scholarly journals The effects of vitamin D, C, E and zinc supplementation in chronic non specific low back pain

2021 ◽  
pp. 008-011
Author(s):  
Mehmet Unal ◽  
Gonul Gulcelik Ertunc ◽  
Ahmet Sezgin Burak ◽  
Muammer Kocaturk
Keyword(s):  
Vitamin D ◽  
Low Back Pain ◽  
Back Pain ◽  
Zinc Supplementation ◽  
Low Back

scholarly journals Assessment of Vitamin D Levels in Patients Presenting With Chronic Low Back Pain at a Tertiary Care Hospital

Cureus ◽  
2020 ◽  
Author(s):  
Mukesh Kumar ◽  
Masroor Ahmed ◽  
Ghulam Hussain ◽  
Muhammad Bux ◽  
Naveed Ahmed ◽  
...  
Keyword(s):  
Vitamin D ◽  
Low Back Pain ◽  
Back Pain ◽  
Chronic Low Back Pain ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Low Back ◽  
Vitamin D Levels

scholarly journals Vitamin D Deficiency Is Associated with Muscle Atrophy and Reduced Mitochondrial Function in Patients with Chronic Low Back Pain

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Katarzyna Patrycja Dzik ◽  
Wojciech Skrobot ◽  
Katarzyna Barbara Kaczor ◽  
Damian Jozef Flis ◽  
Mateusz Jakub Karnia ◽  
...  
Keyword(s):  
Vitamin D ◽  
Low Back Pain ◽  
Back Pain ◽  
Protein Content ◽  
Vitamin D Deficiency ◽  
Muscle Atrophy ◽  
Mitochondrial Function ◽  
Chronic Low Back Pain ◽  
Low Back ◽  
Multifidus Muscle

Recent studies show that vitamin D deficiency may be responsible for muscle atrophy. The purpose of this study was to investigate markers of muscle atrophy, signalling proteins, and mitochondrial capacity in patients with chronic low back pain with a focus on gender and serum vitamin D level. The study involved patients with chronic low back pain (LBP) qualified for posterior lumbar interbody fusion (PLIF). Patients were divided into three groups: supplemented (SUPL) with vitamin D (3200 IU/day for 5 weeks), placebo with normal levels of vitamin D (SUF), and the placebo group with vitamin D deficiency (DEF). The marker of muscle atrophy including atrogin-1 and protein content for IGF-1, Akt, FOXO3a, PGC-1α, and citrate synthase (CS) activity were determined in collected multifidus muscle. In the paraspinal muscle, IGF-1 levels were higher in the SUF group as compared to both the SUPL and DEF groups (p<0.05). In the SUPL group, we found significantly increased protein content for pAkt (p<0.05) and decreased level of FOXO3a (p<0.05). Atrogin-1 content was significantly different between men and women (p<0.05). The protein content of PGC-1α was significantly higher in the SUF group as compared to the DEF group (p<0.05). CS activity in the paraspinal muscle was higher in the SUPL group than in the DEF group (p<0.05). Our results suggest that vitamin D deficiency is associated with elevated oxidative stress, muscle atrophy, and reduced mitochondrial function in the multifidus muscle. Therefore, vitamin D-deficient LBP patients might have reduced possibilities on early and effective rehabilitation after PLIF surgery.

Vitamin D Deficiency and Chronic Low Back Pain in Saudi Arabia

Spine ◽  
2003 ◽  
Vol 28 (2) ◽  
pp. 177-179 ◽  
Author(s):  
Saud Al Faraj ◽  
Khalaf Al Mutairi
Keyword(s):  
Vitamin D ◽  
Saudi Arabia ◽  
Low Back Pain ◽  
Back Pain ◽  
Vitamin D Deficiency ◽  
Chronic Low Back Pain ◽  
Low Back

Vitamin D supplementation attenuates oxidative stress in paraspinal skeletal muscles in patients with low back pain

2017 ◽  
Vol 118 (1) ◽  
pp. 143-151 ◽  
Author(s):  
Katarzyna Dzik ◽  
Wojciech Skrobot ◽  
Damian Jozef Flis ◽  
Mateusz Karnia ◽  
Witold Libionka ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Low Back Pain ◽  
Back Pain ◽  
Skeletal Muscles ◽  
Vitamin D Supplementation ◽  
Low Back

scholarly journals High Prevalence of Hypovitaminosis D in Patients with Low Back Pain: Evidence from Meta-Analysis

2018 ◽  
Vol 1 (21;1) ◽  
pp. E389-E399 ◽  
Author(s):  
Dipika Bansal
Keyword(s):  
Vitamin D ◽  
Sensitivity Analysis ◽  
Low Back Pain ◽  
Back Pain ◽  
Publication Bias ◽  
Meta Analysis ◽  
Hypovitaminosis D ◽  
Low Back ◽  
Pooled Prevalence ◽  
High Prevalence

Background: Emerging evidence suggests an association between vitamin D deficiency and low back pain (LBP). Objective: To pool evidence on the prevalence of hypovitaminosis D in patients with LBP. Study Design: Meta-analysis. Methods: A comprehensive literature search was done in PubMed, Cochrane Database, and Google scholar for observational studies including cohort, cross sectional (CS), and case control (CC) evaluating the prevalence of hypovitaminosis D in LBP patients. The primary outcome assessed was a prevalence of hypovitaminosis D in patients with LBP, presented as weighted pooled prevalence ratio (WPPR) with 95% confidence interval (CI) using the random effects model. Heterogeneity and inconsistency of the measurements were identified through Cochran’s Q statistic and I2 statistic. We also performed sensitivity analysis, publication bias (using funnel plot and Begg’s test), and subgroup analysis. Results: Fourteen studies (6 were CC, 6 CS, and 2 cohort) involving 2602 patients were included in the final analysis. The WPPR (95% CI) of hypovitaminosis D in patients with LBP was found to be 0.72 (0.60–0.83). Marked heterogeneity was observed, median quality score of all studies was 7.5 interquartile range (IQR) (6.2 - 8.7) on a scale of 0 to 11. Sensitivity analysis showed robustness of the results. The WPPR of hypovitaminosis D was lower in CS at 0.60 (0.35–0.85) as compared to CC studies at 0.81 (0.72–0.90) (P < 0.01). The WPPR was lower in men at 0.74 (0.63–0.86) as compared to women at 0.84 (0.78–0.89) (P < 0.01). No publication bias was observed. Limitations: Heterogeneity in the cut off level of vitamin D to classify the included patients as vitamin D deficient. Conclusions: The high prevalence of hypovitaminosis D was observed in patients with LBP. This provides a chance to screen the deficiency and correct it by supplementation, which can be therapeutic adjunct in the management of LBP patients. Key words: Low back pain, hypovitaminosis D, meta-analysis, pooled prevalence, systematic review

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