scholarly journals The analgesic effect of tramadol versus morphine in the treatment of cancer pain in National Cancer Institute, University of Gezira, Sudan (2018)

2021 ◽  
pp. 012-019
Author(s):  
Mohamed Ibrahim Ghazi Gasmalla ◽  
Owish Khalid Abbas ◽  
Zaroug Mohammed Suliman
Keyword(s):  
Cancer Pain ◽  
National Cancer Institute ◽  
Analgesic Effect

Antidepressants in Cancer Pain

1991 ◽  
Vol 7 (4) ◽  
pp. 42-44 ◽  
Author(s):  
Alberto E. Panerai ◽  
Mauro Bianchi ◽  
Paola Sacerdote ◽  
Carla Ripamonti ◽  
Vittorio Ventafridda ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Cancer Pain ◽  
Beneficial Effect ◽  
Nerve Injury ◽  
Analgesic Effect ◽  
Tricyclic Antidepressants ◽  
Antidepressant Drugs ◽  
Depressive Illness ◽  
Morphine Analgesia

Studies conducted in recent years have helped define the role of antidepressant drugs in the management of cancer pain. The anti-nociceptive action of these agents seems to be independent of beneficial effect on depression or mood. Among antidepressant drugs, those of the tricyclic class are preferred when an analgesic effect is sought. Their primary application is for pain due to nerve injury, so-called “neuropathic pain”. Although the co-administration of tricyclic antidepressants may increase plasma morphine concentrations, any potentiation of morphine analgesia is thought not to be due to an increased bioavailability of the opiate, but to an intrinsic analgesic effect of antidepressants. On this basis, the use of antidepressants in combination with opioids for the treatment of cancer pain is suitable when a component of deafferentation is present or when there is concomitant depressive illness.

Analgesic effect of subarachnoid neostigmine in two patients with cancer pain

Pain ◽  
1996 ◽  
Vol 66 (2) ◽  
pp. 389-391 ◽  
Author(s):  
Jyrson G. Klamt ◽  
Marlene P. Dos Reis ◽  
José Barbieri Neto ◽  
Wiliam A. Prado
Keyword(s):  
Cancer Pain ◽  
Analgesic Effect ◽  
Patients With Cancer

Evaluation of analgesic effect and safety of fentanyl transdermal patch for cancer pain as the first line

2010 ◽  
Vol 18 (6) ◽  
pp. 761-764 ◽  
Author(s):  
Yoshiyuki Hoya ◽  
Tomoyoshi Okamoto ◽  
Katsuhiko Yanaga
Keyword(s):  
Cancer Pain ◽  
Analgesic Effect ◽  
Transdermal Patch ◽  
First Line

Blocking EphB1 Receptor Forward Signaling in Spinal Cord Relieves Bone Cancer Pain and Rescues Analgesic Effect of Morphine Treatment in Rodents

2011 ◽  
Vol 71 (13) ◽  
pp. 4392-4402 ◽  
Author(s):  
Su Liu ◽  
Wen-Tao Liu ◽  
Yue-Peng Liu ◽  
Hai-Long Dong ◽  
Mark Henkemeyer ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Cancer Pain ◽  
Analgesic Effect ◽  
Bone Cancer ◽  
Bone Cancer Pain ◽  
Morphine Treatment

scholarly journals Quercetin Reduces Ehrlich Tumor-Induced Cancer Pain in Mice

2015 ◽  
Vol 2015 ◽  
pp. 1-18 ◽  
Author(s):  
Cassia Calixto-Campos ◽  
Mab P. Corrêa ◽  
Thacyana T. Carvalho ◽  
Ana C. Zarpelon ◽  
Miriam S. N. Hohmann ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cancer Pain ◽  
Analgesic Effect ◽  
Biological Effects ◽  
Neutrophil Recruitment ◽  
Mammary Adenocarcinoma ◽  
Myeloperoxidase Activity ◽  
Ehrlich Tumor ◽  
Nociceptive Responses ◽  
And Oxidative Stress

Cancer pain directly affects the patient’s quality of life. We have previously demonstrated that the subcutaneous administration of the mammary adenocarcinoma known as Ehrlich tumor induces pain in mice. Several studies have shown that the flavonoid quercetin presents important biological effects, including anti-inflammatory, antioxidant, analgesic, and antitumor activity. Therefore, the analgesic effect and mechanisms of quercetin were evaluated in Ehrlich tumor-induced cancer pain in mice. Intraperitoneal (i.p.) treatments with quercetin reduced Ehrlich tumor-induced mechanical and thermal hyperalgesia, but not paw thickness or histological alterations, indicating an analgesic effect without affecting tumor growth. Regarding the analgesic mechanisms of quercetin, it inhibited the production of hyperalgesic cytokines IL-1βand TNFαand decreased neutrophil recruitment (myeloperoxidase activity) and oxidative stress. Naloxone (opioid receptor antagonist) inhibited quercetin analgesia without interfering with neutrophil recruitment, cytokine production, and oxidative stress. Importantly, cotreatment with morphine and quercetin at doses that were ineffective as single treatment reduced the nociceptive responses. Concluding, quercetin reduces the Ehrlich tumor-induced cancer pain by reducing the production of hyperalgesic cytokines, neutrophil recruitment, and oxidative stress as well as by activating an opioid-dependent analgesic pathway and potentiation of morphine analgesia. Thus, quercetin treatment seems a suitable therapeutic approach for cancer pain that merits further investigation.

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