. Powered prosthetic ankles can restore primary function of the mono-articular soleus muscle, which contributes to ankle plantarflexion. In effect, a powered ankle acts like an artificial soleus. However, the biarticular gastrocnemius connection that simultaneously contributes to ankle plantarflexion and knee flexion torques remains missing, and there are currently no commercially-available prosthetic ankles that incorporate an artificial gastrocnemius. The goal of this work is to describe the design of a novel emulator capable of independently controlling artificial soleus and gastrocnemius behaviors for transtibial prosthesis users during walking. To evaluate the emulator's efficacy in controlling the artificial gastrocnemius behaviors, a case series walking study was conducted with 4 transtibial prosthesis users. Data from this case series showed that the emulator exhibits low resistances to the user's leg swing, low hysteresis during passive spring emulation, and accurate force tracking for a range of artificial soleus and gastrocnemius behaviors. The emulator presented in this paper is versatile and can facilitate experiments studying the effects of various artificial soleus and gastrocnemius dynamics on gait or other movement tasks. Using this system, it is possible to address existing knowledge gaps and explore a wide range of artificial soleus and gastrocnemius behaviors during gait and potentially other activities of daily living.

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