scholarly journals Laryngeal Primary Amyloidosis: Differential Diagnosis of Localized Granulomatosis with Polyangiitis. Report of Two Cases

2017 ◽  
Vol 1 (1) ◽  
pp. 017-019
Author(s):  
C de Queiroz Pimentel ◽  
LD Lanzarin ◽  
FA de Oliveira Santana ◽  
RM Rodrigues Pereira ◽  
M Levy-Neto
Keyword(s):  
Differential Diagnosis ◽  
Granulomatosis With Polyangiitis ◽  
Primary Amyloidosis

scholarly journals IgG4-associated disease in differential diagnosis of inflammatory orbitopathy

2019 ◽  
Vol 65 (5) ◽  
pp. 367-372
Author(s):  
Yaroslav O. Grusha ◽  
Dilyara S. Ismailova ◽  
Natalya Yu. Sviridenko ◽  
Pavel I. Novikov ◽  
Alla M. Kovrigina
Keyword(s):  
Differential Diagnosis ◽  
Gold Standard ◽  
Granulomatosis With Polyangiitis ◽  
Plasma Cells ◽  
Eye Disease ◽  
Systemic Diseases ◽  
Long Period ◽  
Inappropriate Treatment ◽  
Systemic Inflammatory Disease ◽  
Systemic Process

IgG4-associated disease (IgG4-RD) is a systemic inflammatory disease characterized by tumorlike sclerosing masses in different organs. Differential diagnosis in orbital IgG4-RD includes majority of conditions, such as thyroid eye disease (TED), sarcoidosis, granulomatosis with polyangiitis, idiopatic orbital inflammation, limphoproliferative diseases and others. A case of IgG4-RD with different organs involvement and complicated differential diagnosis is presented. This case demonstrates very uncommon manifestation of IgG4-RD, when orbital involvement was very similar with TED. Systemic process was not recognized during a long period of time and diagnosis of IgG4-RD was established only after biopsy of abnormally increased lacrimal gland. Differential diagnosis included other systemic diseases, first of all sarcoidosis, GPA, and lymphoma. Biopsy results were consistent with the gold standard of diagnosis, e. g. more than 40% of plasma cells were IgG4 positive. This case demonstrates the necessity of orbital biopsy before starting immunosuppression to avoid inappropriate treatment strategy.

scholarly journals Differential diagnosis of granulomatous lung disease: clues and pitfalls

2017 ◽  
Vol 26 (145) ◽  
pp. 170012 ◽  
Author(s):  
Shinichiro Ohshimo ◽  
Josune Guzman ◽  
Ulrich Costabel ◽  
Francesco Bonella
Keyword(s):  
Differential Diagnosis ◽  
Lung Diseases ◽  
Granulomatosis With Polyangiitis ◽  
Wide Spectrum ◽  
Clinical Manifestations ◽  
Needle Aspiration ◽  
Endobronchial Ultrasound ◽  
Eosinophilic Granulomatosis With Polyangiitis ◽  
High Resolution Computed Tomography ◽  
Transbronchial Needle Aspiration

Granulomatous lung diseases are a heterogeneous group of disorders that have a wide spectrum of pathologies with variable clinical manifestations and outcomes. Precise clinical evaluation, laboratory testing, pulmonary function testing, radiological imaging including high-resolution computed tomography and often histopathological assessment contribute to make a confident diagnosis of granulomatous lung diseases. Differential diagnosis is challenging, and includes both infectious (mycobacteria and fungi) and noninfectious lung diseases (sarcoidosis, necrotising sarcoid granulomatosis, hypersensitivity pneumonitis, hot tub lung, berylliosis, granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, rheumatoid nodules, talc granulomatosis, Langerhans cell histiocytosis and bronchocentric granulomatosis). Bronchoalveolar lavage, endobronchial ultrasound-guided transbronchial needle aspiration, transbronchial cryobiopsy, positron emission tomography and genetic evaluation are potential candidates to improve the diagnostic accuracy for granulomatous lung diseases. As granuloma alone is a nonspecific histopathological finding, the multidisciplinary approach is important for a confident diagnosis.

scholarly journals Clinical case of observation of patient with primary systemic amyloidosis

2020 ◽  
pp. 46-48
Author(s):  
Yu. N. Fedulaev ◽  
N. V. Khabazov ◽  
A. Yu. Chuprakova ◽  
M. V. Ezhikova ◽  
A. A. Kurshin ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Histological Examination ◽  
Clinical Picture ◽  
Clinical Case ◽  
Final Diagnosis ◽  
Amyloid Deposition ◽  
Systemic Amyloidosis ◽  
Primary Amyloidosis ◽  
Amyloid Protein

Amyloidosis combines diseases that are characterized by extracellular deposition of a specific insoluble fibrillar amyloid protein. The prevalence of amyloidosis is an average of 10 cases per 100 thousand people. The clinic of the disease is polymorphic and depends on the organ with amyloid deposition. The article discusses the clinical case of systemic amyloidosis with damage to the stomach, liver and other organs. The differential diagnosis was carried out with tuberculosis, cancer, cirrhosis. The final diagnosis was made by histological examination of biopsy samples of the liver and stomach. Difficulties in diagnosing primary amyloidosis are due to the attrition and non‑specificity of the clinical picture of the disease. Amyloidosis is diagnosed based on organ biopsy data.

scholarly journals Difficulties in the differential diagnosis of granulomatosis with polyangiitis and scarring pemphigoid

2020 ◽  
Vol 10 (5) ◽  
pp. 398-402
Author(s):  
N. A. Magdeeva ◽  
A. A. Kobriseva ◽  
M. A. Reznikova ◽  
I. F. Melehina
Keyword(s):  
Differential Diagnosis ◽  
Renal Damage ◽  
Clinical Case ◽  
Granulomatosis With Polyangiitis ◽  
Systemic Vasculitis ◽  
Organ Damage ◽  
Pathological Process ◽  
Poor Knowledge ◽  
Eye Damage ◽  
Positive Results

The article presents a clinical case of a rare pathology. The patient for several years visited various specialists. In connection with a similar clinical picture, multi-organ damage, differential diagnosis was performed between systemic vasculitis (granulomatosis with polyangiitis) and scarring pemphigoid.The mucous membrane of the mouth and nose is involved in the pathological process with granulomatosis with polyangiitis in the form of ulcerative defects, which subsequently lead to deformation of the nose. The danger with this systemic vasculitis is renal damage with the development of nephritis, renal failure. With scarring pemphigoid, eye damage is typical. In granulomatosis with polyangiitis, damage to the organ of vision is also sometimes possible, but mainly in the form of an orbit pseudotumor. Despite the fact that treatment for both forms of pathology involves the use of glucocorticoids and cytostatics, with a scarring pemphigoid, the main care is provided by dermatologists and ophthalmologists, while the diagnosis and treatment of systemic vasculitis is the task of rheumatologists. One of the criteria for a scarring pemphigoid is loss of vision. However, in this case, it was possible to establish a diagnosis, obtain the first positive results of therapy before the patient shows signs of disability. So, there is a hope for the possibility of preserving vision and a favorable outcome. The rarity of the disease and its poor knowledge, difficulties in diagnosis and the absence of certain standards of therapy, this diagnosis requires more attention from the specialists.

scholarly journals Giant Thrombosis at Left Anterior Descending Artery Aneurysm in a 10-Year Old Boy with Granulomatosis with Polyangiitis

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Ehsan Aghaei Moghadam ◽  
Nahid Aslani ◽  
Helia Mojtabavi ◽  
Farnoosh Larti ◽  
Azin Ghamari ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Coronary Artery ◽  
Rare Case ◽  
Granulomatosis With Polyangiitis ◽  
Coronary Artery Aneurysm ◽  
Artery Aneurysm ◽  
Necrotizing Vasculitis ◽  
Annual Incidence Rate ◽  
Case Presentation ◽  
Coronary Aneurysms

Granulomatosis with polyangiitis (GPA), necrotizing vasculitis of small and medium-sized vessels, is traditionally believed to mainly affect respiratory tract with additional focal kidney involvements as its primary manifestations with a relatively rare annual incidence rate of 20-50 cases per million. Six percent of the affected cases have cardiac involvements; among which, aneurysms comprise the lowest penetrance. By this paper, we aim to cast light on clinical diagnostic and treatment methods of a rare case presentation, a 10-year-old male GPA patient, diagnosed with massive thrombosis at his coronary artery aneurysm. GPA should be considered as differential diagnosis of prolong fever and coronary aneurysms in adolescents.

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